diclofenac and nimesulide

diclofenac has been researched along with nimesulide in 68 studies

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.47)	18.7374
1990's	23 (33.82)	18.2507
2000's	21 (30.88)	29.6817
2010's	22 (32.35)	24.3611
2020's	1 (1.47)	2.80

Authors

Authors	Studies
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Alcaro, S; Bolasco, A; Cirilli, R; Fioravanti, R; Manna, F; Orallo, F; Ortuso, F; Rossi, F	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Kourounakis, AP; Matralis, AN	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bernardino, AMR; Boechat, N; Dos Santos, MS; Faria, JV; Miguita, AGC; Vegi, PF	1
Alcaro, S; Angeli, A; Angius, R; Bianco, G; Capasso, C; Cottiglia, F; Del Prete, S; Deplano, S; Distinto, S; Fois, B; Gaspari, M; Maccioni, E; Meleddu, R; Melis, C; Ortuso, F; Supuran, CT; Taverna, D; Yanez, M	1
Ferrari, E; Pratesi, C; Scaricabarozzi, I; Trezzani, R	1
Amodeo, C; De Marco, M; Gambarini, G	1
Beretta, P; Boselli, A; Giroda, M; Persiani, L; Saccomanno, F; Scaricabarozzi, I; Stefanoni, G; Volontieri, G	1
Cereghetti, S; Haeusermann, M; Monti, T; Reiner, M	1
Corli, O; Cozzolino, A; Scaricabarozzi, I	1
Capra, C; Casella, G; Costagli, V; Ramella, G; Scaricabarozzi, I; Sogni, A; Vetere, M	1
Ferrari, E; Pratesi, C; Scaricabarozzi, I	1
Agus, GB; de Angelis, R; Moia, R; Mondani, P	1
Almeida, H; Cunha, MJ; Macciocchi, A; Porto, A	1
Aldini, G; Carini, M; Macciocchi, A; Maffei Facino, R; Saibene, L	1
Awor, L; Gupta, SK; Joshi, S; Prakash, J; Sengupta, S; Velpandian, T	1
Ciccarelli, A; de Crescenzo, G; de Paulis, A; Marinò, D; Marinò, I; Marone, G	1
Gupta, SK; Mathur, P; Sengupta, S; Velpandian, T	1
Alam, CA; Brown, JR; Colville-Nash, PR; Freemantle, CN; Papworth, JL; Seed, MP; Somerville, KW; Willoughby, DA	1
Gupta, SK; Kabir, SR; Sengupta, S; Velpandian, T	1
Gupta, SK; Mathur, P; Sapra, P; Sengupta, S; Velpandian, T	1
Bhardwaj, RK; Gupta, SK; Sengupta, S; Tyagi, P; Velpandian, T	1
Fanti, L; Foppa, L; Guslandi, M; Sorghi, M	1
Diamantopoulos, E; Ifandi, G; Ignatiades, T; Katostaras, F; Liaropoulos, L; Spinthouri, M	1
Wober, W	1
Liaropoulos, L	1
Giuliano, F; Warner, TD	1
Cakir, B; Doğruer, DS; Orhan, H; Sahin, G; Sahin, MF	1
Zgradie, I	1
Deby, CM; Deby-Dupont, GP; Henrotin, YE; Lamy, MM; Mouithys-Mickalad, AM; Reginster, JY; Zheng, SX	1
Huskisson, EC	1
Bianchi, M; Broggini, M	1
Akarsu, ES; Ataoglu, H; Dogan, MD	1
Kalgutkar, AS; Kiefer, JR; Kozak, KR; Kurumbail, RG; Marnett, LJ; Pawlitz, JL; Prusakiewicz, JJ; Rowlinson, SW; Stallings, WC	1
Belton, O; Bresnihan, B; Duffy, T; FitzGerald, D; FitzGerald, O	1
Jain, NK; Kulkarni, SK; Patil, CS; Singh, A	1
Benini, D; Cuzzolin, L; Fanos, V; Tatò, L	1
Chen, BY; Cheng, NN; Li, D; Shi, W; Wang, YM	1
Bjarnason, I; Bjornsson, E; Maiden, L; Premchand, P; Sherwood, R; Smale, S; Takeuchi, K; Thjodleifsson, B	1
Kandefer-Szerszeń, M; Majdan, M; Parada-Turska, J; Rzeski, W; Turski, WA	1
Becker, TL; Gambero, A; Maróstica, M; Pedrazzoli, J	1
Błaszczyk, J; Fijałkowski, P; Kopff, A; Kopff, M; Kowalczyk, E	1
Barskova, VG; Eliseev, MS; Kudaeva, FM; Nasonova, VA	1
Kopff, A; Kopff, M; Kowalczyk, E	2
Bandettini, M; Bertelli, E; Caputi, S; Carraro, M; Garau, V; Levrini, L; Lörincz, A; Pelliccioni, GA; Rizzo, S; Salgarello, S; Szûcs, A	1
Smid, SD; Svensson, KM	1
Kulmacz, RJ; Tsai, AL; Wu, G	1
Bagirova, GG; Chernysheva, TV; Sizova, LV	1
Lee, JY; Sidhu, RS; Smith, WL; Yuan, C	1
Sato, K; Takahashi, H; Toriyama, M	1
Díaz-Rodríguez, L; García-Martínez, O; Morales, MA; Rodríguez-Pérez, L; Rubio-Ruiz, B; Ruiz, C	1
Kalogiannidis, I; Papadopoulos, E; Prapas, N; Prapas, Y; Xiromeritis, P	1
Arcoraci, V; Caputi, AP; Cavagna, L; Fontana, A; Giorgianni, F; Ingrasciotta, Y; Linguiti, C; Nucita, A; Pellegrini, F; Perrotta, M; Santoro, D; Sultana, J; Tari, DU; Trifirò, G	1
Rupasinghe, HP; Sekhon-Loodu, S	1
Adebayo, MA; Cataluña, R; Dotto, GL; Lima, EC; Machado, FM; Pavan, FA; Prola, LDT; Puchana-Rosero, MJ; Saucier, C; Thue, PS	1
