diclofenac and ranitidine

diclofenac has been researched along with ranitidine in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.89)18.7374
1990's9 (16.98)18.2507
2000's16 (30.19)29.6817
2010's25 (47.17)24.3611
2020's2 (3.77)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Faller, B; Wohnsland, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Avdeef, A; Tam, KY1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA1
Bellman, K; Knegtel, RM; Settimo, L1
Artursson, P; Mateus, A; Matsson, P1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Borisevich, SS; Burgart, YV; Khursan, SL; Krasnykh, OP; Ljushina, GA; Markova, LN; Maslova, VV; Saloutin, VI; Shchegol'kov, EV; Shchur, IV; Solodnikov, SY; Trefilova, AN1
Campillo, NE; Cañada, FJ; Canales, A; Carvalho, I; Chierrito, TPC; Martinez, A; Martínez-Gonzalez, L; Pedersoli-Mantoani, S; Perez, C; Pérez, DI; Roca, C; Sebastian-Pérez, V1
Abu-Serie, MM; AlFadly, ED; Bakkar, NZ; Bartolini, M; Belal, ASF; El-Yazbi, AF; Elkazaz, S; Elzahhar, PA; Ghareeb, DA; Iriepa, I; Janockova, J; Kobeissy, F; Moraleda, I; Rafeh, RW; Saudi, MNS; Shaltout, H; Soukup, O; Tramarin, A1
Balliano, TL; Barbosa, G; Carvalho, VF; da Silva, BA; de Souza, ET; Lima, LM; Martins, IRR; Martins, MA; Medeiros, MM; Moraes Junior, MO; Nunes, IKDC; Silva, PMR; Silva, SWD1
Barbosa, G; Ceschi, MA; Dantas, RF; Dardenne, LE; de Salles, CMC; Guedes, IA; Lima, LM; Lopes, JPB; Lüdtke, DS; Ruaro, TC; Senger, MR; Silva, L; Silva-Jr, FP; Zimmer, AR1
Shaw, JH; Wolfe, RR1
Bortolussi, R; Bortoluzzi, F; Cannizzaro, R; Fornasarig, M; Fracasso, A; Grazioli, I; Poletti, M; Sozzi, M; Testa, V; Valentini, M1
Leach, IH; Robinson, MH; Wheatley, T1
Atanasova, I; Terziivanov, D1
McKnight, GW; Wallace, JL1
Alioth, C; Blum, RA; Chan, KK; D'Andrea, DT; Kochak, GM; Schentag, JJ; Teng, L; Ziehmer, BA1
Schmoldt, A; Schulz, M1
Agut, J; Conejo, L; Márquez, M; Ortiz, JA; Palop, D; Sacristán, A1
Newman, L1
Soto Alvarez, J1
Aguilar-Cota, ME; Cabrera, O; Carrasco-Portugal, Mdel C; Flores-Murrieta, FJ; Herrera, JE; Pérez-Urizar, J1
Damaschke, A; Dammann, HG; Sallowsky, E; Schmoldt, A; Simon-Schultz, J; Steinhoff, I1
Farcau, D; Leucuţa, A; Nanulescu, M; Vlase, L1
Barsoum, BN; Kenawi, IM; Youssef, MA1
Fredman, B; Hoppenstein, D; Shabat, S; Shapiro, A; Zaslansky, R; Zohar, E1
Devi, CS; Devi, RS; Mohan, KV; Narayan, S; Sabitha, KE; Srinivasan, P; Vani, G1
Amagase, K; Satoh, H; Takeuchi, K1
Jana, S; Nayak, AK; Samanta, A; Sen, KK1
Brusau, EV; Calvo, NL; Gaitano, RO; Kaufman, TS; Maggio, RM; Narda, GE1
Goda, K; Kobayashi, A; Kuno, H; Shoda, T; Sugai, S; Takahashi, T1
Azevedo, EB; da Silva, THG; Furtado, RXS; Zaiat, M1

Reviews

3 review(s) available for diclofenac and ranitidine

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Nonsteroidal antiinflammatory drug-induced colonic stricture. An unusual cause of large bowel obstruction and perforation.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Colonic Diseases; Delayed-Action Preparations; Dextropropoxyphene; Diclofenac; Drug Combinations; Drug Therapy, Combination; Emergencies; Female; Humans; Intestinal Obstruction; Intestinal Perforation; Middle Aged; Ranitidine

