diclofenac has been researched along with theophylline in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.55) | 18.7374 |
| 1990's | 7 (15.91) | 18.2507 |
| 2000's | 13 (29.55) | 29.6817 |
| 2010's | 19 (43.18) | 24.3611 |
| 2020's | 3 (6.82) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Chang, TT; Chen, CL; Chen, WS; Fu, CW; Hsiao, PW; Li, WS; Tsai, HE | 1 |
| Anderson, KS; Deshmukh, MG; Hollander, K; Ippolito, JA; Isaacs, F; Jorgensen, WL; Liang, Z; Lindenbach, BD; Liosi, ME; Miller, SJ; Reilly, RA; Spasov, KA; Stone, EA; Tirado-Rives, J; Zhang, CH; Zhang, S | 1 |
| Cutrona, KJ; Henry, SP; Ippolito, JA; Jorgensen, WL; Krimmer, SG; Liosi, ME; Mohanty, J; Newton, AS; Olivarez, RA; Schlessinger, J | 1 |
| Barnea, ER; Cohen, Y; Shurtz-Swirski, R | 1 |
| Rehavi, M; Rubinstein, E; Segev, S | 1 |
| Nakano, Y; Nishihata, T; Yamazaki, M | 1 |
| Lamontagne, D; Nakhostine, N | 1 |
| Amon, I; Franke, G; Scheuch, E; Siegmund, W; Stolz, E; Zschiesche, M | 1 |
| Alexandrov, VA; Bespalov, VG; Petrov, AS; Troyan, DN | 1 |
| Kim, CJ | 1 |
| Picker, KM | 1 |
| Lewis, IA; Palmer, J; Pleasance, S; Scott, RJ | 1 |
| Bujak-Gizycka, B; Kłys, M; Latacz, B; Skupień, E | 1 |
| Li, MJ; Lin, KH; Lin, SY | 1 |
| Abbas, MR; Coney, AM; Marshall, JM; Ray, CJ | 1 |
| Chaudhary, A; Di Marco, A; Laufer, R; Marcucci, I; Taliani, M | 1 |
| Chanda, E; Datta, BK; Haider, SS; Quadir, MA; Reza, MD | 1 |
| Krejcová, K; Polásek, E; Prokopová, A; Rabisková, M; Tomásek, V; Vetchý, D | 1 |
| Hao, HP; Peng, Y; Roberts, MS; Shang, LL; Sun, JG; Wang, GJ; Wang, XJ; Xia, CH; Xie, L; Zhang, R; Zhang, XX | 1 |
| Drefko, W; Moroni, A; Thone, G | 1 |
| Huanbutta, K; Limmatvapirat, S; Luangtana-anan, M; Nunthanid, J; Sriamornsak, P; Terada, K; Yonemochi, E; Yoshihashi, Y | 1 |
| Churakov, AV; Kuzmina, LG; Manin, AN; Manin, NG; Perlovich, GL; Surov, AO; Voronin, AP | 1 |
| Zhang, F | 1 |
| Alhnan, MA; Arafat, B; Cieszynska, M; Isreb, A; Okwuosa, TC; Pereira, BC | 1 |
| Al-Huniti, N; Bui, KH; Cheung, SYA; Johnson, TN; Li, J; Xu, H; Zhou, D; Zhou, W | 1 |
| Feng, G; Gu, H; He, X; Li, ZQ; Nyagblordzro, M; Tian, S; Wu, ZG | 1 |
| Chiang, W; Li, ML; Lin, JH; Liu, YT; Yao, HT | 1 |
1 review(s) available for diclofenac and theophylline
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for diclofenac and theophylline
| Article | Year |
|---|---|
Potential pharmacokinetic interactions of nocloprost clathrate with retarded theophylline and enteric coated diclofenac after single and repeated premedication in healthy volunteers.
Topics: Absorption; Adult; Capsules; Chromatography, Gas; Chromatography, High Pressure Liquid; Diclofenac; Drug Administration Schedule; Drug Interactions; Humans; Male; Placebos; Premedication; Prostaglandins F, Synthetic; Single-Blind Method; Tablets, Enteric-Coated; Theophylline; Vasodilator Agents | 1993 |
42 other study(ies) available for diclofenac and theophylline
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis.
