diethylnitrosamine has been researched along with 2-acetylaminofluorene in 262 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 128 (48.85) | 18.7374 |
| 1990's | 71 (27.10) | 18.2507 |
| 2000's | 36 (13.74) | 29.6817 |
| 2010's | 20 (7.63) | 24.3611 |
| 2020's | 7 (2.67) | 2.80 |
| Authors | Studies |
|---|---|
| Farber, E; Medline, A; Solt, DB | 1 |
| Cameron, R; Farber, E; Kellen, J; Kolin, A; Malkin, A | 1 |
| Farber, E; Laishes, BA; Ogawa, K; Roberts, E | 1 |
| Ito, N; Miyata, Y; Shinohara, Y; Shirai, T; Tatematsu, M; Tsuda, H | 1 |
| Hitachi, PM; Takayama, S; Yamada, K | 1 |
| Becker, FF; Sell, S | 1 |
| Katyal, SL; Lombardi, B; Sell, S; Sells, MA; Shinozuka, H | 1 |
| Ito, N; Miyata, Y; Murasaki, G; Nakanishi, K; Shinohara, Y; Tatematsu, M | 1 |
| Becker, FF; Hudig, D; Newell, L; Sell, S | 1 |
| Hancock, MP; Ingleton, PM | 1 |
| Matsushima, T; Sugimura, T | 1 |
| Romanenko, AM; Rubenchik, BL | 1 |
| Albert, RE; Bilger, L; Burns, FJ; Nishizumi, M | 1 |
| Gurkalo, VK; Pliss, GB | 1 |
| Hatayama, I; Imai, F; Ito, N; Sato, K; Takaya, S | 1 |
| Burlakova, EB; Dzhaliabova, MI; Kobliakov, VA; Koliada, AIu; Molochkina, EM | 1 |
| Becker, FF; Lapeyre, JN | 1 |
| Gurkalo, VK | 2 |
| Cikryt, P; Göttlicher, M; Schwarz, LR; Veser, U | 1 |
| Columbano, A; Coni, P; Curto, M; Faa, G; Giacomini, L; Ledda-Columbano, GM; Sarma, DS | 1 |
| Decloître, F; Frayssinet, C; Loridon-Rosa, B; Martin, M; Ould Elhkim, M | 1 |
| Dianzani, MU; Pani, P; Tessitore, L | 2 |
| Hardaker, KJ; Lord, PG; Loughlin, JM; Marsden, AM; Orton, TC | 1 |
| Glauert, HP; Kennan, WS; Lay, LT; Pitot, HC | 1 |
| Hasegawa, R; Ito, N; Ogawa, K; Wada, S; Yamaguchi, S | 1 |
| Schwarz, LR; Thierau, D; Watkins, JB | 1 |
| Comolli, R; Leonardi, MG | 1 |
| De Cannière, D; Dehaye, JP; Pector, JC; Préat, V; Ravelingien, N | 1 |
| McQueen, CA; Way, BM | 1 |
| Hasegawa, R; Imaida, K; Ito, N; Shirai, T; Takahashi, S; Yamaguchi, S | 1 |
| Degawa, M; Hashimoto, Y; Miura, S | 1 |
| Chen, ZY; Eaton, DL | 1 |
| Armstrong, D; Blanck, A; Cameron, RG | 1 |
| Desiderio, MA; Perin, A; Sessa, A | 1 |
| Perin, A; Sessa, A | 1 |
| Li, S | 1 |
| Enomoto, K; Mori, M; Nakajima, Y; Takahashi, H | 1 |
| Klose, U; Schwarz, LR; Thierau, D; Veser, U | 1 |
| Fukushima, S; Hagiwara, A; Hasegawa, R; Ito, N; Yamada, M | 1 |
| Abdellatif, AG; Nilsson, R; Préat, V; Roberfroid, M; Vamecq, J | 1 |
| Glauert, HP; Srinivasan, S | 1 |
| Asamoto, M; Ito, N; Shichino, Y; Tsuda, H | 1 |
| Huang, M; Lindahl, R | 1 |
| Blanck, A; Eriksson, LC; Hällström, IP | 1 |
| Cameron, R; Eriksson, LC; Lee, G | 1 |
| Mori, M; Nagase, S; Ogawa, K; Piao, ZS; Sonoda, T; Yokota, K | 1 |
| Dunsford, HA; Sell, S | 1 |
| Dunsford, HA; Hunt, JM; Karnasuta, C; Sell, S | 1 |
| Blanck, A; Gustafsson, JA; Hällström, IP | 1 |
| Hasegawa, R; Imaida, K; Ito, N; Mutai, M; Tsuda, H; Yamaguchi, S | 1 |
| Decker, RW; Magat, WJ; Malejka-Giganti, D | 1 |
| Asamoto, M; Hashimoto, Y; Ito, N; Kato, T; Masuko, T; Nagase, S; Tsuda, H | 1 |
| Deml, E; Eigenbrodt, E; Gerbracht, U; Oesterle, D; Schlatterer, B | 1 |
| Gebhardt, R; Tanaka, T; Williams, GM | 1 |
| Barbason, H; Castelain, P; Deleener, A; Kirsch-Volders, M | 1 |
| Bernelli-Zazzera, A; Cairo, G; Rappocciolo, E; Schiaffonati, L; Tacchini, L | 1 |
| Cameron, RG | 1 |
| Schwarze, PE; Seglen, PO | 1 |
| Herren-Freund, SL; Pereira, MA | 1 |
| Hoekstra, WG; Laishes, BA; LeBoeuf, RA | 1 |
| Daino, L; Feo, F; Frassetto, S; Garcea, R; Pascale, R; Pirisi, L; Ruggiu, ME | 1 |
| Campbell, HA; Hanigan, MH; Pitot, HC; Xu, YD | 1 |
| Davidson, M; Gregg, RG; Wilce, PA | 1 |
| Ernst, MK; Hillesund, T; Poiley, JA; Raineri, R; Tennant, RW | 1 |
| de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H | 2 |
| Daino, L; Donaera, A; Feo, F; Garcea, R; Pascale, R; Pirisi, L | 1 |
| Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Gaspa, L; Pascale, R; Ruggiu, ME; Vannini, MG | 1 |
| Conway, JG; Garvey, LK; Neptun, DA; Popp, JA | 1 |
| Nesland, JM; Saeter, G; Schwarze, PE; Seglen, PO | 2 |
| Kroese, ED; Meerman, JH; Mulder, GJ; van de Poll, ML | 1 |
| Eriksson, LC; Gustafsson, JA; Möller, L; Torndal, UB | 1 |
| Aaron, CS; Grzegorczyk, CR; Harbach, PR; Smith, AL; Wiser, SK | 1 |
| Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Pascale, R; Ruggiu, ME | 1 |
| Barseghian, G; Carr, BI; Hwang, DL; Lev-Ran, A; Roitman, A | 1 |
| Carr, BI; Hwang, DL; Lev-Ran, A; Roitman, A | 1 |
| Esumi, H; Makino, R; Nagase, S; Negishi, C; Sato, S; Sugimura, T; Takano, M; Tanaka, H | 1 |
| Inoue, K; Ito, N; Masui, T; Ogiso, T; Tsuda, H | 1 |
| Anderson, TM; Cameron, JW; Hatch, GG; Kouri, RE; Lubet, RA; Nims, RW; Putman, DL; Schechtman, LM; Spalding, JW; Tennant, RW | 1 |
| Butler, PC; Embleton, MJ | 1 |
| Aoki, T; Ito, N; Kagawa, M; Mera, Y; Tatematsu, M | 1 |
| Juul, N; Nesland, JM; Pettersen, EO; Saeter, G; Schwarze, PE; Seglen, PO | 1 |
| Hahm, KS; Kim, KS; Kim, YS; Lee, NJ | 1 |
| Saeter, G; Schwarze, E; Seglen, O | 1 |
| Maruyama, H; Tanaka, T; Williams, GM | 1 |
| Kawai, K; Mori, H; Nozawa, Y; Ogihara, Y | 1 |
| Blanck, A; Eriksson, LC; Gustafsson, JA; Hansson, T | 2 |
| Buzin, CH; Carr, BI; Huang, TH; Itakura, K | 1 |
| Saeter, G; Schwarze, PE; Seglen, PO | 1 |
| Eskelson, CD; Mufti, SI; Sipes, IG; Szebeni, J; Watson, RR | 1 |
| Becker, FF; Stout, DL | 1 |
| Hirose, M; Ito, N; Ogiso, T; Shirai, T; Tsuda, H | 1 |
| de Gerlache, J; Lans, M; Préat, V; Roberfroid, M | 1 |
| Alexandre, H; Castelain, P; de Gerlache, J; Deleener, A; Kirsch-Volders, M; Preat, V | 1 |
| Sivak, A; Tu, AS | 1 |
| Den Engelse, L; Hermsen, T; Kriek, E; Menkveld, GJ; Scherer, E; Van der Laken, CJ | 1 |
| Peraino, C; Vesselinovitch, SD | 1 |
| Cameron, RG; Feuer, G; Roomi, MW; Stuhne-Sekalec, L | 1 |
| Pettersen, EO; Schwarze, PE; Seglen, PO | 1 |
| Fujii-Kuriyama, Y; Kitagawa, T; Muramatsu, M; Sugioka, Y | 1 |
| Becker, FF; Capetillo, S; Ramagli, LS; Rodriguez, LV | 1 |
| de Gerlache, J; Deleener, A; Kirsch-Volders, M; Lans, M | 1 |
| Eriksson, LC; Ritter, E | 1 |
| Altanerová, V; Kapeller, K; Pavlíková, D | 1 |
| Laishes, BA; Rolfe, PB | 1 |
| Katayama, S; Ohmori, T; Williams, GM | 1 |
| Ogawa, K; Onoé, T; Tomoyori, T; Yokokawa, K | 1 |
| Enomoto, K; Farber, E | 1 |
| Lombardi, B; Shinozuka, H; Takahashi, S | 1 |
| Dent, JG; Graichen, ME; Leonard, TB; Lyght, O; Popp, JA | 1 |
| Fukushima, S; Hosoda, K; Ito, N; Masui, T; Tamano, S; Tsuda, H | 1 |
| Fujiwara, M; Kobayashi, M; Nagashima, H; Nakatsukasa, H; Sakata, T; Shiota, T; Takei, N; Watanabe, A | 1 |
| Pettersen, EO; Schwarze, PE; Seglen, PO; Shoaib, MC | 1 |
| Benedetti, A; Comporti, M; Fulceri, R; Malvaldi, G | 1 |
| Ito, N; Mera, Y; Moore, MA; Ogiso, T; Tsuda, H | 1 |
| Becker, FF | 2 |
| Gyenes, M; Jeney, A; Lapis, K; Ujhelyi, E | 1 |
| Hasegawa, R; Imaida, K; Ito, N; Tsuda, H | 1 |
| Evarts, RP; Hanna, P; Marsden, E; Thorgeirsson, SS; Wirth, PJ | 1 |
| Bykorez, AI; Vinarchuk, MP | 1 |
| de Gerlache, J; Lans, M; Pector, JC; Préat, V; Roberfroid, M; Taper, H | 1 |
| Hatayama, I; Hoshino, K; Imai, F; Ito, N; Nishimura, K; Sato, K; Sato, T; Tatematsu, M; Tsuchida, S | 1 |
| Kligerman, AD; Michalopoulos, G; Strom, S | 1 |
| Ruoslahti, E; Sell, S | 1 |
| Cayama, E; Enomoto, K; Farber, E; Lee, G; Solt, DB; Tsuda, H | 1 |
| Castonguay, A; Schut, HA | 1 |
| Numoto, S; Williams, GM | 1 |
| Imaida, K; Ito, N; Kitahori, Y; Ohshima, M; Tamano, S; Tsuda, H | 1 |
| Sakata, T | 1 |
| Emmelot, P; Feringa, AW; Scherer, E | 1 |
| Furuya, K; Williams, GM | 2 |
| Ishikawa, T; Ito, N; Kitahara, A; Nishimura, K; Ruike, K; Sato, K; Satoh, K; Tsuda, H | 1 |
| Potter, VR | 1 |
| Imaida, K; Ito, N; Shirai, T; Takano, T; Tatematsu, M | 1 |
| Ito, N; Sato, K; Tsuda, H; Yin, Z | 1 |
| Evces, S; Lindahl, R; Wischusen, SM | 1 |
| Ahluwalia, M; Eriksson, L; Farber, E; Lee, G; Roomi, MJ; Sarma, DS; Spiewak, J | 1 |
| Kitahara, A; Sato, K; Satoh, K | 1 |
| Conway, JG; Ji, S; Popp, JA; Thurman, RG | 1 |
| Carr, BI; Fink, L; Laishes, BA | 1 |
| Enomoto, K; Farber, E; Griffin, MJ; Ying, TS | 1 |
| Kunz, W; Schaude, G; Schwarz, M; Tennekes, H | 1 |
| Becker, FF; Lai, CN | 1 |
| Lindahl, R | 1 |
| Hasegawa, R; Ito, N; Nakanishi, K; Tatematsu, M; Tsuda, H | 1 |
| Dormans, JA; van der Heijden, CA; van Nesselrooij, JH | 1 |
| Lotlikar, PD | 1 |
| Hasegawa, R; Imaida, K; Ito, N; Nakanishi, K; Ogiso, T; Takano, T; Tatematsu, M | 1 |
| Cayama, E; Farber, E; Sarma, DS; Solt, DB | 1 |
| Hasegawa, R; Imaida, K; Ito, N; Murasaki, G; Tatematsu, M | 1 |
