difluoromethylene diphosphonate has been researched along with clodronic acid in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rowe, DJ | 1 |
| Etre, LA; Rowe, DJ | 1 |
| Rowe, DJ; Schmidt, LJ | 1 |
| Shibuya, S | 1 |
| Hikishima, S; Isobe, M; Koyanagi, S; Shibuya, S; Shimeno, H; Soeda, S; Yokomatsu, T | 1 |
| Bearne, SL; Mirzaei, F; Sharifi, A; Taylor, SD | 1 |
| Bzowska, A; Hashimoto, M; Hikishima, S; Magnowska, L; Yokomatsu, T | 1 |
| Berkowitz, DB; Eggen, M; Maeng, JH; Panigrahi, K; Shen, Q | 1 |
| Breer, K; Bzowska, A; Glavas-Obrovac, L; Hashimoto, M; Hikishima, S; Magnowska, L; Suver, M; Wielgus-Kutrowska, B; Yokomatsu, T | 1 |
| Ellman, JA; Grundner, C; Rawls, KA | 1 |
| Yokomatsu, T | 1 |
3 review(s) available for difluoromethylene diphosphonate and clodronic acid
| Article | Year |
|---|---|
[Synthesis of phosphonic acid and phosphinic acid derivatives for development of biologically active compounds].
Topics: Chemistry, Organic; Clodronic Acid; Cyclopropanes; Drug Design; Humans; Nucleotides; Organic Chemistry Phenomena; Organophosphonates; Protein Tyrosine Phosphatases; Sphingomyelin Phosphodiesterase; Sphingomyelins | 2004 |
The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction.
Topics: Clodronic Acid; MAP Kinase Signaling System; Melatonin; Phosphorylation; Phosphoserine; Protein Interaction Domains and Motifs; Signal Transduction; Tumor Suppressor Protein p53 | 2009 |
Development of Biologically Active Compounds on the Basis of Phosphonic and Phosphinic Acid Functionalities.
Topics: Clodronic Acid; Dipeptides; Drug Discovery; Enzyme Inhibitors; Hydrolysis; Organophosphonates; Peptide Hydrolases; Phosphinic Acids; Phosphorous Acids; Protein Tyrosine Phosphatases; Purine-Nucleoside Phosphorylase; Sphingomyelin Phosphodiesterase; Stereoisomerism; Thrombin | 2017 |
8 other study(ies) available for difluoromethylene diphosphonate and clodronic acid
| Article | Year |
|---|---|
Effects of a fluorinated bisphosphonate on bone remodeling in vivo.
Topics: Animals; Body Weight; Bone and Bones; Bone Development; Calcium; Clodronic Acid; Diphosphonates; Etidronic Acid; Fluorine; Growth Plate; Male; Microradiography; Phosphorus; Random Allocation; Rats; Rats, Inbred Strains | 1985 |
Uptake of a fluorinated bisphosphonate by cultured bones.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium Radioisotopes; Clodronic Acid; Culture Techniques; Diphosphonates; Electron Probe Microanalysis; Embryo, Mammalian; Rats; Rats, Inbred Strains; Time Factors | 1988 |
The effects of diphosphonates on alveolar bone loss.
Topics: Animals; Bone Resorption; Clodronic Acid; Diphosphonates; Disease Models, Animal; Female; Male; Periodontitis; Rats | 1987 |
Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors.
Topics: Clodronic Acid; Cyclopropanes; Drug Design; Enzyme Inhibitors; Fluorides; Guanine; Hypoxanthines; Kinetics; Methylation; Phosphoric Acids; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Substrate Specificity | 2006 |
Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate.
Topics: Clodronic Acid; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Uracil Nucleotides | 2006 |
Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.
Topics: Animals; Cattle; Clodronic Acid; Enzyme Inhibitors; Erythrocytes; Guanine; Humans; Models, Molecular; Purine-Nucleoside Phosphorylase; Spleen; Substrate Specificity | 2007 |
9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.
Topics: Biochemistry; Cell Line, Tumor; Cell Membrane; Clodronic Acid; Endocytosis; Guanine; Humans; Jurkat Cells; Kinetics; Lymphocytes; Models, Chemical; Organophosphonates; Permeability; Protein Binding; Purine-Nucleoside Phosphorylase | 2010 |
Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.
Topics: Clodronic Acid; Enzyme Inhibitors; Molecular Structure; Molecular Weight; Mycobacterium tuberculosis; Protein Tyrosine Phosphatases; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2010 |