diethylnitrosamine has been researched along with dimethylnitrosamine in 196 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 130 (66.33) | 18.7374 |
| 1990's | 34 (17.35) | 18.2507 |
| 2000's | 9 (4.59) | 29.6817 |
| 2010's | 15 (7.65) | 24.3611 |
| 2020's | 8 (4.08) | 2.80 |
| Authors | Studies |
|---|---|
| Jurs, PC; Rose, SL | 1 |
| Brewer, WS; Draper, AC | 1 |
| Archer, MC; Rogers, AE; Sanchez, O; Wishnok, JS | 1 |
| Diehl, B; Habs, M; Krüger, FW; Schmähl, D | 1 |
| Terao, K | 1 |
| Arcos, JC; Argus, MF; Bryant, GM; Pastor, KM | 1 |
| Bauknecht, T; Bayer, U; Vogel, W; Wild, D | 1 |
| Freed, HJ; Huberman, E; Langenbach, R | 1 |
| Craddock, VM | 2 |
| Matsushima, T; Sugimura, T | 1 |
| Khudoley, VV | 1 |
| McConn, J; Piette, LH; Ramseyer, J; Saprin, AN | 1 |
| Betz, EH; Fridman-Manduzio, A; Gol-Winkler, R; Goutier, R | 1 |
| Roane, PR | 1 |
| Archer, MC; Chau, IY; Dagani, D | 1 |
| Drevon, C; Kuroki, T; Montesano, R | 1 |
| Den Engelse, L; Philippus, EJ | 1 |
| Bruce, WR; Dion, P; Eng, VW; Furrer, R; Kakizoe, T; Wang, TT | 1 |
| Brian, MJ; Stewart, BW | 1 |
| Den Engelse, L; Floot, BG; Hart, AA; Philippus, EJ | 1 |
| Castegnaro, M; Garren, L; Kowalski, B; Toussaint, G; Walker, EA | 1 |
| Delpino, A; Ferrini, U; Mattei, E | 1 |
| Kouros, M; Manncke, K; Schweinsberg, F | 1 |
| Fine, DH; Ross, R; Rounbehler, DP; Silvergleid, A; Song, L | 1 |
| Doerr, RC; Dooley, CJ; Fiddler, W; Pensabene, JW | 1 |
| Farber, E; Stewart, BW | 1 |
| Khudoley, VV; Syrenko, OA | 1 |
| Shooter, KV | 1 |
| Huang, CC; Sirianni, SR | 2 |
| Stephany, RW; van Broekhoven, LW | 1 |
| Castegnaro, M; Garren, L; Pignatelli, B; Walker, EA | 1 |
| Pegg, AE | 2 |
| Autrup, H; Harris, CC; Trump, BF | 1 |
| Buselmaier, W; Herbold, B | 1 |
| Fahmy, MJ; Fahmy, OG | 1 |
| Thust, R | 1 |
| Kiseleva, NS; Milievskaja, IL | 1 |
| Il'nitskiĭ, AP; Korolev, AA; Mikhaĭlovskiĭ, NIa; Rumiantsev, PG | 1 |
| Chu, C; Mirvish, SS | 1 |
| Castro, JA; Diaz Gomez, MI | 1 |
| Khudoleĭ, VV; Sirenko, OA | 1 |
| Brunnemann, KD; Hoffmann, D; Yu, L | 1 |
| Autrup, H; Harris, CC; McDowell, EM; Schafer, P; Stoner, GD; Trump, BF | 1 |
| Cameron, R; Farber, E; Laishes, B; Medline, A; Ogawa, K; Solt, D | 1 |
| De Vogel, N; Meijers, M; Natarajan, AT; Tates, AD; Van Buul, PP | 1 |
| Iyengar, JR; Miles, WF; Panalaks, T; Sen, NP | 2 |
| Handler, AH; Homburger, F; Hsueh, SS; Russfield, AB; Soto, E; Van Dongen, CG | 1 |
| Groenen, PJ; Jonk, RJ; ten Noever de Brauw, MC; van Ingen, C | 1 |
| Hedler, L; Marquardt, P; Schurr, C | 1 |
| Brusick, D; Weekes, U | 1 |
| Frantz, CN; Malling, HV | 1 |
| Bartsch, H; Camus, M; Malaveille, C; Montesano, R | 1 |
| Fine, DH; Rounbehler, DP | 1 |
| Hicks, RM; Magee, PN; Stewart, BW | 1 |
| Kmoch, N; Mohr, U; Reznik, G | 1 |
| Friedman, MA; Sanders, V | 1 |
| Guo, L; Li, J; Lin, Q; Lu, S; Song, X; Wang, X; Ye, J; Zou, X | 1 |
| Kolar, C; Lawson, T | 1 |
| Guengerich, FP; Inui, Y; Shimada, T; Yamazaki, H; Yun, CH | 1 |
| Funae, Y; Guengerich, FP; Imaoka, S; Inui, Y; Oda, Y; Shimada, T; Yamazaki, H | 1 |
| Ji, C; Li, M | 1 |
| Hoel, DG; Magee, PN; Swenberg, JA | 1 |
| Brantom, P; Grasso, P; Gray, R; Peto, R | 4 |
| Hinuma, K; Kano, M; Matsuda, J; Ohno, T; Shimoyama, T; Tamura, K; Tanida, N | 1 |
| Brady, JF; Hong, JY; Lee, MJ; Li, WS; Ma, BL; Ning, SM; Smith, T; Thomas, PE; Yang, CS | 1 |
| Gorban', GP; Karpilovskaia, ED; Pliss, MB; Svatkov, VI | 1 |
| Roscher, E; Singh, J | 1 |
| Mufti, SI | 1 |
| Arlotto, MP; Crespi, CL; Davies, RL; Leakey, JA; Parkinson, A; Penman, BW; Rudo, K; Stark, A; Steimel, DT; Turner, T | 1 |
| Hinuma, K; Hori, S; Kano, M; Matsuda, J; Ohno, T; Shimoyama, T; Tamura, K; Tanida, N | 1 |
| Ishizaki, H; Yang, CS; Yoo, JS | 1 |
| Litvinov, NN; Parfenov, IuD; Voronin, VM; Zhurkov, VS | 1 |
| Khesina, AIa; Krivosheeva, LV; Smirnov, GA; Solenova, LG | 1 |
| Cliet, I; Cordier, A; Fournier, E; Melcion, C | 1 |
| Den Engelse, L; Scherer, E; Van Den Berg, T; Vermeulen, E; Winterwerp, HH | 1 |
| Klaunig, JE; Pereira, MA; Weghorst, CM | 1 |
| Aaron, CS; Grzegorczyk, CR; Harbach, PR; Smith, AL; Wiser, SK | 1 |
| Artemova, LG; Pakhomov, VIu; Saprin, AN; Shuliakovskaia, TS | 1 |
| Asakawa, M; Ito, N; Nakahara, H; Nakajima, T; Ohta, S; Sato, A; Shirai, T; Yonekura, I | 1 |
| Kiss, E; Kouri, RE; Lubet, RA; McCarvill, J; Nims, R; Schechtman, LM | 1 |
| Homma, H; Matsui, M; Takanashi, H | 1 |
| Bergmark, E; Osterman-Golkar, S | 1 |
| Hirata, M; Hisanaga, A; Inamasu, T; Ishinishi, N; Tanaka, A | 1 |
| den Engelse, L; Jenner, AA; Scherer, E | 1 |
| Guengerich, FP; Yang, CS; Yoo, JS | 1 |
| Goodall, CM; Moore, CM; Stephens, OB | 1 |
| Huang, CC | 1 |
| Archer, MC; Heddle, JA; Mehta, R; Ronen, A; Silinskas, KC; Zucker, PF | 1 |
| Ahotupa, M; Bartsch, H; Béréziat, JC; Bussacchini-Griot, V; Camus, AM | 1 |
| Guo, LP; Li, FM; Li, PZ; Lu, SH; Wang, GJ; Yang, WX; Zhang, JS | 1 |
| de Vogel, N; den Engelse, L; Menkveld, GJ; Neuteboom, I; Rotteveel, AH; Tates, AD | 1 |
| Keefer, LK; Kleihues, P; von Hofe, E | 1 |
| Kleihues, P; von Hofe, E | 1 |
| Dahl, AR | 1 |
| Clapp, NK; Daugherty, JP | 1 |
| Abraham, R; Charles, AK; Timchalk, C | 1 |
| Ziebarth, D | 1 |
| Dietz, D; Kornbrust, D | 1 |
| Alibaud, R; Bontoux, J; Chanal, JL; Lautier, J; Rambaud, A | 1 |
| Allsobrook, AJ; Du Plessis, LS; Harington, JS; Nunn, AJ; Nunn, JR | 1 |
| Archer, MC; Labuc, GE | 1 |
| Margison, GP | 1 |
| Farber, E; Sarma, DS; Ying, TS | 1 |
| Loquet, C; Wiebel, FJ | 1 |
| Dolan, ME; Pegg, AE; Scicchitano, D | 1 |
| Fong, LY; Ton, CC | 1 |
| Baker, MT; Evans, JS; Holmes, D; Wade, AE | 1 |
| Castonguay, A; Schut, HA | 1 |
| Swann, PF | 1 |
| Chang, HW; Lin, JK; Lin-Shiau, SY; Yen, JY | 1 |
| Bojewski, J; Karłowski, K | 1 |
| Gough, TA; Swann, PF; Webb, KS | 1 |
| Lijinsky, W; Reuber, MD; Riggs, CW | 1 |
| Zimmering, S | 1 |
| Imaida, K; Ito, N; Shirai, T; Takano, T; Tatematsu, M | 1 |
| Farber, E | 1 |
| de Vogel, N; den Engelse, L; Neuteboom, I; Tates, AD | 1 |
| de Brij, RJ; den Engelse, L; Floot, BG; Tates, AD | 1 |
| Barbin, A; Bartsch, H; Béréziat, JC | 1 |
| Jiao, BZ | 1 |
| Lijinsky, W | 1 |
| Arcos, JC; Lai, DY | 1 |
| Hayatsu, H; Negishi, T | 1 |
| Bertram, B; Pool, BL; Wiessler, M | 1 |
| Autrup, H; Stoner, GD | 1 |
| Matsui, I; Pegg, AE | 1 |
| Katoh, Y; Takayama, S; Tanaka, M | 1 |
| Eisenbrand, G; Preussmann, R; Spiegelhalder, B | 1 |
| Arai, M; Fukushima, S; Ito, N; Shirai, T; Tsuda, H | 1 |
| Huberman, E; Jones, CA | 1 |
| Kowalski, B; Miller, CT; Sen, NP | 1 |
| Lotlikar, PD | 1 |
| Fliessbach, JH; Guttenplan, JB | 1 |
