Compounds > diclofenac

diclofenac and sulfaphenazole

diclofenac has been researched along with sulfaphenazole in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (17.39)18.2507
2000's8 (34.78)29.6817
2010's7 (30.43)24.3611
2020's4 (17.39)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Dai, R; Liu, Y; She, M; Wu, Z1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Althagafy, HS; Croatt, MP; Graf, TN; Gufford, BT; Oberlies, NH; Paine, MF; Polyak, SJ; Sy-Cordero, AA; Wagoner, J1
Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L1
Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL1
Bertagnin, C; Du, R; Guizzo, L; Hou, L; Huang, B; Jia, R; Ju, H; Kang, D; Kong, X; Li, P; Liu, X; Loregian, A; Ma, X; Murugan, NA; Poongavanam, V; Zhan, P; Zhang, Y1
Chen, FE; De Clercq, E; Huang, WJ; Jin, X; Pannecouque, C; Wang, S; Zhang, YX; Zhao, LM1
Feron, VJ; Groene, EM; Horbach, GJ; Kappers, WA; Kleij, LA; Witkamp, RF; Zweers-Zeilmaker, WM1
Horbach, GJ; Witkamp, RF; Zweers-Zeilmaker, WM1
Attias, R; Dansette, PM; Mansuy, D; Poli-Scaife, S1
Fisher, MB; Haining, RL; Henne, KR; Jones, JP; Koop, DR; Rettie, AE; Trager, WF1
Dunbar, D; Kaminsky, LS; Obach, RS; Zhang, QY1
Agúndez, JA; Benítez, J; García-Gamito, FJ; Gervasini, G; Martínez, C1
Crespi, CL; Miller, VP; Stresser, DM1
Assrir, N; Dansette, PM; Jaouen, M; Jean, P; Mansuy, D; Marques-Soares, C; Melet, A; Pilar Lopez-Garcia, M; Sari, MA1
Boelsterli, UA; Gupta, R; Lim, MS; Lim, PL1
Huang, HH; Lin, LH; Zhang, P; Zhong, DF1
Glatz, Z; Konecný, J; Micíková, I; Remínek, R1
Chang, SY; Cui, D; Li, W; Rodrigues, AD; Traeger, SC; Wang, B; Wen, B; Zhang, H1
Pickova, J; Vestergren, AS; Zamaratskaia, G; Zlabek, V1

Other Studies

23 other study(ies) available for diclofenac and sulfaphenazole

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors.
    Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3

    Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
    Bioorganic & medicinal chemistry, 2013, Jul-01, Volume: 21, Issue:13

    Topics: Antiviral Agents; Aryl Hydrocarbon Hydroxylases; Cell Line; Cell Survival; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Drug Interactions; Glucuronosyltransferase; Hepacivirus; Hepatitis C; Humans; Methylation; Microsomes; Silybum marianum; Silymarin

2013
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
    European journal of medicinal chemistry, 2020, Aug-15, Volume: 200

    Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish

2020
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Development; Enzyme Inhibitors; Freund's Adjuvant; Humans; Lipopolysaccharides; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Structure-Activity Relationship

2021
Identification of C5-NH
    Journal of medicinal chemistry, 2021, 12-23, Volume: 64, Issue:24

    Topics: Animals; Antiviral Agents; Biological Availability; Chick Embryo; Computer Simulation; Half-Life; Influenza A Virus, H5N1 Subtype; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Neuraminidase; Oseltamivir; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2021
Structure-Based Discovery of Novel NH
    Journal of medicinal chemistry, 2022, 06-23, Volume: 65, Issue:12

    Topics: Anti-HIV Agents; Biphenyl Compounds; Drug Design; Heterocyclic Compounds, 1-Ring; HIV Reverse Transcriptase; HIV-1; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2022
Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.
    Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Drug Interactions; Enzyme Inhibitors; Flurbiprofen; Gene Expression; Humans; Hydroxylation; Ketoprofen; Lung; Methylation; Mixed Function Oxygenases; Phenylbutazone; Sulfaphenazole; Tolbutamide; Transfection

1996
Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonamides on hepatic cytochrome P4502C activity in vitro, and correlation with some molecular descriptors in the dwarf goat (Caprus hircus aegagrus).
    Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:8

