diclofenac has been researched along with sulindac in 57 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 16 (28.07) | 18.7374 |
1990's | 12 (21.05) | 18.2507 |
2000's | 11 (19.30) | 29.6817 |
2010's | 17 (29.82) | 24.3611 |
2020's | 1 (1.75) | 2.80 |
Authors | Studies |
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Graves, P; Kuze, K; Leahy, A; Stuhlmann, H; Wilson, P; You, G | 1 |
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
Barreiro, EJ; Fraga, CA; Lima, LM; Romeiro, NC; Sant'Anna, CM | 1 |
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Glen, RC; Lowe, R; Mitchell, JB | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
Horie, T; Horiguchi, A; Kitamura, S; Kotake, Y; Ohshita, H; Ohta, S; Sanoh, S; Sugihara, K; Tateno, C; Tayama, Y | 1 |
Kumar, M; Sinha, VR; Thareja, S | 1 |
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Akgul, O; Alfawaz Altamimi, AS; Angeli, A; Bartolucci, G; Carta, F; Di Cesare Mannelli, L; Ghelardini, C; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K | 1 |
Burdeĭnyĭ, AP | 1 |
Pemberton, RE; Strand, LJ | 1 |
Baumgartner, H | 1 |
Abe, K; Akiu, N; Saito, T; Sato, M; Takeuchi, K; Yasujima, M; Yoshinaga, K | 1 |
de Pouvourville, G | 1 |
Brooks, PM; Johnston, HJ; Kelly, D; Monaghan, JC; Okoro, EO; Stokes, GS | 1 |
Abe, K; Sato, K; Sato, M; Takeuchi, K; Tanno, M; Yasujima, M; Yoshinaga, K | 1 |
Montenegro, MA; Palomino, H | 1 |
Blass, A; Carloni, C; Filipponi, P; Grossi, E; Hruska, KA; Mannarelli, C; Moretti, I; Morucci, P; Pacifici, R; Tini, S | 1 |
de Jong, PE; de Zeeuw, D; Donker, AJ; Pratt, JJ; van der Hem, GK; Vriesendorp, R | 1 |
Altman, R | 1 |
Gribnau, FW; Koopmans, PP; Thien, T | 1 |
Harima, Y; Koshiro, A; Maekawa, T; Miyauchi, Y; Sakabe, T; Tsutsui, T | 1 |
Blake, JW; Tobin, T; Weckman, T; Woods, WE | 1 |
Macauley, D | 1 |
Minker, E; Végh, A | 1 |
Guobis, G; Iushenaite, Ia | 1 |
Obel, AO | 1 |
Nahir, AM; Scharf, Y | 1 |
Pathy, MS | 1 |
Paolaggi, JB | 1 |
Backman, EA; Beckman, EA; Kulling, PE; Skagius, AS | 1 |
Carson, JL; Manoukian, AV | 1 |
Caldwell, J; Kenna, JG; Wade, LT | 1 |
Tolman, KG | 1 |
Russeva, VN; Zhivkova, ZD | 1 |
Giuliano, F; Warner, TD | 1 |
Bhagat, K | 1 |
Brooks, G; Crabbe, MJ; Harper, JV; Shattock, MJ; Wang, Y; Yu, XM | 1 |
Dargan, PI; Jones, AL; O'Connor, N | 1 |
Hartnell, NR; Wilson, JP | 1 |
Bass, SE; Cheng, RY; Del Soldato, P; Macdonald, CJ; Moody, TW; Roberts, DD; Sienkiewicz, P; Sparatore, A; Wink, DA; Yeh, GC | 1 |
Brünnert, D; Bruns, I; Cadeddu, RP; Czibere, A; Fröbel, J; Haas, R; Hartwig, S; Lehr, S; Prenzel, T; Schroeder, T; Singh, R; Wilk, CM; Zerbini, LF | 1 |
Bhasin, M; Cordeiro, J; Correa, RG; Czibere, A; Fisher, PB; Gu, X; Li, L; Libermann, TA; Sarkar, D; Simabuco, FM; Tamura, RE; Wang, Y; Zerbini, LF; Zhou, JR | 1 |
Unlü, B; van Leeuwen, JS; Vermeulen, NP; Vos, JC | 1 |
Honda, H; Ito, Y; Kawamoto, T; Morita, O | 1 |
7 review(s) available for diclofenac and sulindac
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Drug therapy of ankylosing spondyloarthritis (Bechterew's disease)].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Apazone; Butadienes; Cyclophosphamide; Diclofenac; Drug Combinations; Drug Evaluation; Glycolates; Gold; Humans; Ibuprofen; Indomethacin; Ketoprofen; Levamisole; Naproxen; Oxyphenbutazone; Phenylbutazone; Salicylates; Spondylitis, Ankylosing; Sulindac | 1978 |
[Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Eruptions; Drug Interactions; Female; Gastrointestinal Diseases; Headache; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Sulindac | 1981 |
Practical therapeutics: the newer nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Diclofenac; Humans; Ibuprofen; Indomethacin; Naproxen; Phenylbutazone; Phenylbutyrates; Piroxicam; Propionates; Sulindac; Thiazines | 1982 |
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cohort Studies; Diclofenac; Humans; Incidence; Indomethacin; Liver; Liver Diseases; Naproxen; Oxaprozin; Phenylbutazone; Propionates; Risk Factors; Sulindac | 1996 |
Hepatotoxicity of non-narcotic analgesics.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; Humans; Liver Diseases; Risk Factors; Salicylates; Sulindac | 1998 |
Hepatocellular damage from non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Injury; Diclofenac; Disease Susceptibility; Drug Hypersensitivity; Female; Humans; Liver Diseases; Liver Failure, Acute; Middle Aged; Mitochondria, Liver; Risk Factors; Sulindac | 2003 |
9 trial(s) available for diclofenac and sulindac
Article | Year |
---|---|
A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Evaluation; Fenoprofen; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Ibuprofen; Ketoprofen; Naproxen; Phenylbutazone; Registries; Sulindac; Tolmetin | 1979 |
[A clinical comparison of sulindac and diclofenac in the treatment of osteoarthritis (author's transl)].
Topics: Adult; Aged; Diclofenac; Double-Blind Method; Female; Humans; Indenes; Male; Middle Aged; Osteoarthritis; Phenylacetates; Sulindac | 1979 |
The effects of sulindac and diclofenac in essential hypertension controlled by treatment with a beta blocker and/or diuretic.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Creatinine; Diclofenac; Diuretics; Double-Blind Method; Drug Interactions; Female; Humans; Hypertension; Male; Middle Aged; Renin-Angiotensin System; Sulindac | 1991 |
No adverse effect of non-steroidal anti-inflammatory drugs, sulindac and diclofenac sodium, on blood pressure control with a calcium antagonist, nifedipine, in elderly hypertensive patients.
Topics: Aged; Blood Pressure; Diclofenac; Dinoprostone; Drug Therapy, Combination; Female; Humans; Hypertension; Kidney; Nifedipine; Sulindac | 1991 |
International experiences with diclofenac in osteoarthritis.
Topics: Aspirin; Clinical Trials as Topic; Diclofenac; Diflunisal; Double-Blind Method; Gastrointestinal Diseases; Humans; Ibuprofen; Indomethacin; Naproxen; Osteoarthritis; Random Allocation; Sulindac | 1986 |
The influence of ibuprofen, diclofenac and sulindac on the blood pressure lowering effect of hydrochlorothiazide.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Clinical Trials as Topic; Creatinine; Diclofenac; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Ibuprofen; Indenes; Male; Middle Aged; Potassium; Renin; Sulindac | 1987 |
[Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Eruptions; Drug Interactions; Female; Gastrointestinal Diseases; Headache; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Sulindac | 1981 |
A comparative study of diclofenac and sulindac in ankylosing spondylitis.
