diclofenac and naloxone

diclofenac has been researched along with naloxone in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (6.67)	18.7374
1990's	3 (10.00)	18.2507
2000's	12 (40.00)	29.6817
2010's	13 (43.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Chang, TK; Ensom, MH; Kiang, TK	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Galetin, A; Gill, KL; Houston, JB	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Björkman, R; Hedner, J; Hedner, T; Henning, M	1
Shaw, JH; Wolfe, RR	1
Bhattacharya, SK; Parmar, SS	1
Björkman, R	1
Björkman, R; Elam, M	1
Fadishei, M; Hosseinzadeh, H; Mahmoudi, M; Ramezani, M	1
Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA	1
Castañeda-Hernández, G; Granados-Soto, V; Lozano-Cuenca, J	1
Deveci, MS; Dogrul, A; Gul, H; Gülmez, SE; Ossipov, MH; Porreca, F; Tulunay, FC	1
Avila-Peña, D; Peña, N; Quintero, L; Suárez-Roca, H	1
Ojewole, JA	1
Déciga-Campos, M; López-Muñoz, FJ; Montiel-Ruiz, RM; Navarrete-Vázquez, G	1
Gurtskaia, G; Nebieridze, M; Nozadze, I; Tsagareli, MG; Tsiklauri, N	1
Castor, MG; Duarte, ID; Navarro, LC; Romero, TR; Silva, LC	1
Abzianidze, E; Gorgiladze, T; Nozadze, I; Tsagareli, M	1
Abzianidze, E; Gurtskaia, G; Nebieridze, M; Nozadze, I; Pirkulashvili, N; Tsagareli, MG; Tsiklauri, N	1
Costa, FV; Kalueff, AV; Quadros, VA; Rosa, LV; Rosemberg, DB; Santos, ARS	1

Reviews

3 review(s) available for diclofenac and naloxone

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. Acta anaesthesiologica Scandinavica. Supplementum, 1995, Volume: 103 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Brain; Chemoreceptor Cells; Diclofenac; Ibuprofen; Male; Mechanoreceptors; Naloxone; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Serotonin; Spinal Cord; Thermoreceptors	1995

Trials

1 trial(s) available for diclofenac and naloxone

Article	Year
Diclofenac evaluated in a human experimental model of central pain. Pain, 1993, Volume: 54, Issue:2 Topics: Adolescent; Adult; Diclofenac; Double-Blind Method; Electric Stimulation; Electrophysiology; Female; Humans; Laser-Doppler Flowmetry; Male; Median Nerve; Middle Aged; Naloxone; Pain; Pain Measurement; Regional Blood Flow; Skin	1993

