dicumarol and betulin

dicumarol has been researched along with betulin* in 1 studies

Other Studies

1 other study(ies) available for dicumarol and betulin

Article	Year
Nitroaromatic betulin derivatives as redox cycling agents. Biochemistry and molecular biology international, 1997, Volume: 42, Issue:2 We have synthesized nitroaromatic derivatives of triterpenoid betulin (lup-20(29)-ene-3 beta, 28-diol), betulin-(28)-5'-(aziridin-1-yl)-2',4'-dinitrobenzoate and betulin-(28)-5'-nitro-2'-furoate. These compounds were reduced in single-electron way by ferredoxin: NADP+ reductase and flavocytochrome b2 at rates comparable with their simple structure analogs. Besides, these compounds were substrates for DT-diaphorase. Their toxicity to bovine leukemia virus-transformed lamb fibroblast culture was partly prevented by antioxidant N,N'-diphenyl-p-phenylene diamine and desferrioxamine, indicating an involvement of oxidative stress in their cytotoxicity. Topics: Animals; Aziridines; Dicumarol; Dose-Response Relationship, Drug; Ferredoxin-NADP Reductase; Fibroblasts; Furans; Kidney; L-Lactate Dehydrogenase; L-Lactate Dehydrogenase (Cytochrome); Leukemia Virus, Bovine; NAD(P)H Dehydrogenase (Quinone); Nitro Compounds; Nitrobenzoates; Nitrofurantoin; Oxidation-Reduction; Oxidative Stress; Substrate Specificity; Toxicity Tests; Triterpenes	1997

Article

Year

Nitroaromatic betulin derivatives as redox cycling agents.

Biochemistry and molecular biology international, 1997, Volume: 42, Issue:2

We have synthesized nitroaromatic derivatives of triterpenoid betulin (lup-20(29)-ene-3 beta, 28-diol), betulin-(28)-5'-(aziridin-1-yl)-2',4'-dinitrobenzoate and betulin-(28)-5'-nitro-2'-furoate. These compounds were reduced in single-electron way by ferredoxin: NADP+ reductase and flavocytochrome b2 at rates comparable with their simple structure analogs. Besides, these compounds were substrates for DT-diaphorase. Their toxicity to bovine leukemia virus-transformed lamb fibroblast culture was partly prevented by antioxidant N,N'-diphenyl-p-phenylene diamine and desferrioxamine, indicating an involvement of oxidative stress in their cytotoxicity.

Topics: Animals; Aziridines; Dicumarol; Dose-Response Relationship, Drug; Ferredoxin-NADP Reductase; Fibroblasts; Furans; Kidney; L-Lactate Dehydrogenase; L-Lactate Dehydrogenase (Cytochrome); Leukemia Virus, Bovine; NAD(P)H Dehydrogenase (Quinone); Nitro Compounds; Nitrobenzoates; Nitrofurantoin; Oxidation-Reduction; Oxidative Stress; Substrate Specificity; Toxicity Tests; Triterpenes

1997