| Hambali, Z; Kadir, KA; Ngah, WZ; Wahid, SA | 1 |
| Armstrong, MJ; Galloway, SM | 1 |
| Clayson, DB; Jee, P; Laver, G; Lok, E; McMullen, E; Mehta, R; Nera, EA | 1 |
| Comolli, R; La Porta, CA | 1 |
| Cartwright, ME; Cook, WO; Nichols, WW; Soper, KA; Storer, RD | 1 |
| Comolli, R; La Porta, CA; Perletti, GP; Piccinini, F | 1 |
| Daino, L; De Miglio, MR; Feo, F; Gaspa, L; Nufris, A; Pascale, R; Seddaiu, MA; Simile, MM | 1 |
| Khalid, BA; Ong, FB; Shamaan, NA; Top, AG; Wan Ngah, WZ | 1 |
| Assefaw-Redda, Y; Blanck, A; Ekvärn, S; Eriksson, LC; Gustafsson, JA; Hällström, IP | 1 |
| Cattley, RC; Kato, M; Popp, JA; Teets, VJ; Voss, KS | 1 |
| Columbano, A; Coni, P; Curto, M; Giacomini, L; Ledda-Columbano, GM; Pichiri-Coni, G; Sarma, DS; Simbula, G | 1 |
| Atassi, H; Becker, FF; Chan, JY; Estes, M; Kuo, MT; Sell, S; Teeter, LD | 1 |
| Leibold, E; Schwarz, LR | 1 |
| Kurokawa, F | 1 |
| Delzenne, NM; Roberfroid, MB; Taper, HS | 1 |
| Blanck, A; Gustafsson, JA; Kleman, MI; Overvik, E; Porsch-Hällström, I | 1 |
| Castelain, P; Ghahroudi, MA; Kirsch-Volders, M; Van Goethem, F | 1 |
| Nagase, S; Ogawa, K; Ohta, T | 1 |
| Höhne, MW; Kahl, GF; Schwarz, LR; Veser, U; Zieroth, S | 1 |
| Furukawa, F; Kim, HC; Lee, YS; Nishikawa, A; Takahashi, M | 1 |
| Imai, T; Inada, K; Kobayashi, K; Masui, T; Nakamura, T; Nakanishi, H; Tatematsu, M | 1 |
| Novikoff, PM; Oikawa, I; Yam, A | 1 |
| Bralet, MP; Brechot, C; Calise, D; Ferry, N | 1 |
| Galloway, SM; Johnson, TE; Umbenhauer, DR | 1 |
| Mori, H; Okumura, A; Tanaka, T | 1 |
| Comporti, M; Dominici, S; Paolicchi, A; Pompella, A; Tongiani, R | 1 |
| Campbell, HA; Dragan, YP; Pitot, HC; Xu, XH | 1 |
| Ichinose, M; Imai, T; Masegi, T; Masui, T; Muramatsu, M; Nakanishi, H; Tatematsu, M; Yanai, T | 1 |
| Akai, H; Andoh, N; Kobayashi, Y; Konishi, Y; Nakae, D; Ohashi, K; Satoh, H; Tsutsumi, M | 1 |
| Ichinose, M; Imai, T; Kitoh, K; Masegi, T; Nakamura, T; Tatematsu, M; Tsukamoto, T; Yanai, T | 1 |
| Kiehlbauch, CC; Kong, J; Malejka-Giganti, D; Ringer, DP; Vijayaraghavan, P | 1 |
| Archer, MC; Korkola, JE; Lee, VM; Sarma, DS; Wood, GA | 1 |
| Farber, E; Parke, DV; Roomi, MW | 1 |
| Horie, T; Ito, S; Liu, F; Ma, YR; Mizobuchi, Y; Shiba, M; Shimizu, I; Yasuda, M | 1 |
| Dagli, ML; Guerra, JL; Moreno, FS; Penteado, MV; Rizzi, MB; Sinhorini, IL; Wu, TS | 1 |
| Calvisi, D; Carru, A; Daino, L; De Miglio, MR; Deiana, L; Feo, F; Muroni, MR; Pascale, RM; Pusceddu, S; Seddaiu, MA; Simile, MM | 1 |
| Archer, MC; Sarma, DS; Wood, GA | 1 |
| Calvisi, D; Carru, A; De Miglio, MR; Dragani, TA; Feo, F; Gariboldi, M; Manenti, G; Pascale, R | 1 |
| Rajalakshmi, S; Rao, PM; Sarma, DS; Yusuf, A | 1 |
| Eriksson, LC; Olsson, JM; Stål, P; Wang, GS | 2 |
| Enomoto, K; Hattori, A; Mori, M; Sawada, N; Sawaki, M; Tsuzuki, N | 1 |
| Dominguez, S; Macias, RI; Marin, JJ; Monte, MJ; Palomero, MF | 1 |
| Díez, M; Domínguez, M; Marin, JJ; Monte, MJ; Palomero, F; Sainz, GR; Toraño, A | 1 |
| Joo, KW; Kim, DY; Lee, JH; Lee, YS; Yoon, BI | 1 |
| Barbisan, LF; Fávero Salvadori, DM; Kaneno, R; Marchesan Rodrigues, MA; Spinardi-Barbisan, AL; Trindade Moreira, EL; Viana de Camargo, JL | 1 |
| Hur, K; Joo, KH; Jung, SY; Kim, DY; Lee, JH; Lee, YS; Yoon, BI | 1 |
| Ahmed, S; Athar, M; Mathur, M; Rahman, A; Sultana, S | 1 |
| Dagli, ML; Jordão Júnior, AA; Moreno, FS; Naves, MM; Silveira, ER; Vannucchi, H | 1 |
| Chen, HL; Ito, S; Liu, F; Shimizu, I | 1 |
| Chen, G; Cui, R; He, J; Shen, H; Wang, B; Yin, S; Zhang, F | 1 |
| Chen, G; Cui, R; Wang, B; Yin, S; Zhang, F | 1 |
| Nagy, P; Sánchez, A; Thorgeirsson, SS | 1 |
| Arce-Popoca, E; González de Mejía, E; Ramírez-Mares, MV; Villa-Treviño, S; Wallig, M | 1 |
| Espandiari, P; Glauert, HP; Lee, EY; Lehmler, HJ; Robertson, LW; Srinivasan, C | 1 |
| Akahane, M; Hayashi, M; Kuroda, J; Machida, N; Mitsumori, K; Moriwaki, H; Ohnota, H; Shibata, N; Tamura, T | 1 |
| Amin, I; Asmah, R; Koh, BK | 1 |
| Arora, A; Shukla, Y | 1 |
| Beg, ZH; Iqbal, J; Minhajuddin, M | 1 |
| Akahane, M; Hayashi, M; Kashida, Y; Kuroda, J; Mitsumori, K; Ohnota, H; Shibata, N; Tamura, T | 1 |
| Espandiari, P; Glauert, HP; Robertson, LW; Srinivasan, C | 1 |
| Arora, A; Kalra, N; Katiyar, S; Shukla, Y; Siddiqui, IA | 1 |
| Ahmed, S; Jahangir, T; Sharma, S; Sultana, S | 1 |
| Cai, Y; Gong, LK; Liu, LL; Qi, XM; Ren, J; Wang, H; Wu, XF; Xiao, Y | 1 |
| Waddell, WJ | 2 |
| Bollito, E; Tessitore, L | 1 |
| Sehrawat, A; Sultana, S | 1 |
| Arce-Popoca, E; Carrasco-Legleu, CE; Fattel-Fazenda, S; Hernández-García, S; Márquez-Rosado, L; Sánchez-Pérez, Y; Villa-Treviño, S | 1 |
| Alvarez, Mde L; Carnovale, C; Carrillo, MC; Francés, D; Parody, JP; Quiroga, A; Ronco, MT | 1 |
| de Conti, A; Mazzantini, RP; Moreno, FS | 1 |
| Borbath, I; Horsmans, Y; Leclercq, I; Moulin, P; Sempoux, C | 1 |
| Bannasch, P; Groos, J; Kopp-Schneider, A; Schwarz, M | 1 |
| Azuma, T; Hayashi, Y; Kato, H; Kuriyama, M; Miki, A; Seo, Y; Yano, Y | 1 |
| Alemán-Lazarini, L; Arce-Popoca, E; Arellanes-Robledo, J; Beltrán-Ramírez, O; Fattel-Fazenda, S; García-Román, R; Hernández-García, S; Salcido-Neyoy, M; Sierra-Santoyo, A; Vázquez-Vázquez, P; Villa-Treviño, S | 1 |
| Ahmed, S; Jahangir, T; Sultana, S | 1 |
| Cengiz Ustuner, M; Civi, K; Degirmenci, I; Gunes, HV; Kiran, I; Ozden, H; Ustuner, D | 1 |
| Barbisan, LF; Felisbino, SL; Furtado, KS; Justulin, LA; Pires, PW; Rodrigues, MA | 1 |
| Dong, K; Feng, P; Shi, Z; Wang, X; Wen, Z; Xue, X | 1 |
| Abdelwahab, SI; Abdul, AB; Abdullah, R; Ibrahim, TA; Mohan, S; Taha, MM | 1 |
| Alhamdani, A; Alwahaibi, NY; Budin, SB; Mohamed, J | 1 |
| Khan, TH; Sultana, S | 1 |
| Cho, JW; Oh, JH; Park, HJ; Park, SM; Park, SN; Yoon, DY; Yoon, S; Yum, YN | 1 |
| Bhatnagar, S; Chaudhary, N; Jain, SK; Katare, DP; Malik, S | 2 |
| Angeles, E; Beltrán-Ramírez, O; Macías-Pérez, JR; Martínez-Soriano, PA; Ruiz-Sánchez, MB; Salcido-Neyoy, ME; Vásquez-Garzón, VR; Villa-Treviño, S | 1 |
| Khan, AQ; Nafees, S; Sultana, S | 1 |
| Ali, F; Hasan, SK; Khan, AQ; Khan, R; Lateef, A; O'Hamiza, O; Qamar, W; Rehman, MU; Sultana, S; Tahir, M | 1 |
| Bugyik, E; Dezső, K; Nagy, P; Paku, S; Papp, V; Pávai, Z; Rókusz, A; Szabó, V | 1 |
| Chaudhary, H; Jena, PK; Seshadri, S | 1 |
| García-Cuéllar, CM; López Álvarez, GS; Rodríguez-Segura, MÁ; Taja Chayeb, L; Valencia Antúnez, CA; Villa Treviño, S | 1 |
| Mohsenifar, Z; Pourahmad, J; Rasekh, HR; Salimi, A; Seydi, E | 1 |
| Pisani, GB; Quintana, AB; Valenti, JL | 1 |
| Chang, HY; Chen, YC; Huang, GJ; Huang, SS; Lai, HC; Lu, CC; Yang, CH | 1 |
| J Mani, R; Jain, SK; Malik, S; P Katare, D; Ranjpour, M | 1 |
| Amidi, S; Farrokhpayam, H; Hashemi, Z; Motallebi, A; Nazemi, M; Pourahmad, J; Seydi, E | 1 |
| Amin, A; El-Awady, R; Elwy, HM; Hamza, AA; Heeba, GH; Murali, C | 1 |
| El-Tawdi, A; ElGwad, AA; Elmansy, RA; Habib, EK; Hasanin, AH; Ibrahim, D; Matboli, M; Shehata, H; Tash, F | 1 |
| Acharya, R; Bose, P; Jayaprakash, V; Lapenna, A; Pattanayak, SP; Siddique, MUM; Sinha, BN | 1 |
| Cienfuegos, JA; Rotellar, F; Valenti, V | 1 |
| Ahmed, AA; Ahmed, OM; Fahim, HI; Zaky, MY | 1 |
| Kurutaş, EB; Unsal, V | 1 |
| Arellanes-Robledo, J; Castro-Gil, MP; Del-Pozo-Jauner, L; Gabiño-López, NB; López-Torres, CD; Pérez-Carreón, JI; Quintanar-Jurado, V; Sánchez-Rodríguez, R; Torres-Mena, JE; Villa-Treviño, S | 1 |
| Abo-Youssef, A; Ahmed, O; Ali, G; Hersi, F; Mohamed, W; Omar, H | 1 |
| Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM | 1 |
| Abdel-Moneim, A; Ahmed, OM; Morsy, HM; Zoheir, KMA | 1 |
6 review(s) available for diethylnitrosamine and 2-acetylaminofluorene
| Article | Year |
|---|---|
Experimental carcinogenesis in small aquarium fishes.
Topics: 2-Acetylaminofluorene; Adenoma; Adenoma, Bile Duct; Aflatoxins; Animals; Benzopyrenes; Carcinogens; Carcinoma, Hepatocellular; Cycasin; Diethylnitrosamine; Dimethylnitrosamine; Female; Fishes; Goldfish; Liver Neoplasms; Male; Methylcholanthrene; Neoplasms, Experimental; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Sterigmatocystin; Trout | 1976 |
Single-hit versus multi-hit concept of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Phenobarbital; Rats | 1985 |
[Early histochemical markers of hepatocarcinogenesis].
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; alpha-Fetoproteins; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Glycogen Storage Disease Type I; Histocytochemistry; Hyperplasia; Iron Deficiencies; Liver; Liver Glycogen; Liver Neoplasms; Precancerous Conditions; Rats; Time Factors | 1984 |
Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites.
Topics: 1-Naphthylamine; 2-Acetylaminofluorene; 2-Naphthylamine; Alkylation; Amines; Aminobiphenyl Compounds; Animals; Benzidines; Carcinogens; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; DNA; Guinea Pigs; Humans; Methyldimethylaminoazobenzene; Mice; Nicotiana; Nitrosamines; p-Dimethylaminoazobenzene; Plants, Toxic; Rats; Species Specificity | 1984 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Hypertrophy; Liver; Liver Neoplasms; Microsomes, Liver; Neoplasms, Experimental; Organ Size; Oxygenases; Phenobarbital; Precancerous Conditions; Rats | 1982 |
Critique of dose response in carcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplastic; Data Interpretation, Statistical; Diethylnitrosamine; DNA; DNA Adducts; Dose-Response Relationship, Drug; No-Observed-Adverse-Effect Level; Rats; Risk Assessment; Toxicology | 2006 |
256 other study(ies) available for diethylnitrosamine and 2-acetylaminofluorene
| Article | Year |
|---|---|
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Fluorenes; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Time Factors | 1977 |
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms; Liver Regeneration; Male; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred F344 | 1978 |
Gamma-glutamyl transpeptidase: a positive marker for cultured rat liver cells derived from putative premalignant and malignant lesions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Liver Neoplasms; Liver Regeneration; Male; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred F344 | 1978 |
Rapid production of hyperplastic liver nodules in rats treated with carcinogenic chemicals: a new approach for an in vivo short-term screening test for hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; Drug Evaluation, Preclinical; gamma-Glutamyltransferase; Hepatectomy; Hyperplasia; Liver; Liver Neoplasms; Male; Nitrosamines; Quinolines; Rats | 1977 |
Cytologic changes induced in rat livers cells by short-term exposure to chemical substances.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Butanes; Carcinogens; Chromosome Aberrations; DDT; Diethylnitrosamine; Diploidy; Hepatectomy; Hexachlorocyclohexane; Hydrazines; Liver; Liver Neoplasms; Liver Regeneration; Male; Methionine; Mitosis; Nitroso Compounds; Rats | 1975 |
Differences in serum alpha-fetoprotein concentrations during the carcinogenic sequences resulting from exposure to diethylnitrosamine or acetylaminofluorene.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Diethylnitrosamine; Fluorenes; Liver Neoplasms, Experimental; Male; Nitrosamines; Precancerous Conditions; Rats; Rats, Inbred ACI; Time Factors | 1979 |
Effects of a choline-devoid diet on the emergence of gamma-glutamyltranspeptidase-positive foci in the liver of carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Aspartate Aminotransferases; Choline Deficiency; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Rats | 1979 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlorocyclohexane; Hyperplasia; Liver; Liver Diseases; Male; Phenobarbital; Rats | 1979 |
Rat alpha-macrofetoprotein (acute-phase alpha 2-macroglobulin) during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; alpha-Macroglobulins; Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Rats; Rats, Inbred ACI; Time Factors | 1979 |
Pituitary growth hormone and somatotrophs in rats bearing chemically induced hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Growth Hormone; Liver Neoplasms; Lysosomes; Male; Microscopy, Electron; Neoplasms, Experimental; Pituitary Gland; Rats; Ribosomes | 1976 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Ethionine; Hyperplasia; Liver Glycogen; Liver Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Neoplasms, Experimental; p-Dimethylaminoazobenzene; Precancerous Conditions; Rats; Species Specificity | 1976 |
Hepatic cell loss and proliferation induced by N-2-fluorenylacetamide, diethylnitrosamine, and aflatoxin B1 in relation to hepatoma induction.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; DNA; Fluorenes; Liver; Liver Neoplasms; Male; Nitrosamines; Rats; Time Factors | 1977 |
[Influence of chemical carcinogens on the physiological effects of adrenomimetics].
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Interactions; Guinea Pigs; Heart Atria; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Norepinephrine; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sympathomimetics | 1978 |
Different deviation patterns of carbohydrate-metabolizing enzymes in primary rat hepatomas induced by different chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Cell Differentiation; Diethylnitrosamine; Isoenzymes; Liver; Liver Neoplasms; Male; Methyldimethylaminoazobenzene; Neoplasms, Experimental; Rats | 1978 |
[Disorders in the regulation of the activity of microsomal enzymes by lipids during chemical carcinogenesis in the liver].
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Fluorenes; Glucose-6-Phosphatase; Lipid Metabolism; Liver Neoplasms; Male; Membrane Lipids; Microsomes, Liver; Nitrosamines; Oxidation-Reduction; Phosphatidylethanolamines; Phosphatidylserines; Rats | 1978 |
5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Cytosine; Diethylnitrosamine; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; Male; Neoplasms, Experimental; Rats; RNA; RNA, Neoplasm | 1979 |
[Primary mechanism of a reduction in the intensity of extremely weak mitochondrial luminescence in the process of chemical hepatic carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Catalase; Diethylnitrosamine; Enzyme Activation; Liver Neoplasms; Luminescent Measurements; Male; Mitochondria, Liver; Neoplasms, Experimental; Nitrosamines; Rats | 1979 |
The level of aryl hydrocarbon (Ah) receptor and of 4S polycyclic aromatic hydrocarbon (PAH) binding protein in diploid and polyploid hepatocytes of 2-acetylaminofluorene-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carrier Proteins; Centrifugation; Diethylnitrosamine; Glycine N-Methyltransferase; Liver; Male; Methyltransferases; Ploidies; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1992 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Hyperplasia; Lead; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Nitrates; Orotic Acid; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
Role of diethylnitrosamine, 2-acetylaminofluorene and partial hepatectomy in the expression of glutathione-S-transferase-P and gamma-glutamyltranspeptidase in the early steps of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Placenta; Rats; Rats, Inbred F344; Time Factors | 1992 |
Mechanisms of the enhanced liver carcinogenesis by choline in female rats: delay in liver growth after partial hepatectomy and stimulation of 2-AAF mitoinhibition.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline; Diethylnitrosamine; DNA, Neoplasm; Drug Interactions; Female; Hepatectomy; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mitosis; Necrosis; Rats; Rats, Wistar; Sex Factors; Stimulation, Chemical | 1992 |
Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.
Topics: 2-Acetylaminofluorene; Adenoma; Aminobiphenyl Compounds; Animals; Base Sequence; Carcinoma; Diethylnitrosamine; DNA; DNA Mutational Analysis; Genes, ras; Liver Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation | 1992 |
Choline enhances acetylaminofluorene promotion of liver carcinogenesis in female but not in male rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Choline; Diethylnitrosamine; Drug Synergism; Female; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; Sex Characteristics | 1992 |
Effect of dietary fat on the initiation of hepatocarcinogenesis by diethylnitrosamine or 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Dietary Fats; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred Strains | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Glutathione Transferase; Hepatectomy; Injections, Intraperitoneal; Liver; Liver Diseases; Liver Neoplasms, Experimental; Liver Regeneration; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1991 |
Biotransformation in carcinogen-induced diploid and polyploid hepatocytes separated by centrifugal elutriation.
