Compounds > diethylnitrosamine
Page last updated: 2024-08-17

diethylnitrosamine and carbon tetrachloride

diethylnitrosamine has been researched along with carbon tetrachloride in 92 studies

Research

Studies (92)

TimeframeStudies, this research(%)All Research%
pre-199021 (22.83)18.7374
1990's18 (19.57)18.2507
2000's11 (11.96)29.6817
2010's36 (39.13)24.3611
2020's6 (6.52)2.80

Authors

AuthorsStudies
McGuire, LJ; Poound, AW1
Craddock, VM; Henderson, AR1
Ivanov, SD; Voronova, LA1
Letnansky, K; Wenzel, J1
Columbano, A; Coni, P; Curto, M; Faa, G; Giacomini, L; Ledda-Columbano, GM; Sarma, DS1
Jeney, A; Kovalszky, I; Lapis, K; Szeberenyi, S; Vincze, I; Zalatnai, A1
Dianzani, MU; Pani, P; Tessitore, L1
Chelo, A; Columbano, A; Curto, M; Ennas, MG; Ledda-Columbano, GM; Pani, P1
Lapis, K; Lapsis, K; Rot, A; Sárosi, I; Zalatnai, A1
Abdellatif, AG; Nilsson, R; Préat, V; Roberfroid, M; Vamecq, J1
Barbason, H; Castelain, P; Deleener, A; Kirsch-Volders, M1
Boucheron, JA; Dyroff, MC; Popp, JA; Richardson, FC; Swenberg, JA1
Columbano, A; Coni, P; Ledda-Columbano, GM; Liguori, C; Pani, P1
Lapis, K; Zalatnai, A3
Della Porta, G; Dragani, TA; Manenti, G1
Fel', VIa; Khodosova, IA; Zakharova, NV1
Eskelson, CD; Mufti, SI; Sipes, IG; Szebeni, J; Watson, RR1
Columbano, A; Coni, P; Ledda-Columbano, GM; Pani, P1
de Gerlache, J; Deleener, A; Kirsch-Volders, M; Lans, M1
Kazachkov, VI; Litvinov, NN; Voronin, VM1
Fujiwara, M; Kobayashi, M; Nagashima, H; Nakatsukasa, H; Sakata, T; Shiota, T; Takei, N; Watanabe, A1
de Gerlache, J; Lans, M; Pector, JC; Préat, V; Roberfroid, M; Taper, H1
Sakata, T1
Ehlvest, J; Põldvere, E; Veidebaum, T1
Barbin, A; Bartsch, H; Béréziat, JC1
Gans, JH; Mulcahy, LS1
Hasegawa, R; Imaida, K; Ito, N; Murasaki, G; Tatematsu, M1
de Stoppelaar, J; Hoebee, B; Kirsch-Volders, M; Van Goethem, F1
Marselos, M; Nebert, DW; Pappas, P; Vasiliou, V1
Hamura, H; Honda, H; Noguchi, Y; Shibata, H; Takagi, S; Uchida, M1
Castelain, P; Ghahroudi, MA; Kirsch-Volders, M; Van Goethem, F1
Cho, KJ; Jang, JJ1
Columbano, A; Denda, A; Endoh, T; Hasegawa, K; Konishi, Y; Ledda-Columbano, GM; Nakae, D; Noguchi, O; Zedda, AI1
Roberts, SM; Salminen, WF; Voellmy, R1
Akai, H; Andoh, N; Kobayashi, Y; Konishi, Y; Nakae, D; Ohashi, K; Satoh, H; Tsutsumi, M1
Eriksson, LC; Olsson, J; Stål, P; Wang, GS; Xia, L1
Rajalakshmi, S; Rao, PM; Sarma, DS; Yusuf, A1
Buratto, B; Ciurlionis, R; Jolly, RA; Lum, PY; Morfitt, DC; Praestgaard, JT; Roberts, C; Schadt, E; Ulrich, RG; Waring, JF1
Espandiari, P; Glauert, HP; Lee, EY; Lehmler, HJ; Robertson, LW; Srinivasan, C1
Ferencz, V; Folhoffer, A; Gaál, J; Hegedus, D; Horváth, A; Horváth, C; Kári, B; Mészáros, S; Szalay, F; Wolf, Z1
Bollito, E; Tessitore, L1
Dakshayani, KB; Manivasagam, T; Mohamed Essa, M; Subramanian, P1
Elsharkawy, AM; Karin, M; Kim, K; Kim, S; Maeda, S; Naugler, WE; Sakurai, T1
Kuang, ZP; Liang, AM; Luo, XL; Wu, JN; Xie, YA; Yang, F1
Ewertowska, M; Ignatowicz, E; Jodynis-Liebert, J; Kujawska, M; Mikołajczyk, K; Murias, M1
Sarma, BK; Singh, BN; Singh, BR; Singh, HB1
Bahnasy, A; Elgendy, SM; Elmageed, ZY; Kandil, E; Matrougui, K; Mohamed, MS; Shaarawy, SM; Tohamy, AA1
Bhagwat, S; Gupta, S; Khade, B; Maru, G; Poojari, R2
Ewertowska, M; Ignatowicz, E; Jodynis-Liebert, J; Kujawska, M; Oszmiański, J1
Ewertowska, M; Ignatowicz, E; Jodynis-Liebert, J; Kujawska, M; Markowski, J1