Other Studies

26 other study(ies) available for diclofenac and naloxone

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: comparison with liver and intestinal glucuronidation and impact of albumin. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:4 Topics: Adult; Aged; Female; Glucuronides; Glucuronosyltransferase; Humans; In Vitro Techniques; Intestinal Mucosa; Intestines; Kidney; Liver; Male; Metabolic Clearance Rate; Microsomes; Middle Aged; Organ Specificity; Pharmaceutical Preparations; Predictive Value of Tests; Protein Binding; Serum Albumin, Bovine; Substrate Specificity; Young Adult	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Central, naloxone-reversible antinociception by diclofenac in the rat. Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 342, Issue:2 Topics: Analgesics; Animals; Blood Pressure; Diclofenac; Dose-Response Relationship, Drug; Ethacrynic Acid; Heart Rate; Male; Naloxone; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time	1990
Metabolic intervention in surgical patients. An assessment of the effect of somatostatin, ranitidine, naloxone, diclophenac, dipyridamole, or salbutamol infusion on energy and protein kinetics in surgical patients using stable and radioisotopes. Annals of surgery, 1988, Volume: 207, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albuterol; Carbon Isotopes; Carbon Radioisotopes; Diclofenac; Dipyridamole; Energy Metabolism; Evaluation Studies as Topic; Female; Glucose; Humans; Kinetics; Male; Middle Aged; Naloxone; Parenteral Nutrition, Total; Proteins; Ranitidine; Somatostatin; Surgical Procedures, Operative; Tritium	1988
Stress by restraining potentiates morphine catalepsy in rats. Experientia, 1985, Dec-15, Volume: 41, Issue:12 Topics: 5,6-Dihydroxytryptamine; Animals; Benserazide; Catalepsy; Diclofenac; Ditiocarb; Drug Interactions; Fenclonine; Hemicholinium 3; Levodopa; Male; Mefenamic Acid; Morphine; Naloxone; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Physiological	1985
Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2002, Volume: 9, Issue:2 Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Dexamethasone; Diclofenac; Edema; Female; Inflammation; Lamiaceae; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Spectrum Analysis; Toxicity Tests, Acute; Xylenes	2002
Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation. Life sciences, 2004, Apr-02, Volume: 74, Issue:20 Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hyperalgesia; Indomethacin; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide	2004
Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib. European journal of pharmacology, 2005, Apr-18, Volume: 513, Issue:1-2 Topics: Analgesics; Animals; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Glyburide; Guanylate Cyclase; Hindlimb; Injections, Spinal; Injections, Subcutaneous; Methiothepin; Naloxone; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organic Chemicals; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Scorpion Venoms	2005
The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dipyrone; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intradermal; Injections, Intraperitoneal; Ketorolac; Lysine; Male; Mice; Mice, Inbred BALB C; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Reaction Time; Sodium Salicylate; Tail; Time Factors	2007
Antinociceptive activity of Syzygium jambos leaves extract on rats. Journal of ethnopharmacology, 2007, Jun-13, Volume: 112, Issue:2 Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Formaldehyde; Hand Strength; Hot Temperature; Male; Morphine; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Pain Measurement; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Reaction Time; Syzygium	2007
Analgesic and antiinflammatory effects of mollic acid glucoside, a 1 alpha-hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf. Phytotherapy research : PTR, 2008, Volume: 22, Issue:1 Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Combretum; Diclofenac; Edema; Female; Hindlimb; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Morphine; Naloxone; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Saponins	2008
Palmitic acid analogues exhibiting antinociceptive activity in mice. Proceedings of the Western Pharmacology Society, 2007, Volume: 50 Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; ortho-Aminobenzoates; Pain Measurement; Palmitates; Reaction Time	2007
Antinociceptive tolerance to NSAIDs microinjected into dorsal hippocampus. BMC pharmacology & toxicology, 2014, Feb-28, Volume: 15 Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diclofenac; Drug Resistance; Hippocampus; Ketorolac; Male; Microinjections; Naloxone; Narcotic Antagonists; Pain; Piroxicam; Rats; Rats, Wistar	2014
κ-Opioid receptor participates of NSAIDs peripheral antinociception. Neuroscience letters, 2016, 05-27, Volume: 622 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dipyrone; Hindlimb; Hyperalgesia; Male; Naloxone; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2016
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS'S ANTINOCICEPTION MEDIATED BY THE OPIOID MECHANISM IN THE NUCLEUS RAPHE MAGNUS. Georgian medical news, 2017, Issue:265 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dipyrone; Ketorolac; Male; Microinjections; Naloxone; Narcotic Antagonists; Nociception; Nucleus Raphe Magnus; Opioid Peptides; Piroxicam; Rats; Reaction Time	2017
Antinociceptive tolerance to NSAIDs in the anterior cingulate cortex is mediated via endogenous opioid mechanism. BMC pharmacology & toxicology, 2018, 01-06, Volume: 19, Issue:1 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Tolerance; Gyrus Cinguli; Ketorolac; Male; Microinjections; Naloxone; Narcotic Antagonists; Opioid Peptides; Pain; Piroxicam; Rats, Wistar	2018
Understanding nociception-related phenotypes in adult zebrafish: Behavioral and pharmacological characterization using a new acetic acid model. Behavioural brain research, 2019, 02-01, Volume: 359 Topics: Acetic Acid; Analgesics, Opioid; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diclofenac; Disease Models, Animal; Drug Discovery; Drug Interactions; Female; Male; Morphine; Naloxone; Narcotic Antagonists; Nociception; Posture; Random Allocation; Visceral Pain; Zebrafish	2019