diepoxybutane has been researched along with 3,4-epoxy-1-butene in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (5.45) | 18.7374 |
| 1990's | 40 (72.73) | 18.2507 |
| 2000's | 10 (18.18) | 29.6817 |
| 2010's | 2 (3.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Evrard, E; Malvoisin, E; Mercier, M; Roberfroid, M | 1 |
| Chichłowska-Sliwińska, M; Sasiadek, M | 1 |
| Norppa, H; Sasiadek, M; Sorsa, M | 1 |
| Järventaus, H; Sasiadek, M; Sorsa, M | 1 |
| Jelitto, B; Laib, RJ; Vangala, RR | 1 |
| Boucher, R; Luke, CA; Shelby, MD; Tice, RR | 1 |
| Tates, AD; Xiao, Y | 1 |
| Bond, JA; Follansbee, MH; Seaton, MJ | 1 |
| Bechtold, WE; Dahl, AR; Griffith, WC; Henderson, RF; Pei, L; Thornton-Manning, JR | 1 |
| Bechtold, WE; Henderson, RF; Strunk, MR; Thornton-Manning, JR | 1 |
| Asgharian, B; Bond, JA; Himmelstein, MW | 1 |
| Asgharian, B; Bond, JA; Himmelstein, MW; Turner, MJ | 2 |
| Cochrane, JE; Skopek, TR | 2 |
| Jones, NJ; Leuratti, C; Marafante, E; Waters, R | 1 |
| Lin, YP; Sangaiah, R; Swenberg, JA; Upton, PB | 1 |
| Doerr, JK; Hollis, EA; Sipes, IG | 1 |
| Bolt, HM; Capellmann, M; Hindermeier, U; Jelitto, B; Kirkovsky, LI | 1 |
| Himmelstein, MW; Medinsky, MA; Schlosser, PM; Sweeney, LM | 1 |
| Bechtold, WE; Dahl, AR; Henderson, RF; Thornton-Manning, JR | 1 |
| Doerr, CL; Kligerman, AD; Milholland, VS; Tennant, AH | 1 |
| Lähdetie, J; Sjöblom, T | 1 |
| Bond, JA; Janszen, DB; Leavens, TL; Moss, OR; Turner, MJ | 1 |
| Elfarra, AA; Krause, RJ | 1 |
| Bond, JA; Medinsky, MA; Schlosser, PM; Sweeney, LM | 1 |
| Lähdetie, J; Peltonen, K; Sjöblom, T | 1 |
| Nogara, C; Renzi, L; Russo, A; Tommasi, AM | 1 |
| Bond, JA; Boogaard, PJ; Medinsky, MA; Sweeney, LM; Turner, MJ; Valentine, JL | 1 |
| Bond, JA; Farris, GM; James, RA; Leavens, TL; Marshall, MW; Shah, R; Wong, VA | 1 |
| Grawé, J; Lähdetie, J | 1 |
| Anderson, D; Brinkworth, MH; Dobrzyńka, MM; Jackson, LI; Yu, TW | 1 |
| Kilpeläinen, I; Koivisto, P; Lähdetie, J; Landin, H; Osterman-Golkar, S; Peltonen, K; Pérez, HL | 1 |
| Smith, MT; Wang, Y; Xi, L; Zhang, L | 1 |
| Bechtold, WE; Dahl, AR; Griffith, WC; Henderson, RF; Thornton-Manning, JR | 1 |
| Adler, ID; Kliesch, U; Nylund, L; Peltonen, K | 1 |
| de Zwart, FA; Tates, AD; van Dam, FJ; van Teylingen, CM; Zwinderman, AH | 1 |
| Adler, ID; Anderson, D; Brinkworth, M; Demopoulos, NA; Lähdetie, J; Osterman-Golkar, S; Pacchierotti, F; Peltonen, K; Russo, A; Tates, A; Waters, R | 1 |
| Allen, ML; Bechtold, WE; Dahl, AR; Griffith, WC; Henderson, RF; Thornton-Manning, JR | 1 |
| Chiang, SY; Swenberg, JA; Walker, VE | 1 |
| DeMarini, DM; Doerr, CL; Hanley, NM; Kligerman, AD; Milholland, VS; Tennant, AH | 1 |
| Bauer, MJ; Henderson, RF; Meng, Q; Reilly, AA; Walker, DM; Walker, VE | 1 |
| Eastmond, DA; Murg, Mn; Schuler, M | 1 |
| Dahl, AR; Henderson, RF | 1 |
| Jackson, MA; Rice, JM; Stack, HF; Waters, MD | 1 |
| Erexson, GL; Tindall, KR | 1 |
| Bhowmik, S; Csanády, GA; Faller, TH; Filser, JG; Kessler, W; Pütz, C; Schuster, A | 1 |
| Gargas, ML; Himmelstein, MW; Sweeney, LM | 1 |
