diclofenac has been researched along with propranolol in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.20) | 18.7374 |
| 1990's | 5 (5.49) | 18.2507 |
| 2000's | 36 (39.56) | 29.6817 |
| 2010's | 40 (43.96) | 24.3611 |
| 2020's | 8 (8.79) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Briand, X; Faller, B; Lázaro, E; Lowe, PJ | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Aranda, E; Hammel, KE; Hofrichter, M; Kinne, M; Poraj-Kobielska, M; Scheibner, K; Ullrich, R | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Azas, N; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Courtioux, B; Fairlamb, A; Hutter, S; Laget, M; Moreau, A; Mothes, E; Paloque, L; Pedron, J; Pratviel, G; Sournia-Saquet, A; Stigliani, JL; Valentin, A; Vendier, L; Verhaeghe, P; Wyllie, S | 1 |
| Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K | 1 |
| Miao, GX; Wang, YD; Yan, ZW; Zhang, LY | 1 |
| Shvarts, GIa; Siubaev, RD | 1 |
| Coutel-Egros, A; Maitani, Y; Nagai, T; Obata, Y | 1 |
| Neubert, RH; Rüttinger, HH; Schwarz, MA | 1 |
| Ford, JL; McCrystal, CB; Rajabi-Siahboomi, AR | 2 |
| Balon, K; Müller, BW; Riebesehl, BU | 1 |
| Kelly, ML; Staniforth, JN; Tobyn, MJ | 1 |
| Lind, L; Millgård, J; von zur Můhlen, B | 1 |
| Treré, R; Zecchi, V | 1 |
| Andreopoulos, AG; Mamouzelos, NJ; Proikakis, CS; Tarantili, PA | 1 |
| Craig, DQ; Ford, JL; He, R; McCrystal, CB; Rajabi-Siahboomi, AR | 1 |
| Ma, M; Purcell, WM; Xu, J | 2 |
| Badiale Furlong, E; Barros, DM; Cavalli, LS; Cezar-Vaz, MR; Grando, M; Kruel, C; Muccillo-Baisch, AL; Possette, PL; Schmidt, B | 1 |
| Ferrari, B; Fraysse, B; Garric, J; Lo Giudice, R; Mons, R; Paxéus, N; Pollio, A; Vollat, B | 1 |
| Drillia, P; Fountoulakis, M; Lyberatos, G; Stamatelatou, K | 1 |
| Dokianakis, SN; Kornaros, ME; Lyberatos, G | 1 |
| Ambrosi, A; Antiochia, R; Campanella, L; Dragone, R; Lavagnini, I | 1 |
| Drillia, P; Lyberatos, G; Stamatelatou, K | 1 |
| Alnouti, Y; Bi, H; Gusev, AI; Kavetskaia, O; Srinivasan, K; Waddell, D | 1 |
| Biebow, M; Boller, M; Pronk, W | 1 |
| Johnson, AC; Keller, V; Williams, RJ; Young, A | 1 |
| Fountoulakis, MS; Lyberatos, G; Stamatelatou, K | 1 |
| Kalgutkar, AS; Obach, RS; Soglia, JR; Zhao, SX | 1 |
| Reanmongkol, W; Subhadhirasakul, S; Thaina, P; Tungcharoen, P; Wongnawa, M | 1 |
| Honda, K; Manabe, S; Matsuoka, T; Miida, H; Noritake, Y; Sakurai, K; Shimoda, H; Shirai, M; Takasaki, W; Ueno, K | 1 |
| Banks, E; Grover, D; Jiang, JQ; Zhang, ZL; Zhou, JL | 1 |
| Maskaoui, K; Zhou, JL | 1 |
| Khunawattanakul, W; Pongjanyakul, T; Puttipipatkhachorn, S; Rades, T | 1 |
| Ericson, H; Kumblad, L; Thorsén, G | 1 |
| Drefko, W; Moroni, A; Thone, G | 1 |
| Eriksson Wiklund, AK; Kumblad, L; Lindh, K; Oskarsson, H | 1 |
| Arakawa, H; Ikeya, T; Inoue, Y; Iwai, H; Jomura, T; Koeda, A; Kusumoto, K; Nagao, T; Naitoh, K; Ogihara, T; Ohkura, T; Ohta, K; Ozeki, E; Takahashi, N; Ueda, T; Wada, K | 1 |
| Finel, M; Hagström, M; Järvinen, E; Mosorin, J; Muniz, M; Sneitz, N; Troberg, J | 1 |
| Martins, R; Ribeiro, S; Santos, MM; Torres, T | 1 |
| Antunes, SC; de Oliveira, LL; Gonçalves, F; Nunes, B; Rocha, O | 1 |
| Antunes, SC; Gonçalves, F; Nunes, B; Oliveira, LL; Rocha, O | 1 |
| Batley, GE; Hutchinson, TH; Kumar, A; Nidumolu, B | 1 |