| Chiba, K; Murata, N; Sakai, K; Yamane, Y | 1 |
| Hoffmann, D; LaVoie, EJ; Melikian, AA; Wynder, EL | 1 |
| Hofker, M; Neuteboom, I; Tates, AD | 1 |
| Iversen, OH | 1 |
| Farrelly, JG | 1 |
| Appel, KE; Kunz, W; Schrenk, D; Schwarz, M | 1 |
| Crampton, RF | 1 |
| Appel, KE; Dahlhaus, M | 1 |
| Cliet, I; Cordier, A; Melcion, C | 1 |
| Chu, JJ; Xu, YC; Ye, BF | 1 |
| Bäckbro, A; Beije, B; Diaz-Pohl, C; Jenssen, D; Romert, L; Swedmark, S | 1 |
| Asamoto, M; Iwase, T; Kato, T; Matsumoto, K; Montesano, R; Nagao, S; Ozaki, K; Tsuda, H; Wild, CP | 1 |
| Huber, W; Knasmüller, S; Schulte-Hermann, R | 1 |
| Bartsch, H; Béréziat, JC; Camus, AM; Geneste, O; Henderson, CJ; Honkakoski, P; Lang, MA; Wolf, CR | 1 |
| Anver, MR; Merlino, G; Sharp, R; Takagi, H; Takayama, H; Ward, JM | 1 |
| Graves, RJ; Swann, PF | 1 |
| Galloway, SM; Johnson, TE; Umbenhauer, DR | 1 |
| Futakuchi, M; Hasegawa, R; Hirose, M; Ito, N; Lijinsky, W; Shirai, T | 1 |
| Brambilla, G; Mereto, E; Migliazzi Morando, A; Pastore, P; Robbiano, L | 1 |
| Arimoto-Kobayashi, S; Hayatsu, H; Kaji, K; Sweetman, GM | 1 |
| Goto, Y; Hayatsu, H; Huh, NH; Ito, K; Matsuda, T; Negishi, T; Rajewsky, MF; Thomale, J | 1 |
| Khotimchenko, SA; Rodin, VI; Torskaia, MS; Zhukova, GF | 1 |
| Albano, RM; Filho, IM; Godoy, W; Gurski, R; Higa, C; Kruel, CD; Lang, MA; Moraes, EG; Nunes, RA; Pinho, PR; Pinto, LF; Saito, EH; Schirmer, CC | 1 |
| Fukushima, S; Kaneko, M; Kobayashi, Y; Koide, A; Mori, Y; Morimura, K | 1 |
| Lin, K; Lu, S; Shen, W; Shen, Z; Wu, Y | 1 |
| Luepke, NP; Niehaus-Rolf, C; Wolf, T | 1 |
| Berthou, F; Dréano, Y; Le Gal, A; Lucas, D | 1 |
| OOTA, K; TAKAYAMA, S | 1 |
| Hioki, K; Hirose, M; Ishii, Y; Kanki, K; Kodama, Y; Kuroiwa, Y; Kurokawa, Y; Nishikawa, A; Nomura, T; Umemura, T | 1 |
| Andrzejewski, P; Kasprzyk-Hordern, B; Nawrocki, J | 1 |
| Cerven, DR; de George, G; Iatropoulos, MJ; von Keutz, E; Williams, GM | 1 |
| Caixach, J; Palacios, O; Planas, C; Rivera, J; Ventura, F | 1 |
| Calcutt, MW; Chowdhury, G; Guengerich, FP | 1 |
| Baydar, T; Erkekoglu, P | 1 |
| Creus, A; Liviac, D; Marcos, R | 1 |
| Brookes, JD; Dixon, MB; Grasset, C; Ho, L; Hoefel, D; Leusch, FD; Newcombe, G; Saint, CP | 1 |
| Hernández, F; López, FJ; Pitarch, E; Ripollés, C; Sancho, JV | 1 |
| Li, L; Wang, P; Xu, X; Zhou, G | 1 |
| Calcutt, MW; Chowdhury, G; Guengerich, FP; Nagy, LD | 1 |
| Blount, BC; Cowan, EA; Hodgson, JA; Kim, JG; Seyler, TH; Wang, L | 1 |
| Ahn, YG; Choi, NR; Hwang, GS; Ji, WH; Kim, YP | 1 |
| Hodgson, JA; Seyler, TH; Wang, L | 1 |
| Dong, Y; He, Q; He, X; Jia, L; Li, X | 1 |
| Dolgikh, OV; Mal'tseva, OA; Nurislamova, TV; Ulanova, TS; Zaitseva, NV | 1 |
| Ali, AA; Buha, SK; Charoo, NA; Rahman, Z | 1 |
| Abdel-Tawab, M; Besa, A; Bidmon, C; Ermel, S; Holzgrabe, U; Kinzig, M; Scherf-Clavel, O; Schreiber, A; Sörgel, F; Wohlfart, J | 1 |
| Schmidt, AH; Schmidtsdorff, S | 1 |
| Li, Q; Sun, C; Wang, R; Wang, T | 1 |
| Arimoto-Kobayashi, S; Fujii, A; Goto, Y; Miyamoto, K; Mori, E; Negishi, T; Okamoto, K; Taira, K; Yamada, K | 1 |
| Kolonić, T; Sedlo, I; Tomić, S | 1 |
| Elmore, S; Hsieh, CJ; Li, K; Marder, ME; Osborne, G; Ricker, K; Sandy, MS; Schmitz, R; Sun, M; Tsai, FC | 1 |
| Chang, CC; Chang, SH; Ho, HY; Hsu, YH; Lin, MC; Tseng, SH; Wang, DY; Zang, CZ | 1 |
| de Oliveira, DP; Dorta, DJ; Dos Santos, CEM | 1 |
| Breider, F; Gachet Aquillon, C; von Gunten, U | 1 |
| Cen, K; Chen, W; Chen, Y; Ding, Y; Huang, H; Li, S; Liang, Y; Qi, S; Yan, X | 1 |
4 review(s) available for diethylnitrosamine and dimethylnitrosamine
| Article | Year |
|---|---|
Experimental carcinogenesis in small aquarium fishes.
Topics: 2-Acetylaminofluorene; Adenoma; Adenoma, Bile Duct; Aflatoxins; Animals; Benzopyrenes; Carcinogens; Carcinoma, Hepatocellular; Cycasin; Diethylnitrosamine; Dimethylnitrosamine; Female; Fishes; Goldfish; Liver Neoplasms; Male; Methylcholanthrene; Neoplasms, Experimental; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Sterigmatocystin; Trout | 1976 |
Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites.
Topics: 1-Naphthylamine; 2-Acetylaminofluorene; 2-Naphthylamine; Alkylation; Amines; Aminobiphenyl Compounds; Animals; Benzidines; Carcinogens; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; DNA; Guinea Pigs; Humans; Methyldimethylaminoazobenzene; Mice; Nicotiana; Nitrosamines; p-Dimethylaminoazobenzene; Plants, Toxic; Rats; Species Specificity | 1984 |
Minireview: dialkylnitrosamine bioactivation and carcinogenesis.
Topics: Alkylation; Animals; Biotransformation; Chemical Phenomena; Chemistry; Diethylnitrosamine; Dimethylnitrosamine; DNA; Kinetics; Liver Neoplasms; Nitrosamines; Oxidoreductases; Oxidoreductases, N-Demethylating | 1980 |
Presence of nitrosamine impurities in medicinal products.
Topics: Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Drug Contamination; Humans; Nitrosamines | 2021 |
192 other study(ies) available for diethylnitrosamine and dimethylnitrosamine
| Article | Year |
|---|---|
Computer-assisted studies of structure-activity relationships of N-nitroso compounds using pattern recognition.
Topics: Carcinogens; Computers; Nitrosamines; Nitroso Compounds; Pattern Recognition, Automated; Structure-Activity Relationship | 1982 |
Measurement of the aquatic toxicity of volatile nitrosamines.
Topics: Animals; Cnidaria; Cyanobacteria; Diethylnitrosamine; Dimethylnitrosamine; Eukaryota; Fishes; Lethal Dose 50; Nitrosamines; Planarians; Time Factors | 1979 |
Dietary effects on the pharmacokinetics of three carcinogenic nitrosamines.
Topics: Animals; Diet; Diethylnitrosamine; Dimethylnitrosamine; Kinetics; Lipotropic Agents; Liver; Male; Nitrosamines; Rats | 1978 |
Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Disulfiram; Esophageal Neoplasms; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Paranasal Sinus Neoplasms; Rats | 1976 |
The effects of some carcinogenic nitroso compounds on the rat liver nucleolus.
Topics: Animals; Carcinogens; Cell Nucleolus; Diethylnitrosamine; Dimethylnitrosamine; Liver; Male; Nitroso Compounds; Rats | 1976 |
Structural limits of specificity of methylcholanthrene-repressible nitrosamine N-dealkylases. Inhibition by analog substrates.
Topics: Animals; Binding Sites; Dealkylation; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Repression; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Nitrosamines; Oxidoreductases; Rats | 1976 |
Comparative in vivo mutagenicity testing by SCE and micronucleus induction in mouse bone marrow.
