diclofenac and verapamil

diclofenac has been researched along with verapamil in 62 studies

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.61)	18.7374
1990's	5 (8.06)	18.2507
2000's	16 (25.81)	29.6817
2010's	36 (58.06)	24.3611
2020's	4 (6.45)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Dansette, PM; Fontana, E; Poli, SM	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Briand, X; Faller, B; Lázaro, E; Lowe, PJ	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Avdeef, A; Tam, KY	1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Bettis, S; Brun, R; Fomovska, A; Huang, Q; Kaiser, M; Kozikowski, AP; McLeod, R; Mui, E; Pieroni, M; Stec, J; Witola, WH	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Abou-Taleb, N; Amblard, F; Amiralaei, S; Bassit, L; Coats, SJ; Domaoal, RA; Ehteshami, M; Khalil, A; Liu, P; Mahmoud, S; McBrayer, T; Ollinger Russell, O; Sari, O; Schinazi, RF; Schutter, C; Tao, S; Whitaker, T; Zhou, L; Zhou, S	1
Campillo, NE; Cañada, FJ; Canales, A; Carvalho, I; Chierrito, TPC; Martinez, A; Martínez-Gonzalez, L; Pedersoli-Mantoani, S; Perez, C; Pérez, DI; Roca, C; Sebastian-Pérez, V	1
Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L	1
Balliano, TL; Barbosa, G; Carvalho, VF; da Silva, BA; de Souza, ET; Lima, LM; Martins, IRR; Martins, MA; Medeiros, MM; Moraes Junior, MO; Nunes, IKDC; Silva, PMR; Silva, SWD	1
Barbosa, G; Ceschi, MA; Dantas, RF; Dardenne, LE; de Salles, CMC; Guedes, IA; Lima, LM; Lopes, JPB; Lüdtke, DS; Ruaro, TC; Senger, MR; Silva, L; Silva-Jr, FP; Zimmer, AR	1
al-Tuwaijri, AS; Mustafa, AA	1
Förstermann, U; Frölich, JC; Radermacher, J	1
Stahl, H	1
Estler, CJ; Lepper, H; Schmitz, G	1
Shirshev, SV	1
Aparecida De Oliveira, M; Fortes, ZB; Martinez, LL	1
Horie, T; Masubuchi, Y; Nakayama, S	1
Dommerich, S; Graumüller, S; Hoff, M; Ostwald, J	1
Nicholson Roberts, TC; Swart, M	1
Reanmongkol, W; Subhadhirasakul, S; Thaina, P; Tungcharoen, P; Wongnawa, M	1
Chakraborty, S; Khandai, M; Patra, ChN; Patro, VJ; Sen, KK; Sharma, A	1
Hosoi, Y; Kanamaru, T; Konno, T; Nakagami, H; Tajiri, S; Yada, S; Yoshida, K	1
Dickinson, PA; Lennernäs, H; Lundahl, A; Schrickx, JA; Thörn, HA	1
Bavry, AA; Cooper-Dehoff, RM; Gong, Y; Handberg, EM; Khaliq, A; Pepine, CJ	1
Dooley, S; Ehnert, S; Hao, L; Lin, J; Liu, L; Mühl-Benninghaus, R; Neumann, J; Nussler, AK; Nussler, N; Schyschka, L; Stöckle, U	1
Alvaro, R; Brancato, T; D'Ascenzo, R; De Giorgio, G; Nupieri, P; Orsolini, G; Paulis, G	2
Aguilar-de-Leyva, A; Caraballo, I; Cifuentes, C; Rajabi-Siahboomi, AR	1
Aykur, M; Güney, M; Kaplan, Ö; Nazıroğlu, M	1
Alvaro, R; Brancato, T; Cavallini, G; Giorgio, GD; Paulis, G; Quattrocchi, S	1
Harris, G; Landesmann, B; Mennecozzi, M; Palosaari, T; Whelan, M	1
Hofmann, MA; Sintov, AC	1
Ajima, MNO; Kumar, K; Kumar, S; Pandey, PK; Poojary, N	1
Liu, L; Liu, X; Tang, X; Wang, S; Xu, J; Yang, T; Zhang, J	1
Bridges, LR; Elbrecht, D; Funk, C; Hickman, JJ; Long, CJ; Martin, C; McAleer, CW; Roth, AB; Rumsey, JW; Sasserath, T; Schnepper, M; Schuler, F; Shuler, ML; Wang, Y	1
Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N	1
Jang, M; Kim, S; Nam, SN; Park, CM; Taheri-Qazvini, N; Yoon, Y	1