| Meyer, KG; Pluta, LJ; Recio, L; Saranko, CJ; Steen, AM | 1 |
| Donner, EM; Gladnick, NL; Himmelstein, MW; Snyder, RD; Valentine, R | 1 |
| Hu, Y; Kligerman, AD | 1 |
| Hackfeld, LC; Hodge, RP; Meng, Q; Redetzke, DL; Walker, DM; Walker, VE | 1 |
| Alexandrova, E; Anderson, D; Cemeli, E; Chiuchiarelli, G; Mirkova, E | 1 |
| An, J; Wen, Y; Wu, MH; Yu, YX; Zhang, PP; Zhang, XY | 1 |
| Fabiani, R; Fuccelli, R; Morozzi, G; Rosignoli, P; Sepporta, MV; Servili, M | 1 |
2 review(s) available for diepoxybutane and 3,4-epoxy-1-butene
| Article | Year |
|---|---|
[Genotoxic properties of 1,3-butadiene and its derivatives].
Topics: Animals; Butadienes; Chromosome Aberrations; DNA Damage; Epoxy Compounds; In Vitro Techniques; Mice; Mutagenesis; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Rats; Sister Chromatid Exchange | 1991 |
A review of the genetic and related effects of 1,3-butadiene in rodents and humans.
Topics: Air Pollutants, Occupational; Alkylating Agents; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Biotransformation; Butadienes; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; DNA Damage; Epoxy Compounds; Female; Glycols; Hemoglobins; Humans; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Mutagenesis; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Occupational Exposure; Organ Specificity; Oxidation-Reduction; Proteins; Rats; Rats, Sprague-Dawley; Single-Blind Method; Sister Chromatid Exchange; Species Specificity | 2000 |
53 other study(ies) available for diepoxybutane and 3,4-epoxy-1-butene
| Article | Year |
|---|---|
Determination of Kováts retention indices with a capillary column and electron-capture detection: application to the assay of the enzymatic conversion of 3,4-epoxy-1-butene into diepoxybutane.
Topics: Animals; Butanes; Chromatography, Gas; Epoxy Compounds; Ethers, Cyclic; Microsomes, Liver; Mixed Function Oxygenases; Rats | 1979 |
1,3-Butadiene and its epoxides induce sister-chromatid exchanges in human lymphocytes in vitro.
Topics: Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Humans; In Vitro Techniques; Mutagenicity Tests; Mutagens; Sister Chromatid Exchange | 1991 |
Sister-chromatid exchanges induced by 1.3-butadiene and its epoxides in CHO cells.
Topics: Animals; Butadienes; Cells, Cultured; Cricetinae; Cricetulus; Epoxy Compounds; Mutagens; Sister Chromatid Exchange | 1991 |
Species differences in DNA damage by butadiene: role of diepoxybutane.
Topics: Alkylation; Animals; Butadienes; Carcinogens; DNA Damage; Epoxy Compounds; Ethers, Cyclic; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Species Specificity | 1989 |
Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene.
Topics: Animals; Bone Marrow; Butadienes; Cell Nucleus; Chromosome Aberrations; DNA Damage; Epoxy Compounds; Erythrocytes, Abnormal; Gases; Male; Mice; Mitotic Index; Mutagenicity Tests; Sister Chromatid Exchange | 1987 |
Clastogenic effects of 1,3-butadiene and its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in splenocytes and germ cells of rats and mice in vivo.