1995

Trials

4 trial(s) available for diclofenac and ranitidine

ArticleYear
Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Diclofenac; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Misoprostol; Neoplasms; Odds Ratio; Pain; Ranitidine; Risk Factors; Single-Blind Method; Stomach Ulcer

1995
Bioavailability of a formulation containing a diclofenac-ranitidine combination.
    Proceedings of the Western Pharmacology Society, 2002, Volume: 45

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Diclofenac; Drug Combinations; Half-Life; Humans; Male; Ranitidine

2002
Differential effects of misoprostol and ranitidine on the pharmacokinetics of diclofenac and gastrointestinal symptoms.
    British journal of clinical pharmacology, 1993, Volume: 36, Issue:4

    Topics: Administration, Oral; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Chromatography, High Pressure Liquid; Cross-Over Studies; Defecation; Diclofenac; Drug Combinations; Drug Interactions; Feces; Humans; Male; Misoprostol; Ranitidine

1993
No effect of short term ranitidine intake on diclofenac pharmacokinetics.
    Romanian journal of gastroenterology, 2004, Volume: 13, Issue:4

    Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Diclofenac; Drug Interactions; Histamine H2 Antagonists; Humans; Metabolic Clearance Rate; Ranitidine

2004

Other Studies

46 other study(ies) available for diclofenac and ranitidine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
    Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6

    Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water

2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Determination of log D via automated microfluidic liquid-liquid extraction.
    Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16

    Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Polyfluorinated salicylic acid derivatives as analogs of known drugs: Synthesis, molecular docking and biological evaluation.
    Bioorganic & medicinal chemistry, 2017, 01-01, Volume: 25, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Edema; Female; Halogenation; Male; Molecular Docking Simulation; Rats, Sprague-Dawley; Rats, Wistar; Salicylates; Sheep

2017
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.
    European journal of medicinal chemistry, 2018, Feb-10, Volume: 145

    Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Piperidines; Structure-Activity Relationship

2018
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
    European journal of medicinal chemistry, 2019, Apr-01, Volume: 167

    Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Neurons; PC12 Cells; Rats; Semicarbazides; Triazoles

2019
Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies.
    European journal of medicinal chemistry, 2020, Oct-15, Volume: 204

    Topics: Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Design; Enzyme Inhibitors; Humans; Hydrazones; Hypersensitivity; Lung; Male; Mice

2020
Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling.
    MedChemComm, 2019, Dec-01, Volume: 10, Issue:12

    Topics:

2019
Metabolic intervention in surgical patients. An assessment of the effect of somatostatin, ranitidine, naloxone, diclophenac, dipyridamole, or salbutamol infusion on energy and protein kinetics in surgical patients using stable and radioisotopes.
    Annals of surgery, 1988, Volume: 207, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albuterol; Carbon Isotopes; Carbon Radioisotopes; Diclofenac; Dipyridamole; Energy Metabolism; Evaluation Studies as Topic; Female; Glucose; Humans; Kinetics; Male; Middle Aged; Naloxone; Parenteral Nutrition, Total; Proteins; Ranitidine; Somatostatin; Surgical Procedures, Operative; Tritium

1988
Utilization of some NSAID's and a H2-blocker in two hospitals.
    International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:4

    Topics: Bulgaria; Diclofenac; Drug Utilization; Hospitals, University; Hospitals, Urban; Humans; Indomethacin; Random Allocation; Ranitidine; Seasons

1994
Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.
    Canadian journal of physiology and pharmacology, 1993, Volume: 71, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Indomethacin; Male; Misoprostol; Pyloric Antrum; Rabbits; Ranitidine; Stomach Ulcer

1993
Application of dual radiotelemetric technique in studying drug-drug interaction between diclofenac sodium and ranitidine HCl in volunteers.
    Pharmaceutical research, 1993, Volume: 10, Issue:11

    Topics: Adult; Clinical Trials, Phase I as Topic; Diclofenac; Drug Interactions; Gastric Acidity Determination; Gastric Emptying; Humans; Hydrogen-Ion Concentration; Male; Ranitidine; Telemetry

1993
Non-interaction of ranitidine with hydroxylation of diclofenac in rat and human liver microsomes.
    Die Pharmazie, 1993, Volume: 48, Issue:8

