diclofenac has been researched along with rofecoxib in 85 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (3.53) | 18.2507 |
| 2000's | 65 (76.47) | 29.6817 |
| 2010's | 15 (17.65) | 24.3611 |
| 2020's | 2 (2.35) | 2.80 |
| Authors | Studies |
|---|---|
| Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Ethier, D; Evans, JF; Ford-Hutchinson, AW; Gauthier, JY; Gordon, R; Gresser, M; Guay, J; Kargman, S; Kennedy, B; Leblanc, Y; Léger, S; Mancini, J; O'Neill, GP; Ouellet, M; Percival, MD; Perrier, H; Prasit, P; Riendeau, D; Rodger, I; Wang, Z; Zamboni, R | 1 |
| Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N | 1 |
| Byvatov, E; Franke, L; Schneider, G; Schneider, P; Steinhilber, D; Werz, O | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Asif, M; Husain, A; Iqbal, MA; Iram, F; Khan, SA | 1 |
| Adcock, S; Bachmann, KA; Chan, CC; Cohen, RA; Davidson, MH; Dobratz, D; Gertz, BJ; Grasing, K; Hedges, J; Jones, TM; McBride, KJ; Moritz, C; Mukhopadhyay, S; Schwartz, JI | 1 |
| Bolognese, JA; Harper, SE; Jensen, DM; Langman, MJ; Quan, H; Simon, TJ; Watson, DJ; Zhao, PL | 1 |
| Bolognese, J; Caldwell, JR; Cannon, GW; Daniels, B; Ehrich, E; Holt, P; McLean, B; Mukhopadhyay, S; Seidenberg, B | 1 |
| Arnout, J; Buntinx, A; Dallob, A; De Lepeleire, I; De Schepper, PJ; Depré, M; Ebel, DL; Gertz, BJ; Schwartz, JI; Tanaka, W; Van Hecken, A; Wong, PH; Wynants, K | 1 |
| Acevedo, E; Beaulieu, AD; Caeiro, F; Casas, N; Castañeda, O; Garza-Elizondo, M; Gutierrez-Ureña, S; Hinojosa, W; Irazoque, F; Laurenzi, M; Pons-Estel, B; Rodgers, DB; Ugaz, M; Vandormael, K | 1 |
| Browning, RA; Burgess, FW | 1 |
| Deray, G | 1 |
| Catella-Lawson, F; Cucchiara, AJ; DeMarco, S; FitzGerald, GA; Kapoor, SC; Reilly, MP; Tournier, B; Vyas, SN | 1 |
| Isserow, SH; Schellenberg, RR | 1 |
| Barr, E; Reicin, AS; Shapiro, D; Sperling, RS; Yu, Q | 1 |
| Bolognese, JA; Harper, SE; Simon, TJ; Watson, DJ; Zhao, PL | 1 |
| Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS | 1 |
| Chang, DJ; Chen, E; Desjardins, PJ; Geba, GP; McAvoy, M; Mockoviak, SH; Polis, AB | 1 |
| Bianchi, M; Broggini, M | 1 |
| Anderson, GM; Austin, PC; Juurlink, DN; Kopp, A; Laupacis, A; Mamdani, M; Naglie, G; Rochon, PA | 1 |
| Pfeifer, M | 1 |
| Moan, A; Skattebøl, A | 1 |
| Baum, Y; Hoffer, E; Nahir, AM | 1 |
| Cmiel, A; Mejza, F; Szczeklik, A; Tuleja, E | 1 |
| Camici, G; Fiedler, M; Fratton, A; Gay, RE; Gay, S; Hellermann, JP; Hermann, M; Hurlimann, D; Lüscher, TF; Neidhart, M; Ruschitzka, F; Tanner, FC; Thiery, J | 1 |
| Oviedo, JA; Wolfe, MM | 1 |
| Harley, C; Wagner, S | 1 |
| Burian, M; Geisslinger, G | 1 |
| Baumann, PC; Bombeli, T; Haller, U; Hegi, TR; Pasch, T; Seifert, B; Spahn, DR; Zalunardo, MP | 1 |
| Al-Falaki, O; Blaicher, AM; Gruber, D; Hoerauf, K; Landsteiner, HT; Volf, I; Zimpfer, M; Zwerina, J | 1 |
| Chem, YC; Cheng, TT; Chiu, CK; Lai, HM | 1 |
| Fricke, J; Jayawardene, S; Kellstein, D; Ott, D | 1 |
| Bitner, M; Gao, J; Hatfield, C; Kattenhorn, J; Kellstein, D | 1 |
| García Rodríguez, LA; González-Pérez, A; Maguire, A; Varas-Lorenzo, C | 1 |