Blaner, WS; Dapito, DH; Gwak, GY; Jiang, H; Kluwe, J; O'Byrne, SM; Piantedosi, R; Pradere, JP; Schwabe, RF; Siddiqi, M; Troeger, JS; Wongsiriroj, N1
Maeda, M; Sakaida, I; Takami, T; Terai, S1
Alford, JK; Caravan, P; Fuchs, BC; Guimaraes, AR; Lauwers, GY; Loving, GS; Polasek, M; Schühle, DT; Tanabe, KK; Uppal, R; Wei, L; Yamada, S1
Abdel-Ghany, MI; Abdel-Hamid, NM; Amgad, SW; Nazmy, MH1
Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M2
Hayashi, H; Hayashi, M; Mitsumori, K; Morita, R; Nakamura, D; Shibutani, M; Suzuki, K; Taniai, E; Wakita, A1
Ainslie, GR; Bataller, R; Boorman, GA; Bradford, BU; Izawa, T; Kosyk, O; Kutanzi, K; Muskhelishvili, L; Pogribny, IP; Rusyn, I; Shymonyak, S; Uehara, T; Yamate, J1
Bugyik, E; Dezső, K; Nagy, P; Paku, S; Papp, V; Pávai, Z; Rókusz, A; Szabó, V1
Chowdhury, KD; Paul, S; Sadhukhan, GC; Sarkar, A; Sengupta, D1
Huang, SX; Kuang, ZP; Li, YD; Luo, M; Luo, XL; Wu, JN; Xie, YA; Yang, F1
Ding, LH; Feng, ZJ; Gao, SB; Jin, GH; Li, SH; Lin, X; Wang, XM; Xu, B; Yin, ZY; Zhang, S; Zheng, R1
Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T1
Bardeesy, N; Caravan, P; Chen, X; Crenshaw, A; DePeralta, DK; Fuchs, BC; Fujii, T; Golub, TR; Gupta, S; Hoshida, Y; Kuroda, T; Lanuti, M; Lauwers, GY; McGinn, CM; Onofrio, R; Schmitt, AD; Tanabe, KK; Taylor, B; Wei, L; Winckler, W; Yamada, S1
Pogribny, IP; Rusyn, I; Uehara, T1
Caviglia, JM; Schwabe, RF1
Beland, FA; Chappell, G; Marrone, AK; Pogribny, IP; Rusyn, I; Shpyleva, S; Tryndyak, V; Tsuchiya, M; Uehara, T1
Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A1
Li, X; Liu, W; Qiu, B; Yang, J; Zhang, H1
Adili, A; Affò, S; Español-Suñer, R; Heikenwälder, M; Leclercq, IA; Lemaigre, FP; Manco, R; Mederacke, I; Mu, X; Schwabe, RF; Sempoux, C; Unger, K; Weber, A; Yuan, D1
Hu, C; Hui, L; Ji, F; Li, W; Li, Z; Liu, C; Lu, Y; Nie, L; Tao, W; Wang, H; Wei, B; Xiao, J; Xu, M; Xu, X; Xue, S; Zhang, H; Zhang, Y; Zhou, X1
Ge, R; Hu, L; Li, Y; Liu, K; Sun, Y; Wang, K; Xue, F; Yang, L1
Affò, S; Dapito, DH; Friedman, R; Lefkovitch, JH; Mu, X; Pradere, JP; Schwabe, RF1
Grant, DM; Hanna, D; Riedmaier, AE; Sugamori, KS1
Ali, MM; Ghanem, HM; H Abdel-Halim, A; H Borai, I; Mousa, FM1
Cai, LL; Chen, JX; Chen, Y; Guo, WH; Wang, XZ; Wu, Q; Zheng, JF1
Monga, SP; Poddar, M; Preziosi, M; Singh, S1
Barbisan, LF; Cogliati, B; da Silva, TC; Fernandes, AAH; Moreno, FS; Prata, GB; Romualdo, GR1
Choi, JH; Kim, M; Kwon, HM; Lee, C; Lee, JH; Lee, SM; Oh, J; Park, J; Scherer, PE; Shin, HH1
Khan, H; Nabavi, SM; Ullah, H1
Akahori, Y; Ito, Y; Jin, M; Kikuchi, S; Masubuchi, Y; Nakajima, K; Saito, F; Shibutani, M; Yoshida, T1
Abe, T; Iwako, H; Kobayashi, T; Kuroda, S; Ohdan, H; Okimoto, S; Tashiro, H; Yamaguchi, M1
Chen, C; Lei, C; Li, J; Liang, L; Tang, N; Wang, K; Wang, Q; Xia, J; Yang, F; Yang, Y1
Chen, K; Hoshida, Y; Jia, Y; Li, L; Lin, YH; Lu, T; Luo, D; MacConmara, M; Singal, AG; Wang, S; Wang, T; Wen, Z; Xiao, G; Yopp, A; Zhang, S; Zhu, H; Zhu, M1
Adebayo, AH; Adelani, IB; Adesina, GO; Edokwe, CB; Metibemu, DS; Oseha, OE; Yakubu, OF1
Bai, Q; Cui, Y; Guo, H; Han, J; Ji, C; Klos, M; Li, X; Liang, S; Liu, L; Liu, X; Liu, Y; Ma, K; Meng, F; Morgenstern, S; Sun, L; Wang, J; Wang, W; Wang, Y; Wu, D; Yang, G; Yuan, Y; Zhang, B; Zhang, S; Zheng, C; Zhou, S1
Ba, Q; Chen, C; Chu, Q; Li, J; Li, L; Li, X; Liu, C; Qiu, L; Wang, H; Wang, X; Yang, Y1
Arellanes-Robledo, J; Márquez-Quiroga, LV; Muriel, P; Vásquez-Garzón, VR; Villa-Treviño, S1
Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J1

