digoxin and bufotalin

digoxin has been researched along with bufotalin* in 2 studies

Other Studies

2 other study(ies) available for digoxin and bufotalin

ArticleYear
Structure-activity relationship analysis of bufadienolide-induced in vitro growth inhibitory effects on mouse and human cancer cells.
    Journal of natural products, 2013, Jun-28, Volume: 76, Issue:6

    The in vitro growth inhibitory effects of 27 bufadienolides and eight degradation products, with two cardenolides (ouabain and digoxin) chosen as reference compounds, were analyzed by means of an MTT colorimetric assay in six human and two mouse cancer cell lines. A structure-activity analysis was then performed to highlight the most important substituents relating to the in vitro growth inhibitory activity of bufadienolides in cancer cells. Thus, the current study revealed that various bufadienolides, including gamabufotalin rhamnoside (1a), bufotalin (2a), and hellebrin (3a), displayed higher growth inhibitory activities for various human cancer cell lines when compared to ouabain and digoxin. Gamabufotalin rhamnoside (1a) was the only compound that displayed growth inhibitory effects of <1 μM in mouse cancer cells that expressed mutated forms of the Na(+),K(+)-ATPase α-1 subunit. In addition, all genins and degradation products displayed weaker (if any) in vitro growth inhibitory effects on cancer cells when compared to their respective glycosylated homologue, with the exception of hellebrigenin (3b), which was as active as hellebrin (3a).

    Topics: Animals; Bufanolides; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Structure; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship

2013
Digitalis toxicity caused by toad venom.
    Chest, 1992, Volume: 102, Issue:3

    A case of toad venom-induced digitalis toxicity is presented. A pause of 13.5 s was noted in the patient taking a Chinese medication which contained toad venom. This is the first case report of clinical digitalis toxicity related to toad venom in Western society.

    Topics: Aged; Aged, 80 and over; Amphibian Venoms; Arrhythmias, Cardiac; Bufanolides; Digoxin; Drugs, Chinese Herbal; Electrocardiography; Humans; Male; Sodium-Potassium-Exchanging ATPase; Syncope

1992