digoxin has been researched along with mitemcinal* in 1 studies
1 other study(ies) available for digoxin and mitemcinal
Article | Year |
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Nonlinear intestinal pharmacokinetics of mitemcinal, the first acid-resistant non-peptide motilin receptor agonist, in rats.
The objective was to investigate the mechanism of nonlinear pharmacokinetics of mitemcinal, the first acid-resistant non-peptide motilin agonist, in rats. Super-proportional increases of the cumulative rates of radioactivity excreted into bile and urine following oral administration of [3H]-mitemcinal suggested nonlinear absorption of mitemcinal in rats. To evaluate the fraction dose absorbed (Fa) and intestinal availability (Fg), [3H]-mitemcinal was orally administrated to rats, and tritium radioactivity and unchanged mitemcinal concentration were determined in the portal blood. Fa values for 0.2 mg/kg1, 0.5 mg/kg, and 5.0 mg/kg dose groups were 0.314, 0.353, and 0.569, respectively. Corresponding Fg values were 0.243, 0.296, and 0.513, respectively. In Caco-2 experiments, the permeation of [3H]-mitemcinal in the secretory direction was larger than in the absorptive direction and was inhibited by P-glycoprotein (P-gp) substrate digoxin. The results indicate that the saturation of P-gp-mediated membrane permeation and intestinal metabolism causes the nonlinear pharmacokinetics of mitemcinal in rats. Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Caco-2 Cells; Cell Membrane Permeability; Digoxin; Dose-Response Relationship, Drug; Erythromycin; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide | 2007 |