Page last updated: 2024-09-04

didesipramine and diltiazem

didesipramine has been researched along with diltiazem in 1 studies

Compound Research Comparison

Studies (didesipramine)	Trials (didesipramine)	Recent Studies (post-2010) (didesipramine)	Studies (diltiazem)	Trials (diltiazem)	Recent Studies (post-2010) (diltiazem)
15	0	0	6,402	1,073	578

Protein Interaction Comparison

Protein	Taxonomy	diltiazem (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1C	Cavia porcellus (domestic guinea pig)	0.45
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	0.605
Cytochrome P450 3A4	Homo sapiens (human)	1.8366
Voltage-dependent L-type calcium channel subunit alpha-1C	Rattus norvegicus (Norway rat)	0.896
Voltage-dependent L-type calcium channel subunit alpha-1D	Rattus norvegicus (Norway rat)	0.896
Sodium channel protein type 1 subunit alpha	Homo sapiens (human)	9
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	9
Sodium channel protein type 7 subunit alpha	Homo sapiens (human)	9
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	0.605
Voltage-dependent L-type calcium channel subunit alpha-1S	Rattus norvegicus (Norway rat)	0.896
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	0.605
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	0.605
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	9
Sodium channel protein type 9 subunit alpha	Homo sapiens (human)	9
Sodium channel protein type 2 subunit alpha	Homo sapiens (human)	9
Sodium channel protein type 3 subunit alpha	Homo sapiens (human)	9
Sodium channel protein type 11 subunit alpha	Homo sapiens (human)	9
Sodium channel protein type 8 subunit alpha	Homo sapiens (human)	9
Sodium channel protein type 10 subunit alpha	Homo sapiens (human)	9

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Allen, KE; Babu, KN; Hanson, KL; Kunze, KL; Nelson, WL; VandenBrink, BM	1

Other Studies

1 other study(ies) available for didesipramine and diltiazem

Article	Year
Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:6 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Desipramine; Diltiazem; Fluoxetine; Humans; Hydroxylamine; Hydroxylamines; Hydroxylation; Imipramine; Microsomes, Liver; Oxidoreductases, N-Demethylating; Steroid 16-alpha-Hydroxylase	2010

Article

Year

Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem.

Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:6

Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Desipramine; Diltiazem; Fluoxetine; Humans; Hydroxylamine; Hydroxylamines; Hydroxylation; Imipramine; Microsomes, Liver; Oxidoreductases, N-Demethylating; Steroid 16-alpha-Hydroxylase

2010