Compounds > diclofenac

diclofenac and ticrynafen

diclofenac has been researched along with ticrynafen in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (14.29)	18.2507
2000's	4 (28.57)	29.6817
2010's	8 (57.14)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dansette, PM; Fontana, E; Poli, SM	1
Board, PG; Christ, AN; Clark, AG; Flanagan, JU; Hall, R; Hayes, JD; Hume, DA; Oakley, AJ; Smythe, ML; Weber, JE	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Halmes, NC; Pumford, NR	1
Attias, R; Dansette, PM; Mansuy, D; Poli-Scaife, S	1
Assrir, N; Dansette, PM; Jaouen, M; Jean, P; Mansuy, D; Marques-Soares, C; Melet, A; Pilar Lopez-Garcia, M; Sari, MA	1
Masumoto, H; Mitsuru, A; Okazaki, O; Sudo, K; Takakusa, H	1
Kalgutkar, AS; Obach, RS; Soglia, JR; Zhao, SX	1

Reviews

3 review(s) available for diclofenac and ticrynafen

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Protein targets of xenobiotic reactive intermediates. Annual review of pharmacology and toxicology, 1997, Volume: 37 Topics: Acetaminophen; Animals; Diclofenac; Ethanol; Halothane; Immunochemistry; Kidney; Liver; Protein Binding; Proteins; Ticrynafen; Xenobiotics	1997

Other Studies

11 other study(ies) available for diclofenac and ticrynafen

Article	Year
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase. European journal of medicinal chemistry, 2010, Volume: 45, Issue:2 Topics: Binding Sites; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutathione Transferase; Hematopoiesis; Humans; Intramolecular Oxidoreductases; Lipocalins; Models, Molecular; Molecular Conformation; Nocodazole	2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
The substrate binding site of human liver cytochrome P450 2C9: an NMR study. Biochemistry, 1997, Oct-21, Volume: 36, Issue:42 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Isomerism; Kinetics; Lauric Acids; Microsomes, Liver; Models, Chemical; Models, Molecular; NADPH-Ferrihemoprotein Reductase; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Rats; Spectrophotometry; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Ticrynafen	1997
Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid. Archives of biochemistry and biophysics, 2003, Jan-01, Volume: 409, Issue:1 Topics: Amino Acids; Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; Binding Sites; Crystallography, X-Ray; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Diclofenac; Humans; Kinetics; Microsomes; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Software; Spectrophotometry; Substrate Specificity; Sulfaphenazole; Ticrynafen; Time Factors; Ultraviolet Rays; Yeasts	2003
Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:5 Topics: Acetaminophen; Aspirin; Butylated Hydroxyanisole; Carboxylic Ester Hydrolases; Cells, Cultured; Clozapine; Diclofenac; Furosemide; Glucuronosyltransferase; Heme Oxygenase-1; Hepatocytes; Humans; L-Lactate Dehydrogenase; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; RNA, Messenger; Ticlopidine; Ticrynafen	2008
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Chemical research in toxicology, 2008, Volume: 21, Issue:9 Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles	2008