Davydkin, IL; Zolotovskaya, IA	1
Affaitati, G; Cipollone, F; Costantini, R; Giamberardino, MA; Lapenna, D; Lopopolo, M; Martelletti, P; Massimini, F; Tana, C	1
Karateev, DE; Kaysheva, AL; Kopylov, AT; Lisitsa, AV; Novikov, AA; Vykhodets, IT; Zgoda, VG	1
Belal, F; Derayea, S; Hammad, MA; Omar, MA; Saleh, SF; Zayed, S	1
Halling, F; Heymann, P; Neff, A; Ziebart, T	1
Ashimkumar, AR; Jadhav, S; Muralidharan, S; Nambirajan, K	1

Reviews

5 review(s) available for diclofenac and nimesulide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Recently reported biological activities of pyrazole compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antineoplastic Agents; Antiviral Agents; Humans; Pyrazoles	2017
Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide. Rheumatology (Oxford, England), 1999, Volume: 38 Suppl 1 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Bursitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Shoulder Joint; Sulfonamides; Tendinopathy; Treatment Outcome	1999
Nimesulide, a balanced drug for the treatment of osteoarthritis. Clinical and experimental rheumatology, 2001, Volume: 19, Issue:1 Suppl 22 Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Diclofenac; Etodolac; Humans; Naproxen; Osteoarthritis; Stomach Diseases; Sulfonamides; Treatment Outcome	2001
[Meta-analysis on the effect and adverse reaction on patients with osteoarthritis and rheumatoid arthritis treated with non-steroidal anti-inflammatory drugs]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2003, Volume: 24, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; China; Diclofenac; Humans; Ibuprofen; Meloxicam; Nabumetone; Naproxen; Osteoarthritis; Oxaprozin; Propionates; Randomized Controlled Trials as Topic; Sulfonamides; Thiazines; Thiazoles	2003

Trials

19 trial(s) available for diclofenac and nimesulide

Article	Year
[Clinical study of the therapeutic efficacy and tolerance of nimesulide in comparison with a sodium diclofenac in the treatment of acute superficial thrombophlebitis]. Minerva cardioangiologica, 1992, Volume: 40, Issue:11 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Male; Middle Aged; Sulfonamides; Thrombophlebitis	1992
[A clinical study of the efficacy and tolerance of nimesulide compared to flurbiprofen and sodium diclofenac in the prevention and treatment of postoperative pain and inflammatory symptoms in dentistry]. Minerva stomatologica, 1992, Volume: 41, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Drug Tolerance; Female; Flurbiprofen; Humans; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Sulfonamides; Surgery, Oral	1992
[Clinical efficacy of nimesulide compared to diclofenac sodium in the prevention and treatment of postoperative pain-inflammation symptomatology]. Minerva chirurgica, 1990, Volume: 45, Issue:23-24 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Inflammation; Male; Middle Aged; Pain, Postoperative; Postoperative Complications; Sulfonamides; Suppositories	1990
Antipyretic activity of nimesulide suppositories: double blind versus diclofenac and placebo. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:12 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Body Temperature; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Heart Rate; Humans; Male; Middle Aged; Random Allocation; Sulfonamides; Suppositories	1985
Nimesulide and diclofenac in the control of cancer-related pain. Comparison between oral and rectal administration. Drugs, 1993, Volume: 46 Suppl 1 Topics: Administration, Oral; Administration, Rectal; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Male; Middle Aged; Neoplasms; Pain, Intractable; Sulfonamides	1993
Comparison of nimesulide and diclofenac in the prevention and treatment of painful inflammatory postoperative complications of general surgery. Drugs, 1993, Volume: 46 Suppl 1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Inflammation; Male; Middle Aged; Pain, Postoperative; Sulfonamides	1993