Reviews

2 review(s) available for diethylnitrosamine and carbon tetrachloride

ArticleYear
Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 124

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcumin; Diethylnitrosamine; Hexachlorocyclohexane; Humans; Liver; Metals, Heavy; Oxidative Stress; Protective Agents

2019
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma.
    Biochemical pharmacology, 2022, Volume: 195

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Humans; Liver; Liver Neoplasms; Non-alcoholic Fatty Liver Disease

2022

Trials

1 trial(s) available for diethylnitrosamine and carbon tetrachloride

ArticleYear
Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?
    Environmental health and preventive medicine, 2013, Volume: 18, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Enzyme-Linked Immunosorbent Assay; Glucosephosphate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Hexokinase; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Liver Neoplasms, Experimental; Male; Methanol; Nigella sativa; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Seeds; Spectrophotometry

2013

Other Studies

89 other study(ies) available for diethylnitrosamine and carbon tetrachloride

ArticleYear
Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice.
    British journal of cancer, 1978, Volume: 37, Issue:4

    Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Liver Regeneration; Male; Mice; Neoplasms, Experimental; Nitrosamines; Time Factors

1978
De novo and repair replication of DNA in liver of carcinogen-treated animals.
    Cancer research, 1978, Volume: 38, Issue:7

    Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; DNA Repair; DNA Replication; Ethionine; Ethyl Methanesulfonate; Female; Liver; Plants, Toxic; Pyrrolizidine Alkaloids; Rats; Senecio; Thioacetamide; Time Factors

1978
[Hepatic RNA resistance to enzymatic degradation in the process of hepatocarcinogenesis in rats].
    Voprosy onkologii, 1978, Volume: 24, Issue:5

    Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Ribonucleases; RNA; RNA, Neoplasm; Time Factors

1978
The phosphorylation of histones in rat liver undergoing malignant transformation.
    Cancer research, 1977, Volume: 37, Issue:3

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Histones; Liver Neoplasms; Liver Regeneration; Male; Neoplasms, Experimental; Oxidative Phosphorylation; Phosphates; Precancerous Conditions; Rats

1977
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
    Carcinogenesis, 1992, Volume: 13, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Hyperplasia; Lead; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Nitrates; Orotic Acid; Phenobarbital; Rats; Rats, Inbred Strains

1992
Modification of DENA-induced hepatocarcinogenesis by CCl4 cirrhosis. Comparison of the marker enzyme patterns.
    Carcinogenesis, 1992, Volume: 13, Issue:5

    Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Drug Administration Schedule; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344

1992
Choline enhances acetylaminofluorene promotion of liver carcinogenesis in female but not in male rats.
    Carcinogenesis, 1992, Volume: 13, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Choline; Diethylnitrosamine; Drug Synergism; Female; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; Sex Characteristics

1992
Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci.
    Carcinogenesis, 1990, Volume: 11, Issue:5

    Topics: Adenosine Triphosphatases; Animals; Body Weight; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Ethylene Dibromide; gamma-Glutamyltransferase; Hyperplasia; Lead; Liver; Liver Neoplasms; Male; Nafenopin; Nitrates; Propionates; Rats; Rats, Inbred Strains

1990
Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats.
    Cancer letters, 1991, Volume: 57, Issue:1

    Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344

1991
Peroxisome proliferation and modulation of rat liver carcinogenesis by 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, perfluorooctanoic acid and nafenopin.
    Carcinogenesis, 1990, Volume: 11, Issue:11

    Topics: 2-Acetylaminofluorene; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Caprylates; Carbon Tetrachloride; Diethylnitrosamine; Enzyme Induction; Fluorocarbons; Liver Neoplasms, Experimental; Male; Microbodies; Nafenopin; Rats; Rats, Inbred Strains

1990
Cell population kinetics and ploidy rate of early focal lesions during hepatocarcinogenesis in the rat.
    British journal of cancer, 1989, Volume: 60, Issue:6

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Count; Diethylnitrosamine; DNA; Liver; Liver Neoplasms, Experimental; Male; Mitosis; Ploidies; Rats; Rats, Inbred Strains

1989
Biochemical and morphologic studies of heterogeneous lobe responses in hepatocarcinogenesis.
    Carcinogenesis, 1986, Volume: 7, Issue:2

    Topics: Alkylation; Animals; Carbon Radioisotopes; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Guanine; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Thymidine

1986
Liver cell proliferation induced by the mitogen ethylene dibromide, unlike compensatory cell proliferation, does not achieve initiation of rat liver carcinogenesis by diethylnitrosamine.
    Cancer letters, 1987, Volume: 36, Issue:3

    Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Ethylene Dibromide; gamma-Glutamyltransferase; Hydrocarbons, Brominated; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Mitogens; Necrosis; Rats; Rats, Inbred Strains