Topics: Animals; Bromodeoxyuridine; Chromatids; Chromosome Aberrations; Crossing Over, Genetic; Cyclophosphamide; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Floxuridine; Methylnitronitrosoguanidine; Mice; Mutagens; Triazenes; Triaziquone | 1977 |
Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens.
Topics: Adenosine Triphosphatases; Aflatoxins; Animals; Biotransformation; Carcinogens; Cell Line; Diethylnitrosamine; Dimethylnitrosamine; Liver; Mutation; Nitroso Compounds; Ouabain; Rats | 1978 |
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: some N-nitroso compounds.
Topics: Animals; Butylamines; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Ethanolamines; Ethylamines; Ethylnitrosourea; Folic Acid; Humans; Methylamines; Methylnitrosourea; Morpholines; Nicotine; Nitrosamines; Nitroso Compounds; Piperidines; Proline; Propylamines; Research Design; Sarcosine; Streptozocin | 1978 |
Effect of a single treatment with the alkylating carcinogens dimethynitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. I. Test for induction of liver carcinomas.
Topics: Adenocarcinoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethylnitrosamine; Female; Hepatectomy; Kidney Neoplasms; Liver; Liver Neoplasms; Liver Regeneration; Lung Neoplasms; Male; Mesylates; Methyl Methanesulfonate; Neoplasm Metastasis; Nitrosamines; Rats; Time Factors | 1975 |
Effect of a single treatment with the alkylating carcinogens dimethylnitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. II. Alkylation of DNA and inhibition of DNA replication.
Topics: Alkylation; Animals; Carbon Radioisotopes; Diethylnitrosamine; Dimethylnitrosamine; DNA; DNA Replication; Female; Hepatectomy; Liver; Liver Regeneration; Male; Mesylates; Methylguanidine; Nitrosamines; Rats; Thymidine; Time Factors; Tritium | 1975 |
The induction of tumors in Rana temporaria with nitrosamines.
Topics: Adenoma; Animals; Anura; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethylnitrosamine; Hematopoietic System; Liver Neoplasms; Neoplasms, Experimental; Nitrosamines; Rana temporaria; Time Factors | 1977 |
Electron spin resonance and optical spectra of the complexes of dialkylnitrosoamines with cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Electron Spin Resonance Spectroscopy; Microsomes, Liver; Nitrosamines; Protein Binding; Protein Conformation; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet | 1977 |
Tumor frequency and characteristics after a single dose of dimethylnitrosamine or diethylnitrosamine in partially hepatectomized rats.
Topics: Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dimethylnitrosamine; Hepatectomy; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Sarcoma; Teratoma; Thymus Neoplasms | 1977 |
Inhibition of the multiplication of herpes simplex virus by aliphatic nitrosamines.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Diethylnitrosamine; Dimethylnitrosamine; Humans; Microsomes; Nitrosamines; Rats; Simplexvirus; Virus Replication | 1978 |
Kinetic studies on the hepatic microsomal metabolism of dimethylnitrosamine, diethylnitrosamine, and methylethylnitrosamine in the rat.
Topics: Animals; Binding Sites; Binding, Competitive; Dealkylation; Diethylnitrosamine; Dimethylnitrosamine; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nitrosamines; Phenobarbital; Rats | 1978 |
Microsome-mediated mutagenesis in V79 Chinese hamster cells by various nitrosamines.
Topics: Acetonitriles; Animals; Azaguanine; Cell Line; Cell Survival; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Drug Resistance; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Rats; Salmonella typhimurium | 1977 |
In vivo repair of rat liver DNA damaged by dimethylnitrosamine or diethylnitrosamine.
Topics: Alkylation; Animals; Centrifugation, Density Gradient; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Edetic Acid; Female; Liver; Nitrosamines; Rats; Time Factors | 1977 |
Volatile N-nitrosamines in the urine of normal donors and of bladder cancer patients.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Diethylnitrosamine; Dimethylnitrosamine; Humans; Male; Middle Aged; Nitrosamines; Smoking; Urinary Bladder Neoplasms | 1979 |
Evidence of carcinogen-induced replication of partially-repaired DNA in target cells during nitrosamine carcinogenesis.
Topics: Animals; Chromatography, DEAE-Cellulose; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; DNA Replication; DNA, Single-Stranded; Dose-Response Relationship, Drug; Female; Kidney; Kidney Neoplasms; Nitrosamines; Rats | 1979 |
Persistence and accumulation of (potential) single strand breaks in liver DNA of rats treated with diethylnitrosamine or dimethylnitrosamine: correlation with hepatocarcinogenicity.
Topics: Animals; Carcinogens; Centrifugation, Density Gradient; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Drug Administration Schedule; Female; Liver; Nitrosamines; Rats | 1979 |
Intake of volatile nitrosamines from consumption of alcohols.
Topics: Alcoholic Beverages; Alcoholism; Beer; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Humans; Methods; Nitrosamines; Wine | 1979 |
Protein synthesis inhibition induced by dimethylnitrosamine and diethylnitrosamine on isolated rat hepatocytes.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; In Vitro Techniques; Liver; Male; Nitrosamines; Protein Biosynthesis; Rats | 1979 |
[Comparative investigations on the organotropic carcinogenic effect of different N-nitroso compounds with rat after single and chronic treatment (author's transl)].
Topics: Animals; Benzyl Compounds; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Female; Kidney Neoplasms; Liver Neoplasms, Experimental; Neoplasms, Experimental; Organ Specificity; Pharyngeal Neoplasms; Rats; Time Factors | 1979 |
Formation in vivo of volatile N-nitrosamines in man after ingestion of cooked bacon and spinach.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Food Preservatives; Hot Temperature; Humans; Meat; Nitrosamines; Swine; Vegetables | 1977 |
The presence of dimethyl- and diethylnitrosamines in deionized water.
Topics: Chromatography, Gas; Diethylnitrosamine; Dimethylnitrosamine; Food Analysis; Ion Exchange; Nitrosamines; Water | 1977 |
Alterations in thermal stability of rat liver chromatin and DNA induced in vivo by dimethylnitrosamine and diethylnitrosamine.
Topics: Animals; Chromatin; Chromatography; Diethylnitrosamine; Dimethylnitrosamine; DNA; Hot Temperature; Hydroxyapatites; Liver; Male; Nitrosamines; Nucleic Acid Denaturation; Rats; Time Factors | 1978 |
Tumor induction by N-nitroso compounds in bivalve mollusks Unio pictorum.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mollusca; Neoplasms, Experimental; Nitrosamines; Time Factors | 1978 |
DNA phosphotriesters as indicators of cumulative carcinogen-induced damage.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; Esterification; Female; Kidney; Liver; Lung; Nitrosamines; Organophosphorus Compounds; Rats | 1978 |
Sister chromatid exchange induced by promutagens/carcinogens in Chinese hamster cells cultured in diffusion chambers in mice.
Topics: Animals; Bromodeoxyuridine; Carcinogens; Cell Line; Cricetinae; Crossing Over, Genetic; Cyclophosphamide; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Mice; Mice, Inbred C3H; Mutagens; Polycyclic Compounds | 1978 |
Formation in vivo of traces of volatile N-nitrosamines in the cow after direct administration of nitrate into the rumen--preliminary communication.
Topics: Animals; Cattle; Diethylnitrosamine; Dimethylnitrosamine; Female; Nitrates; Nitrosamines; Pyrrolidines; Rumen; Time Factors | 1978 |
Limitations to the protective effect of rubber glvoes for handling nitrosamines.
Topics: Diethylnitrosamine; Diffusion; Dimethylnitrosamine; Hand; Nitrosamines; Protective Clothing; Talc; Time Factors | 1978 |
Effect of pretreatment with other dialkylnitrosamines on excision from hepatic DNA of O6-methylguanine produced by dimethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; Guanine; Liver; Methylation; Nitrosamines; Rats; Time Factors | 1978 |
Metabolism of acyclic and cyclic N-nitrosamines by cultured human colon.
Topics: Biotransformation; Carbon Dioxide; Colon; Culture Techniques; Diethylnitrosamine; Dimethylnitrosamine; DNA; Humans; N-Nitrosopyrrolidine; Nitrosamines | 1978 |
Induction of point mutations by different chemical mechanisms in the liver microsomal assay.
Topics: Animals; Azathioprine; Biotransformation; Captan; Cyclophosphamide; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Genetic Code; Hydrazines; Isoniazid; Male; Mercaptopurine; Methotrexate; Methylnitronitrosoguanidine; Mice; Microsomes, Liver; Mutagens; Protein Biosynthesis; Salmonella typhimurium | 1976 |
Mutagenicity of N-alpha-acetoxyethyl-N-ethylnitrosamine and N,N-diethylnitrosamine in relation to the mechanisms of metabolic activation of dialkylnitrosamines.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Genes, Recessive; Male; Mutagens; Mutation; Nitrosamines; Ribosomes; Sex Chromosomes; Spermatogenesis; Spermatozoa; Structure-Activity Relationship; Time Factors | 1976 |
Screening of potential chemical carcinogens by means of mammalian cells in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cells, Cultured; Cricetinae; DDT; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Ethylnitrosourea; Female; Guinea Pigs; In Vitro Techniques; Methylnitrosourea; Mice; Neoplasms, Experimental; Pregnancy; Rats | 1976 |
Comparative study of the carcinogenic activities of nas and some chemical carcinogens when introduced into the buccal pouch of the Syrian hamster.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cheek; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Female; Male; Mesocricetus; Methylnitrosourea; Mouth Mucosa; Mouth Neoplasms; Neoplasms, Experimental; Nicotiana; Plants, Toxic | 1976 |
[Quantitative determination of carcinogenic N-nitrosamines in water by a gas chromatographic method].
Topics: Carcinogens, Environmental; Chromatography, Gas; Diethylnitrosamine; Dimethylnitrosamine; Nitrosamines; Water Pollutants; Water Pollutants, Chemical | 1977 |
Effects of nine N-nitroso compounds on the specific radioactivity of liver proteins after injection of [14C]leucine into rats.
