didanosine and 5-ethynyl-1-ribofuranosylimidazole-4-carboxamide

didanosine has been researched along with 5-ethynyl-1-ribofuranosylimidazole-4-carboxamide* in 1 studies

Other Studies

1 other study(ies) available for didanosine and 5-ethynyl-1-ribofuranosylimidazole-4-carboxamide

Article	Year
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2',3'-dideoxyinosine on human immunodeficiency virus in peripheral blood lymph Biochemical and biophysical research communications, 1991, Jul-31, Volume: 178, Issue:2 Ribavirin and EICAR are two antiviral agents that share a similar antiviral activity spectrum and are targeted at inosine 5'-monophosphate (IMP) dehydrogenase. Neither ribavirin nor EICAR inhibit the replication of human immunodeficiency virus (HIV) in peripheral blood lymphocyte cells (PBL) at subtoxic concentrations. However, both compounds markedly potentiate the anti-HIV activity of 2',3'-dideoxyinosine (DDI) in PBL cells without a marked increase of toxicity. Both the increased IMP levels and the decreased guanine nucleotide levels caused by ribavirin and EICAR may be responsible for their potentiating effect on the anti-HIV activity of DDI. Topics: Antiviral Agents; Cells, Cultured; Didanosine; Drug Synergism; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; HIV-1; Humans; Inosine Monophosphate; Kinetics; Lymphocytes; Ribavirin; Ribonucleosides	1991

Article

Year

1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2',3'-dideoxyinosine on human immunodeficiency virus in peripheral blood lymph

Biochemical and biophysical research communications, 1991, Jul-31, Volume: 178, Issue:2

Ribavirin and EICAR are two antiviral agents that share a similar antiviral activity spectrum and are targeted at inosine 5'-monophosphate (IMP) dehydrogenase. Neither ribavirin nor EICAR inhibit the replication of human immunodeficiency virus (HIV) in peripheral blood lymphocyte cells (PBL) at subtoxic concentrations. However, both compounds markedly potentiate the anti-HIV activity of 2',3'-dideoxyinosine (DDI) in PBL cells without a marked increase of toxicity. Both the increased IMP levels and the decreased guanine nucleotide levels caused by ribavirin and EICAR may be responsible for their potentiating effect on the anti-HIV activity of DDI.

Topics: Antiviral Agents; Cells, Cultured; Didanosine; Drug Synergism; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; HIV-1; Humans; Inosine Monophosphate; Kinetics; Lymphocytes; Ribavirin; Ribonucleosides

1991