Reviews

3 review(s) available for diclofenac and verapamil

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for diclofenac and verapamil

Article	Year
Efficacy of vitamin E in the conservative treatment of Peyronie's disease: legend or reality? A controlled study of 70 cases. Andrology, 2013, Volume: 1, Issue:1 Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blueberry Plants; Calcium Channel Blockers; Diclofenac; Dietary Supplements; Disease Progression; Drug Therapy, Combination; Fruit; Humans; Injections, Intralesional; Iontophoresis; Male; Middle Aged; Penile Induration; Propolis; Rome; Severity of Illness Index; Time Factors; Treatment Outcome; Verapamil; Vitamin E; Vitamins	2013
Long-term multimodal therapy (verapamil associated with propolis, blueberry, vitamin E and local diclofenac) on patients with Peyronie's disease (chronic inflammation of the tunica albuginea). Results of a controlled study. Inflammation & allergy drug targets, 2013, Volume: 12, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Blueberry Plants; Case-Control Studies; Diclofenac; Humans; Inflammation; Iontophoresis; Male; Middle Aged; Penile Induration; Propolis; Verapamil; Vitamin E; Young Adult	2013

Article

Year

Efficacy of vitamin E in the conservative treatment of Peyronie's disease: legend or reality? A controlled study of 70 cases.

Andrology, 2013, Volume: 1, Issue:1

Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blueberry Plants; Calcium Channel Blockers; Diclofenac; Dietary Supplements; Disease Progression; Drug Therapy, Combination; Fruit; Humans; Injections, Intralesional; Iontophoresis; Male; Middle Aged; Penile Induration; Propolis; Rome; Severity of Illness Index; Time Factors; Treatment Outcome; Verapamil; Vitamin E; Vitamins

2013

Long-term multimodal therapy (verapamil associated with propolis, blueberry, vitamin E and local diclofenac) on patients with Peyronie's disease (chronic inflammation of the tunica albuginea). Results of a controlled study.

Inflammation & allergy drug targets, 2013, Volume: 12, Issue:6

Topics: Adult; Aged; Aged, 80 and over; Blueberry Plants; Case-Control Studies; Diclofenac; Humans; Inflammation; Iontophoresis; Male; Middle Aged; Penile Induration; Propolis; Verapamil; Vitamin E; Young Adult

