diclofenac and warfarin

diclofenac has been researched along with warfarin in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.49)	18.7374
1990's	3 (4.48)	18.2507
2000's	32 (47.76)	29.6817
2010's	28 (41.79)	24.3611
2020's	3 (4.48)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Faller, B; Wohnsland, F	1
Jolivette, LJ; Ward, KW	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Carrupt, PA; Martel, S; Ottaviani, G	1
Ho, A; Marotti, KR; Romero, DL; Sarver, RW; Thorarensen, A; Tian, F	1
Briand, X; Faller, B; Lázaro, E; Lowe, PJ	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Blair, A; Boyd, M; Chalmers, AJ; Malviya, G; Pimlott, SL; Sutherland, A; Zmuda, F	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Azas, N; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Courtioux, B; Fairlamb, A; Hutter, S; Laget, M; Moreau, A; Mothes, E; Paloque, L; Pedron, J; Pratviel, G; Sournia-Saquet, A; Stigliani, JL; Valentin, A; Vendier, L; Verhaeghe, P; Wyllie, S	1
Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K	1
Campbell, AM; Thompson, N	1
Chiba, K; Goldstein, JA; Guengerich, FP; Inoue, K; Kawai, T; Ozawa, N; Shimada, T; Suzuki, Y; Yamazaki, H	1
Fisher, MB; Haining, RL; Henne, KR; Jones, JP; Koop, DR; Rettie, AE; Trager, WF	1
Cannon, JM; Kostoryz, E; Russo, KA; Smith, RE; Yourtee, DM	1
Fujita, K; Kamataki, T; Nakayama, K; Nohmi, T; Tsuruma, K; Yamada, M; Yamazaki, Y	1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K	1
Asakawa, N; Ishihama, Y; Miwa, T	1
Azuma, J; Fukuda, T; Funae, Y; Hanatani, T; Onishi, S	1
Adedoyin, A; Caserta, KA; Jones, SS; Laws, K; Saraswat, LD; Wei, D	1
Brouwers, JR; de Jong-van den Berg, LT; de Vries-Bots, AM; Piersma-Wichers, M; Plat, AW; Slomp, J; van Dijk, AA; van Dijk, KN	1
Dickmann, LJ; Jones, JP; Locuson, CW; Rettie, AE	1
Obach, RS; Walsky, RL	1
Baillie, TA; Evans, DC; Li, Y; Ngui, JS; Shou, M; Stearns, RA; Tang, W; Zhang, Y; Zhang, Z	1
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y	1
Almarzooqi, MH; Elmosallamy, MA; Hassan, SS; Mahmoud, WH	1
Anzenbacher, P; Anzenbacherová, E; Masek, V; Veinlichová, A	1
Chaiyakunapruk, N; Jampachaisri, K; Kotirum, S; Rojnuckarin, P; Wattanasombat, S	1
Gorman, LA; Kumar, V; Rock, DA; Tracy, TS; Wahlstrom, JL; Warren, CJ	1
Carter, GT; Di, L; Kerns, EH; Li, SQ	1
Jones, JP; Locuson, CW; Tracy, TS; Wienkers, LC	1
Hirode, M; Imazawa, T; Kiyosawa, N; Miyagishima, T; Mizukawa, Y; Nagao, T; Omura, K; Ono, A; Shimizu, T; Uehara, T; Urushidani, T	1
Ikegami, Y; Iwakawa, S; Kadobayashi, M; Morii, R; Sugiyama, M; Tatsumi, A	1
Marison, IW; von Stockar, U; Whelehan, M	1
Barter, ZE; Crewe, HK; Rostami-Hodjegan, A; Yeo, KR	1
Hada, Y; Koeda, K; Kushihara, M; Watanabe, K; Yamamoto, I; Yamaori, S	1
Borgiani, P; Falconi, M; Ingelman-Sundberg, M; Johansson, I; Lee, MY; Mkrtchian, S; Oteri, F	1
Ford, KA; Halladay, JS; Hop, CE; Khojasteh, SC; Mukadam, S; Sodhi, JK; Wong, S	1
Finel, M; Ge, GB; Järvinen, E; Troberg, J; Yang, L	1
Bencsik, T; Boda, G; Kroon, PA; Lemli, B; Needs, PW; Poór, M	1
Bedwell, DW; Hall, SD; Mohutsky, MA; Rougée, LRA; Ruterbories, KJ	1
Korkut, O; Solmaz Avcıkurt, A	1
Liu, L; Liu, X; Tang, X; Wang, S; Xu, J; Yang, T; Zhang, J	1
Bálint, M; Bencsik, T; Boda, G; Hetényi, C; Kuzma, M; Mohos, V; Poór, M	1
Escher, BI; Fischer, FC; Henneberger, L; Mühlenbrink, M	1
Cai, JP; Chen, H; Chong, J; Dai, DP; Geng, PW; Liu, J; Lü, Y; Wang, SH; Wu, HL; Yang, JF; Zhou, Q; Zhou, S	1
Halladay, JS; Sodhi, JK	1

Reviews

1 review(s) available for diclofenac and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

66 other study(ies) available for diclofenac and warfarin

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water	2001
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water	2007
Human serum albumin binding assay based on displacement of a non selective fluorescent inhibitor. Bioorganic & medicinal chemistry letters, 2007, Aug-15, Volume: 17, Issue:16 Topics: Albumins; Anti-Bacterial Agents; Binding Sites; Calorimetry; Fluorescence; Humans; ortho-Aminobenzoates; Protein Binding	2007
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results	2011
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo. Journal of medicinal chemistry, 2015, Nov-12, Volume: 58, Issue:21 Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Glioblastoma; Humans; Iodine Radioisotopes; Mice; Mice, Nude; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Tissue Distribution; Tomography, Emission-Computed, Single-Photon	2015
Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study. European journal of medicinal chemistry, 2018, Jul-15, Volume: 155 Topics: Antiprotozoal Agents; Cell Survival; Dose-Response Relationship, Drug; Electrochemical Techniques; Hep G2 Cells; Humans; Kinetoplastida; Leishmania infantum; Molecular Structure; Nitroquinolines; Nitroreductases; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma brucei brucei	2018
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design. Journal of medicinal chemistry, 2020, 02-27, Volume: 63, Issue:4 Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry	2020
Anaesthesia for caesarean section in a patient with myotonic dystrophy receiving warfarin therapy. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:5 Pt 1 Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Asthma; Cesarean Section; Diclofenac; Elective Surgical Procedures; Female; Gravity Suits; Heparin; Humans; Myotonic Dystrophy; Pain, Postoperative; Pregnancy; Transcutaneous Electric Nerve Stimulation; Warfarin	1995
Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes. Biochemical pharmacology, 1998, Jul-15, Volume: 56, Issue:2 Topics: Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; DNA; Flurbiprofen; Heterozygote; Humans; Hydroxylation; Oxidation-Reduction; Polymorphism, Genetic; RNA; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Warfarin	1998
Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding. Biochemistry, 1999, Mar-16, Volume: 38, Issue:11 Topics: Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Binding Sites; Blotting, Western; Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Kinetics; Lauric Acids; Leucine; Mutagenesis, Site-Directed; Phenylalanine; Protein Structure, Secondary; Static Electricity; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Sulfaphenazole; Warfarin	1999
Bisphenol A and its biomaterial monomer derivatives alteration of in vitro cytochrome P450 metabolism in rat, minipig, and human. Biomacromolecules, 2000,Winter, Volume: 1, Issue:4 Topics: Animals; Benzhydryl Compounds; Caffeine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Diclofenac; Enzyme Inhibitors; Humans; Isoenzymes; Liver; Male; Microsomes, Liver; Phenols; Rats; Rats, Sprague-Dawley; Species Specificity; Swine; Swine, Miniature	2000
Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase. Environmental and molecular mutagenesis, 2001, Volume: 38, Issue:4 Topics: Alkylating Agents; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Ethanolamines; Genetic Engineering; Humans; Midazolam; Mixed Function Oxygenases; Mutagenicity Tests; NADP; NADPH-Ferrihemoprotein Reductase; Nitrosamines; Recombinant Proteins; Salmonella typhimurium; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	2001
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochemical pharmacology, 2002, Mar-01, Volume: 63, Issue:5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured	2002
Drug-plasma protein binding assay by electrokinetic chromatography-frontal analysis. Electrophoresis, 2002, Volume: 23, Issue:6 Topics: beta-Cyclodextrins; Blood Proteins; Chromatography, Micellar Electrokinetic Capillary; Cyclodextrins; Diclofenac; Electrophoresis, Capillary; Humans; Ketoprofen; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Serum Albumin; Sulfathiazole; Sulfathiazoles; Warfarin	2002
No major difference in inhibitory susceptibility between CYP2C9.1 and CYP2C9.3. European journal of clinical pharmacology, 2003, Volume: 59, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Microsomes; Nicardipine; Polymorphism, Genetic; Saccharomyces cerevisiae; Tolbutamide; Warfarin	2003
A high-throughput method for enzyme kinetic studies. Journal of biomolecular screening, 2003, Volume: 8, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Evaluation, Preclinical; Enzyme Inhibitors; Enzymes; Half-Life; Humans; Kinetics; Mass Spectrometry; Midazolam; Molecular Biology; Sensitivity and Specificity; Testosterone; Warfarin	2003
Potential interaction between acenocoumarol and diclofenac, naproxen and ibuprofen and role of CYP2C9 genotype. Thrombosis and haemostasis, 2004, Volume: 91, Issue:1 Topics: Acenocoumarol; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Chi-Square Distribution; Cohort Studies; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Diclofenac; Drug Interactions; Female; Genotype; Humans; Ibuprofen; International Normalized Ratio; Male; Middle Aged; Naproxen; Retrospective Studies; Sex Factors; Time Factors; Warfarin	2004
Differential roles of Arg97, Asp293, and Arg108 in enzyme stability and substrate specificity of CYP2C9. Molecular pharmacology, 2004, Volume: 65, Issue:4 Topics: Amino Acid Substitution; Arginine; Aryl Hydrocarbon Hydroxylases; Aspartic Acid; Binding Sites; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Stability; Gene Expression; Histidine; Humans; Kinetics; Models, Molecular; Mutagenesis; Pyrenes; Substrate Specificity; Warfarin	2004