Topics: 2-Acetylaminofluorene; Animals; Cell Separation; Diethylnitrosamine; Diploidy; Enzyme Induction; Hepatectomy; Liver; Male; Polyploidy; Rats; Rats, Inbred Strains | 1992 |
Changes in alanine transport in plasma membrane vesicles from rat liver during the early stages of diethylnitrosamine-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Alanine; Animals; Biological Transport; Cell Membrane; Diethylnitrosamine; Hepatectomy; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Time Factors | 1992 |
Adenylate cyclase activity in crude liver membranes during chemical hepatocarcinogenesis in portacaval shunted rats.
Topics: 2-Acetylaminofluorene; Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Diethylnitrosamine; Glucagon; Guanine Nucleotides; Liver; Liver Neoplasms, Experimental; Male; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains | 1992 |
Sex and strain differences in the hepatocyte primary culture/DNA repair test.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Cell Line; Diethylnitrosamine; DNA Repair; Female; Male; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Species Specificity | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1991 |
Expression and induction of cytochrome P450 isozymes in hyperplastic nodules of rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Blotting, Western; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Hyperplasia; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; p-Aminoazobenzene; Rats; Rats, Inbred F344 | 1991 |
Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alkylation; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Hepatectomy; Hyperplasia; Liver; Male; Oxazines; Phenobarbital; Rats; Rats, Inbred F344; Stimulation, Chemical | 1991 |
Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Deoxycholic Acid; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Orotic Acid; Rats; Rats, Inbred F344; Sex Factors | 1990 |
Diamine oxidase activity in a model of multistep hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Amine Oxidase (Copper-Containing); Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 1990 |
Increased synthesis of N1-acetylspermidine in hepatic preneoplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Diethylnitrosamine; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Polyamines; Precancerous Conditions; Rats; Rats, Inbred F344; Reference Values; Spermidine; Substrate Specificity | 1991 |
[Expression of cellular oncogenes during hepatocarcinogenesis in rats].
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
High sensitivity of the LEC rat liver to the carcinogenic effect of diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Environmental Pollutants; Female; Glutathione Transferase; Hepatectomy; Hepatitis; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; Models, Biological; Rats; Rats, Mutant Strains; Time Factors | 1990 |
Stimulation of DNA synthesis in carcinogen-induced diploid hepatocytes in vitro.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cells, Cultured; Diethylnitrosamine; Diploidy; Epidermal Growth Factor; Flow Cytometry; Insulin; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diethylnitrosamine; Enzyme Induction; Glutathione Transferase; Liver; Male; Nitriles; Phenobarbital; Pyrethrins; Rats; Rats, Inbred F344 | 1990 |
Peroxisome proliferation and modulation of rat liver carcinogenesis by 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, perfluorooctanoic acid and nafenopin.
Topics: 2-Acetylaminofluorene; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Caprylates; Carbon Tetrachloride; Diethylnitrosamine; Enzyme Induction; Fluorocarbons; Liver Neoplasms, Experimental; Male; Microbodies; Nafenopin; Rats; Rats, Inbred Strains | 1990 |
Formation of 5-hydroxymethyl-2'-deoxyuridine in hepatic DNA of rats treated with gamma-irradiation, diethylnitrosamine, 2-acetylaminofluorene or the peroxisome proliferator ciprofibrate.
Topics: 2-Acetylaminofluorene; Animals; Clofibric Acid; Diethylnitrosamine; DNA Damage; Female; Fibric Acids; Liver; Rats; Thymidine | 1990 |
Inhibition of rat hepatic glutathione S-transferase placental form positive foci development by concomitant administration of antioxidants to carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Ascorbic Acid; Butylated Hydroxyanisole; Catechols; Diethylnitrosamine; Enzyme Induction; Glutathione Transferase; Liver; Male; Methyldimethylaminoazobenzene; Rats; Rats, Inbred F344 | 1990 |
Effects of hepatocarcinogenic initiators on aldehyde dehydrogenase gene expression in cultured rat hepatic cells.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Animals; Diethylnitrosamine; Enzyme Induction; Ethionine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Methylcholanthrene; Rats; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1990 |
Loss of sexual differentiation of metabolism of steroids and xenobiotics in nodular hepatic tissue from male and female Wistar rats treated according to the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Female; Hepatectomy; Hydroxylation; Liver; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Oxazines; Rats; Rats, Inbred Strains; Sex Characteristics; Sulfotransferases | 1990 |
Hepatocellular cancer development in spleen of syngenic rats after transfer of potential precursor hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Liver Neoplasms; Liver Neoplasms, Experimental; Neoplasm Transplantation; Precancerous Conditions; Rats; Rats, Inbred F344; Spleen; Time Factors | 1990 |
Albumin-negative hepatocytes in Sprague-Dawley x analbuminemic F1 rats treated with hepatic carcinogens.
Topics: 2-Acetylaminofluorene; Albumins; Animals; Azacitidine; Carcinogens; Cell Division; Diethylnitrosamine; Glutathione Transferase; Histocytochemistry; Immunoenzyme Techniques; Liver; Male; Placenta; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Serum Albumin | 1988 |
Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Diethylnitrosamine; Enzyme-Linked Immunosorbent Assay; Epitopes; Fetus; Fluorescent Antibody Technique; gamma-Glutamyltransferase; Hybridomas; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Precancerous Conditions; Rats; Rats, Inbred F344 | 1989 |
Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Diethylnitrosamine; gamma-Glutamyltransferase; Histocytochemistry; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred ACI; Rats, Inbred F344 | 1989 |
Effects of growth hormone on the expression of c-myc and c-fos during early stages of sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Actins; Animals; Blotting, Northern; Diethylnitrosamine; Female; Gene Expression; Genes; Growth Hormone; Liver; Liver Neoplasms, Experimental; Male; Nucleic Acid Hybridization; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Rats; Rats, Inbred Strains; RNA; Sex Factors; Transcription, Genetic | 1989 |
Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Diethylnitrosamine; Drug Synergism; Glutathione Transferase; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Phenobarbital; Rats; Rats, Inbred F344; Thioacetamide | 1989 |
Modifications of hepatic microsomal 9-oxidation of N-2-fluorenylacetamide in response to gonadectomy and treatment of rats with phenobarbital or diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Castration; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Female; Glucuronidase; Glucuronosyltransferase; Hydroxylation; Male; Microsomes, Liver; NADH Dehydrogenase; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Immunohistochemistry; Isoenzymes; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1989 |
Comparison of three rat liver foci bioassays--incidence of preneoplastic foci initiated by diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Male; Polychlorinated Biphenyls; Precancerous Conditions; Rats; Rats, Inbred Strains; Reference Values; Sex Factors | 1989 |
Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations.
Topics: 2-Acetylaminofluorene; Adenoma; Aflatoxin B1; Aflatoxins; Animals; Biomarkers, Tumor; Diethylnitrosamine; Glutamate-Ammonia Ligase; Immunoenzyme Techniques; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Reference Values | 1989 |
Cell population kinetics and ploidy rate of early focal lesions during hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Count; Diethylnitrosamine; DNA; Liver; Liver Neoplasms, Experimental; Male; Mitosis; Ploidies; Rats; Rats, Inbred Strains | 1989 |
Expression pattern of the genes for different members of the heat-shock protein 70 family, ornithine decarboxylase, and c-Ha-ras during the early stages of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Genes, ras; Heat-Shock Proteins; Hot Temperature; Liver Neoplasms; Liver Neoplasms, Experimental; Liver Regeneration; Male; Ornithine Decarboxylase; Rats; RNA, Neoplasm | 1989 |
Identification of the putative first cellular step of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Resistance; Glutathione Transferase; Hepatectomy; Immunoenzyme Techniques; Liver Neoplasms, Experimental; Liver Regeneration; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1989 |
Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Adenine; Adenosine Triphosphatases; Amino Acids; Animals; Autophagy; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Histocytochemistry; In Vitro Techniques; Kinetics; Liver; Lysosomes; Male; Phagocytosis; Proteins; Rats; Rats, Inbred Strains; Sucrose | 1985 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Selenium | 1985 |
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Polyamines; Putrescine; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Spermidine; Spermine | 1985 |
Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Liver; Liver Neoplasms, Experimental; Phenotype; Precancerous Conditions; Rats; Rats, Inbred F344 | 1986 |
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxymethylglutaryl CoA Reductases; Liver; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1986 |
Increased carcinogen metabolism and survival of retrovirus-infected Fischer rat embryo cells following repetitive carcinogen treatment.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Diethylnitrosamine; Embryo, Mammalian; Female; Kinetics; Pregnancy; Rats; Rats, Inbred F344 | 1985 |
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nafenopin; Phenobarbital; Propionates; Rats; Rats, Inbred Strains | 1986 |
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides | 1987 |
Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Deoxyadenosines; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides | 1987 |
Carcinogen treatment increases glutathione hydrolysis by gamma-glutamyl transpeptidase.
