dicumarol and pyridine

dicumarol has been researched along with pyridine* in 1 studies

Other Studies

1 other study(ies) available for dicumarol and pyridine

Article	Year
Development of pyridine dicoumarols as potent anti HIV-1 leads, targeting HIV-1 associated topoisomeraseIIβ kinase. Future medicinal chemistry, 2017, Volume: 9, Issue:14 A structural study of a series of pyridine dicoumarol derivatives with potential activity against a novel Topoisomerase IIβ kinase which was identified in the HIV-1 viral lysate, compounds were designed and synthesized based on a 3D-QSAR study.. Based on QSAR model we have designed and synthesized a series of pyridine dicoumarol derivatives and characterized by spectral studies, all the molecules are biologically evaluated by kinase assay, cytotoxicity assay, ELISA and PCR method.. We demonstrated the achievement of water soluble disodium pyridine dicoumarate derivatives showing high anti-HIV-1 activity (IC. A new class of anti-HIV-1 lead compounds have been designed and tested. Further studies would result in development of novel and potential drugs. Topics: Anti-HIV Agents; Cell Line; Cell Survival; Dicumarol; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Enzyme-Linked Immunosorbent Assay; HIV Core Protein p24; HIV-1; Humans; Pyridines; Quantitative Structure-Activity Relationship; Topoisomerase II Inhibitors	2017

Article

Year

Development of pyridine dicoumarols as potent anti HIV-1 leads, targeting HIV-1 associated topoisomeraseIIβ kinase.

Future medicinal chemistry, 2017, Volume: 9, Issue:14

A structural study of a series of pyridine dicoumarol derivatives with potential activity against a novel Topoisomerase IIβ kinase which was identified in the HIV-1 viral lysate, compounds were designed and synthesized based on a 3D-QSAR study.. Based on QSAR model we have designed and synthesized a series of pyridine dicoumarol derivatives and characterized by spectral studies, all the molecules are biologically evaluated by kinase assay, cytotoxicity assay, ELISA and PCR method.. We demonstrated the achievement of water soluble disodium pyridine dicoumarate derivatives showing high anti-HIV-1 activity (IC. A new class of anti-HIV-1 lead compounds have been designed and tested. Further studies would result in development of novel and potential drugs.

Topics: Anti-HIV Agents; Cell Line; Cell Survival; Dicumarol; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Enzyme-Linked Immunosorbent Assay; HIV Core Protein p24; HIV-1; Humans; Pyridines; Quantitative Structure-Activity Relationship; Topoisomerase II Inhibitors

2017