digoxin has been researched along with chloramine* in 1 studies
1 other study(ies) available for digoxin and chloramine
Article | Year |
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Development of glycoside-bound radiopharmaceuticals: novel radioiodination method for digoxin.
We combined 2-hydroxy-3-methylbenzoylhydrazide (HMBH) with glycosides as a novel method for the radioiodination of physiologically active glycosides. This method was tested using digoxin, which is one of the cardiac glycosides. A digoxin-HMBH conjugate was synthesized by periodate cleavage of the third sugar ring, and was readily radiolabeled with Na[125I] by the chloramine-T method. 125I labelled digoxin-HMBH conjugate retained Na+, K(+)-ATPase binding in vivo and in vitro, and also retained immunoreactivity to an anti-digoxin antibody. Thus, this 125I labelled digoxin-HMBH conjugate represents a potential radiopharmaceutical for Na+, K(+)-ATPase imaging, as well as for the radioimmunoassay of digoxin. Topics: Animals; Antibody Specificity; Chloramines; Digoxin; Guinea Pigs; Iodine Radioisotopes; Isotope Labeling; Myocardium; Ouabain; Radioimmunoassay; Sodium-Potassium-Exchanging ATPase | 1994 |