| Bird, SR; Black, PM; Chang, DJ; Daniels, S; Desjardins, PJ; Fitzgerald, BJ; Petruschke, RA; Tershakovec, A | 1 |
| Blaicher, AM; Hoerauf, K; Landsteiner, HT; Leitgeb, U; Volf, I; Zwerina, J | 1 |
| Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A | 1 |
| Dahlborg, R; Day, CA; Jacob, RF; Mason, RP; Walter, MF; Weng, Y | 1 |
| Bühler, N; Camici, G; Chenevard, R; Gröne, HJ; Hermann, M; Kiss, E; Lüscher, TF; Ruschitzka, F; Shaw, S | 1 |
| Hollenz, M; Labenz, J | 1 |
| Berlin, JA; Chittams, J; Jaskowiak, J; Kimmel, SE; Kishel, L; Reilly, M; Strom, BL | 1 |
| Lucas, R; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Lacomblez, L | 1 |
| Hochberg, MC | 1 |
| Ackermann, DK; Engeler, DS; Keel, A; Osterwalder, JJ; Schmid, HP | 1 |
| Alanoglu, Z; Ateş, Y; Orbey, BC; Türkçapar, AG | 1 |
| McCarthy, DM | 1 |
| Meechan, J | 1 |
| Brune, K; Dormann, H; Hinz, B | 1 |
| Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Arguelles, J; Cobo, J; Costales, M; de Carlos, F; Díaz-Esnal, B; Vijande, M | 1 |
| García Rodríguez, LA; Hernández-Díaz, S; Varas-Lorenzo, C | 1 |
| Abildstrom, SZ; Buch, P; Friberg, J; Gislason, GH; Jacobsen, S; Køber, L; Madsen, M; Rasmussen, JN; Rasmussen, S; Schramm, TK; Torp-Pedersen, C | 1 |
| de Oliveira, CR; de Paula, EJ; Junior, RM; Namur, GN; Tiseo, BC | 1 |
| Takahira, Y; Takeuchi, K; Tanaka, A; Yokota, A | 1 |
| Henry, D; McGettigan, P | 1 |
| Cheon, YK; Cho, YD; Han, CH; Jang, JY; Kim, BS; Kim, JH; Kim, YS; Kwon, KH; Moon, JH; Shim, CS; Song, HJ | 1 |
| Marwali, MR; Mehta, JL | 1 |
| Brookhart, MA; Rassen, J; Schneeweiss, S; Solomon, DH; Wang, PS | 1 |
| Deray, G; Montalescot, G; Sibilia, J | 1 |
| Deray, G; Héloire, F; Valat, JP | 1 |
| Kong, SX; LeLorier, J; Rahme, E; Toubouti, Y; Watson, DJ | 1 |
| Fu, YF; Ni, J; Ren, J; Shu, YY; Tang, W; Wang, H; Wang, MW; Yang, YF; Zhong, XG; Zhu, YN; Zuo, JP | 1 |
| Ashcroft, DM; Chen, LC | 1 |
| Singh, H | 1 |
| Chantler, I; Fuller, A; Mitchell, D | 1 |
| Chain, A; Danhof, M; Della Pasqua, O; Huntjens, DR; Metcalf, A; Spalding, DJ; Strougo, A; Summerfield, S | 1 |
| Krammer, G; Stricker, K; Yu, S | 1 |
| Li, L | 1 |
| Arbogast, PG; Castellsague, J; Chung, CP; Daugherty, JR; García-Rodríguez, LA; Murray, KT; Ray, WA; Stein, CM; Varas-Lorenzo, C | 1 |
| Chakraborti, AK; Garg, SK; Jadhavar, PS; Kumar, R; Motiwala, HF | 1 |
| Elliott, WJ | 1 |
| Honjo, H; Iwamoto, K; Uwai, Y | 1 |
| Betnér, I; Briem, S; Bueters, T; Dahlström, J; Kvalvågnaes, K | 1 |
| Andersson, C; Folke, F; Fosbøl, EL; Gislason, GH; Hansen, PR; Køber, L; Lindhardsen, J; Nielsen, MB; Olsen, AM; Torp-Pedersen, C | 1 |
| Hu, RW; Li, HY; Li, JS; Miao, XP; Ouyang, Q; Zhang, Y | 1 |
| Chan, TF; Hsu, HK; Hwang, SL; Lee, KS; Lieu, AS; Lin, CL; Su, YF; Yang, YC | 1 |
| Balbontín-Ayala, F; Cañigral, A; Carlos, Fd; Cobo, T; Fernández-González, FJ; Fernández-Vázquez, JP; Gonzalo-Orden, JM; Sánchez-Lasheras, F; Vega, JA | 1 |
| Matteson, EL; Thongprayoon, C; Ungprasert, P | 1 |
| Hansen, SH; Skonberg, C; Syed, M | 1 |
| Choi, HK; Dalal, DS; Dubreuil, M; Felson, DT; Lee, T; Lu, N; Zhang, Y | 1 |