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Female; Goats; Hydroxylation; Kinetics; Liver; Microsomes, Liver; Phenylbutazone; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Sulfonamides; Tolbutamide

1997
The substrate binding site of human liver cytochrome P450 2C9: an NMR study.
    Biochemistry, 1997, Oct-21, Volume: 36, Issue:42

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Isomerism; Kinetics; Lauric Acids; Microsomes, Liver; Models, Chemical; Models, Molecular; NADPH-Ferrihemoprotein Reductase; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Rats; Spectrophotometry; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Ticrynafen

1997
Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.
    Biochemistry, 1999, Mar-16, Volume: 38, Issue:11

    Topics: Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Binding Sites; Blotting, Western; Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Kinetics; Lauric Acids; Leucine; Mutagenesis, Site-Directed; Phenylalanine; Protein Structure, Secondary; Static Electricity; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Sulfaphenazole; Warfarin

1999
Metabolic characterization of the major human small intestinal cytochrome p450s.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:3

    Topics: Adult; Aged; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Enterocytes; Female; Humans; Hydroxylation; Immunoblotting; Intestine, Small; Isoenzymes; Kinetics; Male; Mephenytoin; Microsomes; Middle Aged; Mixed Function Oxygenases; Regression Analysis; Sulfaphenazole; Testosterone; Ticlopidine

2001
Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline.
    Pharmacogenetics, 2001, Volume: 11, Issue:1

    Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Activation; Enzyme Inhibitors; Epinephrine; Humans; Hydroxylation; Microsomes, Liver; Serotonin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole

2001
Design and application of fluorometric assays for human cytochrome P450 inhibition.
    Methods in enzymology, 2002, Volume: 357

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Fluorescent Dyes; Fluorometry; Humans; Itraconazole; Molecular Structure; Nimodipine; Sulfaphenazole

2002
Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid.
    Archives of biochemistry and biophysics, 2003, Jan-01, Volume: 409, Issue:1

    Topics: Amino Acids; Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; Binding Sites; Crystallography, X-Ray; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Diclofenac; Humans; Kinetics; Microsomes; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Software; Spectrophotometry; Substrate Specificity; Sulfaphenazole; Ticrynafen; Time Factors; Ultraviolet Rays; Yeasts

2003
Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes.
    Toxicology and applied pharmacology, 2006, Dec-15, Volume: 217, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aryl Hydrocarbon Hydroxylases; Calcium; Cell Line, Transformed; Cyclosporine; Cytochrome P-450 CYP2C9; Cytosol; Diclofenac; Dose-Response Relationship, Drug; Drug Antagonism; Egtazic Acid; Hepatocytes; Humans; Membrane Potentials; Mitochondria, Liver; Mitochondrial Membranes; Oxidation-Reduction; Permeability; Sulfaphenazole; Superoxides; Uncoupling Agents

2006
[The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:10

    Topics: Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Cunninghamella; Cytochrome P-450 CYP2C9; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Fungal Proteins; Indomethacin; Isoenzymes; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfaphenazole; Tolbutamide; Valproic Acid

2006
Application of micellar electrokinetic capillary chromatography for evaluation of inhibitory effects on cytochrome P450 reaction.
    Journal of chromatography. A, 2008, May-02, Volume: 1189, Issue:1-2

    Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, Micellar Electrokinetic Capillary; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Ketoconazole; Molecular Structure; Reproducibility of Results; Sulfaphenazole

2008
Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12

    Topics: Acetates; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Catalysis; Cyclopropanes; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Genotype; Humans; Hydroxylation; Ibuprofen; Ketoconazole; Kinetics; Mephenytoin; Microsomes, Liver; Quinolines; Recombinant Proteins; Stereoisomerism; Sulfaphenazole; Sulfides; Tandem Mass Spectrometry

2008
Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).
    Molecular biology reports, 2012, Volume: 39, Issue:6

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diclofenac; Dioxoles; Ellipticines; Fish Proteins; Fluconazole; Hydroxylation; Ketoconazole; Kinetics; Lignans; Microsomes, Liver; Oxazines; Salmo salar; Sulfaphenazole; Tolbutamide

2012