digoxin and barium-chloride

Antiarrhythmic activity of Mexicord-Poland and Mexitil-Böehringer Ingelheim (D) was compared. In three models of experimentally evoked arrhythmia in animals, in used doses, both of examined preparations in the same degree prevented the occurrence of arrhythmia.

Topics: Aconitine; Animals; Arrhythmias, Cardiac; Barium Compounds; Chlorides; Digoxin; Electrocardiography; Female; Guinea Pigs; Male; Mexiletine; Rats

In pentobarbital-anaesthetized (60 mg/kg i.p.) guinea-pigs injections of Na salicylate (50 and 100 mg/kg i.v.) had a protective effect against arrhythmias induced by digoxin or BaCl2. A lower (25 mg/kg) and a higher (200 mg/kg) dose exerted no clearcut antiarrhythmic effect. Plasma concentrations of Na salicylate up to 1 mg/ml influenced neither the heart rate nor the ECG parameters. The antiarrhythmic effect of the drug may be explained by an inhibition of cardiac cyclooxygenase.

Topics: Animals; Arrhythmias, Cardiac; Barium; Barium Compounds; Blood Pressure; Chlorides; Digoxin; Electrocardiography; Guinea Pigs; Heart Rate; Male; Sodium Salicylate