| Arfè, A; Castellsague, J; Garbe, E; Herings, R; Kollhorst, B; Lucchi, S; Masclee, GMC; Perez-Gutthann, S; Romio, S; Schade, R; Schink, T; Schuemie, MJ; Scotti, L; Straatman, H; Sturkenboom, MCJM; Valkhoff, VE; Varas-Lorenzo, C; Villa, M | 1 |
| Moore, N | 1 |
| Hjemdahl, P; Stiller, CO | 1 |
19 review(s) available for diclofenac and rofecoxib
| Article | Year |
|---|---|
Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antineoplastic Agents; Antiviral Agents; Humans; Molecular Structure | 2019 |
Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Nabumetone; Osteoarthritis; Peptic Ulcer; Proportional Hazards Models; Prostaglandin-Endoperoxide Synthases; Randomized Controlled Trials as Topic; Sulfones | 1999 |
Gastroprotection by coxibs: what do the Celecoxib Long-Term Arthritis Safety Study and the Vioxx Gastrointestinal Outcomes Research Trial tell us?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Enzyme Inhibitors; Gastrointestinal Hemorrhage; Humans; Lactones; Misoprostol; Omeprazole; Osteoarthritis; Proton Pump Inhibitors; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones | 2003 |
[Clinical pharmacology of the selective COX-2 inhibitors].
Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones | 2003 |
COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cost-Benefit Analysis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Etoricoxib; Humans; Isoxazoles; Lactones; Membrane Proteins; Organic Chemicals; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Randomized Controlled Trials as Topic; Rheumatology; Sulfonamides; Sulfones; Treatment Outcome | 2005 |
Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Gastrointestinal Hemorrhage; Helicobacter Infections; Humans; Ibuprofen; Lactones; Naproxen; Peptic Ulcer; Risk Factors; Sulfones | 2002 |
Non-steroidal antiinflammatory drugs and the risk of acute myocardial infarction.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cohort Studies; Diclofenac; Dose-Response Relationship, Drug; Humans; Ibuprofen; Lactones; Myocardial Infarction; Naproxen; Risk Factors; Sulfones | 2006 |
Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Humans; Lactones; Naproxen; Pyrazoles; Risk; Sulfonamides; Sulfones | 2006 |
COX-2 inhibitors and cardiovascular risk. Inferences based on biology and clinical studies.
Topics: Animals; Blood Platelets; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Labeling; Endothelium, Vascular; Epoprostenol; Humans; Lactones; Platelet Aggregation; Product Surveillance, Postmarketing; Pyrazoles; Randomized Controlled Trials as Topic; Risk Assessment; Sulfonamides; Sulfones; Thromboxane A2 | 2006 |
[What do we know about the cardiovascular toxicity of the NSAIDs?].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Follow-Up Studies; Humans; Isoxazoles; Lactones; Meta-Analysis as Topic; Middle Aged; Naproxen; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Sulfones; Thrombosis; Time Factors | 2006 |
[Are there any differences in the cardiovascular tolerance between classical NSAIDs and coxibs?].
