dicumarol and thymoquinone

dicumarol has been researched along with thymoquinone* in 1 studies

Other Studies

1 other study(ies) available for dicumarol and thymoquinone

Article	Year
NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis. Biochemical and biophysical research communications, 2012, Sep-28, Volume: 426, Issue:3 Thymoquinone (TQ), a bioactive component of black caraway seed (Nigella sativa) oil, is reported to have antineoplastic properties. In this study we investigated the effect of TQ on a panel of human breast cancer cell lines. Cell viability assays showed that TQ killed T-47D, MDA-MB-231, and MDA-MB-468 cells via p53-independent induction of apoptosis; however, MCF-7 cells were refractory to the cytotoxic action of TQ. Western Blot analysis showed that MCF-7 cells expressed high levels of cytoprotective NADPH quinone oxidoreductase 1 (NQO1), which was responsible for TQ-resistance since inhibition of NQO1 with dicoumarol rendered MCF-7 cells TQ-sensitive. These findings may be clinically important when considering TQ as a possible adjunct treatment for breast cancer since a high percentage of breast tumors express NQO1. Topics: Antineoplastic Agents; Apoptosis; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Dicumarol; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; NAD(P)H Dehydrogenase (Quinone)	2012

Article

Year

NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis.

Biochemical and biophysical research communications, 2012, Sep-28, Volume: 426, Issue:3

Thymoquinone (TQ), a bioactive component of black caraway seed (Nigella sativa) oil, is reported to have antineoplastic properties. In this study we investigated the effect of TQ on a panel of human breast cancer cell lines. Cell viability assays showed that TQ killed T-47D, MDA-MB-231, and MDA-MB-468 cells via p53-independent induction of apoptosis; however, MCF-7 cells were refractory to the cytotoxic action of TQ. Western Blot analysis showed that MCF-7 cells expressed high levels of cytoprotective NADPH quinone oxidoreductase 1 (NQO1), which was responsible for TQ-resistance since inhibition of NQO1 with dicoumarol rendered MCF-7 cells TQ-sensitive. These findings may be clinically important when considering TQ as a possible adjunct treatment for breast cancer since a high percentage of breast tumors express NQO1.

Topics: Antineoplastic Agents; Apoptosis; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Dicumarol; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; NAD(P)H Dehydrogenase (Quinone)

2012