Topics: Administration, Inhalation; Animals; Body Weight; Butadienes; Chromosomes; Epoxy Compounds; Germ Cells; Golgi Apparatus; Male; Mice; Micronucleus Tests; Mutagens; Organ Size; Rats; Rats, Inbred Lew; Species Specificity; Spermatids; Spermatozoa; Spleen; Testis | 1995 |
Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes.
Topics: Animals; Biotransformation; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Epoxy Compounds; Humans; Kinetics; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Mutagens; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1995 |
Gender differences in the metabolism of 1,3-butadiene in Sprague-Dawley rats following a low level inhalation exposure.
Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Female; Male; Rats; Rats, Sprague-Dawley; Sex Factors; Species Specificity | 1995 |
Analysis of butadiene, butadiene monoxide, and butadiene dioxide in blood by gas chromatography/gas chromatography/mass spectroscopy.
Topics: Animals; Butadienes; Carcinogens; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Male; Mice; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 1995 |
High concentrations of butadiene epoxides in livers and lungs of mice compared to rats exposed to 1,3-butadiene.
Topics: Animals; Butadienes; Epoxy Compounds; Glutathione; Liver; Lung; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley | 1995 |
Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation.
Topics: Administration, Inhalation; Animals; Butadienes; Epoxy Compounds; In Vitro Techniques; Male; Mice; Rats; Rats, Sprague-Dawley; Respiration; Species Specificity | 1994 |
Mutagenicity of 1,3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F1 mice.
Topics: Animals; Butadienes; Cells, Cultured; Epoxy Compounds; Male; Mice; Mice, Inbred Strains; Mutagens; Mutation; T-Lymphocytes | 1993 |
Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice.
Topics: Animals; Butadienes; Epoxy Compounds; Female; Hypoxanthine Phosphoribosyltransferase; Male; Mice; Mice, Inbred C57BL; Mutagenesis; Mutagens; Point Mutation; Spleen; T-Lymphocytes | 1994 |
Detection by HPLC-32P-postlabelling of DNA adducts formed after exposure to epoxybutene and diepoxybutane.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Damage; Environmental Monitoring; Epoxy Compounds; Evaluation Studies as Topic; Humans; In Vitro Techniques; Mutagens; Phosphorus Radioisotopes | 1993 |
Macromolecular adducts of butadiene.
Topics: Adenine; Animals; Butadienes; DNA; Epoxy Compounds; Female; Globins; Guanine; Guanosine; Humans; Male; Mice; Rats; Species Specificity | 1996 |
Species difference in the ovarian toxicity of 1,3-butadiene epoxides in B6C3F1 mice and Sprague-Dawley rats.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Mice; Mutagens; Ovary; Rats; Rats, Sprague-Dawley; Species Specificity | 1996 |
Differential reactivities of the mono- and di-epoxide of 1,3-butadiene.
Topics: Carcinogens; Deoxyguanosine; DNA; Epoxy Compounds; Guanosine | 1996 |
Metabolism of 1,3-butadiene: inhalation pharmacokinetics and tissue dosimetry of butadiene epoxides in rats and mice.
Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Glutathione; Male; Mice; Rats; Rats, Sprague-Dawley; Species Specificity | 1996 |
Physiologically based pharmacokinetic modeling of blood and tissue epoxide measurements for butadiene.
Topics: Animals; Carcinogens; Epoxy Compounds; Glutathione; Mice; Models, Biological; Rats | 1996 |
Gender and species differences in the metabolism of 1,3-butadiene to butadiene monoepoxide and butadiene diepoxide in rodents following low-level inhalation exposures.
Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Female; Male; Mice; Rats; Rats, Sprague-Dawley; Sex Factors; Species Specificity | 1996 |
Cytogenetic effects of butadiene metabolites in rat and mouse splenocytes following in vitro exposures.