Topics: Animals; Cycloleucine; Diethylnitrosamine; Dimethylnitrosamine; Leucine; Liver; Liver Neoplasms; Male; Methylnitrosourea; Morpholines; Necrosis; Nitroso Compounds; Piperazines; Piperidines; Proteins; Rats; Sarcosine; Time Factors | 1977 |
Spectral changes resulting from the interaction of some N-alkyl nitrosamines and rat liver microsomes.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Kinetics; Male; Microsomes, Liver; Nitrosamines; Rats; Spectrophotometry; Structure-Activity Relationship | 1977 |
[Development of tumors in Unio pictorum bivalve mollusks under the influence of N-nitroso compounds].
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Methylnitronitrosoguanidine; Mollusca; Neoplasms, Experimental; Nitroso Compounds | 1977 |
Assessment of carcinogenic volatile N-nitrosamines in tobacco and in mainstream and sidestream smoke from cigarettes.
Topics: Chromatography, Gas; Diethylnitrosamine; Dimethylnitrosamine; Microchemistry; Nitrosamines; Pyrrolidines; Smoking | 1977 |
Metabolism of acyclic and cyclic N-nitrosamines in cultured human bronchi.
Topics: Bronchi; Carbon Dioxide; Culture Techniques; Diethylnitrosamine; Dimethylnitrosamine; DNA; Humans; Nitrosamines; Piperazines; Piperidines; Proteins; Pyrrolidines | 1977 |
Newer insights into the pathogenesis of liver cancer.
Topics: Aflatoxins; Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylnitrosamine; Hepatectomy; Hydroxyacetylaminofluorene; Liver Neoplasms; Methylazoxymethanol Acetate; Methyldimethylaminoazobenzene; Neoplasms, Experimental; Precancerous Conditions; Skin Neoplasms | 1977 |
Cytogenetic effects of mutagens/carcinogens after activation in a microsomal system in vitro I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence of ra
Topics: Carcinogens; Cell Line; Chromatids; Chromosome Aberrations; Diethylnitrosamine; Dimethylnitrosamine; Microsomes, Liver; Mutagens; Nitrosamines | 1976 |
A survey of fish products for volatile N-nitrosamines.
Topics: Animals; Cooking; Diethylnitrosamine; Dimethylnitrosamine; Fish Products; Fishes; Nitrates; Nitrites; Nitrosamines; Piperidines; Pyrrolidines; Shellfish | 1976 |
Adenocarcinoma of the glandular stomach following 3-methylcholanthrene, N-nitrosodiethylamine, or N-nitrosodimethylamine feeding in carcinogen-susceptible inbred Syrian.
Topics: Adenocarcinoma; Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Female; Male; Mesocricetus; Methylcholanthrene; Neoplasms, Experimental; Nitrosamines; Species Specificity; Stomach Neoplasms | 1976 |
Determination of eight volatile nitrosamines in thirty cured meat products with capillary gas chromatography-high-resolution mass spectrometry: the presence of nitrosodiethylamine and the absence of nitrosopyrrolidine.
Topics: Animals; Chromatography, Gas; Diethylnitrosamine; Dimethylnitrosamine; Food Preservation; Horses; Mass Spectrometry; Meat; Nitrites; Nitrosamines; Pyrrolidines; Swine | 1976 |
Nitrosamines in cured meat products.
Topics: Animals; Canada; Chromatography, Gas; Condiments; Diethylnitrosamine; Dimethylnitrosamine; Food Preservation; Food-Processing Industry; Mass Spectrometry; Meat; Nitrates; Nitrites; Nitrosamines; Piperidines; Pyrrolidines; Swine; Time Factors | 1976 |
The relation between the determinable quantities of volatile N-nitroso compounds and the peroxide number in soya bean oil.
Topics: Chemical Phenomena; Chemistry; Diethylnitrosamine; Dimethylnitrosamine; Glycine max; Nitrosamines; Oils; Peroxides; Temperature; Time Factors; Vitamin E | 1976 |
In vitro metabolic activation of chemical mutagens. II. The relationships among mutagen formation, metabolism and carcinogenicity for dimethylnitrosamine and diethylnitrosamine in the livers, kidneys and lungs of BALB/cJ, C57BL/6J and RF/J mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Female; Kidney; Liver; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mutagens; Nitrosamines; Salmonella typhimurium | 1975 |
Factors affecting metabolism and mutagenicity of dimethylnitrosamine and diethylnitrosamine.
Topics: Animals; Carcinogens; Dealkylation; Diethylamines; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Histidine; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Proadifen; Salmonella typhimurium; Time Factors; Valerates | 1975 |
Proceedings: Comparative mutagenicity studies with S. typhimurium of dimethylnitrosamine (DMN) and diethylnitrosamine (DEN), after metabolic activation with liver and lung microsomes.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Lung; Mice; Microsomes; Microsomes, Liver; Mutagens; Rats; Salmonella typhimurium | 1975 |
Trace analysis of volatile N-nitroso compounds by combined gas chromatography and thermal energy analysis.
Topics: Chromatography, Gas; Cold Temperature; Diethylnitrosamine; Dimethylnitrosamine; Methylene Chloride; Nitrosamines; Nitroso Compounds; Piperidines; Pyrrolidines; Sarcosine | 1975 |
Acute biochemical and morphological effects of N-nitrosomorpholine in comparison to dimethyl- and diethylnitrosamine.
Topics: Animals; Cell Nucleolus; Chromatin; Diethylnitrosamine; Dimethylnitrosamine; Female; Leucine; Liver; Microscopy, Electron; Morpholines; Nitrosamines; Nitroso Compounds; Orotic Acid; Protein Biosynthesis; Rats | 1975 |
Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine.
Topics: Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Esophageal Neoplasms; Female; Liver Neoplasms; Lung Neoplasms; Male; Neoplasm Metastasis; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Stomach Neoplasms | 1976 |
Acute toxicity of dimethylnitrosamine in the presence of inhibitors of DMN demethylase.
Topics: Animals; Computers; Diethylnitrosamine; Dimethylnitrosamine; Drug Synergism; Lethal Dose 50; Male; Mice; Nitrosamines; Oxidoreductases, N-Demethylating | 1976 |
Volatile N-nitrosamines in salted fish samples from high- and low-risk areas for NPC in China.
Topics: Animals; China; Diethylnitrosamine; Dimethylnitrosamine; Fishes; Food Preservation; Humans; Nasopharyngeal Neoplasms; Nitrosamines; Risk Factors | 1992 |
Mutation of V79 cells by N-dialkylnitrosamines after activation by hamster pancreas duct cells.
Topics: Analysis of Variance; Animals; Biotransformation; Cell Line; Cricetinae; Culture Media; Dexamethasone; Diethylnitrosamine; Dimethylnitrosamine; Liver; Male; Mesocricetus; Mutagenicity Tests; Mutagens; Nitrosamines; Pancreatic Ducts | 1992 |
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.
Topics: Animals; Antibodies; Biotransformation; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Activation; Humans; Microsomes, Liver; Nicotiana; Nitrosamines; Oxidoreductases, N-Demethylating; Oxygenases; Plants, Toxic; Rabbits | 1992 |
Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009).
Topics: Acetyltransferases; Animals; Biotransformation; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Hydroxylation; Male; Methylation; Microsomes, Liver; Nitroso Compounds; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1992 |
[Studies of pickled vegetables and cause of esophageal cancer in Linxian. II. Determination of nitrosamines and their precursors].
Topics: Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Food Preservation; Humans; Nitrates; Nitrites; Vegetables | 1991 |
Mechanistic and statistical insight into the large carcinogenesis bioassays on N-nitrosodiethylamine and N-nitrosodimethylamine.
Topics: Animals; Carcinogenicity Tests; Diethylnitrosamine; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Follow-Up Studies; Methylation; Rats | 1991 |
Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose-response study.
Topics: Animals; Bile Duct Neoplasms; Carcinogenicity Tests; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Esophageal Neoplasms; Female; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; Sex Factors | 1991 |
Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine.
Topics: Age Factors; Animals; Carcinogenicity Tests; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Esophageal Neoplasms; Female; Life Expectancy; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Chronic nitrosamine ingestion in 1040 rodents: the effect of the choice of nitrosamine, the species studied, and the age of starting exposure.
Topics: Age Factors; Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Liver Neoplasms, Experimental; Mesocricetus; Mice; N-Nitrosopyrrolidine; Nitrosamines; Rats; Respiratory Tract Neoplasms; Sex Factors; Species Specificity | 1991 |
N-nitrosamines in gastric juice of patients with gastric ulcer before and during treatment with histamine H2-receptor antagonists.
Topics: Adult; Aged; Diethylnitrosamine; Dimethylnitrosamine; Female; Gastric Acidity Determination; Gastric Juice; Histamine H2 Antagonists; Humans; Male; Middle Aged; Nitrosamines; Stomach Ulcer | 1990 |
Metabolism of carcinogenic nitrosamines by rat nasal mucosa and the effect of diallyl sulfide.
Topics: Acetone; Age Factors; Allyl Compounds; Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Female; Male; Microsomes; Nasal Mucosa; Nitrosamines; Rats; Rats, Inbred Strains; Sex Factors; Sulfides | 1991 |
[Repercussions of receptor-substrate relations in the organization of a toxicological experiment on combined action of chemical factors (for example, a nitrosamine combination)].
Topics: Alanine Transaminase; Animals; Diethylnitrosamine; Dimethylnitrosamine; Drug Antagonism; Drug Synergism; L-Iditol 2-Dehydrogenase; Liver; Male; Nitrosamines; Rats; Receptors, Drug; Substrate Specificity | 1991 |
Induction of DNA damage by N-nitrosodiethylamine in rat hepatoma cells: correlation with cytochrome P450-mediated aldrin epoxidase activity.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; DNA Damage; DNA Repair; Enzyme Induction; Liver; Liver Neoplasms, Experimental; Mixed Function Oxygenases; Rats; Tumor Cells, Cultured | 1991 |
Free radicals generated in ethanol metabolism may be responsible for tumor promoting effects of ethanol.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Ethanol; Free Radicals; Glutathione; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains | 1991 |
Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1.