1987
Diethyl-nitrosamine hepatocarcinogenesis in cirrhotic rats.
    Acta morphologica Hungarica, 1987, Volume: 35, Issue:3-4

    Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity

1987
Enhancing effects of carbon tetrachloride in mouse hepatocarcinogenesis.
    Cancer letters, 1986, Volume: 31, Issue:2

    Topics: Animals; Carbon Tetrachloride; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Mice; Mitosis; Necrosis

1986
[Detection of cells resistant to the cytotoxic action of CCl4 in rat hepatocyte populations following a single exposure to diethylnitrosamine and subsequent injections of phenobarbital].
    Tsitologiia, 1986, Volume: 28, Issue:8

    Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Drug Resistance; Histocytochemistry; Liver; Male; Mitochondria, Liver; Phenobarbital; Rats; Succinate Dehydrogenase; Time Factors

1986
Inhibition of ethanol induced ethane exhalation by carcinogenic pretreatment of rats 12 months earlier.
    Life sciences, 1986, Dec-29, Volume: 39, Issue:26

    Topics: 2-Acetylaminofluorene; Animals; Breath Tests; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Interactions; Ethane; Ethanol; Lipid Peroxides; Liver; Male; Rats; Rats, Inbred Strains; Time Factors

1986
Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis.
    Carcinogenesis, 1987, Volume: 8, Issue:2

    Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Hepatectomy; Lead; Liver Neoplasms; Liver Neoplasms, Experimental; Methylnitrosourea; Mitogens; Nitrates; Rats

1987
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
    Cancer genetics and cytogenetics, 1985, Volume: 17, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Histocytochemistry; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains

1985
[Experimental study of the effect of combinations of chemical water pollutants on carcinogenesis].
    Gigiena i sanitariia, 1985, Issue:12

    Topics: Animals; Benzene; Cadmium; Carbon Tetrachloride; Cocarcinogenesis; Diethylnitrosamine; Female; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Neoplasms, Experimental; Time Factors; Water Pollutants; Water Pollutants, Chemical

1985
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
    Annals of the New York Academy of Sciences, 1983, Volume: 417

    Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nitrosamines; Rats; Rats, Inbred Strains

1983
[Promoting effect of portacaval anastomosis in experimental hepatic carcinogenesis].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1984, Volume: 178, Issue:4

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains

1984
Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma.
    Acta medica Okayama, 1984, Volume: 38, Issue:6

    Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitrosamine; Drug Interactions; Hyperplasia; Isoenzymes; Leucine Transaminase; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Transaminases

1984
Role of mitotic activity in target tissues in N-nitrosodiethylamine carcinogenesis.
    IARC scientific publications, 1983, Issue:51

    Topics: Animals; Carbon Tetrachloride; Cell Division; Cell Transformation, Neoplastic; Dexamethasone; Diethylnitrosamine; DNA; Liver; Lung; Mice; Mice, Inbred C3H; Mitosis; Nitrosamines

1983
Evaluation of DNA damage by the alkaline elution technique in liver, kidneys and lungs of rats and hamsters treated with N-nitrosodialkylamines.
    Carcinogenesis, 1983, Volume: 4, Issue:5

    Topics: Animals; Carbon Tetrachloride; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; DNA; Kidney; Liver; Lung; Male; Mesocricetus; Nitrosamines; Rats; Tetraethylammonium Compounds

1983
The fidelity of mouse liver mitochondrial DNA polymerase following long-term administration of carbon tetrachloride, diethylnitrosamine, or phenobarbital.
    Molecular pharmacology, 1983, Volume: 24, Issue:2

    Topics: Animals; Carbon Tetrachloride; Chromatography, DEAE-Cellulose; Diethylnitrosamine; DNA-Directed DNA Polymerase; Male; Mice; Mitochondria, Liver; Nitrosamines; Phenobarbital

1983
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
    Gan, 1980, Volume: 71, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Male; Organ Specificity; Rats; Saccharin; Tetradecanoylphorbol Acetate

1980
Identification of clastogenic and/or aneugenic events during the preneoplastic stages of experimental rat hepatocarcinogenesis by fluorescence in situ hybridization.
    Carcinogenesis, 1995, Volume: 16, Issue:8

    Topics: Aneuploidy; Animals; Carbon Tetrachloride; Chromosome Aberrations; Diethylnitrosamine; In Situ Hybridization, Fluorescence; Liver Neoplasms, Experimental; Male; Micronuclei, Chromosome-Defective; Precancerous Conditions; Rats; Rats, Wistar

1995
Simultaneous induction of liver cirrhosis and hepatocellular carcinomas in F-344 rats: establishment of a short hepatocarcinogenesis model.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1994, Volume: 46, Issue:3

    Topics: Animals; Carbon Tetrachloride; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Hepatectomy; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Time Factors

1994
Lack of response of the rat liver "class 3" cytosolic aldehyde dehydrogenase to toxic chemicals, glutathione depletion, and other forms of stress.
    Biochemical pharmacology, 1994, Aug-17, Volume: 48, Issue:4

    Topics: Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Carbon Tetrachloride; Cytosol; Diethylnitrosamine; Enzyme Induction; Glutathione; Hepatectomy; Liver; Male; p-Dimethylaminoazobenzene; Rats; Rats, Wistar