A comparison of nimesulide and diclofenac in the treatment of acute superficial thrombophlebitis. Drugs, 1993, Volume: 46 Suppl 1 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged; Sulfonamides; Thrombophlebitis	1993
Double-blind comparison of nimesulide and diclofenac in the treatment of superficial thrombophlebitis with telethermographic assessment. Drugs, 1993, Volume: 46 Suppl 1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged; Sulfonamides; Thrombophlebitis	1993
Double-blind study evaluating by endoscopy the tolerability of nimesulide and diclofenac on the gastric mucosa in osteoarthritic patients. European journal of rheumatology and inflammation, 1994, Volume: 14, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Endoscopy; Female; Gastric Mucosa; Humans; Male; Middle Aged; Osteoarthritis; Pain; Sulfonamides; Treatment Outcome	1994
Analgesic efficacy and pharmacokinetics of topical nimesulide gel in healthy human volunteers: double-blind comparison with piroxicam, diclofenac and placebo. European journal of clinical pharmacology, 1998, Volume: 54, Issue:7 Topics: Administration, Topical; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Male; Ointments; Piroxicam; Sulfonamides	1998
Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide. Rheumatology (Oxford, England), 1999, Volume: 38 Suppl 1 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Bursitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Shoulder Joint; Sulfonamides; Tendinopathy; Treatment Outcome	1999
Comparison of therapeutic efficacy of nimesulide and diclofenac in patients with degenerative joint diseases. Journal of the Indian Medical Association, 1999, Volume: 97, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Lumbosacral Region; Male; Middle Aged; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Pain; Spinal Diseases; Sulfonamides; Treatment Outcome	1999
Anti-hyperalgesic effects of nimesulide: studies in rats and humans. International journal of clinical practice. Supplement, 2002, Issue:128 Topics: Aged; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Diclofenac; Double-Blind Method; Female; Humans; Hyperalgesia; Lactones; Male; Middle Aged; Models, Animal; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones	2002
Inhibition of PGE2 production by nimesulide compared with diclofenac in the acutely inflamed joint of patients with arthritis. Drugs, 2003, Volume: 63 Suppl 1 Topics: Acute Disease; Administration, Oral; Arthralgia; Arthritis; Cyclooxygenase 1; Cyclooxygenase 2; Diclofenac; Dinoprostone; Double-Blind Method; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Synovial Fluid	2003
[Comparison of the time to analgetic and anti-inflammatory effect in the treatment of gouty arthritis with nimesulide and sodium diclofenac]. Terapevticheskii arkhiv, 2007, Volume: 79, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Diclofenac; Female; Humans; Male; Pain; Powders; Severity of Illness Index; Sulfonamides; Tablets; Time Factors; Treatment Outcome	2007
[Comparative analysis of effectiveness and safety of diclofenac and nimesulide in patients with early rheumatoid arthritis]. Klinicheskaia meditsina, 2009, Volume: 87, Issue:10 Topics: Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Sulfonamides; Time Factors; Treatment Outcome	2009
Improved recovery using multimodal perioperative analgesia in minimally invasive myomectomy: a randomised study. The Australian & New Zealand journal of obstetrics & gynaecology, 2011, Volume: 51, Issue:4 Topics: Acetaminophen; Adult; Analgesics; Clinical Protocols; Diclofenac; Drug Therapy, Combination; Female; Humans; Hysteroscopy; Leiomyoma; Pain Measurement; Pain, Postoperative; Premenopause; Prospective Studies; Sulfonamides; Treatment Outcome; Uterine Neoplasms	2011