| Baron, MG; Hetheridge, MJ; Jackson, SK; Jha, AN; Mintram, KS; Moody, AJ; Owen, SF; Purcell, WM | 1 |
| Horvath, V; Renkecz, T | 1 |
| Hagström, M; Kidron, H; Rimpelä, AK; Urtti, A | 1 |
| Cilurzo, F; Fedele, G; Franzé, S; Minghetti, P; Musazzi, UM | 1 |
| Hagström, M; Hellinen, L; Knuutila, H; Reinisalo, M; Ruponen, M; Urtti, A | 1 |
| Barbosa, J; Cabral, HN; Duarte, IA; Fonseca, VF; Freitas, A; Lemos, MFL; Novais, SC; Pouca, ASV; Rato, LD; Reis-Santos, P | 1 |
| Pongjanyakul, T; Rongthong, T; Siepmann, F; Siepmann, J; Sungthongjeen, S | 1 |
| Chen, F; Gao, H; Guo, R; Liu, H; Sun, P; Wang, B; Wang, S; Yang, K | 1 |
| Aboshanab, KM; Aboulwafa, MM; Ahmed, MT; Anwer, BE; Mohammed, MA | 1 |
| Ahmad, S; Baker, D; Gerhard, U; Murnane, D; Spooner, N | 1 |
| Lee, W; Ngoc, NM; Park, S; Yaqub, M | 1 |
1 review(s) available for diclofenac and propranolol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
90 other study(ies) available for diclofenac and propranolol
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.
Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Determination of log D via automated microfluidic liquid-liquid extraction.
Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with a fungal peroxygenase.
Topics: Agrocybe; Biocatalysis; Cytochrome P-450 Enzyme System; Diclofenac; Hydrogen Peroxide; Mixed Function Oxygenases; Propranolol; Stereoisomerism | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results | 2011 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study.
Topics: Antiprotozoal Agents; Cell Survival; Dose-Response Relationship, Drug; Electrochemical Techniques; Hep G2 Cells; Humans; Kinetoplastida; Leishmania infantum; Molecular Structure; Nitroquinolines; Nitroreductases; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma brucei brucei | 2018 |
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry | 2020 |
Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors.
Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Glycogen Phosphorylase; Hep G2 Cells; Hepatocytes; Humans; Hypoglycemic Agents; Indoles; Mice; Molecular Structure; Rats; Structure-Activity Relationship | 2020 |
[Experimental study of the interaction of nonsteroidal anti-inflammatory agents--voltaren and acetylsalicylic acid--with beta-adrenoblockers].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Drug Interactions; Male; Phenylacetates; Pindolol; Propranolol; Rats | 1984 |
Prediction of skin permeabilities of diclofenac and propranolol from theoretical partition coefficients determined from cohesion parameters.
Topics: Animals; Diclofenac; Mathematics; Permeability; Propranolol; Rats; Skin; Solubility | 1993 |
Application of capillary electrophoresis of characterizing interactions between drugs and bile salts. Part I.
Topics: Atenolol; Bile Acids and Salts; Chloramphenicol; Diclofenac; Electrophoresis, Capillary; Glycochenodeoxycholic Acid; Glycocholic Acid; Glycodeoxycholic Acid; Hydrogen-Ion Concentration; Micelles; Models, Chemical; Osmolar Concentration; Pharmaceutical Preparations; Propranolol; Quinine; Salicylates; Taurocholic Acid; Tetracycline | 1996 |
Water distribution studies within cellulose ethers using differential scanning calorimetry. 1. Effect of polymer molecular weight and drug addition.