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Case-Control Studies; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Diclofenac; Edema; Heart Failure; Humans; Hypertension; Isoxazoles; Lactones; Meta-Analysis as Topic; Middle Aged; Odds Ratio; Placebos; Prospective Studies; Pyrazoles; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonamides; Sulfones; Thrombosis; Time Factors | 2006 |
Risk of myocardial infarction associated with selective COX-2 inhibitors: meta-analysis of randomised controlled trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Etoricoxib; Humans; Isoxazoles; Lactones; Models, Statistical; Myocardial Infarction; Naproxen; Odds Ratio; Pyrazoles; Pyridines; Randomized Controlled Trials as Topic; Risk; Risk Factors; Sulfonamides; Sulfones | 2007 |
Progress in COX-2 inhibitors: a journey so far.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Heterocyclic Compounds; Lactones; Models, Molecular; Sulfones | 2010 |
Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Humans; Hypertension; Isoxazoles; Lactones; Pyrazoles; Pyridines; Risk; Risk Factors; Sulfonamides; Sulfones | 2010 |
Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of inflammatory bowel disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Colitis, Ulcerative; Crohn Disease; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Humans; Isoxazoles; Lactones; Pyrazoles; Pyridines; Randomized Controlled Trials as Topic; Safety-Based Drug Withdrawals; Sulfonamides; Sulfones | 2014 |
Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Remodeling; Celecoxib; Clodronic Acid; Diclofenac; Diphosphonates; Humans; Imidazoles; Interferon-gamma; Isoxazoles; Lactones; Mice; Orthodontic Anchorage Procedures; Osteoclasts; Osteoprotegerin; Pamidronate; Rats; Resveratrol; Stilbenes; Sulfones; Tooth Mobility; Tooth Movement Techniques; Zoledronic Acid | 2015 |
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cerebral Hemorrhage; Diclofenac; Humans; Ibuprofen; Incidence; Indomethacin; Lactones; Meloxicam; Naproxen; Observational Studies as Topic; Odds Ratio; Piroxicam; Proportional Hazards Models; Stroke; Sulfones; Thiazines; Thiazoles | 2016 |
Coronary Risks Associated with Diclofenac and Other NSAIDs: An Update.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiotoxicity; Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Diclofenac; Humans; Lactones; Meta-Analysis as Topic; Myocardial Infarction; Risk Factors; Stroke; Sulfones | 2020 |
Lessons from 20 years with COX-2 inhibitors: Importance of dose-response considerations and fair play in comparative trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Fibrinolytic Agents; Humans; Ibuprofen; Lactones; Naproxen; Prostaglandins; Prostaglandins I; Sulfones; Thromboxanes | 2022 |
21 trial(s) available for diclofenac and rofecoxib
| Article | Year |
|---|---|
Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans.
Topics: Administration, Oral; Analysis of Variance; Animals; Body Temperature; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Drug Administration Schedule; Fever; Ibuprofen; Isoenzymes; Lactones; Lipopolysaccharides; Prostaglandin-Endoperoxide Synthases; Saimiri; Sulfones; Treatment Outcome | 1999 |
Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip. Rofecoxib Phase III Protocol 035
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Lactones; Male; Middle Aged; Osteoarthritis, Hip; Osteoarthritis, Knee; Sulfones; Therapeutic Equivalency | 2000 |
Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.
Topics: Adolescent; Adult; Bleeding Time; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Lipopolysaccharides; Meloxicam; Membrane Proteins; Middle Aged; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfones; Thiazines; Thiazoles; Thromboxane B2 | 2000 |
Tolerability profiles of rofecoxib (Vioxx) and Arthrotec. A comparison of six weeks treatment in patients with osteoarthritis.
Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diarrhea; Diclofenac; Double-Blind Method; Drug Combinations; Female; Humans; Lactones; Male; Middle Aged; Misoprostol; Osteoarthritis; Severity of Illness Index; Sulfones; Treatment Outcome | 2001 |
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Interactions; Drug Therapy, Combination; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sulfones; Thromboxane B2 | 2001 |
Comparison of the analgesic efficacy of rofecoxib and enteric-coated diclofenac sodium in the treatment of postoperative dental pain: a randomized, placebo-controlled clinical trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Lactones; Male; Pain Measurement; Pain, Postoperative; Sulfones; Tooth Extraction | 2002 |
Anti-hyperalgesic effects of nimesulide: studies in rats and humans.
Topics: Aged; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Diclofenac; Double-Blind Method; Female; Humans; Hyperalgesia; Lactones; Male; Middle Aged; Models, Animal; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones | 2002 |
Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy men.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Endothelium, Vascular; Fibrinolytic Agents; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Sulfones; Thrombin; Thromboxane B2 | 2003 |
Effect of rofecoxib on platelet aggregation and blood loss in gynaecological and breast surgery compared with diclofenac.
Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Blood Loss, Surgical; Breast Neoplasms; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Hemostasis, Surgical; Humans; Hysterectomy; Lactones; Middle Aged; Morphine; Pain Measurement; Platelet Aggregation; Pregnancy; Prospective Studies; Sulfones; Treatment Outcome | 2004 |
Acetylsalicylic acid, diclofenac, and lornoxicam, but not rofecoxib, affect platelet CD 62 expression.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Flow Cytometry; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Piroxicam; Platelet Function Tests; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Selectins; Sulfones | 2004 |
A single-blind, randomized, controlled trial to assess the efficacy and tolerability of rofecoxib, diclofenac sodium, and meloxicam in patients with acute gouty arthritis.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Diclofenac; Female; Humans; Lactones; Male; Meloxicam; Middle Aged; Single-Blind Method; Sulfones; Thiazines; Thiazoles | 2004 |
Analgesic efficacy of a single dose of lumiracoxib compared with rofecoxib, celecoxib and placebo in the treatment of post-operative dental pain.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Lactones; Male; Molar, Third; Organic Chemicals; Pain, Postoperative; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction; Treatment Outcome | 2004 |
Efficacy and tolerability of lumiracoxib in the treatment of primary dysmenorrhoea.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Drug Therapy, Combination; Dysmenorrhea; Female; Humans; Isoenzymes; Lactones; Membrane Proteins; Middle Aged; Organic Chemicals; Prostaglandin-Endoperoxide Synthases; Sulfones; Treatment Outcome | 2004 |
A randomized controlled study comparing rofecoxib, diclofenac sodium, and placebo in post-bunionectomy pain.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Hallux Valgus; Humans; Lactones; Male; Middle Aged; Orthopedic Procedures; Pain Measurement; Pain, Postoperative; Placebos; Sulfones | 2004 |
Effect of non-selective, non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors on the PFA-100 closure time.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Perioperative Care; Piroxicam; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Sulfones | 2004 |
A double-blind, placebo controlled comparison of the morphine sparing effect of oral rofecoxib and diclofenac for acute renal colic.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Kidney Diseases; Lactones; Male; Middle Aged; Morphine; Multivariate Analysis; Pain Measurement; Sulfones | 2005 |
Preoperative use of selective COX-II inhibitors for pain management in laparoscopic nissen fundoplication.
Topics: Adult; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Double-Blind Method; Female; Fundoplication; Humans; Lactones; Laparoscopy; Male; Pain, Postoperative; Preoperative Care; Prospective Studies; Pyrazoles; Sulfonamides; Sulfones | 2005 |
COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Isoxazoles; Lactones; Pain, Postoperative; Preanesthetic Medication; Prodrugs; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction | 2006 |
More pronounced inhibition of cyclooxygenase 2, increase in blood pressure, and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxib.
Topics: Blood Pressure; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Heart Rate; Humans; Lactones; Male; Middle Aged; Pyrazoles; Sulfonamides; Sulfones | 2006 |
The effect of three cyclo-oxygenase inhibitors on intensity of primary dysmenorrheic pain.
Topics: Adult; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Dysmenorrhea; Female; Humans; Lactones; Meloxicam; Pain Measurement; Self Medication; Sulfones; Thiazines; Thiazoles | 2008 |
A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients.