Topics: Animals; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Epoxy Compounds; Male; Mice; Mutagens; Rats; Sister Chromatid Exchange; Species Specificity; Spleen | 1996 |
Micronuclei are induced in rat spermatids in vitro by 1,2,3,4-diepoxybutane but not by 1,2-epoxy-3-butene and 1,2-dihydroxy-3,4-epoxybutane.
Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Glycols; Male; Meiosis; Micronucleus Tests; Mutagens; Rats; Rats, Sprague-Dawley; Spermatids | 1996 |
Metabolic interactions of 1,3-butadiene and styrene in male B6C3F1 mice.
Topics: Animals; Butadienes; Epoxy Compounds; Male; Mice; Mutagens; Styrene; Styrenes | 1996 |
Oxidation of butadiene monoxide to meso- and (+/-)-diepoxybutane by cDNA-expressed human cytochrome P450s and by mouse, rat, and human liver microsomes: evidence for preferential hydration of meso-diepoxybutane in rat and human liver microsomes.
Topics: Adolescent; Adult; Animals; Cytochrome P-450 Enzyme System; DNA, Complementary; Epoxy Compounds; Female; Humans; Hydrolysis; Kinetics; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1997 |
Physiologically based pharmacokinetic modeling of 1,3-butadiene, 1,2-epoxy-3-butene, and 1,2:3,4-diepoxybutane toxicokinetics in mice and rats.
Topics: Administration, Inhalation; Animals; Butadienes; Epoxy Compounds; Injections, Intravenous; Mice; Models, Biological; Rats; Species Specificity | 1997 |
Germ cell mutagenicity of three metabolites of 1,3-butadiene in the rat: induction of spermatid micronuclei by butadiene mono-, di-, and diolepoxides in vivo.
Topics: Animals; Body Weight; Butadienes; Cell Survival; DNA Replication; Epoxy Compounds; Glycols; Male; Micronucleus Tests; Mutagens; Organ Size; Rats; Rats, Sprague-Dawley; Spermatids; Testis | 1997 |
Micronucleus induction in germ and somatic cells of the mouse after exposure to the butadiene metabolites diepoxybutane and epoxybutene.
Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Germ Cells; Golgi Apparatus; Male; Meiosis; Mice; Mice, Inbred BALB C; Micronucleus Tests; Reticulocytes; Spermatids | 1997 |
Disposition of butadiene epoxides in Sprague-Dawley rats.
Topics: Animals; Area Under Curve; Carcinogens; Chromatography, Gas; Dose-Response Relationship, Drug; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Half-Life; Hematocrit; Injections, Intravenous; Male; Mutagens; Rats; Rats, Sprague-Dawley; Reference Standards; Software | 1997 |
Genotoxicity and cytotoxicity in male B6C3F1 mice following exposure to mixtures of 1,3-butadiene and styrene.
Topics: Animals; Bone Marrow; Butadienes; Carcinogens; Dose-Response Relationship, Drug; Drug Synergism; Epoxy Compounds; Erythrocytes; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Spleen; Styrene; Styrenes; Thymus Gland; Toxicity Tests | 1997 |
Flow cytometric analysis of micronucleus induction in rat bone marrow polychromatic erythrocytes by 1,2;3,4-diepoxybutane, 3,4-epoxy-1-butene, and 1,2-epoxybutane-3,4-diol.
Topics: Animals; Benzimidazoles; Bone Marrow Cells; Cell Separation; Epoxy Compounds; Erythrocyte Aging; Erythrocytes; Flow Cytometry; Fluorescent Dyes; Glycols; Male; Mice; Micronucleus Tests; Mutagens; Rats; Rats, Sprague-Dawley | 1997 |
Somatic and germ cell effects in rats and mice after treatment with 1,3-butadiene and its metabolites, 1,2-epoxybutene and 1,2,3,4-diepoxybutane.
Topics: Administration, Inhalation; Animals; Bone Marrow; Butadienes; DNA; Dose-Response Relationship, Drug; Electrophoresis; Epoxy Compounds; Liver; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Rats; Rats, Sprague-Dawley; Species Specificity; Spermatozoa; Testis | 1997 |
Haemoglobin adducts of epoxybutanediol from exposure to 1,3-butadiene or butadiene epoxides.