Topics: Animals; Animals, Genetically Modified; Breast Neoplasms; Catalysis; Cell Line, Tumor; Enzyme Inhibitors; Female; Focal Adhesion Protein-Tyrosine Kinases; Glycoproteins; Humans; Integrins; Isoenzymes; Molecular Docking Simulation; Neoplasm Metastasis; NF-kappa B; Paxillin; Phosphorylation; Sialyltransferases; Signal Transduction; Talin; Zebrafish | 2021 |
Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.
Topics: | 2021 |
Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.
Topics: Humans; Janus Kinase 2; Janus Kinases; Ligands; Mutation; Myeloproliferative Disorders; Signal Transduction; STAT Transcription Factors | 2022 |
Patterns of secretion of human chorionic gonadotrophin by superfused placental explants and the embryo--placental relationship following maternal use of medications.
Topics: Chorionic Gonadotropin; Codeine; Diclofenac; Female; Humans; Lorazepam; Maternal-Fetal Exchange; Organ Culture Techniques; Perfusion; Placenta; Pregnancy; Pregnancy Trimester, First; Spinal Cord; Theophylline; Thioridazine; Trophoblasts | 1992 |
Quinolones, theophylline, and diclofenac interactions with the gamma-aminobutyric acid receptor.
Topics: Animals; Ciprofloxacin; Diclofenac; Drug Synergism; GABA Antagonists; In Vitro Techniques; Male; Muscimol; Nalidixic Acid; Ofloxacin; Quinolones; Rats; Rats, Inbred Strains; Receptors, GABA-A; Theophylline | 1988 |
Use of hydrogenated soya phospholipids as a diluent: preparation of sustained-release tablets of theophylline and sodium diclofenac.
Topics: Animals; Delayed-Action Preparations; Diclofenac; Dogs; Excipients; Glycine max; Male; Phospholipids; Theophylline | 1987 |
Contribution of prostaglandins in hypoxia-induced vasodilation in isolated rabbit hearts. Relation to adenosine and KATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cyclic AMP; Diclofenac; Epoprostenol; Heart; Hypoxia; Myocardium; Potassium Channels; Prostaglandins; Rabbits; Theophylline; Vasodilation | 1994 |
Study of post-natal effect of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. III. Inhibitory action of indomethacin, voltaren, theophylline and epsilon-aminocaproic acid.
Topics: Aminocaproic Acid; Animals; Anticarcinogenic Agents; Brain Neoplasms; Carcinogens; Central Nervous System Neoplasms; Diclofenac; Ethylnitrosourea; Female; Indomethacin; Kidney Neoplasms; Maternal-Fetal Exchange; Neoplasms, Experimental; Peripheral Nervous System Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Spinal Cord Neoplasms; Theophylline | 1996 |
Effects of drug solubility, drug loading, and polymer molecular weight on drug release from Polyox tablets.
Topics: Diclofenac; Drug Delivery Systems; Excipients; Molecular Weight; Polyethylene Glycols; Salicylic Acid; Solubility; Sulfathiazole; Sulfathiazoles; Tablets; Theophylline; Water | 1998 |
Matrix tablets of carrageenans. II. Release behavior and effect of added cations.
Topics: Adsorption; Carrageenan; Cations; Diclofenac; Diffusion; Excipients; Kinetics; Rheology; Solubility; Solutions; Tablets; Theophylline; Thermodynamics; Viscosity; Water | 1999 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline | 1999 |
[Two complex suicidal poisonings with drugs and their medicolegal aspects].
Topics: Adult; Atenolol; Chromatography, High Pressure Liquid; Diclofenac; Estazolam; Fatal Outcome; Female; Humans; Ibuprofen; Illicit Drugs; Ketoprofen; Male; Metronidazole; Naproxen; Poland; Suicide, Attempted; Theophylline; Tolperisone | 2001 |
Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets.
Topics: Albuterol; Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diclofenac; Drug Compounding; Excipients; Hardness; Kinetics; Osmosis; Particle Size; Pharmaceutical Preparations; Powders; Pressure; Sodium Chloride; Solubility; Tablets; Theophylline; Time Factors | 2002 |
Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies.
Topics: Adenosine; Animals; Aorta; Cyclooxygenase Inhibitors; Diclofenac; Hypoxia; In Vitro Techniques; Indomethacin; Male; Muscle, Skeletal; Nitric Oxide; Prostaglandins; Rats; Rats, Wistar; Theophylline; Vasodilation | 2002 |
Development and validation of a high-throughput radiometric cyp2c9 inhibition assay using tritiated diclofenac.