Topics: Adult; Clinical Trials as Topic; Diclofenac; Female; Humans; Indenes; Male; Middle Aged; Phenylacetates; Spondylitis, Ankylosing; Sulindac | 1980 |
Effects of non-steroidal anti-inflammatory drugs on hypertension control using angiotensin converting enzyme inhibitors and thiazide diuretics.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Diclofenac; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Ibuprofen; Lisinopril; Middle Aged; Osteoarthritis; Sulindac; Treatment Outcome | 2001 |
42 other study(ies) available for diclofenac and sulindac
Article | Year |
---|---|
Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; COS Cells; Glycosylation; Histidine; In Situ Hybridization; Kidney; Kinetics; Mice; p-Aminohippuric Acid; Probenecid; Protein Processing, Post-Translational; Renal Agents; Substrate Specificity; Tunicamycin | 1999 |
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Catalytic Domain; Computational Biology; Drug Design; Ligands; Models, Molecular; PPAR gamma; Protein Conformation; Software | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver.
Topics: Animals; Cells, Cultured; Child, Preschool; Chimera; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Drugs, Investigational; Female; Half-Life; Hepatocytes; Humans; Immunomagnetic Separation; Liver; Male; Metabolic Clearance Rate; Mice; Mice, SCID; Recombinant Proteins; Species Specificity; Urokinase-Type Plasminogen Activator | 2012 |
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbonic Anhydrase Inhibitors; Humans; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 2018 |
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry | 2020 |
Effect of sulindac on prostaglandin synthesis in human and in cultured rat renal and vascular smooth muscle cells.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Animals; Arachidonic Acids; Cells, Cultured; Creatinine; Diclofenac; Dinoprostone; Female; Humans; Ibuprofen; Kidney; Kidney Glomerulus; Male; Middle Aged; Muscle, Smooth, Vascular; Prostaglandins; Rats; Rats, Sprague-Dawley; Sulindac | 1992 |
The economic consequences of NSAID-induced gastropathy: the French context.
Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Cost of Illness; Diclofenac; Duodenal Ulcer; Economics, Hospital; Etodolac; France; Gastrointestinal Diseases; Humans; Ketoprofen; Naproxen; National Health Programs; Piroxicam; Rheumatic Diseases; Sulindac | 1992 |
Induction of cleft palate in mice by inhibitors of prostaglandin synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cleft Palate; Diclofenac; Female; Indomethacin; Injections, Intramuscular; Maternal-Fetal Exchange; Mice; Microscopy; Naproxen; Organ Culture Techniques; Palate; Pregnancy; Sulindac | 1990 |
Evidence for a prostaglandin-mediated bone resorptive mechanism in subjects with fasting hypercalciuria.
Topics: Adolescent; Adult; Bone Resorption; Calcium; Diclofenac; Female; Humans; Male; Metabolic Diseases; Middle Aged; Parathyroid Hormone; Prostaglandins; Sulindac | 1988 |
Reduction of urinary protein and prostaglandin E2 excretion in the nephrotic syndrome by non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Diclofenac; Dinoprostone; Flurbiprofen; Glomerular Filtration Rate; Humans; Indomethacin; Male; Middle Aged; Nephrotic Syndrome; Prostaglandins E; Proteinuria; Renin; Sulindac | 1986 |
Intoxication with sulindac, tiaramide hydrochloride and diclofenac sodium.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Diclofenac; Female; Hemoperfusion; Humans; Piperazines; Suicide, Attempted; Sulindac | 1987 |
Effects of phenylbutazone and oxyphenbutazone on acidic drug detection in high performance thin layer chromatographic systems.