2013

Other Studies

57 other study(ies) available for diclofenac and verapamil

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results	2011
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7 Topics: Antimalarials; Benzamides; Imides; Leishmania donovani; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture. Journal of medicinal chemistry, 2017, 07-13, Volume: 60, Issue:13 Topics: Antiviral Agents; Cells, Cultured; Dose-Response Relationship, Drug; Genotype; Hep G2 Cells; Hepacivirus; Humans; Microbial Sensitivity Tests; Molecular Structure; Prodrugs; Ribonucleotides; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication	2017
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors. European journal of medicinal chemistry, 2018, Feb-10, Volume: 145 Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Piperidines; Structure-Activity Relationship	2018
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties. European journal of medicinal chemistry, 2020, Aug-15, Volume: 200 Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish	2020
Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European journal of medicinal chemistry, 2020, Oct-15, Volume: 204 Topics: Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Design; Enzyme Inhibitors; Humans; Hydrazones; Hypersensitivity; Lung; Male; Mice	2020
Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. MedChemComm, 2019, Dec-01, Volume: 10, Issue:12 Topics:	2019
Verapamil enhances the inhibitory effect of diclofenac on the chemiluminescence of human polymorphonuclear leukocytes and carrageenan-induced rat's paw oedema. International journal of immunopharmacology, 1992, Volume: 14, Issue:1 Topics: Animals; Cell Survival; Diclofenac; Drug Synergism; Edema; Luminescent Measurements; Male; Neutrophils; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Verapamil; Zymosan	1992
Endothelium-derived relaxing factor influences renal vascular resistance. The American journal of physiology, 1990, Volume: 259, Issue:1 Pt 2 Topics: Acetylcholine; Adenosine Triphosphate; Animals; Arginine; Diclofenac; Dose-Response Relationship, Drug; Endothelium, Vascular; Gossypol; Hemodynamics; Kidney; Male; Methylene Blue; Nitric Oxide; Nitroglycerin; Nitroprusside; Prostaglandins; Rats; Rats, Inbred Strains; Renal Circulation; Vascular Resistance; Vasodilation; Verapamil	1990
[The family physician and drug side-effects. Observations from general practice--conclusions for general practice]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1989, Aug-15, Volume: 78, Issue:33 Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Cosyntropin; Diclofenac; Digoxin; Drug Eruptions; Drug Hypersensitivity; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Nitrofurantoin; Penicillin G Procaine; Risk Factors; Verapamil	1989
Failure of calcium antagonistic agents to prevent hepatotoxicity induced by diclofenac. Pharmacology & toxicology, 1995, Volume: 77, Issue:1 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Chelating Agents; Diclofenac; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Liver; Male; Rats; Rats, Wistar; Verapamil	1995
[Mechanisms of chorionic gonadotropin action on splenocytes, suppressed in their humoral immune response]. Biokhimiia (Moscow, Russia), 1995, Volume: 60, Issue:11 Topics: Animals; Antibody Formation; Calcium Channel Blockers; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Cyclooxygenase Inhibitors; Diclofenac; Female; Mice; Mice, Inbred CBA; Radioimmunoassay; Second Messenger Systems; Spleen; T-Lymphocytes, Regulatory; Verapamil	1995
Influence of verapamil and diclofenac on leukocyte migration in rats. Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:4 Pt 2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion Molecules; Cell Movement; Diclofenac; Endothelium, Vascular; Leukocytes; Male; Rats; Rats, Wistar; Vasodilator Agents; Verapamil	1999
Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclosporine; Diclofenac; Hepatocytes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; NADP; Permeability; Rats; Rats, Wistar; Sulfhydryl Compounds; Verapamil	2002
[Influence of rhinologic usual and unusual drugs on fibroblasts from nasal polyps in cell culture]. Laryngo- rhino- otologie, 2003, Volume: 82, Issue:6 Topics: Administration, Topical; Adrenergic beta-Antagonists; Androstadienes; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Beclomethasone; Calcium Channel Blockers; Cells, Cultured; Culture Media; Diclofenac; Fibroblasts; Fluticasone; Glucocorticoids; Hematologic Agents; Humans; In Vitro Techniques; Mesalamine; Methylprednisolone; Mometasone Furoate; Muscarinic Agonists; Nasal Polyps; Pentoxifylline; Pilocarpine; Piroxicam; Prednisolone; Pregnadienediols; Time Factors; Timolol; Verapamil	2003
Enteral drugs given through a central venous catheter. Anaesthesia, 2007, Volume: 62, Issue:6 Topics: Aged; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Central Venous; Diclofenac; Female; Humans; Intubation, Gastrointestinal; Medication Errors; Postoperative Care; Respiratory Insufficiency; Verapamil	2007
Uterine relaxant effects of Curcuma aeruginosa Roxb. rhizome extracts. Journal of ethnopharmacology, 2009, Jan-30, Volume: 121, Issue:3 Topics: Acetylcholine; Animals; Atropine; Calcium Channel Blockers; Curcuma; Diclofenac; Dinoprost; Female; Isoproterenol; Oxytocics; Oxytocin; Parasympatholytics; Plant Extracts; Propranolol; Rats; Rats, Wistar; Rhizome; Uterine Contraction; Uterus; Vasodilator Agents; Verapamil	2009
Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations. Acta pharmaceutica (Zagreb, Croatia), 2009, Volume: 59, Issue:3 Topics: Chemistry, Pharmaceutical; Delayed-Action Preparations; Diclofenac; Hypromellose Derivatives; Methylcellulose; Solubility; Tablets; Verapamil; Water	2009
The relationship between the drug concentration profiles in plasma and the drug doses in the colon. Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:10 Topics: Administration, Oral; Animals; Anti-Allergic Agents; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Area Under Curve; Biological Availability; Colon; Delayed-Action Preparations; Diclofenac; Diltiazem; Dogs; Dose-Response Relationship, Drug; Hypoglycemic Agents; Metformin; Muscarinic Agonists; Quinuclidines; Terfenadine; Thiophenes; Verapamil	2010
Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Jun-14, Volume: 43, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP-Binding Cassette Transporters; Biotransformation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Gene Expression; Glucuronosyltransferase; Humans; Jejunum; Ketoconazole; Liver; Male; Microsomes, Liver; RNA, Messenger; Species Specificity; Swine; Testosterone; Verapamil	2011
Harmful effects of NSAIDs among patients with hypertension and coronary artery disease. The American journal of medicine, 2011, Volume: 124, Issue:7 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Celecoxib; Confounding Factors, Epidemiologic; Coronary Artery Disease; Diclofenac; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hypertension; Ibuprofen; Indoles; Kaplan-Meier Estimate; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Myocardial Infarction; Naproxen; Odds Ratio; Proportional Hazards Models; Pyrazoles; Randomized Controlled Trials as Topic; Stroke; Sulfonamides; Verapamil	2011
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. Archives of toxicology, 2012, Volume: 86, Issue:1 Topics: Acetaminophen; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 Enzyme System; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Hepatocytes; Humans; Isoenzymes; Liver Neoplasms; Oxidative Stress; Pharmaceutical Preparations; Verapamil	2012
Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie's disease: a study of 151 cases. International journal of andrology, 2012, Volume: 35, Issue:4 Topics: Adult; Aged; Antioxidants; Blueberry Plants; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Diclofenac; Humans; Iontophoresis; Male; Middle Aged; Penile Erection; Penile Induration; Penis; Plant Extracts; Propolis; Retrospective Studies; Surveys and Questionnaires; Treatment Outcome; Verapamil; Vitamin E; Young Adult	2012
Critical points in ethylcellulose matrices: influence of the polymer, drug and filler properties. Acta pharmaceutica (Zagreb, Croatia), 2013, Volume: 63, Issue:1 Topics: Carbamazepine; Cellulose; Chemistry, Pharmaceutical; Diclofenac; Drug Compounding; Kinetics; Lactose; Particle Size; Polymers; Porosity; Pressure; Solubility; Tablets; Verapamil; Viscosity	2013
Non-steroidal anti-inflammatory drug modulates oxidative stress and calcium ion levels in the neutrophils of patients with primary dysmenorrhea. Journal of reproductive immunology, 2013, Volume: 100, Issue:2 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Boron Compounds; Calcium; Calcium Channels; Cells, Cultured; Diclofenac; Diltiazem; Dysmenorrhea; Female; Glutathione Peroxidase; Humans; Lipid Peroxidation; Neutrophil Activation; Neutrophils; Oxidative Stress; Verapamil; Young Adult	2013
Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro? PloS one, 2015, Volume: 10, Issue:4 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Calcium; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Chlorpromazine; Diclofenac; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Omeprazole; Primary Cell Culture; Sex Characteristics; Verapamil	2015
A novel thermo-mechanical system enhanced transdermal delivery of hydrophilic active agents by fractional ablation. International journal of pharmaceutics, 2016, Sep-25, Volume: 511, Issue:2 Topics: Animals; Ascorbic Acid; Diclofenac; Drug Delivery Systems; Hot Temperature; Humans; Injections, Intradermal; Phenolsulfonphthalein; Skin; Skin Absorption; Swine; Verapamil	2016
Evaluation of DNA damage and physiological responses in Nile tilapia, Oreochromis niloticus (Linnaeus, 1758) exposed to sub-lethal diclofenac (DCF). Aquatic toxicology (Amsterdam, Netherlands), 2017, Volume: 186 Topics: Animals; Antioxidants; Catalase; Cichlids; Comet Assay; Diclofenac; DNA Damage; Glutathione Peroxidase; Glutathione Transferase; Lipid Peroxidation; Liver; Oxidative Stress; Principal Component Analysis; Protein Carbonylation; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase; Verapamil; Water Pollutants, Chemical	2017
Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2 Topics: Atorvastatin; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Kinetics; Microsomes, Liver; Midazolam; Protein Isoforms; Testosterone; Tolbutamide; Verapamil; Warfarin	2019
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics. Science translational medicine, 2019, 06-19, Volume: 11, Issue:497 Topics: Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Diclofenac; Drug Evaluation, Preclinical; Humans; Imatinib Mesylate; Lab-On-A-Chip Devices; Tamoxifen; Verapamil	2019
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:4 Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil	2020
Effect of single and multilayered Ti Journal of hazardous materials, 2022, 03-15, Volume: 426 Topics: Adsorption; Diclofenac; Oxidation-Reduction; Titanium; Verapamil	2022