diethyl-maleate and (sulfobromophthalein)glutathione-conjugate

diethyl-maleate has been researched along with (sulfobromophthalein)glutathione-conjugate* in 1 studies

Other Studies

1 other study(ies) available for diethyl-maleate and (sulfobromophthalein)glutathione-conjugate

Article	Year
Effect of diethyl maleate on the biliary excretion rate of infused sulfobromophthalein-glutathione. Biochemical pharmacology, 1982, Aug-15, Volume: 31, Issue:16 Diethyl maleate (DEM) was given intraperitoneally to rats in a dose (4.3 mmoles/kg) known to markedly decrease glutathione levels in liver. DEM induced a choleresis previously shown to be due to the osmotic activity of DEM conjugates (DEM-glutathione and subsequent metabolic products) excreted into bile. Coincident with the choleresis, the biliary excretory Tm for the infused glutathione conjugate of sulfobromophthalein (BSP-GSH) was depressed significantly. The data are interpreted as indicating that DEM-GSH conjugates compete with BSP-GSH conjugates for a canalicular carrier mechanism. Topics: Animals; Bile; Electrolytes; Glutathione; Male; Maleates; Rats; Rats, Inbred Strains; Sulfobromophthalein; Time Factors	1982

Article

Year

Effect of diethyl maleate on the biliary excretion rate of infused sulfobromophthalein-glutathione.

Biochemical pharmacology, 1982, Aug-15, Volume: 31, Issue:16

Diethyl maleate (DEM) was given intraperitoneally to rats in a dose (4.3 mmoles/kg) known to markedly decrease glutathione levels in liver. DEM induced a choleresis previously shown to be due to the osmotic activity of DEM conjugates (DEM-glutathione and subsequent metabolic products) excreted into bile. Coincident with the choleresis, the biliary excretory Tm for the infused glutathione conjugate of sulfobromophthalein (BSP-GSH) was depressed significantly. The data are interpreted as indicating that DEM-GSH conjugates compete with BSP-GSH conjugates for a canalicular carrier mechanism.

Topics: Animals; Bile; Electrolytes; Glutathione; Male; Maleates; Rats; Rats, Inbred Strains; Sulfobromophthalein; Time Factors

1982