1994
[Acidified aspirin-induced gastric lesion in rats with hepatic cirrhosis produced by N-nitrosodiethylamine or carbon tetrachloride. Effect of aldioxa on gastric lesions].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1994, Volume: 103, Issue:3

    Topics: Allantoin; Aluminum Hydroxide; Animals; Antacids; Aspirin; Carbon Tetrachloride; Diethylnitrosamine; Disease Models, Animal; Gastric Emptying; Gastric Mucosa; Liver Cirrhosis, Experimental; Male; Rats; Rats, Sprague-Dawley

1994
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
    Cancer letters, 1994, Apr-29, Volume: 79, Issue:1

    Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors

1994
Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Diethylnitrosamine; DNA; Liver; Liver Neoplasms, Experimental; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mitotic Index; Phenobarbital; Rats; Rats, Wistar

1993
Effects of carbon tetrachloride, ethanol and acetaldehyde on diethylnitrosamine-induced hepatocarcinogenesis in rats.
    Cancer letters, 1993, Jun-15, Volume: 70, Issue:1-2

    Topics: Acetaldehyde; Animals; Animals, Newborn; Body Weight; Carbon Tetrachloride; Diethylnitrosamine; Ethanol; Glutathione Transferase; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Rats; Rats, Sprague-Dawley

1993
Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis.
    Carcinogenesis, 1996, Volume: 17, Issue:3

    Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogens; Cell Death; Cell Division; Diethylnitrosamine; DNA; Glutathione Transferase; Lead; Liver; Liver Neoplasms, Experimental; Male; Mitogens; Necrosis; Nitrates; Rats; Rats, Wistar

1996
Induction of hsp 70 in HepG2 cells in response to hepatotoxicants.
    Toxicology and applied pharmacology, 1996, Volume: 141, Issue:1

    Topics: Bromobenzenes; Cadmium; Carbon Tetrachloride; Carcinogens; Cells, Cultured; Chromatography, Gas; Cocaine; Cyclophosphamide; Diethylnitrosamine; Electrophoresis, Polyacrylamide Gel; Heat-Shock Response; HSP70 Heat-Shock Proteins; Humans; Liver Neoplasms

1996
Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine.
    Cancer research, 1997, Apr-01, Volume: 57, Issue:7

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Colchicine; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Guanine; Kidney; Linear Models; Liver Neoplasms; Lung; Male; Myocardium; Pancreas; Rats; Rats, Inbred F344; Risk Assessment; Time Factors

1997
Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis, and antioxidation.
    Journal of hepatology, 1999, Volume: 30, Issue:4

    Topics: Animals; Antioxidants; Apoptosis; Body Weight; Carbon Tetrachloride; Carcinogens; Cell Division; Diet; Diethylnitrosamine; Iron; Kupffer Cells; Liver; Liver Neoplasms, Experimental; Male; Necrosis; Organ Size; Rats; Rats, Wistar; Ubiquinone; Vitamin E

1999
Development of resistance during the early stages of experimental liver carcinogenesis.
    Carcinogenesis, 1999, Volume: 20, Issue:8

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Hepatectomy; Liver Neoplasms, Experimental; Male; Orotic Acid; Phenotype; Precancerous Conditions; Rats; Rats, Inbred F344

1999
Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.
    Toxicology and applied pharmacology, 2001, Aug-15, Volume: 175, Issue:1

    Topics: Amiodarone; Animals; Carbon Tetrachloride; Chlorodiphenyl (54% Chlorine); Diethylnitrosamine; Gene Expression; Gene Expression Profiling; Liver; Male; Phylogeny; Propanols; Rats; Rats, Sprague-Dawley; Toxins, Biological

2001
Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 79, Issue:1

    Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Administration, Oral; Animals; Biphenyl Compounds; Body Weight; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Administration Schedule; Drug Evaluation, Preclinical; gamma-Glutamyltransferase; Hydroxylation; Injections, Intraperitoneal; Intubation, Intratracheal; Liver; Liver Neoplasms, Experimental; Male; Models, Biological; Organ Size; Quinones; Rats; Rats, Inbred F344; Time Factors

2004
Bone disorders in experimentally induced liver disease in growing rats.
    World journal of gastroenterology, 2005, Dec-07, Volume: 11, Issue:45

    Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Liver Diseases; Male; Phenobarbital; Rats; Rats, Inbred F344

2005
Early induction of TGF-beta1 through a fasting-re-feeding regimen promotes liver carcinogenesis by a sub-initiating dose of diethylnitrosamine.
    Cell proliferation, 2006, Volume: 39, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Eating; Fasting; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation

2006
Metabolic normalization of alpha-ketoglutarate against N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:5

    Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspartate Aminotransferases; Carbon Tetrachloride; Diethylnitrosamine; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Ketoglutaric Acids; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances

2006
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.
    Science (New York, N.Y.), 2007, Jul-06, Volume: 317, Issue:5834

    Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Estradiol; Female; Hepatocytes; Interleukin-6; Kupffer Cells; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; Necrosis; Ovariectomy; RNA, Messenger; Sex Characteristics

2007
[Dendritic cell vaccine modified by murine mAFP gene enhances immunoprotective effect on liver carcinogenesis and tumor development in mice].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2008, Volume: 30, Issue:4