Topics: Calorimetry, Differential Scanning; Cellulose; Diclofenac; Differential Thermal Analysis; Ethers; Gels; Lactose; Methylcellulose; Molecular Weight; Oxazines; Pharmaceutical Preparations; Propranolol; Thermodynamics; Water | 1999 |
Water distribution studies within cellulose ethers using differential scanning calorimetry. 2. Effect of polymer substitution type and drug addition.
Topics: Calorimetry, Differential Scanning; Cellulose; Diclofenac; Differential Thermal Analysis; Ethers; Gels; Lactose; Methylcellulose; Molecular Weight; Oxazines; Pharmaceutical Preparations; Propranolol; Thermodynamics; Water | 1999 |
Determination of liposome partitioning of ionizable drugs by titration.
Topics: Chemical Phenomena; Chemistry, Physical; Diclofenac; Hydrogen-Ion Concentration; Liposomes; Membranes, Artificial; Particle Size; Pharmaceutical Preparations; Propranolol; Reproducibility of Results; Solubility; Temperature | 1999 |
Tablet and capsule hydrophilic matrices based on heterodisperse polysaccharides having porosity-independent in vitro release profiles.
Topics: Benzamides; Capsules; Delayed-Action Preparations; Diclofenac; In Vitro Techniques; Mercury; Polysaccharides; Porosity; Propranolol; Solubility; Tablets; Time Factors | 2000 |
Divergent effects of different beta-blocking agents on endothelium-dependent vasodilatation in the human forearm.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Atenolol; Blood Pressure; Diclofenac; Endothelium, Vascular; Female; Forearm; Heart Rate; Humans; Injections, Intra-Arterial; Labetalol; Male; Methacholine Chloride; Nitroprusside; Plethysmography; Propranolol; Receptors, Adrenergic, alpha-1; Receptors, Muscarinic; Vasodilation; Vasodilator Agents | 2000 |
Hydrogels formed by cross-linked polyvinylalcohol as colon-specific drug delivery systems.
Topics: Algorithms; Chemical Phenomena; Chemistry, Physical; Colon; Cross-Linking Reagents; Diclofenac; Drug Delivery Systems; Hydrogels; Molecular Weight; Particle Size; Polyvinyl Alcohol; Propranolol; Solutions; Vitamin B 6 | 2001 |
Release of propranolol and diclofenac from low Mw DL-poly(lactic acid).
Topics: Biocompatible Materials; Calorimetry, Differential Scanning; Delayed-Action Preparations; Diclofenac; Drug Carriers; Hydrogen-Ion Concentration; Lactic Acid; Molecular Weight; Polyesters; Polymers; Propranolol; Spectroscopy, Fourier Transform Infrared; Viscosity | 2002 |
Characterisation of water behaviour in cellulose ether polymers using low frequency dielectric spectroscopy.
Topics: Cellulose; Diclofenac; Electric Conductivity; Gels; Methylcellulose; Molecular Weight; Polymers; Propranolol; Spectrum Analysis; Temperature; Water | 2002 |
Characterisation of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. I. Glucose metabolism and enzyme release as cytotoxic markers.
Topics: Acetaminophen; Animals; Cell Survival; Diclofenac; Galactosamine; gamma-Glutamyltransferase; Glucose; Hepatocytes; L-Lactate Dehydrogenase; Liver; Male; Models, Biological; Propranolol; Rats; Rats, Sprague-Dawley; Spheroids, Cellular; Toxicity Tests; Xenobiotics | 2003 |
Characterisation of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. II. Spheroid cell spreading inhibition as a new cytotoxic marker.
Topics: Acetaminophen; Animals; Cell Movement; Cell Survival; Culture Media; Diclofenac; Galactosamine; Hepatocytes; Liver; Male; Propranolol; Rats; Rats, Sprague-Dawley; Spheroids, Cellular; Toxicity Tests; Xenobiotics | 2003 |
Fish Balistes capriscus skin extract-induced relaxation in mesenteric arterial bed of rat.