Topics: Animals; Chromatography, Thin Layer; Diclofenac; Female; Fenoprofen; Horses; Hydrogen-Ion Concentration; Ibuprofen; Oxyphenbutazone; Pharmaceutical Preparations; Phenylbutazone; Piroxicam; Sulindac | 1986 |
Worldwide experience with diclofenac in rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Humans; Indomethacin; Naproxen; Osteoarthritis; Sulindac; Tolmetin | 1985 |
Ganglionic blocking effect of indomethacin and other prostaglandin synthetase inhibitors.
Topics: Animals; Cats; Diclofenac; Fenoprofen; Ganglia, Sympathetic; In Vitro Techniques; Indomethacin; Niflumic Acid; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Rana esculenta; Sulindac; Synaptic Transmission | 1980 |
Osteoarthritis and non-steroidal and anti-inflammatory drugs: a multi-centre comparative study.
Topics: Aged; Diclofenac; Female; Hip Joint; Humans; Ibuprofen; Indenes; Knee Joint; Male; Naproxen; Osteoarthritis; Sulindac | 1982 |
[New non-steroidal anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents; Child; Diclofenac; Female; Humans; Male; ortho-Aminobenzoates; Phenothiazines; Phenylbutyrates; Pregnancy; Propionates; Pyrazoles; Sulindac | 1980 |
Renal impairment after acute diclofenac, naproxen, and sulindac overdoses.
Topics: Acute Kidney Injury; Adolescent; Adult; Alcoholic Intoxication; Creatinine; Diclofenac; Drug Interactions; Female; Humans; Male; Middle Aged; Naproxen; Sulindac | 1995 |
Immunochemical identification of mouse hepatic protein adducts derived from the nonsteroidal anti-inflammatory drugs diclofenac, sulindac, and ibuprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Ibuprofen; Immune Sera; Immunoblotting; Immunochemistry; Liver; Mice; Mice, Inbred Strains; Proteins; Rabbits; Sulindac | 1997 |
Protein binding of some nonsteroidal anti-inflammatory drugs studied by high-performance liquid affinity chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Chromatography, High Pressure Liquid; Diclofenac; Indomethacin; Protein Binding; Serum Albumin; Sulindac | 1999 |
Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Blood Pressure; Carcinoma; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indans; Isoenzymes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salicylates; Substrate Specificity; Sulfonamides; Sulindac; Thromboxane B2; Tumor Cells, Cultured | 1999 |
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit vascular smooth muscle cell proliferation via differential effects on the cell cycle.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Cell Division; Cell Line; Diclofenac; Dose-Response Relationship, Drug; Flow Cytometry; Ibuprofen; Indomethacin; Muscle, Smooth, Vascular; Rats; Sodium Salicylate; Sulindac | 2003 |
Replication of the Weber effect using postmarketing adverse event reports voluntarily submitted to the United States Food and Drug Administration.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Diflunisal; Epidemiologic Measurements; Flurbiprofen; Humans; Incidence; Piroxicam; Retrospective Studies; Sulindac; Time Factors; United Kingdom; United States; United States Food and Drug Administration | 2004 |
Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cell Line, Tumor; Colorectal Neoplasms; Cytochrome P-450 CYP1A1; Diclofenac; Humans; Liver Neoplasms; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; RNA, Messenger; Sulindac; Thiones | 2009 |
The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cloning, Molecular; Diclofenac; Flow Cytometry; Fos-Related Antigen-2; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Vectors; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia, Myeloid, Acute; Nuclear Proteins; Proto-Oncogene Proteins c-jun; RNA Interference; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulindac; Transcription Factor AP-1; Transcriptional Activation | 2011 |
Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Diclofenac; Drug Synergism; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Mice, SCID; NF-kappa B; Nuclear Proteins; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sesquiterpenes; Sulindac; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts | 2012 |
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.
Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; Dose-Response Relationship, Drug; Flutamide; Gene Expression; Humans; Imipramine; Inflammation; Ketoconazole; Liver; Methyltestosterone; Oxidative Stress; Rats; Risk Assessment; Sulindac; Tamoxifen; Toxicogenetics | 2017 |