    Topics: Adenoviridae; alpha-Fetoproteins; Animals; B7-1 Antigen; Cancer Vaccines; Carbon Tetrachloride; Cells, Cultured; Dendritic Cells; Diethylnitrosamine; Ethanol; Genetic Vectors; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Intercellular Adhesion Molecule-1; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Random Allocation; Recombinant Proteins; Transfection

2008
Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats.
    Journal of agricultural and food chemistry, 2009, Mar-25, Volume: 57, Issue:6

    Topics: Animals; Beta vulgaris; Beverages; Carbon Tetrachloride; Diet; Diethylnitrosamine; DNA Damage; Lipid Peroxidation; Liver; Male; Oxidative Stress; Plant Roots; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Xenobiotics

2009
Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark.
    Chemico-biological interactions, 2009, Sep-14, Volume: 181, Issue:1

    Topics: Acacia; Animals; Biomarkers, Tumor; Body Weight; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Flavonoids; Liver; Liver Neoplasms, Experimental; Organ Size; Phenols; Plant Bark; Plant Extracts; Polyphenols; Rats

2009
Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity.
    International journal of biological sciences, 2009, Aug-11, Volume: 5, Issue:6

    Topics: Animals; Apoptosis; Carbon Tetrachloride; Diethylnitrosamine; Flow Cytometry; Garlic; Glutathione; Glutathione Reductase; Glutathione Transferase; Immunohistochemistry; Liver; Male; Microtubule-Associated Proteins; Oxidative Stress; Plant Extracts; Rats; Silymarin; Solvents; Superoxide Dismutase; Survivin

2009
Sida rhombifolia ssp. retusa seed extract inhibits DEN induced murine hepatic preneoplasia and carbon tetrachloride hepatotoxicity.
    Asian Pacific journal of cancer prevention : APJCP, 2009, Volume: 10, Issue:6

    Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferase, Mitochondrial; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Diethylnitrosamine; Free Radical Scavengers; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Male; Malvaceae; Medicine, Ayurvedic; Mice; Plant Extracts; Precancerous Conditions; Rats; Rats, Wistar; Seeds

2009
Protective effect of chokeberry on chemical-induced oxidative stress in rat.
    Human & experimental toxicology, 2011, Volume: 30, Issue:3

    Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Drug Administration Schedule; Fruit; Male; Oxidative Stress; Photinia; Plant Extracts; Rats; Rats, Wistar

2011
Cloudy apple juice protects against chemical-induced oxidative stress in rat.
    European journal of nutrition, 2011, Volume: 50, Issue:1

    Topics: Alkylating Agents; Animals; Aryldialkylphosphatase; Beverages; Carbon Tetrachloride; Comet Assay; Diethylnitrosamine; DNA Damage; Flavonoids; Fruit; Lipid Peroxidation; Liver; Male; Malus; Oxidants; Oxidative Stress; Oxidoreductases; Phenols; Polyphenols; Protein Carbonylation; Rats; Rats, Wistar

2011
Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver.
    Asian Pacific journal of cancer prevention : APJCP, 2010, Volume: 11, Issue:4

    Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzoquinones; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Embelia; Fruit; Liver; Male; Mice; Plant Extracts; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Rats, Wistar

2010
Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis.
    Gut, 2011, Volume: 60, Issue:9

    Topics: Acyltransferases; Animals; Carbon Tetrachloride; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Down-Regulation; Hepatic Stellate Cells; Liver Cirrhosis; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL

2011
Autologous bone marrow cell infusions suppress tumor initiation in hepatocarcinogenic mice with liver cirrhosis.
    Journal of gastroenterology and hepatology, 2012, Volume: 27 Suppl 2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Deoxyguanosine; Diethylnitrosamine; Green Fluorescent Proteins; Homeostasis; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Superoxide Dismutase; Time Factors; Transplantation, Autologous

2012
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models.
    Journal of hepatology, 2012, Volume: 57, Issue:3

    Topics: Animals; Carbon Tetrachloride; Collagen Type I; Contrast Media; Diethylnitrosamine; Disease Models, Animal; Gadolinium; Half-Life; Hydroxyproline; Liver; Liver Cirrhosis; Magnetic Resonance Imaging; Male; Mice; Molecular Imaging; Molecular Probes; Rats; Rats, Wistar

2012
Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:8

    Topics: alpha-Fetoproteins; Animals; Anticarcinogenic Agents; Carbon Tetrachloride; Carcinoembryonic Antigen; Carcinoma, Hepatocellular; Diethylnitrosamine; Lipid Peroxidation; Liver; Liver Neoplasms; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Tephrosia

2012
Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl4-induced hepatocellular carcinoma in Wistar rats.
    Asian Pacific journal of tropical medicine, 2012, Volume: 5, Issue:8

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Body Weight; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fumaria; Liver; Liver Neoplasms, Experimental; Mice; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Treatment Outcome

2012
Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and β-naphthoflavone.
    The Journal of toxicological sciences, 2012, Volume: 37, Issue:5

    Topics: Animals; beta-Naphthoflavone; Carbon Tetrachloride; Carcinogens; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Diethylnitrosamine; Drug Synergism; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Oligonucleotide Array Sequence Analysis; Omeprazole; Proton Pump Inhibitors; Quinoxalines; Rats; Rats, Inbred F344