Topics: Air Pollutants, Occupational; Animals; Butadienes; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Glycols; Hemoglobins; Humans; Magnetic Resonance Spectroscopy; Male; Micronucleus Tests; Rats; Rats, Sprague-Dawley; Rats, Wistar; Valine | 1997 |
Induction of chromosome-specific aneuploidy and micronuclei in human lymphocytes by metabolites of 1,3-butadiene.
Topics: Aneuploidy; Butadienes; Carcinogens; Cells, Cultured; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 7; Diploidy; Epoxy Compounds; Genotype; Glutathione Transferase; Humans; Interphase; Lymphocytes; Male; Metaphase; Micronuclei, Chromosome-Defective; Micronucleus Tests | 1997 |
Comparison of the disposition of butadiene epoxides in Sprague-Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation.
Topics: Adipose Tissue; Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Female; Femur; Lung; Mammary Glands, Animal; Mice; Rats; Rats, Sprague-Dawley | 1997 |
In vitro and in vivo mutagenicity of the butadiene metabolites butadiene diolepoxide, butadiene monoepoxide and diepoxybutane.
Topics: Animals; Bone Marrow Cells; Butadienes; Crosses, Genetic; Epoxy Compounds; Female; Fetal Death; Genes, Lethal; Glycols; Litter Size; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Pregnancy; Salmonella typhimurium; Structure-Activity Relationship | 1997 |
Comparison of induction of hprt mutations by 1,3-butadiene and/or its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in lymphocytes from spleen of adult male mice and rats in vivo.
Topics: Age Factors; Animals; Butadienes; Cells, Cultured; Clone Cells; Enzyme Induction; Epoxy Compounds; Ethylnitrosourea; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Male; Mice; Mice, Inbred Strains; Mutagens; Mutation; Rats; Rats, Inbred Lew; Spleen | 1998 |
Genetic effects of 1,3-butadiene and associated risk for heritable damage.
Topics: Animals; Butadienes; DNA Adducts; Embryo, Mammalian; Epoxy Compounds; Germ Cells; Humans; Mice; Mutagenicity Tests; Mutagens; Rats; Risk Factors; Translocation, Genetic | 1998 |
Disposition of butadiene epoxides in Sprague-Dawley rats following exposures to 8000 ppm 1,3-butadiene: comparisons with tissue epoxide concentrations following low-level exposures.
Topics: Animals; Biotransformation; Butadienes; Carcinogens; Epoxy Compounds; Female; Inhalation Exposure; Mutagens; Rats; Rats, Sprague-Dawley | 1998 |
Quantitative analysis of 1,3-butadiene-induced DNA adducts in vivo and in vitro using liquid chromatography electrospray ionization tandem mass spectrometry.
Topics: Animals; Butadienes; Cattle; Cells, Cultured; Chromatography, Gas; Chromatography, Liquid; DNA; DNA Adducts; Epoxy Compounds; Humans; Hydrolysis; Lymphocytes; Mass Spectrometry; Mice; Mice, Inbred Strains; Mutagens; Rats; Rats, Inbred F344 | 1998 |
Comparison of cytogenetic effects of 3,4-epoxy-1-butene and 1,2:3, 4-diepoxybutane in mouse, rat and human lymphocytes following in vitro G0 exposures.
Topics: Animals; Butadienes; Carcinogens; Cell Cycle; Chromosome Aberrations; Epoxy Compounds; Erythrocytes; Genotype; Glutathione Transferase; Humans; Interphase; Lymphocytes; Mice; Mutagenicity Tests; Rats; Regression Analysis; Sister Chromatid Exchange | 1999 |
Mutagenicity of the racemic mixtures of butadiene monoepoxide and butadiene diepoxide at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats.
Topics: Administration, Inhalation; Animals; Clone Cells; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Hypoxanthine Phosphoribosyltransferase; Mice; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Inbred F344; Species Specificity; Spleen; Stereoisomerism; T-Lymphocytes; Time Factors | 1999 |
Evaluation of micronuclei and chromosomal breakage in the 1cen-q12 region by the butadiene metabolites epoxybutene and diepoxybutane in cultured human lymphocytes.
