digoxin and biotin-hydrazide

digoxin has been researched along with biotin-hydrazide* in 1 studies

Other Studies

1 other study(ies) available for digoxin and biotin-hydrazide

Article	Year
Synthesis and structural characterization of a cardioactive biotinylated digoxin analogue. Clinical biochemistry, 1991, Volume: 24, Issue:6 We have biotinylated the terminal glycose of digoxin by reaction of the periodate-oxidized steroid with biotin hydrazide. A biotinylated product (BD-1) was formed which retained significant digoxin receptor (Na+/K+ ATPase) binding activity. Sustained reaction resulted in a second biotinylated product (BD-2) which showed reduced receptor binding activity. The products were characterized by FAB mass spectroscopy and shown to be the mono- and di-biotinylated digoxin conjugates of the oxidized glycose moiety. These analogues may prove useful in determining the subcellular site of digoxin binding. Topics: Biotin; Carbohydrate Sequence; Cardiotonic Agents; Digoxin; Humans; Molecular Sequence Data; Molecular Structure; Receptors, Drug	1991

Article

Year

Synthesis and structural characterization of a cardioactive biotinylated digoxin analogue.

Clinical biochemistry, 1991, Volume: 24, Issue:6

We have biotinylated the terminal glycose of digoxin by reaction of the periodate-oxidized steroid with biotin hydrazide. A biotinylated product (BD-1) was formed which retained significant digoxin receptor (Na+/K+ ATPase) binding activity. Sustained reaction resulted in a second biotinylated product (BD-2) which showed reduced receptor binding activity. The products were characterized by FAB mass spectroscopy and shown to be the mono- and di-biotinylated digoxin conjugates of the oxidized glycose moiety. These analogues may prove useful in determining the subcellular site of digoxin binding.

Topics: Biotin; Carbohydrate Sequence; Cardiotonic Agents; Digoxin; Humans; Molecular Sequence Data; Molecular Structure; Receptors, Drug

1991