Topics: Adrenergic beta-Antagonists; Animals; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Propranolol; Rats; Rats, Wistar; Skin; Tetraodontiformes; Vasodilation; Vasodilator Agents | 2003 |
Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?
Topics: Animals; Carbamazepine; Clofibric Acid; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Environmental Monitoring; France; Germany; Humans; Ofloxacin; Pharmaceutical Preparations; Propranolol; Risk Assessment; Sulfamethoxazole; Toxicity Tests; Water Pollutants, Chemical | 2004 |
Toxic effect of pharmaceuticals on methanogenesis.
Topics: Bacteria, Anaerobic; Biomass; Carbamazepine; Clofibric Acid; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Methane; Methanomicrobiales; Ofloxacin; Pharmaceutical Preparations; Propranolol; Sewage; Sulfamethoxazole; Time Factors; Toxicity Tests; Waste Disposal, Fluid | 2004 |
On the effect of pharmaceuticals on bacterial nitrite oxidation.
Topics: Bacteria, Anaerobic; Biodegradation, Environmental; Bioreactors; Carbamazepine; Cities; Clofibrate; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Kinetics; Nitrites; Nitrogen; Ofloxacin; Oxidation-Reduction; Pharmaceutical Preparations; Propranolol; Sewage; Sulfamethoxazole; Triclosan; Waste Disposal, Fluid; Water Purification | 2004 |
Electrochemical determination of pharmaceuticals in spiked water samples.
Topics: Clofibric Acid; Diclofenac; Electrochemistry; Environmental Monitoring; Fresh Water; Ofloxacin; Pharmaceutical Preparations; Propranolol; Reproducibility of Results; Sensitivity and Specificity; Water Pollutants, Chemical; Water Pollution, Chemical | 2005 |
Fate and mobility of pharmaceuticals in solid matrices.
Topics: Adsorption; Aluminum Silicates; Bacteria, Aerobic; Bacteria, Anaerobic; Carbamazepine; Carbon; Clay; Clofibric Acid; Diclofenac; Models, Theoretical; Ofloxacin; Pharmaceutical Preparations; Propranolol; Sewage; Soil; Sulfamethoxazole; Water Movements; Water Pollutants, Chemical | 2005 |
Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma.
Topics: Chemical Fractionation; Chromatography, High Pressure Liquid; Diclofenac; Ibuprofen; Ketoconazole; Mass Spectrometry; Online Systems; Pharmaceutical Preparations; Propranolol; Reproducibility of Results | 2005 |
Electrodialysis for recovering salts from a urine solution containing micropollutants.
Topics: Carbamazepine; Dialysis; Diclofenac; Electrochemistry; Ibuprofen; Propranolol; Salts; Water Pollutants, Chemical | 2006 |
A practical demonstration in modelling diclofenac and propranolol river water concentrations using a GIS hydrology model in a rural UK catchment.
Topics: Computer Simulation; Diclofenac; Environmental Monitoring; Geographic Information Systems; Models, Theoretical; Propranolol; Rivers; Sewage; United Kingdom; Water Movements; Water Pollutants, Chemical; Water Purification | 2007 |
The effect of pharmaceuticals on the kinetics of methanogenesis and acetogenesis.
Topics: Acetates; Diclofenac; Kinetics; Methane; Ofloxacin; Propranolol | 2008 |
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles | 2008 |
Uterine relaxant effects of Curcuma aeruginosa Roxb. rhizome extracts.
Topics: Acetylcholine; Animals; Atropine; Calcium Channel Blockers; Curcuma; Diclofenac; Dinoprost; Female; Isoproterenol; Oxytocics; Oxytocin; Parasympatholytics; Plant Extracts; Propranolol; Rats; Rats, Wistar; Rhizome; Uterine Contraction; Uterus; Vasodilator Agents; Verapamil | 2009 |
Decrease in protein binding and its effect on toxicokinetics (TK)/toxicodynamics (TD) of diclofenac and propranolol in pregnant rats.