Topics: Aflatoxin B1; Aflatoxins; Base Sequence; Benzo(a)pyrene; Biotransformation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; DNA; Humans; Molecular Sequence Data; Mutagens | 1990 |
N-nitrosamines in the stomach with special reference to in vitro formation, and kinetics after intragastric or intravenous administration in rats.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Female; Gastric Juice; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Middle Aged; Nitrites; Nitrosation; Rats; Rats, Inbred Strains | 1990 |
Roles of cytochrome P450IIE1 in the dealkylation and denitrosation of N-nitrosodimethylamine and N-nitrosodiethylamine in rat liver microsomes.
Topics: Animals; Antibodies, Monoclonal; Cytochrome P-450 CYP2E1; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Liver; Male; Microsomes; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred Strains | 1990 |
[Calculation of maximum allowable concentration of N-nitrosodimethylamine and N-nitrosodiethylamine based on chronic experiments in mice].
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Female; Male; Maximum Allowable Concentration; Mice; Mice, Inbred C57BL; Mice, Inbred CBA | 1990 |
[N-nitrosamines in the air of an enterprise producing rubber footwear and rubber technology articles].
Topics: Air Pollutants, Occupational; Diethylnitrosamine; Dimethylnitrosamine; Nitrosamines; Rubber | 1990 |
In vivo micronucleus test using mouse hepatocytes.
Topics: Aminobiphenyl Compounds; Aminophenols; Animals; Cell Cycle; Cell Survival; Diethylnitrosamine; Dimethylhydrazines; Dimethylnitrosamine; Liver; Male; Mice; Micronucleus Tests; Mutagens; Propiolactone | 1989 |
Immunocytochemical analysis of O6-alkylguanine shows tissue specific formation in and removal from esophageal and liver DNA in rats treated with methylbenzylnitrosamine, dimethylnitrosamine, diethylnitrosamine and ethylnitrosourea.
Topics: Animals; Carcinogens; Cell Nucleus; Diethylnitrosamine; Dimethylnitrosamine; DNA Damage; DNA Repair; Esophagus; Ethylnitrosourea; Female; Guanine; Immunoenzyme Techniques; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains; Substrate Specificity | 1989 |
Strain differences in hepatic tumor promotion by phenobarbital in diethylnitrosamine- and dimethylnitrosamine-initiated infant male mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Drug Interactions; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Phenobarbital; Reference Values; Species Specificity | 1989 |
The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes. Validation of improved methods for primary culture including data on the lack of effect of ionizing radiation.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Collagen; Diethylnitrosamine; Dimethylnitrosamine; DNA Replication; Liver; Male; Methyl Methanesulfonate; Rats; Rats, Inbred F344; Rats, Inbred Strains; Ultraviolet Rays; X-Rays | 1989 |
[Modifying effect of antioxidants on the biotransformation of dialkyl-N-nitrosamines in microsomes. A spin trap method].
Topics: Animals; Antioxidants; Biotransformation; Carcinogens; Dealkylation; Diethylamines; Diethylnitrosamine; Dimethylamines; Dimethylnitrosamine; Electron Spin Resonance Spectroscopy; Free Radicals; Male; Microsomes, Liver; Rats; Rats, Inbred Strains | 1986 |
Augmentation of ethanol-induced enhancement of dimethylnitrosamine and diethylnitrosamine metabolism by lowered carbohydrate intake.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Diethylnitrosamine; Dimethylnitrosamine; Ethanol; In Vitro Techniques; Kinetics; Liver; Male; Mutagenicity Tests; Proteins; Rats; Rats, Inbred Strains | 1986 |
A method for the amplification of chemically induced transformation in C3H/10T1/2 clone 8 cells: its use as a potential screening assay.
Topics: 2-Naphthylamine; Aflatoxin B1; Aflatoxins; Animals; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Clone Cells; Diethylnitrosamine; Dimethylnitrosamine; Male; Methylcholanthrene; Methylnitronitrosoguanidine; Rats; Rats, Inbred F344 | 1987 |
Effects of administration of N-nitrosodialkylamines and N-nitrodiethylamine on hepatic UDP-glucuronosyltransferase activity in Wistar rats.
Topics: Aminophenols; Animals; Body Weight; Diethylamines; Diethylnitrosamine; Dimethylnitrosamine; Glucuronosyltransferase; Injections, Intraperitoneal; Male; Microsomes, Liver; Nitrophenols; Nitrosamines; Organ Size; Rats; Rats, Inbred Strains | 1988 |
Alkylation of haemoglobin, plasma proteins and DNA in the mouse by diethylnitrosamine.
Topics: Alkylation; Animals; Blood Proteins; Diethylnitrosamine; Dimethylnitrosamine; DNA Damage; Dose-Response Relationship, Drug; Hemoglobins; Liver; Mice | 1988 |
A comparison of the carcinogenicity of N-nitrosodiethylamine and N-nitrosodimethylamine after intratracheal instillation into Syrian golden hamsters.
Topics: Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mesocricetus; Neoplasms, Experimental | 1988 |
Immunocytochemical studies on the formation and repair of O6-alkylguanine in rat tissues.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Ethylnitrosourea; Guanine; Immunohistochemistry; Islets of Langerhans; Kidney Glomerulus; Liver; Male; Muscle, Smooth; Precancerous Conditions; Rats; Spermatogonia; Tissue Distribution | 1987 |
Metabolism of N-nitrosodialkylamines by human liver microsomes.
Topics: Cytochrome P-450 Enzyme System; Dealkylation; Diethylnitrosamine; Dimethylnitrosamine; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Nitrosamines | 1988 |
Comparative sensitivity of survival-adjusted chi-square and normal statistics for the mutagenesis fluctuation assay.
Topics: Cell Survival; Diethylnitrosamine; Dimethylnitrosamine; Mutagenicity Tests; Salmonella typhimurium; Statistics as Topic | 1986 |
Retinol (vitamin A) inhibition of dimethylnitrosamine (DMN) and diethylnitrosamine (DEN) induced sister-chromatid exchanges in V79 cells and mutations in Salmonella/microsome assays.
Topics: Animals; Biotransformation; Cell Line; Cricetinae; Cricetulus; Diethylnitrosamine; Dimethylnitrosamine; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Salmonella typhimurium; Sister Chromatid Exchange; Vitamin A | 1987 |
Comparison of S9 fractions from rats, mice, and Chinese hamsters to metabolize dimethylnitrosamine and diethylnitrosamine to intermediates that induce sister-chromatid exchanges in V79 cells.
Topics: Animals; Biotransformation; Cell Line; Cricetinae; Cricetulus; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Fibroblasts; Lung; Male; Mice; Microsomes, Liver; Mutagenicity Tests; Rats; Rats, Inbred Strains; Sister Chromatid Exchange; Species Specificity | 1987 |
Micronucleus formation induced in rat liver and esophagus by nitrosamines.
Topics: Animals; Cell Nucleus; Chromosome Aberrations; Diethylnitrosamine; Dimethylnitrosamine; Esophagus; Liver; Male; Mutagenicity Tests; Mutagens; Nitrosamines; Rats; Rats, Inbred Strains | 1987 |
Rapid oxidative stress induced by N-nitrosamines.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Ethane; Glutathione; Kinetics; Lipid Peroxides; Liver; Male; Nitrosamines; Peroxidases; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Vitamin A | 1987 |
Determination of N-nitrosamines in gastric juice and urine and a comparison of endogenous formation of N-nitrosoproline and its inhibition in subjects from high- and low-risk areas for oesophageal cancer.
Topics: China; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Gastric Juice; Humans; Nitrosamines; Risk Factors | 1987 |
Persistence of preclastogenic damage in hepatocytes of rats exposed to ethylnitrosourea, diethylnitrosamine, dimethylnitrosamine and methyl methanesulphonate. Correlation with DNA O-alkylation.
Topics: Alkylation; Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; Ethylnitrosourea; Hepatectomy; Liver; Male; Methyl Methanesulfonate; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Extent of DNA 2-hydroxyethylation by N-nitrosomethylethylamine and N-nitrosodiethylamine in vivo.
Topics: Alkylation; Animals; Carbon Radioisotopes; Diethylnitrosamine; Dimethylnitrosamine; DNA; Liver; Male; Rats; Rats, Inbred F344 | 1986 |
Comparative studies on hepatic DNA alkylation in rats by N-nitrosomethylethylamine and N-nitrosodimethylamine plus N-nitrosodiethylamine.
Topics: Alkylation; Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Male; Mathematics; Rats; Rats, Inbred F344 | 1986 |
Mutagenicity of some dialkylnitrosamines, cyclic nitrosamines and N,N-diethanolnitrosamine in Salmonella typhimurium with rat and rabbit nasal, lung and liver S9 homogenates.
Topics: Animals; Biotransformation; Diethylnitrosamine; Dimethylnitrosamine; Lung; Male; Microsomes; Microsomes, Liver; Mutagenicity Tests; N-Nitrosopyrrolidine; Nasal Mucosa; Nitrosamines; Organ Specificity; Rabbits; Rats; Salmonella typhimurium; Species Specificity | 1985 |
Association of nitrosamine-derived radioactivity with nuclear and mitochondrial DNA in mice.
Topics: Animals; Carbon Radioisotopes; Cell Nucleus; Diethylnitrosamine; Dimethylnitrosamine; DNA; DNA Repair; DNA, Mitochondrial; Gastric Mucosa; Kinetics; Liver; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosamines | 1985 |
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; Insecticides; Liver; Liver Neoplasms; Male; Mirex; Neoplasm Proteins; Phenobarbital; Precancerous Conditions; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1985 |
[Formation of volatile carcinogenic N-nitroso compounds from drugs under simulated human gastric conditions].