2012
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 132, Issue:1

    Topics: Animals; Animals, Newborn; Carbon Tetrachloride; Cell Transformation, Neoplastic; Diethylnitrosamine; Female; Immunohistochemistry; Liver Cirrhosis; Liver Neoplasms, Experimental; Mice; Pregnancy; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction

2013
Expansion of hepatic stem cell compartment boosts liver regeneration.
    Stem cells and development, 2014, Jan-01, Volume: 23, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hepatocytes; Liver; Liver Neoplasms; Liver Regeneration; Male; Rats; Rats, Inbred F344; Stem Cells

2014
Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma.
    Biochimica et biophysica acta, 2014, Volume: 1840, Issue:1

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Berberine; Blotting, Western; Carbon Tetrachloride; Carcinoma, Hepatocellular; Caspase 3; Cells, Cultured; Cysteine; Cytochrome P-450 CYP2E1; Cytochromes c; Diethylnitrosamine; Flow Cytometry; Hepatocytes; Histone Deacetylase 1; Immunoenzyme Techniques; Immunoprecipitation; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mice; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Reactive Oxygen Species

2014
Two-stage model of chemically induced hepatocellular carcinoma in mouse.
    Oncology research, 2013, Volume: 20, Issue:11

    Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Monomeric GTP-Binding Proteins; Proto-Oncogene Proteins c-myc; Tumor Suppressor Protein p53

2013
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-22, Volume: 110, Issue:43

    Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Chromatin Immunoprecipitation; Diethylnitrosamine; Epigenesis, Genetic; Female; Hep G2 Cells; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Oligonucleotide Array Sequence Analysis; Phosphoproteins; Proto-Oncogene Proteins; RNA Interference; Up-Regulation; Xenograft Model Antitumor Assays; YAP-Signaling Proteins

2013
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
    International journal of cancer, 2014, Jun-15, Volume: 134, Issue:12

    Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chromatin; Diethylnitrosamine; Disease Models, Animal; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Genomic Instability; Hepatocyte Nuclear Factor 1-alpha; Histone-Lysine N-Methyltransferase; Histones; Liver; Liver Cirrhosis; Liver Neoplasms; Long Interspersed Nucleotide Elements; Male; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras); Short Interspersed Nucleotide Elements; Transcription Factors

2014
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:4

    Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Hepatic Stellate Cells; Hepatocytes; Humans; Ligation; Liver Cirrhosis; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Phosphorylation; Prognosis; Quinazolines; Rats; Rats, Wistar; Transcriptome

2014
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
    Current protocols in pharmacology, 2014, Sep-02, Volume: 66

    Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, Animal; Liver; Liver Cirrhosis; Liver Neoplasms, Experimental; Male; Mice

2014
Mouse models of liver cancer.
    Methods in molecular biology (Clifton, N.J.), 2015, Volume: 1267

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Models, Animal; Female; Gene Knockout Techniques; Humans; Liver; Liver Neoplasms; Male; MAP Kinase Kinase Kinases; Mice; Organ Specificity; PTEN Phosphohydrolase

2015
Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.
    Molecular carcinogenesis, 2016, Volume: 55, Issue:5

    Topics: Animals; Carbon Tetrachloride; Cell Line, Tumor; Diethylnitrosamine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Mice; MicroRNAs

2016
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
    Cell death and differentiation, 2015, Volume: 22, Issue:12

    Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclin D1; Diethylnitrosamine; Disease Models, Animal; Hepatocytes; Hydrogen Peroxide; Inflammation; Interleukin-6; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; Pyridines; Tumor Necrosis Factor-alpha

2015
p53-p66(shc)/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma.
    Toxicology letters, 2015, Nov-04, Volume: 238, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Diethylnitrosamine; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Liver Neoplasms; Mice; MicroRNAs; Pentacyclic Triterpenes; Random Allocation; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Superoxide Dismutase; Triterpenes; Tumor Suppressor Protein p53

2015
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.
    The Journal of clinical investigation, 2015, Oct-01, Volume: 125, Issue:10

    Topics: alpha-Fetoproteins; Animals; Bile Ducts; Biomarkers, Tumor; Carbon Tetrachloride; Carcinogens; Cell Dedifferentiation; Cell Lineage; Cocarcinogenesis; Comparative Genomic Hybridization; Diethylnitrosamine; Gene Expression Profiling; Genes, Reporter; Hepatocytes; Keratin-19; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Mice; Mice, Transgenic; Microfilament Proteins; Neoplastic Stem Cells; Osteopontin; Precancerous Conditions; PTEN Phosphohydrolase; Tamoxifen

2015
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
    The Journal of clinical investigation, 2015, Nov-02, Volume: 125, Issue:11

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Escherichia coli Infections; Female; HEK293 Cells; Hepatitis, Animal; Humans; Immunity, Innate; Interferon-beta; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver Neoplasms; Liver Neoplasms, Experimental; Lung; Macrophages; Male; Mice; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Signal Transduction; Specific Pathogen-Free Organisms; STAT3 Transcription Factor; Toll-Like Receptors; Transcription Factor RelA

2015
Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation.
    Cancer letters, 2016, Feb-01, Volume: 371, Issue:1

    Topics: Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; DNA Damage; DNA Repair; Liver; Liver Neoplasms; Liver Regeneration; Male; Mitochondria, Liver; Proteins; Rats, Inbred F344; Reactive Oxygen Species; RNA Interference; Signal Transduction; Stem Cells; Time Factors; Transfection; Ubiquitin-Activating Enzymes

