dicumarol and sodium-arsenite

This study demonstrates the menadione-dependent reduction of imipramine N-oxide, a tertiary amine N-oxide, to imipramine by rat liver cytosol in the presence of NADH or NADPH. A mechanism for the cytosolic reduction of the tertiary amine N-oxide is proposed. Menadione is converted to its reduced form by a menadione-reducing enzyme such as DT-diaphorase and the reduced pyridine nucleotide, followed by reduction of the tertiary amine N-oxide to the amine by the heme group of catalytic hemoproteins in the presence of reduced menadione as an electron donor.

Topics: Animals; Arsenites; Carbon Monoxide; Catalase; Cytosol; Dicumarol; Hemin; Hemoglobins; Imipramine; Liver; Male; Myoglobin; NAD; NADP; Oxidation-Reduction; Potassium Cyanide; Rats; Rats, Wistar; Sodium Compounds; Vitamin K