Topics: Aminopyrine; Amitriptyline; Clomiphene; Diethylamines; Diethylnitrosamine; Dimethylnitrosamine; Disulfiram; Doxycycline; Humans; Models, Biological; Nitroso Compounds; Oxytetracycline; Pharmaceutical Preparations; Probenecid; Stomach | 1985 |
Effects of pretreatment with pyrazole and inducers of mixed function oxidases on DNA repair elicited by dimethylnitrosamine in rat hepatocytes in vivo and in vitro.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2E1; DDT; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Enzyme Induction; Liver; Male; Methyl Methanesulfonate; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1985 |
Toxicokinetic and metabolic study of dimethylnitrosamine and diethylnitrosamine in crayfish Austropotamobius pallipes.
Topics: Animals; Astacoidea; Diethylnitrosamine; Dimethylnitrosamine; Kinetics; Liver; Male; Mass Spectrometry; Muscles; Pancreas | 1985 |
N-nitrosamines in the human vaginal vault.
Topics: Cervix Uteri; Diethylnitrosamine; Dimethylnitrosamine; Female; Humans; Leukorrhea; Nitrosamines; Pregnancy; Pregnancy Complications; Trichomonas vaginalis; Vagina | 1974 |
Comparative tumor initiating activities of N-nitrosomethylbenzylamine and N-nitrosodimethylamine in rat liver.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; gamma-Glutamyltransferase; Hepatectomy; Injections, Intraperitoneal; Liver Neoplasms; Male; Microsomes, Liver; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred Strains | 1982 |
Chronic or acute administration of various dialkylnitrosamines enhances the removal of O6-methylguanine from rat liver DNA in vivo.
Topics: Animals; Chromatography, Gel; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Guanine; Liver; Male; Nitrosamines; Purines; Rats; RNA | 1982 |
The sequential analysis of liver cell necrosis: inhibition of diethylnitrosamine- and dimethylnitrosamine-induced acute liver cell death by posttreatment with diethyldithiocarbamate.
Topics: Animals; Carcinogens; Cell Survival; Diethylnitrosamine; Dimethylnitrosamine; Ditiocarb; Dose-Response Relationship, Drug; L-Iditol 2-Dehydrogenase; Liver; Male; Necrosis; Nitrosamines; Rats; Thiocarbamates; Time Factors; Transaminases | 1980 |
Geno- and cytotoxicity of nitrosamines, aflatoxin B1, and benzo[a]-pyrene in continuous cultures of rat hepatoma cells.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Survival; Clone Cells; Dexamethasone; Diethylnitrosamine; Dimethylnitrosamine; Ethylnitrosourea; Kinetics; Liver Neoplasms, Experimental; Methylnitronitrosoguanidine; Mutation; Nitrosamines; Rats | 1982 |
Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.
Topics: Alkylation; Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; DNA Repair; Escherichia coli; Kinetics; Liver; Male; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains | 1984 |
The effects of ascorbic acid deficiency and excess on the metabolism and toxicity of N-nitrosodimethylamine and N-nitrosodiethylamine in the guinea pig.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Diethylnitrosamine; Dimethylnitrosamine; Guinea Pigs; Kinetics; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitrosamines | 1984 |
Influence of dietary thiamin on phenobarbital induction of rat hepatic enzymes responsible for metabolizing drugs and carcinogens.
Topics: Aniline Compounds; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Diethylnitrosamine; Dimethylnitrosamine; Ethylmorphine; Female; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Organ Size; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Thiamine; Thiamine Deficiency | 1983 |
Effect of ethanol on nitrosamine metabolism and distribution. Implications for the role of nitrosamines in human cancer and for the influence of alcohol consumption on cancer incidence.
Topics: Alcohol Drinking; Animals; Cocarcinogenesis; Diethylnitrosamine; Dimethylnitrosamine; Ethanol; Humans; Kinetics; Neoplasms; Nitrosamines; Rats; Tissue Distribution | 1984 |
Properties of the O6-alkylguanine-DNA repair system of mammalian cells.
Topics: Adenine; Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Guanine; In Vitro Techniques; Liver; Nitroso Compounds; Rats | 1984 |
Nitrosamine carcinogenesis in 5120 rodents: chronic administration of sixteen different concentrations of NDEA, NDMA, NPYR and NPIP in the water of 4440 inbred rats, with parallel studies on NDEA alone of the effect of age of starting (3, 6 or 20 weeks) a
Topics: Age Factors; Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Female; Male; Mesocricetus; Mice; Mice, Inbred Strains; N-Nitrosopyrrolidine; Neoplasms; Nitrosamines; Rats; Rats, Inbred Strains; Species Specificity | 1984 |
N-nitrosophenacetin: its synthesis, characterization, mutagenicity, and teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry; Chick Embryo; Diethylnitrosamine; Dimethylnitrosamine; Lethal Dose 50; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenicity Tests; Mutagens; Nitrosamines; Rats; Rats, Inbred Strains; Spectrophotometry; Teratogens | 1984 |
[N-nitrosamines in beer].
Topics: Beer; Diethylnitrosamine; Dimethylnitrosamine; Edible Grain; Nitrosamines; Poland | 1983 |
An examination of human blood for the presence of volatile nitrosamines.
Topics: Adult; Animals; Diethylnitrosamine; Dimethylnitrosamine; Environmental Exposure; Female; Food; Half-Life; Humans; Male; Middle Aged; Nitrosamines; Rabbits; Saliva | 1983 |
Carcinogenesis by combinations of N-nitroso compounds in rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Drug Interactions; Female; Nitrosamines; Nitrosomethylurethane; Rats; Rats, Inbred F344 | 1983 |
Review of the current status of the mei-9a test for chromosome loss in Drosophila melanogaster: an assay with radically improved detection capacity for chromosome lesions induced by methyl methanesulfonate (MMS), dimethylnitrosamine (DMN), and especially
Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Diethylnitrosamine; Dimethylnitrosamine; Drosophila melanogaster; Methyl Methanesulfonate; Mutagenicity Tests; Mutagens; Procarbazine | 1981 |
Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Hepatectomy; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; p-Dimethylaminoazobenzene; Rats | 1981 |
Chemicals, evolution, and cancer development: Rous-Whipple Award Lecture.
Topics: Adult; Aflatoxin B1; Aflatoxins; Animals; Biological Evolution; Carcinogens; Carcinogens, Environmental; Cell Differentiation; Cytoplasm; Diethylnitrosamine; Dimethylnitrosamine; Humans; Liver; Liver Neoplasms; Methylazoxymethanol Acetate; Mice; Models, Biological; Neoplasms; Neoplasms, Experimental; Precancerous Conditions; Rats; Time Factors | 1982 |
The induction of chromosomal damage in rat hepatocytes and lymphocytes. I. Time-dependent changes of the clastogenic effects of diethylnitrosamine, dimethylnitrosamine and ethyl methanesulfonate.
Topics: Animals; Carcinogens; Cells, Cultured; Crossing Over, Genetic; Diethylnitrosamine; Dimethylnitrosamine; Ethyl Methanesulfonate; Kinetics; Liver; Lymphocytes; Male; Nitrosamines; Rats; Rats, Inbred Strains; Sister Chromatid Exchange | 1983 |
The induction of chromosomal damage in rat hepatocytes and lymphocytes. II. Alkylation damage and repair of rat-liver DNA after diethylnitrosamine, dimethylnitrosamine and ethyl methanesulphonate in relation to clastogenic effects.
Topics: Alkylation; Animals; Carcinogens; Chromosome Aberrations; Diethylnitrosamine; Dimethylnitrosamine; DNA; Ethyl Methanesulfonate; Liver; Lymphocytes; Male; Nitrosamines; Rats; Rats, Inbred Strains | 1983 |
Evaluation of DNA damage by the alkaline elution technique in liver, kidneys and lungs of rats and hamsters treated with N-nitrosodialkylamines.
Topics: Animals; Carbon Tetrachloride; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; DNA; Kidney; Liver; Lung; Male; Mesocricetus; Nitrosamines; Rats; Tetraethylammonium Compounds | 1983 |
[Studies on canceration of esophageal epithelium--(SEM) and (TEM) observations].
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylnitrosamine; Epithelium; Esophageal Neoplasms; Esophagus; Mice; Microscopy, Electron; Microscopy, Electron, Scanning; Neoplasms, Experimental; Nitrosamines | 1983 |
Species specificity in nitrosamine carcinogenesis.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Rats; Species Specificity; Structure-Activity Relationship; Urinary Bladder Neoplasms | 1983 |
The pH-dependent response of Salmonella typhimurium TA100 to mutagenic N-nitrosamines.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; N-Nitrosopyrrolidine; Nitrosamines; Rats; Salmonella typhimurium | 1980 |
Mutagenicity and synthesis of alpha-substituted N-nitrosamines: derivatives with dithiocarbamic acid.
Topics: Chemical Phenomena; Chemistry; Cocarcinogenesis; Diethylnitrosamine; Dimethylnitrosamine; Disulfiram; Mutagenicity Tests; Nitrosamines; Salmonella typhimurium; Structure-Activity Relationship; Thiocarbamates | 1982 |
Metabolism of N-nitrosamines by cultured human and rat esophagus.
Topics: Alkylation; Animals; Cells, Cultured; Diethylnitrosamine; Dimethylnitrosamine; DNA; Esophagus; Humans; Male; Nitrosamines; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1982 |
Induction of spermidine N1-acetyltransferase by dialkylnitrosamines.
Topics: Acetyltransferases; Animals; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Female; Kinetics; Liver; Nitrosamines; Rats; Rats, Inbred Strains | 1982 |
Higher efficiency of hamster hepatocytes than rat hepatocytes for detecting dimethylnitrosamine and diethylnitrosamine in hepatocyte-mediated Chinese hamster V79 cell mutagenesis assay.
Topics: Animals; Biotransformation; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Drug Resistance; Liver; Mutagenicity Tests; Nitrosamines; Ouabain; Rats; Species Specificity | 1982 |
Urinary excretion of N-nitrosamines in rats and humans.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Ethanol; Humans; Nitrosamines; Rats | 1982 |
Induction of preneoplastic and neoplastic lesions in rats treated N-nitroso compounds.