Topics: Aged; Arthralgia; Blood Pressure; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Edema; Europe; Female; Gastrointestinal Tract; Humans; Incidence; Kidney; Lactones; Longitudinal Studies; Male; Middle Aged; Osteoarthritis; Sulfones | 2008 |
45 other study(ies) available for diclofenac and rofecoxib
| Article | Year |
|---|---|
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
Topics: Administration, Oral; Animals; Biological Availability; CHO Cells; Cricetinae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Sulfones | 1999 |
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors | 2003 |
Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors.
Topics: Binding Sites; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Thrombin | 2005 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Etodolac; Humans; Ibuprofen; Indomethacin; Ketorolac; Lactones; Nabumetone; Naproxen; Pain, Postoperative; Piroxicam; Pyrazoles; Sulfonamides; Sulfones; Time Factors | 2001 |
[Renal tolerance of selective inhibitors of cyclooxygenase type 2].
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Celecoxib; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Kidney; Kidney Diseases; Lactones; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rats; Risk Factors; Sulfonamides; Sulfones; Water-Electrolyte Imbalance | 2001 |
Anaphylactoid reaction to a cyclooxygenase-2 inhibitor in a patient who had a reaction to a cyclooxygenase-1 inhibitor.
Topics: Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Drug Combinations; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Misoprostol; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Sulfones | 2001 |
Comparison of cardiovascular thrombotic events in patients with osteoarthritis treated with rofecoxib versus nonselective nonsteroidal anti-inflammatory drugs (ibuprofen, diclofenac, and nabumetone).
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cardiovascular Diseases; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diclofenac; Female; Humans; Ibuprofen; Incidence; Lactones; Male; Middle Aged; Nabumetone; Osteoarthritis; Proportional Hazards Models; Randomized Controlled Trials as Topic; Risk; Sulfones; Thrombosis; Treatment Outcome | 2002 |
Gastrointestinal medications and procedures in osteoarthritis patients treated with rofecoxib compared with nonselective NSAIDs.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Lactones; Male; Middle Aged; Nabumetone; Osteoarthritis; Randomized Controlled Trials as Topic; Sulfones | 2001 |
A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Edema; Female; Humans; Hypertension; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Nabumetone; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Renal Circulation; Safety; Sulfones | 2002 |
Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cohort Studies; Cyclooxygenase 2; Diclofenac; Drug Combinations; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Hospitalization; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Misoprostol; Multivariate Analysis; Proportional Hazards Models; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Risk Factors; Sulfonamides; Sulfones | 2002 |
[Analgesic in osteoporosis. Why so conservative with dosage?].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Humans; Ibuprofen; Lactones; Middle Aged; Osteoporosis; Pyrazoles; Risk Factors; Sulfonamides; Sulfones | 2002 |
[...bad example of a miserable "research on order"].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Data Interpretation, Statistical; Diclofenac; Humans; Lactones; Pain, Postoperative; Placebos; Randomized Controlled Trials as Topic; Research Design; Sulfones; Tooth Extraction | 2002 |
N-Acetylcysteine enhances the action of anti-inflammatory drugs as suppressors of prostaglandin production in monocytes.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Drug Synergism; Expectorants; Humans; In Vitro Techniques; Lactones; Lipopolysaccharides; Monocytes; Sulfones | 2002 |
Differential effects of selective cyclooxygenase-2 inhibitors on endothelial function in salt-induced hypertension.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Endothelium, Vascular; Enzyme Inhibitors; F2-Isoprostanes; Hypertension; Interleukin-1; Isoenzymes; Lactones; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Dahl; Safety; Sodium Chloride, Dietary; Sulfonamides; Sulfones; Vasodilation | 2003 |
Persistence with COX-2 inhibitors in managed care: an analysis of claims data.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Drug Utilization Review; Female; Health Care Costs; Humans; Ibuprofen; Insurance Claim Review; Isoenzymes; Lactones; Male; Managed Care Programs; Membrane Proteins; Middle Aged; Naproxen; Patient Compliance; Proportional Hazards Models; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Regression Analysis; Sulfonamides; Sulfones; United States | 2003 |
Nonsteroidal antiinflammatory drugs and the risk of myocardial infarction in the general population.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Case-Control Studies; Cohort Studies; Comorbidity; Coronary Disease; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Drug Utilization; Female; Follow-Up Studies; Humans; Ibuprofen; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Odds Ratio; Risk Factors; Spain; Sulfones | 2004 |
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flurbiprofen; Ibuprofen; Isoenzymes; Lactones; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thrombosis | 2004 |
Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs.