    Topics: Animals; Diclofenac; Humans; Hydroxylation; In Vitro Techniques; Male; Microsomes, Liver; Ranitidine; Rats; Rats, Wistar

1993
Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:4A

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Diclofenac; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastrins; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Pentagastrin; Ranitidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiazoles

1997
Upper gastrointestinal bleeding following major maxillofacial surgery.
    The British journal of oral & maxillofacial surgery, 1997, Volume: 35, Issue:3

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carcinoma, Squamous Cell; Chemoprevention; Diclofenac; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Mouth Neoplasms; Pain, Postoperative; Ranitidine; Stomach Ulcer

1997
[Economic evaluation of the use of diclofenac/misoprostol in the treatment of osteoarticular diseases].
    Anales de medicina interna (Madrid, Spain : 1984), 2000, Volume: 17, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Decision Trees; Diclofenac; Gastrointestinal Diseases; Humans; Misoprostol; Omeprazole; Osteoarthritis; Ranitidine

2000
Drug-drug interaction between diclofenac, cetirizine and ranitidine.
    Journal of pharmaceutical and biomedical analysis, 2005, Apr-01, Volume: 37, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cetirizine; Diclofenac; Differential Thermal Analysis; Drug Combinations; Histamine H1 Antagonists; Histamine H2 Antagonists; Magnetic Resonance Spectroscopy; Molecular Weight; Ranitidine; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

2005
The frequency and timing of respiratory depression in 1524 postoperative patients treated with systemic or neuraxial morphine.
    Journal of clinical anesthesia, 2005, Volume: 17, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Depression, Chemical; Diclofenac; Female; Histamine H2 Antagonists; Humans; Infusions, Intravenous; Injections, Spinal; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Ranitidine; Respiratory Mechanics; Retrospective Studies

2005
Ulcer protective effect of Terminalia arjuna on gastric mucosal defensive mechanism in experimental rats.
    Phytotherapy research : PTR, 2007, Volume: 21, Issue:8

    Topics: Animals; Dexamethasone; Diclofenac; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Gastrointestinal Agents; Male; Phytotherapy; Plant Extracts; Ranitidine; Rats; Stomach Ulcer; Terminalia

2007
Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 348, Issue:2

    Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Dose-Response Relationship, Drug; Gastric Mucins; Gastrointestinal Agents; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Male; Misoprostol; Mucus; Omeprazole; Protective Agents; Proton Pump Inhibitors; Quinolones; Ranitidine; Rats; Rats, Wistar; Sus scrofa; Triazines

2014
Novel alginate hydrogel core-shell systems for combination delivery of ranitidine HCl and aceclofenac.
    International journal of biological macromolecules, 2015, Volume: 74

    Topics: Alginates; Chemistry, Pharmaceutical; Diclofenac; Drug Delivery Systems; Drug Liberation; Glucuronic Acid; Hexuronic Acids; Hydrogel, Polyethylene Glycol Dimethacrylate; Microspheres; Particle Size; Polymethacrylic Acids; Ranitidine; Spectroscopy, Fourier Transform Infrared; Viscosity

2015
Preparation and Physical Characterization of a Diclofenac-Ranitidine Co-precipitate for Improving the Dissolution of Diclofenac.
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:3

    Topics: Chemical Precipitation; Diclofenac; Microscopy, Electron, Scanning; Particle Size; Powders; Ranitidine; Solubility; Temperature; X-Ray Diffraction

2016
Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury.
    The Journal of toxicological sciences, 2016, Volume: 41, Issue:5

    Topics: Acetaminophen; Apoptosis; Biological Assay; Biomarkers; Caspase 3; Caspase 7; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromans; Diclofenac; Dose-Response Relationship, Drug; Ethanol; Hepatocytes; Humans; Isoxazoles; Leflunomide; Liver; Mitochondria, Liver; Oxygen Consumption; Primary Cell Culture; Ranitidine; Risk Assessment; Thiazolidinediones; Time Factors; Toxicity Tests; Troglitazone

2016
Tandem anaerobic-aerobic degradation of ranitidine, diclofenac, and simvastatin in domestic sewage.
    The Science of the total environment, 2020, Jun-15, Volume: 721

    Topics: Anaerobiosis; Bioreactors; Diclofenac; Ranitidine; Sewage; Simvastatin; Waste Disposal, Fluid

2020