difluoromethylene diphosphonate has been researched along with guanine in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hikishima, S; Isobe, M; Koyanagi, S; Shibuya, S; Shimeno, H; Soeda, S; Yokomatsu, T | 1 |
| Bzowska, A; Hashimoto, M; Hikishima, S; Magnowska, L; Yokomatsu, T | 1 |
| Breer, K; Bzowska, A; Glavas-Obrovac, L; Hashimoto, M; Hikishima, S; Magnowska, L; Suver, M; Wielgus-Kutrowska, B; Yokomatsu, T | 1 |
3 other study(ies) available for difluoromethylene diphosphonate and guanine
| Article | Year |
|---|---|
Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors.
Topics: Clodronic Acid; Cyclopropanes; Drug Design; Enzyme Inhibitors; Fluorides; Guanine; Hypoxanthines; Kinetics; Methylation; Phosphoric Acids; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Substrate Specificity | 2006 |
Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.
Topics: Animals; Cattle; Clodronic Acid; Enzyme Inhibitors; Erythrocytes; Guanine; Humans; Models, Molecular; Purine-Nucleoside Phosphorylase; Spleen; Substrate Specificity | 2007 |
9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.
Topics: Biochemistry; Cell Line, Tumor; Cell Membrane; Clodronic Acid; Endocytosis; Guanine; Humans; Jurkat Cells; Kinetics; Lymphocytes; Models, Chemical; Organophosphonates; Permeability; Protein Binding; Purine-Nucleoside Phosphorylase | 2010 |