[Effect of nonsteroidal anti-inflammatory drugs on the indicators of cardiovascular risk in patients with acute nonspecific back pain]. Terapevticheskii arkhiv, 2015, Volume: 87, Issue:12 Topics: Acute Pain; Aged; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Female; Humans; Male; Meloxicam; Middle Aged; Pyridines; Sulfonamides; Sulfones; Thiazines; Thiazoles; Treatment Outcome	2015
Quantitative assessment of betamethasone dual-acting formulation in urine of patients with rheumatoid arthritis and ankylosing spondylitis after single-dose intramuscular administration and its application to long-term pharmacokinetic study. Journal of pharmaceutical and biomedical analysis, 2018, Feb-05, Volume: 149 Topics: Adult; Arthritis, Rheumatoid; Betamethasone; Diclofenac; Drug Combinations; Ethanol; Female; Glucocorticoids; Half-Life; Humans; Injections, Intramuscular; Male; Prospective Studies; Renal Elimination; Sex Factors; Spondylitis, Ankylosing; Sulfonamides	2018

Other Studies

45 other study(ies) available for diclofenac and nimesulide

Article	Year
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism	2005
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:12 Topics: Animals; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Insecta; Models, Molecular; Molecular Structure; Pyrazoles; Stereoisomerism; Structure-Activity Relationship	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity. Journal of medicinal chemistry, 2014, Mar-27, Volume: 57, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; Carrageenan; Cholesterol, Dietary; Cyclooxygenase Inhibitors; Diet, High-Fat; Drug Design; Edema; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hypolipidemic Agents; In Vitro Techniques; Indicators and Reagents; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Mice; Microsomes; Phenothiazines; Picrates; Rats	2014
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides. ACS medicinal chemistry letters, 2018, Oct-11, Volume: 9, Issue:10 Topics:	2018
Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model. International journal of tissue reactions, 1993, Volume: 15, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Diclofenac; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Indomethacin; Liposomes; Membranes, Artificial; Models, Biological; Phosphatidylcholines; Sulfonamides	1993
Anti-inflammatory activity of topical nimesulide gel in various experimental models. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:12 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Disease Models, Animal; Edema; Female; Gels; Male; Piroxicam; Rats; Rats, Wistar; Sulfonamides	1996
Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. Arthritis and rheumatism, 1997, Volume: 40, Issue:3 Topics: Adenosine; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chymases; Cyclosporine; Diclofenac; Histamine Release; Humans; Immunoglobulin E; Immunosuppressive Agents; Leukotriene C4; Mast Cells; Methotrexate; Middle Aged; Polyenes; Prostaglandins D; Rheumatic Diseases; Serine Endopeptidases; Sirolimus; Substance P; Sulfonamides; Synovial Membrane; Tacrolimus; Tryptases	1997
Comparative analgesic activity of nimesulide and diclofenac by intramuscular route: correlation with pharmacokinetic profile of nimesulide. Pharmacology, 1998, Volume: 56, Issue:3 Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclooxygenase Inhibitors; Diclofenac; Female; Injections, Intramuscular; Male; Mice; Pain; Sulfonamides	1998
Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan. Advances in experimental medicine and biology, 1997, Volume: 433 Topics: Administration, Topical; Animals; Apoptosis; Aspirin; Cell Division; Cell Survival; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Drug Carriers; Female; Hyaluronic Acid; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred BALB C; Necrosis; Neovascularization, Pathologic; Piroxicam; Prostaglandin-Endoperoxide Synthases; Sulfonamides	1997