Validated assays for human cytochrome P450 activities. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:6 Topics: Amodiaquine; Bupropion; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Drug Design; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Mass Spectrometry; Microsomes, Liver; Phenacetin; Recombinant Proteins; Reproducibility of Results	2004
Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:5 Topics: Animals; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Drug Interactions; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Microsomes, Liver; Models, Biological; Piroxicam; Quinidine; Recombinant Proteins; Warfarin	2004
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:9 Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone	2004
Iron(II)-phthalocyanine as a novel recognition sensor for selective potentiometric determination of diclofenac and warfarin drugs. Journal of pharmaceutical and biomedical analysis, 2005, Sep-01, Volume: 39, Issue:1-2 Topics: Calibration; Diclofenac; Ferrous Compounds; Hydrogen-Ion Concentration; Indoles; Ions; Pharmaceutical Preparations; Potentiometry; Quality Control; Sensitivity and Specificity; Warfarin	2005
Comparison of "high throughput" micromethods for determination of cytochrome P450 activities with classical methods using HPLC for product identification. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2005, Volume: 149, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Male; Mixed Function Oxygenases; Testosterone	2005
Utilization review of concomitant use of potentially interacting drugs in Thai patients using warfarin therapy. Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:2 Topics: Acetaminophen; Adult; Ambulatory Care; Analgesics, Non-Narcotic; Anticoagulants; Antithyroid Agents; Aspirin; Diclofenac; Drug Interactions; Drug Monitoring; Drug Prescriptions; Drug Utilization Review; Female; Follow-Up Studies; Humans; International Normalized Ratio; Male; Middle Aged; Polypharmacy; Propylthiouracil; Retrospective Studies; Thailand; Warfarin	2007
CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:12 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Inhibitors; Flurbiprofen; Genotype; In Vitro Techniques; Pharmacogenetics; Phenytoin; Piroxicam; Tolbutamide; Warfarin	2006
Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS. International journal of pharmaceutics, 2007, Apr-20, Volume: 335, Issue:1-2 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Drug Design; Drug Interactions; Enzyme Inhibitors; Ethanolamines; Fluorescent Dyes; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Liver; Microsomes, Liver; Midazolam; Recombinant Proteins; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Substrate Specificity; Tandem Mass Spectrometry	2007
CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:7 Topics: Allosteric Regulation; Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 CYP2C9; Cytochromes b5; Diclofenac; Flurbiprofen; Heme; Humans; Hydrogen Peroxide; Kinetics; Models, Biological; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Protein Conformation; Rats; Recombinant Proteins; Warfarin; Water	2007
Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans. Human & experimental toxicology, 2008, Volume: 27, Issue:1 Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Chemical and Drug Induced Liver Injury; Coumarins; Data Interpretation, Statistical; Diclofenac; Gene Expression; Hepatocytes; Humans; Male; Microscopy, Electron, Scanning; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Risk Assessment; Species Specificity; Toxicogenetics	2008
Effect of ethanol on S-warfarin and diclofenac metabolism by recombinant human CYP2C9.1. Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Ethanol; Humans; In Vitro Techniques; Microsomes; Recombinant Proteins; Stereoisomerism; Warfarin	2009
Removal of pharmaceuticals from water: using liquid-core microcapsules as a novel approach. Water research, 2010, Volume: 44, Issue:7 Topics: Capsules; Carbamazepine; Clofibric Acid; Diclofenac; Environmental Monitoring; Feasibility Studies; Fresh Water; Furosemide; Kinetics; Metoprolol; Pharmaceutical Preparations; Reproducibility of Results; Sulfamethoxazole; Warfarin; Water Pollutants, Chemical; Water Purification; Water Supply	2010
Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors. Biopharmaceutics & drug disposition, 2011, Volume: 32, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Cytochromes b5; Diclofenac; Enzyme Assays; Forecasting; Humans; Hypoglycemic Agents; Liver; Microsomes, Liver; Models, Biological; Recombinant Proteins; Tolbutamide; Warfarin	2011
Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. Drug metabolism and pharmacokinetics, 2012, Volume: 27, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Cannabidiol; Cannabinoids; Cannabinol; Cannabis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Diclofenac; Dronabinol; Enzyme Inhibitors; Female; Humans; Hydroxylation; Kinetics; Microsomes, Liver; Middle Aged; Plant Leaves; Polycyclic Aromatic Hydrocarbons; Recombinant Proteins; Smoke; Warfarin	2012
High warfarin sensitivity in carriers of CYP2C935 is determined by the impaired interaction with P450 oxidoreductase. The pharmacogenomics journal, 2014, Volume: 14, Issue:4* Topics: Anticoagulants; Benzene Derivatives; Cells, Cultured; Cytochrome P-450 CYP2C9; Diclofenac; Heterozygote; Humans; Hydroxylation; NADP; NADPH-Ferrihemoprotein Reductase; Warfarin	2014
1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:5 Topics: Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Diclofenac; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Protein Binding; Substrate Specificity; Tandem Mass Spectrometry; Time Factors; Triazoles; Warfarin	2014
UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated? Molecular pharmaceutics, 2017, 09-05, Volume: 14, Issue:9 Topics: Animals; Blotting, Western; Camptothecin; Chromatography, High Pressure Liquid; Coumarins; Diclofenac; Estradiol; Estrone; Flavonoids; Glucuronosyltransferase; Humans; Hymecromone; Intestinal Mucosa; Irinotecan; Kinetics; Microsomes, Liver	2017
Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88 Topics: Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Diclofenac; Drug Interactions; Flavonoids; Humans; Metabolome; Quercetin; Serum Albumin; Spectrometry, Fluorescence; Ultrafiltration; Warfarin	2017
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:9 Topics: Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Drug Interactions; Female; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Midazolam; Plasma; Testosterone; Warfarin	2017
Effect of certain non-steroidal anti-inflammatory drugs on the paraoxonase 2 (PON2) in human monocytic cell line U937. Archives of physiology and biochemistry, 2018, Volume: 124, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Coumarins; Diclofenac; Humans; Kinetics; Monocytes; Phenylacetates; Piroxicam; Spectrophotometry, Ultraviolet; Substrate Specificity	2018
Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2 Topics: Atorvastatin; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Kinetics; Microsomes, Liver; Midazolam; Protein Isoforms; Testosterone; Tolbutamide; Verapamil; Warfarin	2019
Pharmacokinetic interaction of diosmetin and silibinin with other drugs: Inhibition of CYP2C9-mediated biotransformation and displacement from serum albumin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 102 Topics: Anisotropy; Biotransformation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Diclofenac; Drug Interactions; Flavonoids; Humans; Kinetics; Molecular Docking Simulation; Serum Albumin; Serum Albumin, Bovine; Silybin; Silymarin; Spectrometry, Fluorescence; Time Factors; Ultrafiltration; Warfarin	2018
C18-Coated Solid-Phase Microextraction Fibers for the Quantification of Partitioning of Organic Acids to Proteins, Lipids, and Cells. Chemical research in toxicology, 2019, 01-22, Volume: 32, Issue:1 Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Cattle; Cells, Cultured; Diclofenac; Genistein; HEK293 Cells; Humans; Ibuprofen; Kinetics; Liposomes; Naproxen; Phospholipids; Serum Albumin, Bovine; Solid Phase Microextraction; Torsemide; Warfarin	2019
An identification and functional evaluation of a novel CYP2C9 variant CYP2C962. Chemico-biological interactions, 2020, Aug-25, Volume: 327* Topics: Aged, 80 and over; Alleles; Animals; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Assays; Humans; Kinetics; Losartan; Male; Microsomes; Point Mutation; Polymorphism, Genetic; Recombinant Proteins; Spodoptera; Tolbutamide; Vitamin K Epoxide Reductases; Warfarin	2020
Case Study 9: Probe-Dependent Binding Explains Lack of CYP2C9 Inactivation by 1-Aminobenzotriazole (ABT). Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2342 Topics: Binding Sites; Crystallography, X-Ray; Cytochrome P-450 CYP2C9; Diclofenac; Drug Interactions; Gene Silencing; Humans; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Time Factors; Triazoles; Warfarin	2021