Topics: 2-Acetylaminofluorene; Animals; Bile; Carcinogens; Cysteine; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione; Glycine; Hydrolysis; Liver; Male; Perfusion; Rats; Rats, Inbred F344; Taurine | 1987 |
2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Phenotype; Precancerous Conditions; Rats; Rats, Inbred WKY | 1988 |
The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxyacetylaminofluorene; Liver; Liver Neoplasms, Experimental; Male; Pentachlorophenol; Precancerous Conditions; Rats; Rats, Inbred Strains; Sulfates; Sulfotransferases | 1988 |
The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Air Pollutants; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Fluorenes; Liver Neoplasms, Experimental; Male; Mutagens; Rats; Rats, Inbred Strains | 1989 |
The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes. Validation of improved methods for primary culture including data on the lack of effect of ionizing radiation.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Collagen; Diethylnitrosamine; Dimethylnitrosamine; DNA Replication; Liver; Male; Methyl Methanesulfonate; Rats; Rats, Inbred F344; Rats, Inbred Strains; Ultraviolet Rays; X-Rays | 1989 |
Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Diploidy; DNA, Neoplasm; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred Strains | 1989 |
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1987 |
Binding of growth hormone to rat liver during experimental chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Golgi Apparatus; Growth Hormone; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Somatotropin | 1986 |
Binding of epidermal growth factor and insulin and the autophosphorylation of their receptors in experimental primary hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Epidermal Growth Factor; ErbB Receptors; Golgi Apparatus; Insulin; Liver; Liver Neoplasms, Experimental; Male; Phosphorylation; Rats; Receptor, Insulin; Receptors, Cell Surface | 1986 |
Presence of albumin-positive cells in the liver of analbuminemic rats and their increase on treatment with hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Diethylnitrosamine; Hepatectomy; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Methyldimethylaminoazobenzene; Mutation; Rats; Rats, Inbred Strains; Serum Albumin | 1986 |
Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aniline Compounds; Animals; Body Weight; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Diethylnitrosamine; Eating; Ethoxyquin; Glutathione; Liver Neoplasms, Experimental; Male; Quinolines; Rats; Rats, Inbred F344; Vitamin E | 1986 |
Analysis of the interlaboratory and intralaboratory reproducibility of the enhancement of simian adenovirus SA7 transformation of Syrian hamster embryo cells by model carcinogenic and noncarcinogenic compounds.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adenoviridae; Adenoviruses, Simian; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chromates; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Lead; Mesocricetus; Methylnitronitrosoguanidine | 1986 |
Reactivity of monoclonal antibodies to oncoproteins with normal rat liver, carcinogen-induced tumours, and premalignant liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Diethylnitrosamine; Immunoenzyme Techniques; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Proto-Oncogene Proteins; Proto-Oncogenes; Radioimmunoassay; Rats; Rats, Inbred F344 | 1988 |
Reciprocal relationship between development of glutathione S-transferase positive liver foci and proliferation of surrounding hepatocytes in rats.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxyanisole; Cell Division; Diethylnitrosamine; Glutathione Transferase; Histocytochemistry; Liver; Liver Neoplasms, Experimental; Male; Rats | 1988 |
The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Diploidy; DNA; DNA, Neoplasm; Flow Cytometry; Liver; Liver Neoplasms, Experimental; Male; Polyploidy; Rats; Rats, Inbred WKY | 1988 |
Characterization of tumor specific antigens on the plasma membrane surface of rat hepatomas induced by 3'-Me DAB and identification of the common tumor specific antigens from rat hepatomas induced by different chemical hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Antigens, Surface; Diethylnitrosamine; Liver Neoplasms, Experimental; Methyldimethylaminoazobenzene; Rats; Rats, Inbred Strains | 1988 |
Shift from polyploidizing to nonpolyploidizing growth in carcinogen-treated rat liver.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Flow Cytometry; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Polyploidy; Precancerous Conditions; Rats; Rats, Inbred WKY | 1988 |
Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Organ Size; Phthalic Acids; Precancerous Conditions; Rats; Rats, Inbred F344 | 1987 |
Inhibition of mitochondrial respiration by flavoskyrin, a toxic metabolite of Penicillium islandicum Sopp.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphate; Animals; Anthraquinones; Diethylnitrosamine; DNA; DNA Repair; Mice; Mice, Inbred C3H; Mitochondria, Liver; Oxidative Phosphorylation; Oxidoreductases; Oxygen Consumption; Rats; Rats, Inbred ACI | 1986 |
Pituitary grafts modify sex differences in liver tumor formation in the rat following initiation with diethylnitrosamine and different promotion regimens.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Disease Models, Animal; Female; Hydroxyacetylaminofluorene; Liver Neoplasms, Experimental; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Sex Factors | 1986 |
Induction of heat shock gene expression without heat shock by hepatocarcinogens and during hepatic regeneration in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Heat-Shock Proteins; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Proto-Oncogenes; Rats; Rats, Inbred F344; Transcription, Genetic | 1986 |
Changes in cellular ploidy and autophagic responsiveness during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Autophagy; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Phagocytosis; Ploidies; Proteins; Rats; Rats, Inbred Strains | 1986 |
Inhibition of ethanol induced ethane exhalation by carcinogenic pretreatment of rats 12 months earlier.
Topics: 2-Acetylaminofluorene; Animals; Breath Tests; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Interactions; Ethane; Ethanol; Lipid Peroxides; Liver; Male; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Heme enzyme patterns in rat liver nodules and tumors.
Topics: 2-Acetylaminofluorene; 5-Aminolevulinate Synthetase; Animals; Catalase; Chemical and Drug Induced Liver Injury; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Diethylnitrosamine; Heme; Indoleamine-Pyrrole 2,3,-Dioxygenase; Liver Diseases; Liver Neoplasms; Liver Regeneration; Male; Rats; Rats, Inbred Strains; Tryptophan Oxygenase | 1987 |
Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Drug Interactions; Esophageal Neoplasms; Ethinyl Estradiol; Glutathione Transferase; Isoenzymes; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Thyroid Neoplasms; Urinary Bladder Neoplasms | 1987 |
Promoting effect of oxazepam in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Oxazepam; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Changes in nucleolar transcriptional activity and nuclear DNA content during the first steps of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Cell Nucleolus; Diethylnitrosamine; DNA, Neoplasm; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Nucleolus Organizer Region; Precancerous Conditions; RNA, Neoplasm; Silver; Transcription, Genetic | 1987 |
Use of rodent hepatocytes for metabolic activation in transformation assays.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Liver; Methylcholanthrene; Mice; Phenobarbital; Rats; Species Specificity | 1985 |
Immunohistochemical localization of O6-ethyldeoxyguanosine and deoxyguanosin-8-yl-(acetyl)aminofluorene in liver sections of rats treated with diethylnitrosamine, ethylnitrosourea or N-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Deoxyguanosine; Diethylnitrosamine; DNA; Ethylnitrosourea; Female; Histocytochemistry; Immunoenzyme Techniques; Liver; Nitrosamines; Nitrosourea Compounds; Rats; Rats, Inbred Strains | 1985 |
Changes in progesterone binding and metabolism in liver microsomes from persistent hepatocyte nodules and hepatomas in male rats.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Intracellular Membranes; Liver; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Progesterone; Rats; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1986 |
Characterization of hepatocytes from carcinogen-treated rats by two-parametric flow cytometry.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; DNA; Flow Cytometry; Liver; Male; Rats; Rats, Inbred Strains | 1986 |
Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Methyldimethylaminoazobenzene; Molecular Weight; Neoplasm Proteins; Peptides; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
Alterations in nonhistone chromatin proteins during hepatocarcinogenesis induced by diverse acting carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Cell Cycle; Chromatin; Chromosomal Proteins, Non-Histone; Diethylnitrosamine; Electrophoresis, Polyacrylamide Gel; Liver Neoplasms, Experimental; Liver Regeneration; Male; Rats; Rats, Inbred Strains | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Histocytochemistry; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
Aldehyde dehydrogenase activities in hepatocyte nodules and hepatocellular carcinomas from Wistar rats.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Animals; Diethylnitrosamine; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains | 1985 |
Alkaline phosphatase in rat liver during early stages of experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Diethylnitrosamine; Histocytochemistry; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Quantitative assessment of liver colony formation and hepatocellular carcinoma incidence in rats receiving intravenous injections of isogeneic liver cells isolated during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Neoplasm Transplantation; Rats; Rats, Inbred F344; Transplantation, Isogeneic | 1980 |
Enhancement of hepatocarcinogenesis by sequential administration of chemicals: summation versus promotion effects.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Iron; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred F344 | 1981 |
Induction of gamma-glutamyltranspeptidase-positive altered hepatocytic lesions by combination of transplacental-initiation and postanal-selection.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Hyperplasia; Liver; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Inbred Strains | 1982 |
Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Rats | 1982 |
Progression of carcinogen-induced foci of gamma-glutamyltranspeptidase-positive hepatocytes to hepatomas in rats fed a choline-deficient diet.
Topics: 2-Acetylaminofluorene; Animal Feed; Animals; Cell Transformation, Neoplastic; Choline Deficiency; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains | 1982 |
Comparison of hepatic carcinogen initiation-promotion systems.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; Epoxide Hydrolases; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; Mixed Function Oxygenases; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1982 |
Dose and sex dependent effects of 2-acetylaminofluorene, 3'-methyl-4-dimethylaminoazobenzene and DL-ethionine in induction of gamma-glutamyl transpeptidase-positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Ethionine; Female; gamma-Glutamyltransferase; Liver Neoplasms; Male; Methyldimethylaminoazobenzene; Precancerous Conditions; Rats; Rats, Inbred F344; Sex Factors | 1983 |
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nitrosamines; Rats; Rats, Inbred Strains | 1983 |
Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Aggregation; Cell Nucleus; Diethylnitrosamine; Diploidy; DNA; Flow Cytometry; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains | 1984 |
Loss of lipid peroxidation as a histochemical marker for preneoplastic hepatocellular foci of rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Histocytochemistry; Indicators and Reagents; Lipid Peroxides; Liver; Liver Neoplasms, Experimental; Malondialdehyde; Precancerous Conditions; Rats; Rats, Inbred Strains | 1984 |
Enhancement of phenotypic instability by alpha-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Anisoles; Butylated Hydroxyanisole; Diethylnitrosamine; Eflornithine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver; Liver Neoplasms, Experimental; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Phenobarbital; Phenotype; Rats; Rats, Inbred F344; Stimulation, Chemical; Time Factors | 1984 |
The direct and indirect effects of promoters may depend upon the nature of the initiated cell.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Mice; Phenobarbital | 1983 |
[Comparative systemic analysis of experimental models of chemical hepatic carcinogenesis in the rat].
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Rats; Rats, Inbred Strains | 1984 |
Alterations of markers during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Ethylmorphine-N-Demethylase; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Liver; Liver Neoplasms; Male; Microsomes, Liver; Nitrosamines; Rats; Rats, Inbred F344; Time Factors | 1984 |
Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Hexachlorocyclohexane; Liver Neoplasms; Liver Neoplasms, Experimental; Precancerous Conditions; Rats | 1983 |
Isolation of preneoplastic rat liver cells by centrifugal elutriation and binding to asialofetuin.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Cell Separation; Cells, Cultured; Centrifugation; Diethylnitrosamine; Fetuins; Liver; Liver Neoplasms, Experimental; Male; Orosomucoid; Precancerous Conditions; Rats; Rats, Inbred F344; Receptors, Immunologic; Tritium | 1984 |
[Promoting effect of portacaval anastomosis in experimental hepatic carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains | 1984 |
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Methyldimethylaminoazobenzene; Phosphotransferases; Pyruvate Kinase; Rats | 1981 |
Comparisons of the effects of chemical carcinogens in mixed cultures of rat hepatocytes and human fibroblasts.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Bromodeoxyuridine; Carcinogens; Cells, Cultured; Diethylnitrosamine; DNA; Fibroblasts; Humans; Liver; Male; Rats; Rats, Inbred Strains | 1981 |
Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fibronectins; Glycoproteins; Hepatectomy; Laminin; Liver; Liver Neoplasms; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1982 |
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride Poisoning; Cocarcinogenesis; Diet; Diethylnitrosamine; Dimethylhydrazines; Hepatectomy; Liver Neoplasms; Male; Methylnitrosourea; Rats; Rats, Inbred F344 | 1983 |
On mechanisms of sex differences in chemical carcinogenesis: effects of implantation of ectopic pituitary grafts on the early stages of liver carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Female; Hepatectomy; Hypothalamo-Hypophyseal System; Liver Neoplasms, Experimental; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Sex Factors; Steroids; Testosterone | 1984 |
Promotion of mouse liver neoplasms by the organochlorine pesticides chlordane and heptachlor in comparison to dichlorodiphenyltrichloroethane.