Topics: Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Automation; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Inhibitors; Humans; Hydroxylation; Microsomes, Liver; Radiometry; Reproducibility of Results; Theophylline; Tritium; Water | 2005 |
Evaluation of ethylcellulose as matrices for controlled release drug delivery.
Topics: Cellulose; Compressive Strength; Delayed-Action Preparations; Diclofenac; Diltiazem; Drug Carriers; Hydrogen-Ion Concentration; Kinetics; Solubility; Tablets; Technology, Pharmaceutical; Theophylline; Time Factors | 2005 |
The influence of drug solubility and particle size on the pellet formulation in a rotoprocessor.
Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Bronchodilator Agents; Calcium Channel Blockers; Cellulose; Chemistry, Pharmaceutical; Diclofenac; Diltiazem; Drug Compounding; Excipients; Lactase; Particle Size; Solubility; Theophylline; Water | 2006 |
Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats.
Topics: Animals; Area Under Curve; Chlorzoxazone; Cytochrome P-450 Enzyme System; Diclofenac; Drug Combinations; Drugs, Chinese Herbal; Herb-Drug Interactions; Inactivation, Metabolic; Inhibitory Concentration 50; Injections; Liver; Male; Midazolam; Ophiopogon; Panax; Plant Roots; Rats; Rats, Sprague-Dawley; Theophylline | 2010 |
Formulations of zero-order, pH-dependent, sustained release matrix systems by ionotropic gelation of alginate-containing mixtures.
Topics: Alginates; Calcium; Delayed-Action Preparations; Diclofenac; Drug Stability; Excipients; Gels; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Hypromellose Derivatives; Methylcellulose; Polysaccharides, Bacterial; Propranolol; Solubility; Tablets; Theophylline; Time Factors | 2011 |
Swelling kinetics of spray-dried chitosan acetate assessed by magnetic resonance imaging and their relation to drug release kinetics of chitosan matrix tablets.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bronchodilator Agents; Chitosan; Diclofenac; Humans; Magnetic Resonance Imaging; Solubility; Tablets; Theophylline | 2011 |
Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline.
Topics: Calorimetry, Differential Scanning; Diclofenac; Diflunisal; Models, Molecular; Solubility; Theophylline | 2014 |
Melt-Extruded Eudragit® FS-Based Granules for Colonic Drug Delivery.
Topics: Chemistry, Pharmaceutical; Colon; Diclofenac; Drug Delivery Systems; Hydrogen-Ion Concentration; Mesalamine; Particle Size; Polymers; Polymethacrylic Acids; Solubility; Technology, Pharmaceutical; Theophylline | 2016 |
Fabricating a Shell-Core Delayed Release Tablet Using Dual FDM 3D Printing for Patient-Centred Therapy.
Topics: Budesonide; Capsules; Delayed-Action Preparations; Diclofenac; Drug Compounding; Drug Liberation; Hot Temperature; Humans; Patient-Centered Care; Polymers; Povidone; Printing, Three-Dimensional; Tablets; Theophylline | 2017 |
Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.
Topics: Acetates; Analgesics, Opioid; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Bronchodilator Agents; Child; Child, Preschool; Cyclopropanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Esomeprazole; Histamine H1 Antagonists, Non-Sedating; Humans; Infant; Infant, Newborn; Itraconazole; Lansoprazole; Loratadine; Models, Biological; Ondansetron; Pharmaceutical Preparations; Pharmacokinetics; Proton Pump Inhibitors; Quinolines; Serotonin Antagonists; Sufentanil; Sulfides; Theophylline; Tramadol | 2018 |
In Vitro-In Vivo Predictive Dissolution-Permeation-Absorption Dynamics of Highly Permeable Drug Extended-Release Tablets via Drug Dissolution/Absorption Simulating System and pH Alteration.
Topics: Administration, Oral; Animals; Delayed-Action Preparations; Diclofenac; Dogs; Drug Liberation; Forecasting; Hydrogen-Ion Concentration; Male; Permeability; Rats; Rats, Sprague-Dawley; Solubility; Tablets; Theophylline | 2018 |
Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats.
Topics: Administration, Intravenous; Administration, Oral; Animals; Capsaicin; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Diltiazem; Food-Drug Interactions; Intestinal Absorption; Intestines; Liver; Male; Plant Oils; Rats, Sprague-Dawley; Risk Assessment; Theophylline | 2019 |