Topics: Animals; Blood Proteins; Diclofenac; Female; Gastrointestinal Tract; Male; Metabolic Clearance Rate; Plasma Volume; Pregnancy; Propranolol; Protein Binding; Rats; Rats, Sprague-Dawley; Tissue Distribution; Toxicity Tests | 2008 |
Pharmaceutical residues in wastewater treatment works effluents and their impact on receiving river water.
Topics: Carbamazepine; Diclofenac; Indomethacin; Pharmaceutical Preparations; Propranolol; Rivers; Sulfamethoxazole; United Kingdom; Water Pollutants, Chemical | 2009 |
Colloids as a sink for certain pharmaceuticals in the aquatic environment.
Topics: Carbamazepine; Colloids; Diclofenac; Environmental Restoration and Remediation; Fresh Water; Indomethacin; Meclofenamic Acid; Pharmaceutical Preparations; Phenethylamines; Propranolol; Sewage; Sulfamethoxazole; Tamoxifen; Thioridazine; Water Pollutants, Chemical | 2010 |
Chitosan-magnesium aluminum silicate nanocomposite films: physicochemical characterization and drug permeability.
Topics: Acetaminophen; Aluminum Compounds; Aluminum Silicates; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chitosan; Diclofenac; Diffusion; Drug Carriers; Drug Compounding; Hydrogen Bonding; Magnesium; Magnesium Compounds; Nanocomposites; Permeability; Pliability; Powder Diffraction; Propranolol; Silicates; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties; Tablets; Technology, Pharmaceutical; Temperature; Tensile Strength; Water | 2010 |
Physiological effects of diclofenac, ibuprofen and propranolol on Baltic Sea blue mussels.
Topics: Animals; Diclofenac; Ibuprofen; Mytilus edulis; Propranolol; Sewage; Water Pollutants, Chemical | 2010 |
Formulations of zero-order, pH-dependent, sustained release matrix systems by ionotropic gelation of alginate-containing mixtures.
Topics: Alginates; Calcium; Delayed-Action Preparations; Diclofenac; Drug Stability; Excipients; Gels; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Hypromellose Derivatives; Methylcellulose; Polysaccharides, Bacterial; Propranolol; Solubility; Tablets; Theophylline; Time Factors | 2011 |
Effect studies of human pharmaceuticals on Fucus vesiculosus and Gammarus spp.
Topics: Amphipoda; Animals; Diclofenac; Fucus; Humans; Ibuprofen; Oceans and Seas; Pharmaceutical Preparations; Propranolol; Sewage; Sweden; Water Pollutants, Chemical | 2012 |
Evaluation of human hepatocytes cultured by three-dimensional spheroid systems for drug metabolism.
Topics: Acetaminophen; Albuterol; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Diclofenac; Glucuronosyltransferase; Hepatocytes; Humans; Lamotrigine; Midazolam; Pharmaceutical Preparations; Propranolol; Spheroids, Cellular; Tandem Mass Spectrometry; Triazines | 2014 |
Dog UDP-glucuronosyltransferase enzymes of subfamily 1A: cloning, expression, and activity.
Topics: Animals; Catalysis; Cloning, Molecular; Diclofenac; DNA, Complementary; Dogs; Estradiol; Glucuronides; Glucuronosyltransferase; Humans; Intestinal Mucosa; Liver; Microsomes; Propranolol; Substrate Specificity | 2015 |
Toxicity screening of diclofenac, propranolol, sertraline and simvastatin using Danio rerio and Paracentrotus lividus embryo bioassays.
Topics: Animals; Biological Assay; Diclofenac; Ecotoxicology; Embryo, Nonmammalian; Paracentrotus; Propranolol; Risk Assessment; Sensitivity and Specificity; Sertraline; Simvastatin; Toxicity Tests; Water Pollutants, Chemical; Zebrafish | 2015 |
Acute and chronic ecotoxicological effects of four pharmaceuticals drugs on cladoceran Daphnia magna.
Topics: Acetaminophen; Animals; Chlorpromazine; Daphnia; Diclofenac; Dose-Response Relationship, Drug; Female; Propranolol; Rats, Wistar; Reproduction; Toxicity Tests, Acute; Toxicity Tests, Chronic; Water Pollutants, Chemical | 2016 |
Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers.