Topics: Butadienes; Carcinogens; Cells, Cultured; Centromere; Chromosome Breakage; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 9; Dose-Response Relationship, Drug; Epoxy Compounds; Humans; In Situ Hybridization, Fluorescence; Kinetochores; Lymphocytes; Male; Micronucleus Tests; Mutagens; Polymerase Chain Reaction | 1999 |
Comparative metabolism of low concentrations of butadiene and its monoepoxide in human and monkey hepatic microsomes.
Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Humans; Macaca fascicularis; Microsomes, Liver; Oxidation-Reduction; Species Specificity | 2000 |
Micronuclei and gene mutations in transgenic big Blue((R)) mouse and rat fibroblasts after exposure to the epoxide metabolites of 1, 3-butadiene.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Apoptosis; Biotransformation; Butadienes; Cell Survival; Cells, Cultured; Epoxy Compounds; Fibroblasts; Glycols; Humans; Mice; Mice, Transgenic; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenicity Tests; Rats; Rats, Mutant Strains | 2000 |
First-pass metabolism of 1,3-butadiene in once-through perfused livers of rats and mice.
Topics: Aldehydes; Animals; Biotransformation; Butadienes; Epoxy Compounds; Glycols; Kinetics; Liver; Male; Mice; Perfusion; Rats; Rats, Sprague-Dawley; Species Specificity | 2001 |
Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment.
Topics: Animals; Butadienes; Epoxy Compounds; Female; Humans; Mice; Models, Biological; Rats; Risk Assessment; Sensitivity and Specificity; Species Specificity | 2001 |
Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms.
Topics: Air Pollutants; Animals; Bacterial Proteins; Butadienes; Cell Line; Epoxy Compounds; Escherichia coli Proteins; Female; Humans; Lac Repressors; Male; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Rats; Repressor Proteins; Spleen | 2001 |
In vitro genotoxicity testing of (1-chloroethenyl)oxirane, a metabolite of beta-chloroprene.
Topics: Animals; Chloroprene; Epoxy Compounds; Ethylene Oxide; Frameshift Mutation; In Vitro Techniques; Liver; Mutagenicity Tests; Mutagens; Point Mutation; Rats; Salmonella typhimurium | 2001 |
Some insights into the mode of action of butadiene by examining the genotoxicity of its metabolites.
Topics: Animals; Butadienes; Cell Cycle; Cell Separation; Cells, Cultured; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, Drug; Epoxy Compounds; Glutathione; Glutathione Transferase; Humans; Lymphocytes; Mice; Mutagens; Rats; Resting Phase, Cell Cycle; Sister Chromatid Exchange | 2007 |
Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells.
Topics: Cell Death; Cell Survival; DNA; Dose-Response Relationship, Drug; Enzyme Induction; Epoxy Compounds; Exons; Genome, Human; Genomics; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Mutagenesis; Mutagenicity Tests; Mutant Proteins; Mutation; Polymerase Chain Reaction; Stereoisomerism; Thymidine Kinase | 2007 |
Investigation on the mechanisms of genotoxicity of butadiene, styrene and their combination in human lymphocytes using the Comet assay.
Topics: Adult; Butadienes; Cohort Studies; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Humans; In Vitro Techniques; Lymphocytes; Male; Mutagens; Occupational Exposure; Reactive Oxygen Species; Rubber; Styrene | 2009 |
DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells.
Topics: Butadienes; Butylene Glycols; Carcinogens; Cell Line, Transformed; Comet Assay; DNA Breaks, Single-Stranded; DNA Damage; Epoxy Compounds; Hepatocytes; Humans; Mutagens | 2012 |
Preventive activity of olive oil phenolic compounds on alkene epoxides induced oxidative DNA damage on human peripheral blood mononuclear cells.
Topics: Acetylcysteine; Butadienes; Catalase; Comet Assay; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Epoxy Compounds; Humans; Leukocytes, Mononuclear; Olive Oil; Oxidative Stress; Phenols; Plant Oils | 2014 |