Topics: 2-Acetylaminofluorene; Animals; Chlordan; DDT; Diethylnitrosamine; Environmental Exposure; Heptachlor; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains | 1984 |
Three-dimensional observations by scanning electron microscopy on the blood supply and organization of vasculature during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Microscopy, Electron, Scanning; Perfusion; Rats; Rats, Inbred F344; Time Factors | 1984 |
Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitrosamine; Drug Interactions; Hyperplasia; Isoenzymes; Leucine Transaminase; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Transaminases | 1984 |
Initiation-promotion-initiation. Induction of neoplastic foci within islands of precancerous liver cells in the rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Ethylnitrosourea; Female; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; Nitrosamines; Nitrosourea Compounds; Precancerous Conditions; Rats; Rats, Inbred Strains | 1984 |
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms; Male; Nitrosamines; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1984 |
Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Diethylnitrosamine; Female; Fetus; Glutathione Transferase; Kinetics; Liver; Liver Neoplasms, Experimental; Placenta; Precancerous Conditions; Pregnancy; Rats | 1984 |
Use of two sequential applications of initiators in the production of hepatomas in the rat: an examination of the Solt-Farber protocol.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Interactions; Liver; Liver Neoplasms, Experimental; Nitrosamines; Rats; Research Design | 1984 |
Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Diethylnitrosamine; DNA; Drug Synergism; Liver Neoplasms; Male; Methapyrilene; Rats; Rats, Inbred F344 | 1984 |
Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Hepatectomy; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; p-Dimethylaminoazobenzene; Rats | 1981 |
Changes in activities of uridine diphosphate-glucuronyltransferases during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxyanisole; Diethylnitrosamine; Enzyme Induction; Glucuronosyltransferase; Hyperplasia; Liver; Liver Neoplasms; Male; Methylcholanthrene; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1982 |
Changes in aldehyde dehydrogenase activity during diethylnitrosamine- or 2-acetylaminofluorene-initiated rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Rats; Rats, Inbred Strains | 1983 |
Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Resistance; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1983 |
Properties of the increased glutathione S-transferase A form in rat preneoplastic hepatic lesions induced by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Immunochemistry; Liver; Liver Neoplasms; Male; Precancerous Conditions; Rats; Rats, Inbred Strains | 1983 |
Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Fluorescein; Fluoresceins; Liver; Liver Circulation; Liver Neoplasms; Male; Neoplasms, Experimental; Oxygen; Oxygen Consumption; Portal System; Precancerous Conditions; Rats; Rats, Inbred F344 | 1983 |
A liver colony assay for a new hepatocyte phenotype as a step toward purifying new cellular phenotypes that arise during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Anti-Bacterial Agents; Cell Separation; Cells, Cultured; Clone Cells; Diethylnitrosamine; Hepatectomy; Liver; Liver Neoplasms; Male; Phenotype; Rats | 1980 |
Immunohistochemical study of epoxide hydrolase during experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Epoxide Hydrolases; Histocytochemistry; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Time Factors | 1981 |
Alterations of bioelectric potential in primary hepatocellular carcinomas induced by N-2-fluorenylacetamide or diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Electrophysiology; Female; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mixed Function Oxygenases; Rats; Rats, Inbred Strains | 1982 |
Induction of aldehyde dehydrogenases during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine; Enzyme Induction; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Phenotype; Precancerous Conditions; Rats | 1982 |
Route-dependent, organ-specific effects of carcinogens on induction of hyperplastic liver nodules in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hyperplasia; Liver; Male; Methyldimethylaminoazobenzene; Methylnitronitrosoguanidine; Organ Specificity; Rats | 1982 |
Short term induction of preneoplastic nodules in the rat liver. I. The role of 2-AAF as selecting agent.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Drug; Hepatectomy; Liver; Liver Neoplasms; Male; Nitrosamines; Precancerous Conditions; Rats | 1980 |
The influence of hepatocarcinogens on the central effects of phenobarbital an D-amphetamine.
Topics: 2-Acetylaminofluorene; Animals; Behavior, Animal; Brain; Dextroamphetamine; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobarbital; Rats; Sympathetic Nervous System; Synapses | 1980 |
Metabolic activation of aromatic amines and dialkylnitrosamines.
Topics: 2-Acetylaminofluorene; Amines; Animals; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Dealkylation; Diethylnitrosamine; Dimethylnitrosamine; Female; Guinea Pigs; Hydroxylation; Male; Mice; Nitrosamines; Rats | 1981 |
The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Drug Evaluation, Preclinical; Enzyme Induction; Hepatectomy; Hyperplasia; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Precancerous Conditions; Rats | 1980 |
Presidential address. Recent concepts of initiation and promotion in carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; DNA; Humans; Intestinal Polyps; Liver Neoplasms, Experimental; Mice; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Persistence of resistant putative preneoplastic hepatocytes induced by N-nitrosodiethylamine or N-methyl-N-nitrosourea.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Drug Resistance; Hepatectomy; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Nitrosamines; Nitrosourea Compounds; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 1980 |
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Male; Organ Specificity; Rats; Saccharin; Tetradecanoylphorbol Acetate | 1980 |
Effect of ovariectomy and sex hormone replacement on glutathione and glutathione-related enzymes in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Diethylnitrosamine; Estradiol; Female; Glutathione; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Ovariectomy; Progesterone; Rats; Reticulin | 1995 |
Micronuclei induced in peripheral blood of E mu-PIM-1 transgenic mice by chronic oral treatment with 2-acetylaminofluorene or benzene but not with diethyl-nitrosamine or 1,2-dichloroethane.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Benzene; Chromosome Aberrations; Diethylnitrosamine; Erythrocytes; Ethylene Dichlorides; Female; Male; Mice; Mice, Transgenic; Micronucleus Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Time Factors | 1993 |
The effect of butylated hydroxytoluene on the growth of enzyme-altered foci in male Fischer 344 rat liver tissue.
Topics: 2-Acetylaminofluorene; Analysis of Variance; Animals; Antioxidants; Body Weight; Butylated Hydroxytoluene; Carcinogens; Cell Division; Diet; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Hepatectomy; Liver; Male; Nucleolus Organizer Region; Organ Size; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; RNA, Ribosomal; Transcription, Genetic | 1995 |
Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Caseins; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Precancerous Conditions; Protein Kinase C; Rats; Rats, Inbred F344; Reference Values | 1995 |
Short-term carcinogenesis bioassay of genotoxic procarcinogens in PIM transgenic mice.
Topics: 2-Acetylaminofluorene; Animals; Benzene; Biotransformation; Body Weight; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Ethylene Dichlorides; Female; Hemangiosarcoma; Lymphoma; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Oncogenes; Prodrugs; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Stomach Neoplasms | 1995 |
Analysis of calcium-dependent protein kinase C isoforms in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Cell Division; Chromatography; Diethylnitrosamine; Durapatite; gamma-Glutamyltransferase; Hepatectomy; Histocytochemistry; Hydrogen-Ion Concentration; Immunohistochemistry; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Models, Biological; Protein Kinase C; Rats; Rats, Inbred F344; Subcellular Fractions | 1993 |
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, ras; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Wistar; Regression Analysis; RNA, Messenger; S-Adenosylmethionine; Time Factors; Transcription, Genetic | 1994 |
Vitamin E, glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured hepatocytes of rats treated with carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Male; Rats; Thymidine; Tocotrienols; Vitamin E | 1994 |
Growth hormone administration after treatment in the resistant hepatocyte model does not affect progression of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Body Weight; Cell Division; Diethylnitrosamine; Female; Growth Hormone; Injections, Subcutaneous; Kidney Neoplasms; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Rats; Rats, Wistar; Sex Characteristics | 1994 |
Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Microbodies; Pyrimidines; Rats; Rats, Inbred F344 | 1994 |
Different effects of regenerative and direct mitogenic stimuli on the growth of initiated cells in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Hepatectomy; Lead; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mitogens; Nitrates; Rats; Rats, Wistar | 1993 |
Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Carrier Proteins; Cell Transformation, Neoplastic; Cloning, Molecular; Diethylnitrosamine; DNA Primers; DNA, Neoplasm; Drug Resistance; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Kidney; Liver Neoplasms, Experimental; Liver Regeneration; Male; Membrane Glycoproteins; Molecular Sequence Data; Neoplasm Proteins; Polymerase Chain Reaction; Rats; Rats, Inbred F344; RNA, Messenger; Sequence Homology, Nucleic Acid; Transcription, Genetic | 1993 |
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Wistar | 1993 |
Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Immunohistochemistry; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Phenotype; Precancerous Conditions; Radioimmunoassay; Rats; Rats, Inbred F344 | 1994 |
Changes in bile acids metabolism during rat hepatocarcinogenesis: causative or unrelated?
Topics: 2-Acetylaminofluorene; Animals; Bile Acids and Salts; Cholic Acid; Cholic Acids; Deoxycholic Acid; Diethylnitrosamine; Lithocholic Acid; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Wistar | 1994 |
The heterocyclic amines IQ and MeIQx show no promotive effect in a short-term in vivo liver carcinogenesis assay.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Quinolines; Quinoxalines; Rats; Rats, Wistar | 1993 |
Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Diethylnitrosamine; DNA; Liver; Liver Neoplasms, Experimental; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mitotic Index; Phenobarbital; Rats; Rats, Wistar | 1993 |
Analbuminemia does not significantly influence hepatocarcinogenesis on comparing F344 rats and a congenic line carrying the analbuminemic mutation.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Diethylnitrosamine; DNA Primers; Liver Neoplasms, Experimental; Male; Molecular Sequence Data; Mutation; Neoplasm Transplantation; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Serum Albumin; Species Specificity | 1994 |
Carcinogen-induced diploid hepatocytes: sensitive target cells for transformation by mutated c-Ha-ras oncogene.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Cell Separation; Cell Transformation, Neoplastic; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, ras; In Situ Hybridization; Liver; Liver Neoplasms; Male; Molecular Sequence Data; Oligodeoxyribonucleotides; Ploidies; Proto-Oncogene Mas; Rats; Rats, Wistar; RNA, Messenger; Transfection; Transforming Growth Factor alpha | 1993 |
Enhancement of GST-P positive liver cell foci development by a medium-term carcinogenicity bioassay using repeated administration of D-galactosamine.
Topics: 2-Acetylaminofluorene; Analysis of Variance; Animals; Biological Assay; Carcinogenicity Tests; Carcinogens, Environmental; Diethylnitrosamine; Drug Synergism; Enzyme Induction; Galactosamine; Glutathione Transferase; Hepatectomy; Immunoenzyme Techniques; Injections, Intraperitoneal; Liver; Liver Neoplasms, Experimental; Male; Placenta; Rats; Rats, Inbred F344 | 1995 |
Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Hepatocyte Growth Factor; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Proto-Oncogene Proteins c-met; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; RNA, Messenger | 1996 |
Blast-like cell compartment in carcinogen-induced proliferating bile ductules.
Topics: 2-Acetylaminofluorene; Actins; Animals; Bile Ducts, Intrahepatic; Carcinogens; Cell Communication; Cell Differentiation; Cell Division; Cell Nucleus; Desmosomes; Diethylnitrosamine; Epithelium; Fibroblasts; Hepatectomy; Immunohistochemistry; Keratins; Lymphocytes; Male; Microscopy, Electron; Microvilli; Phenotype; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 1996 |
In vivo cell lineage analysis during chemical hepatocarcinogenesis using retroviral-mediated gene transfer.