Topics: Animals; Antioxidants; Celecoxib; Cholesterol, LDL; Chromans; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Isoprostanes; Isoxazoles; Lactones; Meloxicam; Naproxen; Oxidation-Reduction; Pyrazoles; Sulfonamides; Sulfones; Thiazines; Thiazoles | 2004 |
Selective COX-2 inhibitors and renal injury in salt-sensitive hypertension.
Topics: Animals; Blood Pressure; Blood Vessels; C-Reactive Protein; CD8-Positive T-Lymphocytes; Celecoxib; Cell Count; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Hemodynamics; Hypertension; Immunohistochemistry; Kidney; Kidney Cortex; Kidney Glomerulus; Lactones; Monocytes; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Dahl; RNA, Messenger; Sodium Chloride; Sulfonamides; Sulfones | 2005 |
[Gastrointestinal complications under NSAID treatment in the doctor's office].
Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Clinical Trials as Topic; Diclofenac; Dose-Response Relationship, Drug; Dyspepsia; Endoscopy, Digestive System; Humans; Ibuprofen; Lactones; Peptic Ulcer; Smoking; Spondylitis; Sulfones | 2004 |
Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bias; Case-Control Studies; Celecoxib; Confounding Factors, Epidemiologic; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Odds Ratio; Pyrazoles; Risk Factors; Sulfonamides; Sulfones | 2005 |
Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cell Line; Cyclooxygenase Inhibitors; Diclofenac; Enzyme Activation; Humans; Ibuprofen; Indomethacin; Lactones; Lung; Naproxen; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Sulfones; tert-Butylhydroperoxide; Transcription, Genetic | 2005 |
[Inflammation, nonsteroidal anti-inflammatory drugs and Alzheimer disease].
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Indomethacin; Inflammation; Inflammation Mediators; Lactones; Risk Factors; Sulfones | 2004 |
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2 | 2006 |
Orthodontic tooth movement after inhibition of cyclooxygenase-2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Remodeling; Cyclooxygenase 2 Inhibitors; Dental Stress Analysis; Diclofenac; Lactones; Male; Rats; Rats, Wistar; Statistics, Nonparametric; Sulfones; Tooth Movement Techniques | 2006 |
Risk of death or reinfarction associated with the use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflammatory drugs after acute myocardial infarction.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Confidence Intervals; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Denmark; Diclofenac; Dose-Response Relationship, Drug; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Patient Readmission; Proportional Hazards Models; Pyrazoles; Recurrence; Registries; Retrospective Studies; Risk Factors; Sulfonamides; Sulfones | 2006 |
Experimental study of the action of COX-2 selective nonsteroidal anti-inflammatory drugs and traditional anti-inflammatory drugs in bone regeneration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Regeneration; Bony Callus; Cyclooxygenase 2 Inhibitors; Diclofenac; Lactones; Osteotomy; Radiography; Rats; Rats, Wistar; Sulfones; Time Factors | 2006 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lactones; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones; Time Factors; Up-Regulation | 2006 |
[A case of complete regression of hepatocellular carcinoma during administration of COX-2 inhibitor].
Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Humans; Lactones; Liver Neoplasms; Pyrazoles; Sulfonamides; Sulfones | 2006 |
Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Gastrointestinal Diseases; Humans; Ibuprofen; Lactones; Male; Multivariate Analysis; Myocardial Infarction; Naproxen; Pyrazoles; Rheumatic Diseases; Risk Assessment; Risk Factors; Sulfonamides; Sulfones | 2006 |
Association between nonnaproxen NSAIDs, COX-2 inhibitors and hospitalization for acute myocardial infarction among the elderly: a retrospective cohort study.