2016
Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma.
    Gastroenterology, 2016, Volume: 150, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Bile Duct Neoplasms; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholangiocarcinoma; Diethylnitrosamine; Epithelial Cells; Genetic Predisposition to Disease; Hepatocytes; Humans; Liver; Liver Cirrhosis, Experimental; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Protein Serine-Threonine Kinases; PTEN Phosphohydrolase; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Time Factors

2016
Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
    Toxicology, 2016, Dec-12, Volume: 373

    Topics: Aging; Alanine Transaminase; Aminobiphenyl Compounds; Animals; Animals, Newborn; Carbon Tetrachloride; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; DNA Damage; Female; Heme Oxygenase-1; Inflammation; Interleukin-6; Liver Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Sex Characteristics

2016
The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 98

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cell Proliferation; Diethylnitrosamine; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methanol; Neovascularization, Pathologic; Plant Extracts; Rats

2018
The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.
    Cell death & disease, 2018, 02-14, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemokines, CC; Diethylnitrosamine; Female; Gene Expression Regulation, Neoplastic; Hemangioma; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; Middle Aged; Phosphatidylinositol 3-Kinases; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Receptors, CCR10; Signal Transduction; Tumor Necrosis Factor-alpha

2018
Hepatocyte Wnts Are Dispensable During Diethylnitrosamine and Carbon Tetrachloride-Induced Injury and Hepatocellular Cancer.
    Gene expression, 2018, 08-22, Volume: 18, Issue:3

    Topics: Animals; beta Catenin; Cadherins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatocytes; Liver Neoplasms; Male; Mice; Nuclear Proteins; Proto-Oncogene Proteins c-myc; Transcription Factors; Wnt Proteins

2018
Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models.
    PloS one, 2018, Volume: 13, Issue:9

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Susceptibility; Female; Liver; Liver Cirrhosis; Liver Neoplasms, Experimental; Male; Mice, Inbred C3H; Sex Characteristics

2018
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
    The Journal of pathology, 2019, Volume: 247, Issue:1

    Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical and Drug Induced Liver Injury; Collagen Type VI; Diethylnitrosamine; Disease Models, Animal; Enzyme Activation; Extracellular Matrix; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms; Mice, Transgenic; Mitogen-Activated Protein Kinase 8; Peptide Fragments; Signal Transduction

2019
Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 05-01, Volume: 169, Issue:1

    Topics: Animals; Cadherins; Carbon Tetrachloride; Cell Proliferation; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Liver; Liver Neoplasms; Male; NFI Transcription Factors; Precancerous Conditions; Protein C; Rats, Inbred F344; Repressor Proteins; Signal Transduction; Time Factors

2019
Antithrombin Insufficiency Promotes Susceptibility to Liver Tumorigenesis.
    The Journal of surgical research, 2019, Volume: 236

    Topics: Animals; Antithrombin III; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Humans; Inflammation Mediators; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Transgenic

2019
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
    Journal of experimental & clinical cancer research : CR, 2019, Oct-30, Volume: 38, Issue:1

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; Down-Regulation; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Hep G2 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Lipid Peroxidation; Liver Neoplasms; Mice; Neoplasm Transplantation; NF-E2-Related Factor 2; Oxidative Stress; Prognosis; Signal Transduction

2019
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
    Gastroenterology, 2020, Volume: 158, Issue:6

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Exome Sequencing; Female; Gene Knockdown Techniques; Hepatectomy; Hepatocytes; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mice; Mice, Transgenic; Microfilament Proteins; Polyploidy; Primary Cell Culture; Protective Factors; RNA-Seq

2020
Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131

    Topics: Animals; Annona; Antineoplastic Agents, Phytogenic; Antioxidants; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Male; Plant Extracts; Rats; Rats, Wistar

2020
Inhibition of TGFβ1 accelerates regeneration of fibrotic rat liver elicited by a novel two-staged hepatectomy.
    Theranostics, 2021, Volume: 11, Issue:10

    Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Hepatectomy; Hepatic Stellate Cells; Hepatocytes; Ligation; Liver; Liver Cirrhosis; Liver Regeneration; Portal Vein; Primary Cell Culture; Pyrazoles; Quinolines; Rats; Signal Transduction; Transforming Growth Factor beta1

2021
Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice.
    Nature communications, 2021, 09-30, Volume: 12, Issue:1

    Topics: Animals; B7-H1 Antigen; Carbon Tetrachloride; Chemokine CCL2; Diethylnitrosamine; Drug Resistance, Neoplasm; Hepatic Stellate Cells; Hepatocytes; Humans; Immune Checkpoint Inhibitors; Liver; Liver Neoplasms, Experimental; Male; Mice; Neuroimmunomodulation; Organoids; Receptors, Adrenergic, beta; Receptors, CCR2; Signal Transduction; Stress, Psychological; Sympathetic Nervous System; Tumor Escape; Tumor Microenvironment

2021
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
    Stem cell research & therapy, 2022, 10-04, Volume: 13, Issue:1

    Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fibrosis; Glutamate-Ammonia Ligase; Glutamine; Hepatic Stellate Cells; Homeostasis; Liver Cirrhosis; Liver Neoplasms; Mice; Stromal Cells; Transforming Growth Factor beta

2022