Topics: 2-Acetylaminofluorene; Animals; beta-Galactosidase; Biomarkers, Tumor; Carcinogens; Cell Count; Cell Division; Cell Line; Cell Lineage; Diethylnitrosamine; Disease Models, Animal; Gene Transfer Techniques; Genetic Vectors; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Wistar; Retroviridae; Time Factors | 1996 |
Human liver S-9 metabolic activation: proficiency in cytogenetic assays and comparison with phenobarbital/beta-naphthoflavone or aroclor 1254 induced rat S-9.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Humans; Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Rats | 1996 |
Simultaneous measurement of unscheduled and replicating DNA synthesis by means of a new cell culture insert DNA retention method: rapid induction of replicating DNA synthesis in response to genotoxic carcinogens.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Autoradiography; Carcinogens; Cells, Cultured; Diethylnitrosamine; DNA; DNA Replication; Hydroxyurea; Liver; Male; Mutagens; Nafenopin; Phenobarbital; Rats; Scintillation Counting | 1996 |
Selective colocalization of lipid peroxidation and protein thiol loss in chemically induced hepatic preneoplastic lesions: the role of gamma-glutamyltranspeptidase activity.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Lipid Peroxidation; Liver; Liver Neoplasms; Male; Microsomes, Liver; Precancerous Conditions; Proteins; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds | 1996 |
Quantitative stereological studies of a 'selection' protocol of hepatocarcinogenesis following initiation in neonatal male and female rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glutathione Transferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Placenta; Pregnancy; Rats; Rats, Inbred F344; Sex Factors | 1997 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Glutathione Transferase; Hepatectomy; In Situ Hybridization; Isoenzymes; Liver; Liver Diseases; Liver Neoplasms, Experimental; Liver Regeneration; Male; Precancerous Conditions; Rats; Rats, Inbred F344; RNA, Messenger | 1997 |
Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Colchicine; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Guanine; Kidney; Linear Models; Liver Neoplasms; Lung; Male; Myocardium; Pancreas; Rats; Rats, Inbred F344; Risk Assessment; Time Factors | 1997 |
Sparse distribution of hepatocyte growth factor-producing cells inside hepatocellular foci in rats treated with hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Hepatocyte Growth Factor; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats | 1997 |
Aryl sulfotransferase IV deficiency in rat liver carcinogenesis initiated with diethylnitrosamine and promoted with N-2-fluorenylacetamide or its C-9-oxidized metabolites.
Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Carcinogens; Diethylnitrosamine; Down-Regulation; Drug Synergism; Female; Isoenzymes; Liver; Liver Neoplasms; Male; Rats; Rats, Sprague-Dawley; Sulfates | 1997 |
Resistance of Copenhagen rats to chemical induction of glutathione S-transferase 7-7-positive liver foci.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Resistance; Enzyme Induction; Glutathione Transferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Rats; Rats, Inbred F344; Species Specificity | 1997 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Fibric Acids; Hepatectomy; Hypolipidemic Agents; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Reactive Oxygen Species | 1997 |
Suppressive effect of oestradiol on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Estradiol; Female; Glutathione Transferase; Hepatectomy; Immunohistochemistry; Liver Neoplasms, Experimental; Male; Orchiectomy; Organ Size; Ovariectomy; Rats; Rats, Inbred F344; Receptors, Androgen; Receptors, Estradiol; Testosterone | 1998 |
Beta-carotene reduces the ductular (oval) cell reaction in the liver of Wistar rats submitted to the resistant hepatocyte model of carcinogenesis.
Topics: 2-Acetylaminofluorene; Actins; Animals; beta Carotene; Bile Ducts, Intrahepatic; Collagen; Diethylnitrosamine; Fibroblasts; Glutathione Transferase; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Wistar; Vitamin A | 1998 |
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Cell Transformation, Neoplastic; Chloroform; Diethylnitrosamine; Disease Progression; Disease Susceptibility; Gene Amplification; Gene Dosage; Gene Expression; Genes, myc; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Pancreatic Elastase; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Wistar; RNA, Messenger; Time Factors | 1999 |
Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Bromodeoxyuridine; Cell Division; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity; Time Factors | 1999 |
Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Chromosome Mapping; Diethylnitrosamine; Genetic Markers; Liver; Liver Neoplasms; Loss of Heterozygosity; Male; Microsatellite Repeats; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred BN; Rats, Inbred F344 | 1999 |
Development of resistance during the early stages of experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Hepatectomy; Liver Neoplasms, Experimental; Male; Orotic Acid; Phenotype; Precancerous Conditions; Rats; Rats, Inbred F344 | 1999 |
Effects of dietary iron overload on progression in chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Chromatography, High Pressure Liquid; Diethylnitrosamine; Disease Progression; Glutathione Transferase; Hemochromatosis; Iron; Iron, Dietary; Liver; Liver Neoplasms, Experimental; Male; Oxidative Stress; Rats; Rats, Wistar; Ubiquinone; Vitamin E | 1999 |
Elevation of metallothionein level in preneoplastic lesions during chemical hepatocarcinogenesis of the Fischer 344 rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Metallothionein; Mutagens; Precancerous Conditions; Rats; Rats, Inbred F344 | 1999 |
Further evidence of the usefulness of bile acids as molecules for shuttling cytostatic drugs toward liver tumors.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Bile Acids and Salts; Cells, Cultured; Cisplatin; Diethylnitrosamine; Glutathione Transferase; Glycocholic Acid; Hepatectomy; Immunohistochemistry; Liver Neoplasms, Experimental; Male; Microscopy, Fluorescence; Organoplatinum Compounds; Rats; Rats, Wistar | 1999 |
Diet restriction increases ubiquinone contents and inhibits progression of hepatocellular carcinoma in the rat.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Apoptosis; Carcinogens; Cell Division; Diethylnitrosamine; Disease Progression; Energy Intake; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Oxidation-Reduction; Rats; Rats, Wistar; Ubiquinone; Vitamin E | 2000 |
Bile acid secretion during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Bile; Carcinoma, Hepatocellular; Cell Differentiation; Cholic Acids; Chromatography, Thin Layer; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Immunoenzyme Techniques; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar | 2000 |
Isolation of liver oval cells from hamsters treated with diethylnitrosamine and 2-acetyl aminofluorene.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Carcinogens; Cell Separation; Cell Size; Cricetinae; Diethylnitrosamine; Humans; Liver; Male; Mesocricetus; Microscopy, Electron | 2000 |
Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Alkylating Agents; Animals; Body Weight; Butylhydroxybutylnitrosamine; Carcinogenicity Tests; Carcinogens; Concanavalin A; Diethylnitrosamine; Flow Cytometry; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Rats, Wistar; Spleen; T-Lymphocyte Subsets; Tissue Distribution | 2000 |
Differentiation of hamster liver oval cell following Clonorchis sinensis infection.
Topics: 2-Acetylaminofluorene; Albumins; Alkylating Agents; alpha-Fetoproteins; Animals; Carcinogens; Clonorchiasis; Clonorchis sinensis; Cricetinae; Diethylnitrosamine; Immunohistochemistry; Keratins; Liver; Liver Diseases, Parasitic; Male; Mesocricetus; Microscopy, Electron; Rodent Diseases | 2000 |
Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogens; Catalase; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glutathione Peroxidase; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Plant Extracts; Rats; Rats, Wistar; Seeds; Thymidine; Time Factors | 2001 |
Vitamin A and all-trans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats.
Topics: 2-Acetylaminofluorene; Alitretinoin; Animals; Anticarcinogenic Agents; Bromodeoxyuridine; Carcinogens; Cell Division; Diethylnitrosamine; DNA; Glutathione Transferase; Immunohistochemistry; Liver; Liver Neoplasms; Male; Rats; Rats, Wistar; Tretinoin; Vitamin A | 2001 |
[Effects of sex hormones on the expression of placenta form glutathione S-transferase (GST-P) in rat induced hepatocarcinoma].
Topics: 2-Acetylaminofluorene; Animals; Castration; Diethylnitrosamine; Estradiol; Female; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Rats; Testosterone | 1998 |
Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Astragalus Plant; Astragalus propinquus; Blotting, Northern; Blotting, Western; Diethylnitrosamine; Female; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Phytotherapy; Plant Extracts; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2003 |
Suppressive effect of herbal compound 861 on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Blotting, Western; Body Weight; Diethylnitrosamine; Drugs, Chinese Herbal; Female; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Organ Size; Rats; Rats, Sprague-Dawley | 2003 |
STAT-3 activity in chemically-induced hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Antineoplastic Agents, Hormonal; Blotting, Northern; Carcinogens; Carcinoma, Hepatocellular; Dexamethasone; Diethylnitrosamine; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Interleukin-6; Liver Neoplasms; Male; Rats; RNA; STAT3 Transcription Factor; Trans-Activators; Tumor Necrosis Factor-alpha | 2003 |
Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Antineoplastic Agents; Ardisia; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Plant Extracts; Plant Leaves; Precancerous Conditions; Rats; Rats, Wistar | 2004 |
Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Administration, Oral; Animals; Biphenyl Compounds; Body Weight; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Administration Schedule; Drug Evaluation, Preclinical; gamma-Glutamyltransferase; Hydroxylation; Injections, Intraperitoneal; Intubation, Intratracheal; Liver; Liver Neoplasms, Experimental; Male; Models, Biological; Organ Size; Quinones; Rats; Rats, Inbred F344; Time Factors | 2004 |
Inhibitory effects of KAT-681, a liver-selective thyromimetic, on development of hepatocellular proliferative lesions in rats induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Body Weight; Carcinogens; Cell Proliferation; Diethylnitrosamine; Eating; Glutathione Transferase; Hepatectomy; Hepatocytes; Hydrogen-Ion Concentration; Immunohistochemistry; Liver; Male; Malonates; Organ Size; Phenyl Ethers; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Thyroid Gland | 2004 |
Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Analysis of Variance; Animals; Biomarkers, Tumor; Cacao; Cell Transformation, Neoplastic; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Reductase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phytotherapy; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2004 |
Induction of preneoplastic altered hepatic foci following dietary sulphur supplementation.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Biomarkers, Tumor; Carcinogens; Dietary Supplements; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Wistar; Sulfur | 2004 |
Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Anticholesteremic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Lipid Peroxidation; Liver Neoplasms; Male; Neoplasms, Experimental; Oxidative Stress; Plant Oils; Proteins; Rats; Rats, Sprague-Dawley; Rice Bran Oil; Tocotrienols | 2004 |
Different inhibitory effects in the early and late phase of treatment with KAT-681, a liver-selective thyromimetic, on rat hepatocarcinogenesis induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Carcinogens; Cell Proliferation; Diethylnitrosamine; Eating; Glutathione Transferase; Hepatectomy; Immunohistochemistry; Liver; Liver Neoplasms; Male; Malonates; Organ Size; Phenyl Ethers; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Thyroid Hormones | 2005 |
Comparison of different initiation protocols in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Animals, Newborn; Carcinogens; Diethylnitrosamine; Fasting; Female; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344 | 2005 |
Chemopreventive effect of indole-3-carbinol on induction of preneoplastic altered hepatic foci.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Diethylnitrosamine; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Glutathione Transferase; Indoles; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Wistar | 2004 |
Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apium; Cell Proliferation; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Plant Extracts; Rats; Rats, Wistar; Seeds | 2005 |
Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; Carcinogens; Cocarcinogenesis; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Diethylnitrosamine; Ditiocarb; Liver Neoplasms, Experimental; Male; Malondialdehyde; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 2005 |
Comparisons of thresholds for carcinogenicity on linear and logarithmic dosage scales.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Eugenol; Female; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms; Rats; Rats, Inbred F344; Risk Factors; Sex Factors; Species Specificity; Time Factors; Urethane | 2005 |
Early induction of TGF-beta1 through a fasting-re-feeding regimen promotes liver carcinogenesis by a sub-initiating dose of diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Eating; Fasting; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation | 2006 |
Evaluation of possible mechanisms of protective role of Tamarix gallica against DEN initiated and 2-AAF promoted hepatocarcinogenesis in male Wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Oxidative Stress; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Tamaricaceae | 2006 |
A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Animals; Caffeic Acids; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cytotoxins; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Gene Expression Regulation, Enzymologic; Glutathione S-Transferase pi; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; NF-kappa B; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Wistar; RNA, Messenger | 2006 |
Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; ATP-Binding Cassette Transporters; Carcinogens; Cell Survival; Cells, Cultured; Diethylnitrosamine; Diuretics; Drug Resistance; Ethacrynic Acid; Glutathione; Glutathione Transferase; Hepatocytes; L-Lactate Dehydrogenase; Liver Neoplasms; Male; Precancerous Conditions; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Diethylnitrosamine; Disease Progression; DNA Replication; Gene Expression Regulation; Hepatectomy; Hepatocytes; Liver Diseases; Liver Neoplasms, Experimental; Liver Regeneration; Male; NF-kappa B; Precancerous Conditions; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Inbred F344; Transcription Factor RelA; Tumor Suppressor Protein p53 | 2008 |
The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Chemoprevention; Diethylnitrosamine; Immunohistochemistry; Ki-67 Antigen; Liver Neoplasms; Male; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Thiazolidinediones | 2007 |
Comparison of mode of action of four hepatocarcinogens: a model-based approach.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Diethylnitrosamine; Female; Liver Neoplasms; Male; Models, Biological; Nitrosamines; Phenobarbital; Rats; Rats, Wistar; Sex Characteristics; Substrate Specificity | 2007 |
Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Algorithms; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progression; Gene Expression Regulation, Neoplastic; Interferon alpha-2; Interferon-alpha; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Polyethylene Glycols; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Recombinant Proteins; Tumor Stem Cell Assay | 2008 |
Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Caffeic Acids; Cytochrome P-450 Enzyme System; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatocytes; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Phenylethyl Alcohol; Rats; Rats, Inbred F344 | 2008 |
Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Dose-Response Relationship, Drug; Fruit; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Medicine, Traditional; Phyllanthus emblica; Plant Extracts; Rats; Rats, Wistar | 2008 |
The protective effects of demethoxyviridine and 1-alpha-hydroxy-demethoxyviridine in the livers of male rats treated with diethylnitrosamine and 2-acetylaminflourene.