Topics: Acetaminophen; Animals; Biomarkers; Catalase; Chlorpromazine; Daphnia; Diclofenac; Ecotoxicology; Environmental Exposure; Glutathione Peroxidase; Glutathione Transferase; Oxidative Stress; Prescription Drugs; Propranolol | 2015 |
Derivation of water quality guidelines for priority pharmaceuticals.
Topics: Animals; Aquatic Organisms; Carbamazepine; Diclofenac; Fluoxetine; Fresh Water; Guidelines as Topic; Pharmaceutical Preparations; Propranolol; Toxicity Tests, Chronic; Water Pollutants, Chemical; Water Quality | 2016 |
Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance.
Topics: Animals; Atenolol; Biotransformation; Carbamazepine; Diazepam; Diclofenac; Drug Evaluation, Preclinical; Female; Kinetics; Liver; Metoprolol; Models, Animal; Oncorhynchus mykiss; Phenylbutazone; Propranolol; Tandem Mass Spectrometry; Water Pollutants, Chemical; Xenobiotics | 2017 |
Preparation of Molecularly Imprinted Microspheres by Precipitation Polymerization.
Topics: Chemical Precipitation; Diclofenac; Microspheres; Molecular Imprinting; Particle Size; Polymerization; Propranolol | 2017 |
Melanin targeting for intracellular drug delivery: Quantification of bound and free drug in retinal pigment epithelial cells.
Topics: Animals; Biological Transport; Cell Line; Chloroquine; Diclofenac; Epithelial Cells; Humans; Melanins; Methotrexate; Molecular Targeted Therapy; Propranolol; Retinal Pigment Epithelium; Swine; Timolol | 2018 |
Design of in vitro skin permeation studies according to the EMA guideline on quality of transdermal patches.
Topics: Adult; Diclofenac; Europe; Female; Government Agencies; Guidelines as Topic; Humans; Middle Aged; Nitroglycerin; Propranolol; Skin; Skin Absorption; Transdermal Patch | 2018 |
Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model.
Topics: Animals; Biological Transport; Cell Line; Chloroquine; Diclofenac; Humans; Melanins; Melanosomes; Methotrexate; Phagocytosis; Pigmentation; Propranolol; Retina; Retinal Pigment Epithelium; Retinal Pigments; Swine | 2019 |
Depressed, hypertense and sore: Long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fish.
Topics: Animals; Biomarkers; Diclofenac; Fishes; Fluoxetine; Oxidative Stress; Propranolol; Water Pollutants, Chemical | 2020 |
Eudragit RL-based film coatings: How to minimize sticking and adjust drug release using MAS.
Topics: Acetaminophen; Aluminum Compounds; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diclofenac; Drug Liberation; Excipients; Magnesium Compounds; Polymers; Propranolol; Silicates; Tablets; Temperature | 2020 |
β-Cyclodextrin Polymerized in Cross-Flowing Channels of Biomass Sawdust for Rapid and Highly Efficient Pharmaceutical Pollutants Removal from Water.
Topics: Amitriptyline; Biomass; Cellulose; Chlortetracycline; Cyclodextrins; Diclofenac; Drug Contamination; Levofloxacin; Particle Size; Propranolol; Surface Properties; Water Pollutants, Chemical; Wood | 2020 |
Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones.
Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Chlorpromazine; Ciprofloxacin; Cross Infection; Diclofenac; Disk Diffusion Antimicrobial Tests; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Synergism; Egypt; Fluoroquinolones; Humans; Levofloxacin; Propranolol | 2020 |
Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis.
Topics: Animals; Blood Proteins; Chromatography, Liquid; Dialysis; Diclofenac; Metoprolol; Propranolol; Protein Binding; Rats; Solid Phase Microextraction; Tandem Mass Spectrometry | 2021 |
Predictive modeling of pharmaceutical product removal by a managed aquifer recharge system: Comparison and optimization of models using ensemble learners.
Topics: Diclofenac; Groundwater; Pharmaceutical Preparations; Propranolol; Reproducibility of Results; Trimethoprim; Water; Water Pollutants, Chemical | 2022 |