Comparative analgesic efficacy of nimesulide and diclofenac gels after topical application on the skin. Skin pharmacology and applied skin physiology, 1998, Volume: 11, Issue:4-5 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Female; Formaldehyde; Gels; Male; Mice; Pain Measurement; Reaction Time; Sulfonamides	1998
Anti-inflammatory activity and pharmacokinetic profile of a new parenteral formulation of nimesulide. Pharmacological research, 1999, Volume: 39, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dose-Response Relationship, Drug; Edema; Female; Injections, Intramuscular; Male; Rats; Sulfonamides	1999
Nonsteroidal anti-inflammatory drugs and gastric mucosal blood flow. Journal of clinical gastroenterology, 1999, Volume: 28, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Blood Flow Velocity; Diclofenac; Endoscopy, Digestive System; Female; Follow-Up Studies; Gastric Mucosa; Humans; Laser-Doppler Flowmetry; Male; Middle Aged; Piroxicam; Stomach Ulcer; Sulfonamides	1999
Economic evaluation of nimesulide versus diclofenac in the treatment of osteoarthritis in Greece. PharmacoEconomics, 1998, Volume: 14, Issue:5 Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit Analysis; Diclofenac; Greece; Hospital Costs; Humans; Osteoarthritis; Randomized Controlled Trials as Topic; Sensitivity and Specificity; Sulfonamides	1998
Economic comparison of nimesulide and diclofenac, and the incidence of adverse events in the treatment of rheumatic disease in Greece. Rheumatology (Oxford, England), 1999, Volume: 38 Suppl 1 Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit Analysis; Cyclooxygenase Inhibitors; Diclofenac; Gastrointestinal Diseases; Greece; Hospitalization; Humans; Incidence; Rheumatic Diseases; Sulfonamides	1999
Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs. British journal of pharmacology, 1999, Volume: 126, Issue:8 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Blood Pressure; Carcinoma; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indans; Isoenzymes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salicylates; Substrate Specificity; Sulfonamides; Sulindac; Thromboxane B2; Tumor Cells, Cultured	1999
The in vitro effects of new non-steroidal antiinflammatory compounds on antioxidant system of human erythrocytes. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1999, Volume: 51, Issue:4-5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Benzoxazoles; Catalase; Cyclooxygenase Inhibitors; Diclofenac; Erythrocytes; Free Radical Scavengers; Glutathione Peroxidase; Glutathione Transferase; Humans; Sulfonamides; Superoxide Dismutase	1999
In vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR). Free radical research, 2000, Volume: 33, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Chlorine; Diclofenac; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; In Vitro Techniques; Indicators and Reagents; Indomethacin; Iron; Kinetics; Lipid Peroxidation; Luminescent Measurements; Neutrophil Activation; Neutrophils; Nitrates; Reactive Oxygen Species; Sodium Hypochlorite; Spectrophotometry, Ultraviolet; Sulfonamides; Tetradecanoylphorbol Acetate	2000
Nimesulide and diclofenac inhibit lipopolysaccharide-induced hypothermia and tumour necrosis factor-alpha elevation in rats. Fundamental & clinical pharmacology, 2002, Volume: 16, Issue:4 Topics: Analysis of Variance; Animals; Body Temperature Regulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Fever; Hypothermia; Isoenzymes; Lipopolysaccharides; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Rectum; Sulfonamides; Tumor Necrosis Factor-alpha	2002
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. The Journal of biological chemistry, 2003, Nov-14, Volume: 278, Issue:46 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arginine; Binding, Competitive; Cell Line; Crystallography, X-Ray; Cyclooxygenase 2; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insecta; Isoenzymes; Mice; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Piroxicam; Prostaglandin-Endoperoxide Synthases; Protein Binding; Serine; Sulfonamides; Time Factors; Tyrosine	2003