Topics: 2-Acetylaminofluorene; Androstenes; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethyl Sulfoxide; Liver; Male; Microsomes, Liver; Olive Oil; Plant Oils; Rats; Rats, Sprague-Dawley | 2008 |
Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diethylnitrosamine; Disease Progression; Glutathione S-Transferase pi; Immunohistochemistry; Liver; Liver Neoplasms, Experimental; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Organ Size; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar | 2009 |
Modulation of energy metabolic enzyme expression in N-nitrosodiethylamine-mediated hepatocarcinogenesis by Chinese herbs, Huqi San.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drugs, Chinese Herbal; Energy Metabolism; gamma-Glutamyltransferase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucose-6-Phosphatase; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Wistar; Succinate Dehydrogenase | 2008 |
Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet).
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Chemoprevention; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Liver; Liver Neoplasms; Male; Malondialdehyde; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Rhizome; Serum; Sesquiterpenes; Zingiber officinale | 2010 |
Nuclear factor-kappa B as a promising target for selenium chemoprevention in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Cyclin D1; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Liver; Liver Neoplasms, Experimental; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Selenite; Time Factors; Transforming Growth Factor alpha | 2010 |
Effect of Aegle marmelos on DEN initiated and 2-AAF promoted hepatocarcinogenesis: a chemopreventive study.
Topics: 2-Acetylaminofluorene; Aegle; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinogens; Cell Proliferation; Cocarcinogenesis; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Glutathione; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Oxidative Stress; Oxidoreductases; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 2011 |
Identification of biomarkers of chemically induced hepatocarcinogenesis in rasH2 mice by toxicogenomic analysis.
Topics: 1-Naphthylisothiocyanate; 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinogens; Cluster Analysis; Diethylnitrosamine; Gene Expression Regulation; Genes, ras; Humans; Injections, Intraperitoneal; Liver Neoplasms, Experimental; Male; Melphalan; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mutagens; Toxicogenetics | 2011 |
DEN+2-AAF-induced multistep hepatotumorigenesis in Wistar rats: supportive evidence and insights.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Diethylnitrosamine; Disease Models, Animal; Lipid Peroxidation; Liver; Liver Neoplasms, Experimental; Male; Random Allocation; Rats; Rats, Wistar | 2013 |
Elevated expression of complement C3 protein in chemically induced hepatotumorogenesis in Wistar rats: a correlative proteomics and histopathological study.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Biomarkers; Blotting, Western; Complement C3; Diethylnitrosamine; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Liver Neoplasms, Experimental; Male; Molecular Sequence Data; Proteomics; Rats; Rats, Wistar; Tandem Mass Spectrometry | 2013 |
The effect of caffeic acid phenethyl ester analogues in a modified resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Acetanilides; Animals; Anticarcinogenic Agents; Antioxidants; Caffeic Acids; Carcinogens; Cell Division; Cinnamates; Diethylnitrosamine; Drug Evaluation, Preclinical; Drug Resistance; Glutathione S-Transferase pi; Hepatectomy; Hepatocytes; Ki-67 Antigen; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Molecular Structure; Phenylethyl Alcohol; Precancerous Conditions; Rats; Rats, Inbred F344; Transcription Factor RelA | 2013 |
Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspartate Aminotransferases; Biomarkers, Tumor; Catalase; Cell Proliferation; Diethylnitrosamine; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; L-Lactate Dehydrogenase; Liver; Liver Neoplasms; Male; Monoterpenes; Ornithine Decarboxylase; Oxidative Stress; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Thymidine Phosphorylase; Tumor Suppressor Protein p53 | 2013 |
Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model.
Topics: 2-Acetylaminofluorene; Animals; Cell Proliferation; Cyclooxygenase 2; Diethylnitrosamine; Diosmin; Disease Models, Animal; Female; Immunohistochemistry; Ki-67 Antigen; Liver Neoplasms, Experimental; NF-kappa B; Nitric Oxide Synthase Type II; Ornithine Decarboxylase; Oxidative Stress; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2013 |
Expansion of hepatic stem cell compartment boosts liver regeneration.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hepatocytes; Liver; Liver Neoplasms; Liver Regeneration; Male; Rats; Rats, Inbred F344; Stem Cells | 2014 |
In vivo evaluation of Eclipta alba extract as anticancer and multidrug resistance reversal agent.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Antineoplastic Agents, Phytogenic; Aspartate Aminotransferases; Cholesterol, HDL; Diethylnitrosamine; DNA Fragmentation; Drug Resistance, Neoplasm; Eclipta; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; Plant Extracts; Rats; Rats, Wistar; Reactive Oxygen Species | 2014 |
DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
Topics: 2-Acetylaminofluorene; Animals; Cyclin-Dependent Kinase Inhibitor p16; Diethylnitrosamine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Male; Rats; Tissue Inhibitor of Metalloproteinase-3; Tumor Suppressor Proteins | 2014 |
Myricetin Selectively Induces Apoptosis on Cancerous Hepatocytes by Directly Targeting Their Mitochondria.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Apoptosis; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Caspase 3; Cytochromes c; Diethylnitrosamine; Disease Models, Animal; Flavonoids; Hepatocytes; Liver; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Swelling; Organ Size; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2016 |
Hepatic preneoplasia induction in male Wistar rats: histological studies up to five months post treatment.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hepatocytes; Liver; Liver Neoplasms, Experimental; Lung; Male; Precancerous Conditions; Rats; Rats, Wistar | 2016 |
Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Basidiomycota; Carcinogenesis; Cytoprotection; Diethylnitrosamine; Ethanol; Liver Neoplasms, Experimental; Male; Phellinus; Plant Extracts; Protective Agents; Rats; Rats, Sprague-Dawley | 2017 |
Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Apolipoprotein A-I; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; Genetic Predisposition to Disease; Liver Neoplasms; Male; Mutation; Prealbumin; Protein Binding; Proteomics; Rats, Wistar; Sequence Homology, Amino Acid; Thyroxine | 2018 |
Identification of (Z)-2,3-Diphenylacrylonitrileas Anti-Cancer Molecule in Persian Gulf Sea Cucumber Holothuria parva.
Topics: 2-Acetylaminofluorene; Acrylonitrile; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chromatography, Thin Layer; Cytochromes c; Diethylnitrosamine; Holothuria; Humans; Indian Ocean; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Membrane Potential, Mitochondrial; Mitochondria, Liver; Rats; Rats, Wistar; Reactive Oxygen Species; Stilbenes | 2017 |
Molecular characterization of the grape seeds extract's effect against chemically induced liver cancer: In vivo and in vitro analyses.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Cycle Checkpoints; Diethylnitrosamine; Grape Seed Extract; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Male; Rats; Rats, Wistar | 2018 |
Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Models, Animal; Exosomes; Liver; Liver Neoplasms; Male; MicroRNAs; Pantoprazole; Precancerous Conditions; Proton Pump Inhibitors; Proton Pumps; rab GTP-Binding Proteins; Rats; Rats, Wistar; RNA, Long Noncoding; Vacuolar Proton-Translocating ATPases | 2019 |
Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Antioxidants; Carcinogenesis; Carcinogens; Cytochrome P-450 CYP1B1; Diethylnitrosamine; Down-Regulation; Humans; Kelch-Like ECH-Associated Protein 1; Lipid Peroxidation; Liver; Male; NF-E2-Related Factor 2; Quinazolinones; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; RNA, Messenger | 2020 |
Hepatocyte transplantation.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Hepatocytes; Liver; Rats; Rats, Wistar | 2019 |
Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Diethylnitrosamine; Flavanones; Inflammation; Liver; Male; Oxidative Stress; Quercetin; Rats; Rats, Wistar | 2022 |
Investigation of the Effects of Octreotide Agent on Oxidative Stress, 8-Hydroxy Deoxyguanosine in Experimental Hepatic Carcinogenesis Rat Model.
Topics: 2-Acetylaminofluorene; 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Hormonal; Carcinogens; Carcinoma, Hepatocellular; Catalase; Diethylnitrosamine; Glutathione Peroxidase; HSP70 Heat-Shock Proteins; Lipid Peroxidation; Liver; Liver Neoplasms, Experimental; Malondialdehyde; Nitric Oxide; Octreotide; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2020 |
Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Hepatomegaly; Liver Neoplasms; Male; Rats, Inbred F344; Stem Cells; Transforming Growth Factor beta1 | 2021 |
The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; Dinoprostone; Etoricoxib; Female; Humans; Liver Neoplasms; Male; NF-kappa B; Rats; Rats, Wistar | 2022 |
Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Rats; Rats, Wistar | 2023 |
The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Diethylnitrosamine; Eugenol; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; NF-kappa B; Rats; Rats, Wistar | 2023 |