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Prescriptions; Drug Utilization; Female; Hospitalization; Humans; Ibuprofen; Lactones; Male; Myocardial Infarction; Product Surveillance, Postmarketing; Proportional Hazards Models; Pyrazoles; Quebec; Retrospective Studies; Sex Factors; Sulfonamides; Sulfones | 2007 |
COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression.
Topics: Animals; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; Interferon-gamma; Interleukin-10; Lactones; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Sulfones; T-Box Domain Proteins; T-Lymphocytes; Time Factors | 2007 |
Treating osteoarthritis in the elderly: should recent data on NSAIDs change our way of practice?
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Databases, Factual; Diclofenac; Gastrointestinal Diseases; Humans; Ibuprofen; Kidney Diseases; Lactones; Myocardial Infarction; Osteoarthritis; Retrospective Studies; Sulfones | 2007 |
Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats.
Topics: Administration, Oral; Animals; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Enterohepatic Circulation; Infusions, Intravenous; Injections, Intraperitoneal; Lactones; Male; Models, Biological; Nonlinear Dynamics; Rats; Rats, Sprague-Dawley; Species Specificity; Sulfones; Time Factors | 2008 |
A conditional sequential sampling procedure for drug safety surveillance.
Topics: Aged; Computer Simulation; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Evaluation; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Product Surveillance, Postmarketing; Risk; Sulfones | 2009 |
Cardiovascular risks of nonsteroidal antiinflammatory drugs in patients after hospitalization for serious coronary heart disease.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cohort Studies; Coronary Artery Disease; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Follow-Up Studies; Hospitalization; Humans; Ibuprofen; Incidence; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Outpatients; Pyrazoles; Retrospective Studies; Risk Factors; Stroke; Sulfonamides; Sulfones; Tennessee | 2009 |
Inhibitory effect of selective cyclooxygenase-2 inhibitor lumiracoxib on human organic anion transporters hOAT1 and hOAT3.
Topics: Animals; Binding, Competitive; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Estrone; Etoricoxib; Humans; Inhibitory Concentration 50; Isoxazoles; Kinetics; Lactones; Methotrexate; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Pyrazoles; Pyridines; RNA, Complementary; Sulfonamides; Sulfones; Xenopus laevis | 2010 |
High-throughput analysis of standardized pharmacokinetic studies in the rat using sample pooling and UPLC-MS/MS.
Topics: Administration, Oral; Animals; Chemistry, Pharmaceutical; Chromatography; Chromatography, High Pressure Liquid; Diclofenac; Ions; Lactones; Male; Mass Spectrometry; Morphine; Phenytoin; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sulfones | 2011 |
Cause-specific cardiovascular risk associated with nonsteroidal anti-inflammatory drugs among myocardial infarction patients--a nationwide study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Denmark; Diclofenac; Female; Follow-Up Studies; Hospitalization; Humans; Lactones; Male; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Registries; Risk Factors; Sulfones | 2013 |
Toona sinensis leaf extract has antinociceptive effect comparable with non-steroidal anti-inflammatory agents in mouse writhing test.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclooxygenase 2 Inhibitors; Diclofenac; Humans; Lactones; Male; Meliaceae; Mice, Inbred ICR; Pain; Phytotherapy; Plant Extracts; Plant Leaves; Sulfones | 2015 |
Mitochondrial toxicity of selective COX-2 inhibitors via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria.
Topics: Adenosine Triphosphate; Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Isoxazoles; Lactones; Male; Mitochondria, Liver; Oxidative Phosphorylation; Pyridines; Rats, Sprague-Dawley; Sulfonamides; Sulfones | 2016 |
Use of non-steroidal anti-inflammatory drugs correlates with the risk of venous thromboembolism in knee osteoarthritis patients: a UK population-based case-control study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Humans; Ibuprofen; Lactones; Logistic Models; Male; Meloxicam; Middle Aged; Naproxen; Odds Ratio; Osteoarthritis, Knee; Risk Factors; Sulfones; Thiazines; Thiazoles; Treatment Outcome; United Kingdom; Venous Thromboembolism | 2016 |
Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Diclofenac; Etoricoxib; Female; Humans; Indomethacin; Ketorolac; Lactones; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Risk Factors; Sulfones | 2018 |