Topics: Animals; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Precancerous Conditions; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1982 |
A sensitive hepatocyte-mediated assay for the metabolism of nitrosamines to mutagens for mammalian cells.
Topics: Animals; Cells, Cultured; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Drug Resistance; In Vitro Techniques; Liver; Male; Mixed Function Oxygenases; Mutagens; Nitrosamines; Ouabain; Rats; Thioguanine | 1980 |
Studies on the in vivo formation of nitrosamines in rats and humans after ingestion of various meals.
Topics: Animals; Diet; Diethylnitrosamine; Dimethylnitrosamine; Food Analysis; Humans; Nitrates; Nitrites; Nitrosamines; Rats; Species Specificity | 1980 |
Metabolic activation of aromatic amines and dialkylnitrosamines.
Topics: 2-Acetylaminofluorene; Amines; Animals; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Dealkylation; Diethylnitrosamine; Dimethylnitrosamine; Female; Guinea Pigs; Hydroxylation; Male; Mice; Nitrosamines; Rats | 1981 |
Salivary levels of N-nitrosamines and some metabolites after IP injection of N-nitrosamines in rats.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Injections, Intraperitoneal; Nitrosamines; Rats; Rats, Inbred Strains; Saliva | 1981 |
Effect of copper administration on the incorporation of [3H]-thymidine into the liver DNA of rats stimulated by dimethylnitrosamine and diethylnitrosamine.
Topics: Animals; Copper; Diethylnitrosamine; Dimethylnitrosamine; DNA Replication; Kinetics; Lead; Liver; Male; Nickel; Nitrosamines; Rats; Rats, Inbred Strains; Silver; Thymidine; Tritium | 1981 |
Volatile nitrosamines: analysis in breast fluid and blood of non-lactating women.
Topics: Body Fluids; Breast; Breast Diseases; Diethylnitrosamine; Dimethylnitrosamine; Female; Humans; Nitrosamines | 1981 |
A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo.
Topics: Animals; Carcinogens; Cell Nucleus; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Liver; Liver Regeneration; Mutagens; Rats | 1980 |
Tumorigenicity of N-nitroso-diaethyl, -dimethyl and -diphenyl-amines in skin painting experiments. A study utilizing the tetrazolium test and skin applications on hairless mice.
Topics: Adenoma; Animals; Diethylnitrosamine; Dimethylnitrosamine; Female; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitroblue Tetrazolium; Nitrosamines; Skin Neoplasms | 1980 |
A new assay for the microsomal metabolism of nitrosamines.
Topics: Acetaldehyde; Aldehydes; Animals; Carcinogens; Chromatography, High Pressure Liquid; Diethylnitrosamine; Dimethylnitrosamine; Dinitrobenzenes; Formaldehyde; Kinetics; Male; Microsomes, Liver; Nitrosamines; Rats | 1980 |
Effect of ethanol on microsomal metabolism of dimethylnitrosamine.
Topics: Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Ethanol; Female; In Vitro Techniques; Male; Microsomes, Liver; Rats | 1980 |
Carcinogenic dose-related response to nitrosamines.
Topics: Administration, Oral; Animals; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Female; Male; Mice; Neoplasms, Experimental; Nitrosamines; Pilot Projects; Rats | 1980 |
N-nitrosodimethylamine, N-nitrosodiethylamine, and N-nitrosomorpholine fail to generate 8-hydroxy-2'-deoxyguanosine in liver DNA of male F344 rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; Diethylnitrosamine; Dimethylnitrosamine; DNA; DNA Damage; Liver; Male; Nitrosamines; Oxidation-Reduction; Rats; Rats, Inbred F344 | 1993 |
Lack of predictivity of bone marrow micronucleus test versus testis micronucleus test: comparison with four carcinogens.
Topics: Animals; Bone Marrow; Carcinogens; Diethylnitrosamine; Dimethylhydrazines; Dimethylnitrosamine; Male; Mice; Micronucleus Tests; Predictive Value of Tests; Propiolactone; Spermatids; Testis | 1993 |
[N-nitroso-compounds of pickles in the areas with high incidence of digestive cancers and their mutagenic effects].
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Food Preservation; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Micronucleus Tests; Stomach Neoplasms; Vegetables; Water Pollutants, Chemical | 1994 |
Comparison of co-cultivation of V79 cells with rat hepatocytes and rat H4IIE hepatoma cells for studying nitrosamine-induced hprt gene mutations.
Topics: Animals; Biotransformation; Cells, Cultured; Cricetinae; Cricetulus; Culture Techniques; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Fibroblasts; Genes; Hypoxanthine Phosphoribosyltransferase; Liver; Liver Neoplasms, Experimental; Male; Mutagenesis; Mutagenicity Tests; Mutagens; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Wistar; Tumor Cells, Cultured | 1994 |
Decreased dimethylnitrosamine-induced O6- and N7-methyldeoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Deoxyguanosine; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Glutathione Transferase; Immunohistochemistry; Liver Neoplasms; Male; Neoplasm Transplantation; Rats; Rats, Inbred F344 | 1993 |
Prevention of genotoxic effects by dietary constituents in various organs of mice treated with nitrosamines.
Topics: Animals; Antimutagenic Agents; Brassica; Carcinogens; Diet; Diethylnitrosamine; Dimethylnitrosamine; DNA Damage; DNA Repair; Escherichia coli; Hydroxylation; Isothiocyanates; Male; Mice; Mutagenicity Tests; Mutagens; N-Methylaspartate; N-Nitrosopyrrolidine; Nitrosamines; Oleic Acid; Oleic Acids; Organ Specificity; Tissue Extracts; Triolein; Vitamin A | 1993 |
High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Humans; Kinetics; Male; Mice; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Pyrazoles; Reference Values | 1993 |
Collaboration between growth factors and diverse chemical carcinogens in hepatocarcinogenesis of transforming growth factor alpha transgenic mice.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; ErbB Receptors; Female; Liver Neoplasms, Experimental; Male; Mice; Mice, Transgenic; Transforming Growth Factor alpha | 1993 |
Clearance of N-nitrosodimethylamine and N-nitrosodiethylamine by the perfused rat liver. Relationship to the Km and Vmax for nitrosamine metabolism.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; Ethanol; Female; Humans; In Vitro Techniques; Liver; Male; Middle Aged; Perfusion; Rats; Rats, Wistar | 1993 |
Human liver S-9 metabolic activation: proficiency in cytogenetic assays and comparison with phenobarbital/beta-naphthoflavone or aroclor 1254 induced rat S-9.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Humans; Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Rats | 1996 |
Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Nitrosamines; Nitroso Compounds; Precancerous Conditions; Rats; Rats, Inbred F344 | 1996 |
An in vivo micronucleus assay for detecting the clastogenic effect in rat kidney cells.
Topics: Animals; Cells, Cultured; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Kidney; Male; Methylnitrosourea; Micronucleus Tests; Mutagens; Rats; Rats, Sprague-Dawley | 1997 |
Mutation and formation of methyl- and hydroxylguanine adducts in DNA caused by N-nitrosodimethylamine and N-nitrosodiethylamine with UVA irradiation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Bacterial Proteins; Deoxyguanosine; Diethylnitrosamine; Dimethylnitrosamine; DNA; DNA Adducts; DNA Repair; Dose-Response Relationship, Drug; Escherichia coli; Escherichia coli Proteins; Guanine; Methyltransferases; Mutagenesis; Mutagenicity Tests; Oxidation-Reduction; Plasmids; Salmonella typhimurium; Ultraviolet Rays | 1997 |
Mutagenicities of N-nitrosodimethylamine and N-nitrosodiethylamine in Drosophila and their relationship to the levels of O-alkyl adducts in DNA.
Topics: Alkylation; Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA Adducts; Drosophila melanogaster; Female; Male; Mutagens; Mutation; Recombination, Genetic | 1999 |
[N-nitrosamines and nitrites in meat and meat products].
Topics: Carcinogens; Chromatography, Gas; Diethylnitrosamine; Dimethylnitrosamine; Luminescent Measurements; Meat; Meat Products; Nitrites; Nitrosamines | 1999 |
CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.
Topics: Alkylating Agents; Aryl Hydrocarbon Hydroxylases; Carcinoma, Squamous Cell; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diethylnitrosamine; Dimethylnitrosamine; Esophagus; Humans; Microsomes; Mixed Function Oxygenases; Mouth Mucosa; Mouth Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2002 |
Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver.
Topics: Animals; Blotting, Western; Carcinogens; Cytochrome P-450 CYP2E1; Densitometry; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Ethanol; Glucuronosyltransferase; Immunoblotting; Liver; Male; Mutagens; Mutation; Nitrosamines; Rats; Rats, Inbred F344; Rats, Wistar; Solvents | 2002 |
Dietary exposure and urinary excretion of total N-nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high- and low-risk areas for esophageal cancer in southern China.
Topics: Adult; Carboxylic Acids; China; Diet; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Humans; Inositol Phosphates; Male; Middle Aged; N-Nitrosopyrrolidine; Nitrosamines; Nitroso Compounds; Thiazoles; Thiazolidines | 2002 |
Investigating genotoxic and hematotoxic effects of N-nitrosodimethylamine, N-nitrosodiethylamine and N-nitrosodiethanolamine in the hen's egg-micronucleus test (HET-MN).
Topics: Animals; Chick Embryo; Chickens; Cyclophosphamide; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Erythrocyte Count; Female; Hematologic Diseases; Micronucleus Tests; Mutagens | 2003 |
Diversity of selective environmental substrates for human cytochrome P450 2A6: alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine.
Topics: Adult; Antibodies, Blocking; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Coumarins; Cytochrome P-450 CYP2A6; Diethylnitrosamine; Dimethylnitrosamine; Environmental Pollutants; Enzyme Inhibitors; Ethers; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Nicotine; Substrate Specificity | 2003 |
INDUCTION OF MALIGNANT TUMORS IN VARIOUS STRAINS OF MICE BY ORAL ADMINISTRATION OF N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE.