Modulatory effect of cyclooxygenase inhibitors on sildenafil-induced antinociception. Pharmacology, 2003, Volume: 69, Issue:4 Topics: Animals; Carrageenan; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Synergism; Enzyme Inhibitors; Female; Male; Mice; NG-Nitroarginine Methyl Ester; Pain; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfonamides; Sulfones	2003
In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure. Pediatric nephrology (Berlin, Germany), 2004, Volume: 19, Issue:2 Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Infant, Newborn; Lumbosacral Plexus; Neuritis; Pregnancy; Prenatal Exposure Delayed Effects; Sciatic Nerve; Sulfonamides	2004
Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:2 Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colitis, Ulcerative; Crohn Disease; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Indomethacin; Inflammatory Bowel Diseases; Male; Middle Aged; Nabumetone; Naproxen; Prevalence; Recurrence; Sulfonamides	2006
Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro. European journal of pharmacology, 2006, Mar-27, Volume: 535, Issue:1-3 Topics: Animals; Antirheumatic Agents; Benzodiazepines; Benzodiazepinones; Celecoxib; Cell Line; Cell Proliferation; Cell Survival; Diclofenac; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Methotrexate; Naproxen; Pyrazoles; Quinoxalines; Sulfasalazine; Sulfonamides; Synovial Membrane	2006
Effect of different cyclooxygenase inhibitors on gastric adaptive cytoprotection induced by 20% ethanol. Digestive diseases and sciences, 2007, Volume: 52, Issue:2 Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytoprotection; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gastric Acid; Gastric Mucosa; Ibuprofen; Irritants; Male; Meloxicam; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyrazoles; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides; Thiazines; Thiazoles	2007
[The influence of selected nonsteroidal anti-inflammatory drugs on antioxidative enzymes activity]. Polskie Archiwum Medycyny Wewnetrznej, 2006, Volume: 115, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Catalase; Cyclooxygenase Inhibitors; Diclofenac; Glutathione Peroxidase; Instillation, Drug; Male; Oxidants; Rats; Rats, Wistar; Sulfonamides; Superoxide Dismutase	2006
[The effect of nonsteroidal anti-inflammatory drugs on oxidative/antioxidative balance]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2007, Volume: 23, Issue:135 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Female; Male; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reactive Oxygen Species; Sulfonamides	2007
[The influence of nonsteroidal anti-inflammatory drugs on deaminase adenosine activity]. Polskie Archiwum Medycyny Wewnetrznej, 2006, Volume: 116, Issue:3 Topics: Adenosine Deaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Erythrocytes; Female; Isoenzymes; Male; Rats; Rats, Wistar; Sulfonamides	2006
Prescriptions of NSAIDs to patients undergoing third molar surgery : an observational, prospective, multicentre survey. Clinical drug investigation, 2008, Volume: 28, Issue:10 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Dental Health Surveys; Diclofenac; Drug Prescriptions; Female; Humans; Hungary; Ibuprofen; Italy; Ketoprofen; Male; Molar, Third; Pain Measurement; Pain, Postoperative; Prospective Studies; Sulfonamides; Treatment Outcome	2008
Inhibition of cyclooxygenase-2 and EP1 receptor antagonism reduces human colonic longitudinal muscle contractility in vitro. Prostaglandins & other lipid mediators, 2009, Volume: 88, Issue:3-4 Topics: Acetylcholine; Amides; Bimatoprost; Cloprostenol; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Skeletal; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Sulfonamides	2009
Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2. Biochemistry, 2009, Dec-22, Volume: 48, Issue:50 Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Binding, Competitive; Catalysis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Enzyme Activation; Enzyme Stability; Flurbiprofen; Free Radicals; Humans; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thermodynamics; Tyrosine	2009
Comparison of cyclooxygenase-1 crystal structures: cross-talk between monomers comprising cyclooxygenase-1 homodimers. Biochemistry, 2010, Aug-24, Volume: 49, Issue:33 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Catalytic Domain; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Diclofenac; Flurbiprofen; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Protein Multimerization; Sheep; Sulfonamides	2010
Depigmenting mechanism of NSAIDs on B16F1 melanoma cells. Archives of dermatological research, 2011, Volume: 303, Issue:3 Topics: alpha-MSH; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Intramolecular Oxidoreductases; Mefenamic Acid; Melanins; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Oxidoreductases; Pigmentation Disorders; Skin Pigmentation; Sulfonamides	2011
Effects of indomethacin, nimesulide, and diclofenac on human MG-63 osteosarcoma cell line. Biological research for nursing, 2012, Volume: 14, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Diclofenac; Flow Cytometry; Humans; Indomethacin; Osteocalcin; Osteosarcoma; Sulfonamides	2012
The burden of nephrotoxic drug prescriptions in patients with chronic kidney disease: a retrospective population-based study in Southern Italy. PloS one, 2014, Volume: 9, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Contraindications; Diclofenac; Humans; Italy; Kidney; Medical Records Systems, Computerized; Prescriptions; Renal Insufficiency, Chronic; Retrospective Studies; Sulfonamides	2014
Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. International immunopharmacology, 2015, Volume: 25, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Docosahexaenoic Acids; Fruit; Humans; Inflammation; Lipopolysaccharides; Macrophages; Malus; NF-kappa B; Phloretin; Phlorhizin; Sulfonamides	2015
Microwave-assisted activated carbon from cocoa shell as adsorbent for removal of sodium diclofenac and nimesulide from aqueous effluents. Journal of hazardous materials, 2015, May-30, Volume: 289 Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Cacao; Carbon; Charcoal; Diclofenac; Drug Residues; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Medical Waste; Medical Waste Disposal; Microwaves; Sulfonamides; Thermodynamics	2015
Use of Nonsteroidal Anti-Inflammatory Drugs for Symptomatic Treatment of Episodic Headache. Pain practice : the official journal of World Institute of Pain, 2017, Volume: 17, Issue:3 Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Follow-Up Studies; Headache; Humans; Italy; Male; Middle Aged; Migraine Disorders; Retrospective Studies; Sulfonamides; Treatment Outcome; Tryptamines	2017
Simultaneous Determination of Tizanidine, Nimesulide, Aceclofenac and Paracetamol in Tablets and Biological Fluids Using Micellar Liquid Chromatography. Journal of chromatographic science, 2018, Mar-01, Volume: 56, Issue:3 Topics: Acetaminophen; Chromatography, Liquid; Clonidine; Diclofenac; Humans; Limit of Detection; Linear Models; Micelles; Reproducibility of Results; Sulfonamides; Tablets	2018
Analgesic prescribing patterns of dental practitioners in Germany. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2018, Volume: 46, Issue:10 Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Prescriptions; Germany; Humans; Ibuprofen; Practice Patterns, Dentists'; Practice Patterns, Physicians'; Sulfonamides	2018
Nimesulide poisoning in white-rumped vulture Gyps bengalensis in Gujarat, India. Environmental science and pollution research international, 2021, Volume: 28, Issue:41 Topics: Animals; Diclofenac; Falconiformes; India; Sulfonamides	2021