Topics: Adenocarcinoma; Adenoma; Administration, Oral; Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Dysgerminoma; Female; Hemangiosarcoma; Humans; Kidney Neoplasms; Leukemia; Liver Neoplasms; Lung Neoplasms; Male; Mice; Nitroso Compounds; Ovarian Neoplasms; Papilloma; Pathology; Research; Skin Neoplasms; Stomach Neoplasms; Testicular Neoplasms | 1965 |
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Antioxidants; Benzo(a)pyrene; Butylated Hydroxytoluene; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Incidence; Lung Neoplasms; Male; Methylcholanthrene; Mice; Mice, Transgenic; Oncogene Protein p21(ras) | 2006 |
N-nitrosodimethylamine (NDMA) formation during ozonation of dimethylamine-containing waters.
Topics: Diethylamines; Diethylnitrosamine; Dimethylamines; Dimethylnitrosamine; Hydrogen-Ion Concentration; Oxidants; Ozone; Water Pollutants, Chemical; Water Purification | 2008 |
Reduction by dietary matrix metalloproteinase inhibitor BAY 12-9566N of neoplastic development induced by diethylnitrosamine, N-nitrosodimethylamine, or 7,12-dimethylbenz(a)anthracene in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Antineoplastic Agents; Biphenyl Compounds; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Drug Screening Assays, Antitumor; Female; Liver Neoplasms; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Matrix Metalloproteinase Inhibitors; Neoplasms; Organic Chemicals; Phenylbutyrates; Rats; Rats, Wistar; Sex Factors | 2008 |
Analysis of nitrosamines in water by automated SPE and isotope dilution GC/HRMS Occurrence in the different steps of a drinking water treatment plant, and in chlorinated samples from a reservoir and a sewage treatment plant effluent.
Topics: Automation; Chlorine; Chromatography, Gas; Diethylnitrosamine; Dimethylnitrosamine; Kinetics; Nitrosamines; Ozone; Quality Control; Sewage; Solid Phase Extraction; Time Factors; Water; Water Purification; Water Supply | 2008 |
Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps.
Topics: Aldehydes; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Carbon Radioisotopes; Carboxylic Acids; Cytochrome P-450 CYP2A6; Deuterium; Diethylnitrosamine; Dimethylnitrosamine; Humans; Kinetics; Mass Spectrometry; Methane; Models, Chemical; NADP; Oxidation-Reduction; Substrate Specificity | 2010 |
Evaluation of the protective effect of ascorbic acid on nitrite- and nitrosamine-induced cytotoxicity and genotoxicity in human hepatoma line.
Topics: Antioxidants; Ascorbic Acid; Carcinoma, Hepatocellular; Cell Survival; Comet Assay; Cytoprotection; Diethylnitrosamine; Dimethylnitrosamine; DNA Damage; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver Neoplasms; Mutagens; Nitrites; Nitrosamines; Oxidative Stress; Reactive Oxygen Species; Time Factors | 2010 |
Genotoxic evaluation of the non-halogenated disinfection by-products nitrosodimethylamine and nitrosodiethylamine.
Topics: Animals; Cell Line; Comet Assay; Diethylnitrosamine; Dimethylnitrosamine; Disinfectants; DNA Damage; Humans; Male; Micronucleus Tests; Mutagens; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2011 |
Assessing granular media filtration for the removal of chemical contaminants from wastewater.
Topics: Atrazine; Biodegradation, Environmental; Charcoal; Diethylnitrosamine; Dimethylnitrosamine; Endocrine Disruptors; Estrone; Ethinyl Estradiol; Filtration; Nitrosamines; Waste Disposal, Fluid; Water Pollutants, Chemical | 2011 |
Determination of eight nitrosamines in water at the ng L(-1) levels by liquid chromatography coupled to atmospheric pressure chemical ionization tandem mass spectrometry.
Topics: Atmospheric Pressure; Chromatography, Liquid; Diethylnitrosamine; Dimethylnitrosamine; Drinking Water; Nitrosamines; Reference Standards; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2011 |
Influence of various cooking methods on the concentrations of volatile N-nitrosamines and biogenic amines in dry-cured sausages.
Topics: Animals; Biogenic Amines; Chemical Phenomena; Chromatography, High Pressure Liquid; Cooking; Diethylnitrosamine; Dimethylnitrosamine; Meat Products; Microwaves; N-Nitrosopyrrolidine; Swine; Volatile Organic Compounds | 2012 |
Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Deuterium; Diethylnitrosamine; Dimethylnitrosamine; Humans; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2012 |
Quantitation of urinary volatile nitrosamines from exposure to tobacco smoke.
Topics: Cotinine; Diethylnitrosamine; Dimethylnitrosamine; Gas Chromatography-Mass Spectrometry; Humans; Liquid-Liquid Extraction; N-Nitrosopyrrolidine; Nicotiana; Nitrosamines; Reproducibility of Results; Smoking; Volatile Organic Compounds | 2013 |
Identification and quantification of seven volatile n-nitrosamines in cosmetics using gas chromatography/chemical ionization-mass spectrometry coupled with head space-solid phase microextraction.
Topics: Cosmetics; Diethylnitrosamine; Dimethylnitrosamine; Gas Chromatography-Mass Spectrometry; Nitrosamines; Solid Phase Microextraction; Volatile Organic Compounds | 2016 |
Long-Term Stability of Volatile Nitrosamines in Human Urine.
Topics: Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Humans; N-Nitrosopyrrolidine; Nitrosamines; Tobacco Smoke Pollution; Urine | 2016 |
Analysis of N-nitrosodiethylamine by ion chromatography coupled with UV photolysis pretreatment.
Topics: Chromatography; Diethylnitrosamine; Dimethylnitrosamine; Hydrogen-Ion Concentration; Nitrites; Nitrosamines; Photolysis; Ultraviolet Rays | 2016 |
Diagnostics of Early Changes in the Immune System Due to Low Concentration of N-Nitrosamines in the Blood.
Topics: Case-Control Studies; Child; Child, Preschool; Diethylnitrosamine; Dimethylnitrosamine; Drinking Water; Female; Gene Expression Regulation; Humans; Immune System; Immunoglobulin G; Leukotrienes; Male; Nitrates; Tumor Suppressor Protein p53 | 2018 |
Lesson Learnt from Recall of Valsartan and Other Angiotensin II Receptor Blocker Drugs Containing NDMA and NDEA Impurities.
Topics: Angiotensin II Type 1 Receptor Blockers; Diethylnitrosamine; Dimethylnitrosamine; Drug Compounding; Drug Contamination; Drug Industry; Drug Recalls; Humans; Mutagens; Patient Safety; United States; United States Food and Drug Administration; Valsartan | 2019 |
The contamination of valsartan and other sartans, part 1: New findings.
Topics: China; Chromatography, Liquid; Diethylnitrosamine; Dimethylnitrosamine; Drug Contamination; Gas Chromatography-Mass Spectrometry; Nitrosamines; Tandem Mass Spectrometry; Valsartan; Water Pollutants, Chemical | 2019 |
Simultaneous detection of nitrosamines and other sartan-related impurities in active pharmaceutical ingredients by supercritical fluid chromatography.
Topics: Angiotensin II Type 1 Receptor Blockers; Chromatography, Supercritical Fluid; Diethylnitrosamine; Dimethylnitrosamine; Drug Contamination; Limit of Detection; Losartan; Nitrosamines; Propylamines; Quality Control; Reference Standards; Risk Assessment; Valsartan | 2019 |
Primary evaluation of nine volatile N-nitrosamines in raw red meat from Tianjin, China, by HS-SPME-GC-MS.
Topics: Animals; China; Diethylnitrosamine; Dimethylnitrosamine; Food Analysis; Food Contamination; Gas Chromatography-Mass Spectrometry; Limit of Detection; Nitrosamines; Red Meat; Reproducibility of Results; Solid Phase Microextraction; Species Specificity; Volatile Organic Compounds | 2020 |
Mismatch repair systems might facilitate the chromosomal recombination induced by N-nitrosodimethylamine, but not by N-nitrosodiethylamine, in Drosophila.
Topics: Animals; Chromosome Aberrations; Chromosomes; Diethylnitrosamine; Dimethylnitrosamine; DNA Breaks, Double-Stranded; DNA Mismatch Repair; DNA Repair; Drosophila melanogaster; Mutagenesis; Recombination, Genetic | 2020 |
Estimated Cancer Risks Associated with Nitrosamine Contamination in Commonly Used Medications.
Topics: Animals; Carcinogens; Diabetes Mellitus, Type 2; Diethylnitrosamine; Dimethylnitrosamine; Neoplasms; Nitrosamines | 2021 |
Evaluation and optimization of a HS-SPME-assisted GC-MS/MS method for monitoring nitrosamine impurities in diverse pharmaceuticals.
Topics: Angiotensin II Type 1 Receptor Blockers; Diethylnitrosamine; Dimethylnitrosamine; Gas Chromatography-Mass Spectrometry; Metformin; Nitrosamines; Pharmaceutical Preparations; Ranitidine; Sodium Chloride; Solid Phase Microextraction; Tandem Mass Spectrometry | 2022 |
Setting limits for N-nitrosamines in drugs: A defined approach based on read-across and structure-activity relationship for N-nitrosopiperazine impurities.
Topics: Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Nitrosamines; Structure-Activity Relationship | 2022 |
A survey of industrial N-nitrosamine discharges in Switzerland.
Topics: Diethylnitrosamine; Dimethylnitrosamine; Ecosystem; Humans; Nitrosamines; Switzerland | 2023 |
Occurrence and transport of N-nitrosamines in the urban water systems of the Pearl River Delta, southern China.
Topics: Child; China; Diethylnitrosamine; Dimethylnitrosamine; Drinking Water; Humans; Nitrosamines; Rivers; Wastewater | 2023 |