diclofenac and midazolam

diclofenac has been researched along with midazolam in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (8.93)	18.2507
2000's	19 (33.93)	29.6817
2010's	29 (51.79)	24.3611
2020's	3 (5.36)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Dai, R; Liu, Y; She, M; Wu, Z	1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Furukawa, T; Hosoya, K; Kadono, K; Moriguchi, H; Nakamori, F; Naritomi, Y; Teramura, T; Terashita, S; Tetsuka, K; Yamano, K	1
Kanebratt, KP; Sjögren, E; Svanberg, P	1
Artursson, P; Mateus, A; Matsson, P	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Blank, BR; Gut, J; Renslo, AR; Rosenthal, PJ	1
Demarest, K; Du, F; Gaul, MD; Hinke, S; Huebert, ND; Kirchner, T; Kuo, GH; Lee, S; Liang, Y; Murray, W; Silva, J; Wallace, N; Xu, G; Xu, JZ	1
Peng, Y; Welsh, WJ; Zhang, Q	1
Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL	1
Bonnabry, P; Dayer, P; Leemann, T	1
Asano, M; Maekawa, N; Mikawa, K; Nishina, K; Obara, H	1
Beaune, P; Dayer, P; Lecoeur, S; Leemann, T; Transon, C	1
Aguado, L; Ariño, P; Baltasar, M; Cortada, V; Puig, MM	1
Lewis, IA; Palmer, J; Pleasance, S; Scott, RJ	1
Dickins, M; Gibson, A; Palmer, JL; Pleasance, S; Scott, RJ	1
Fujita, K; Kamataki, T; Nakayama, K; Nohmi, T; Tsuruma, K; Yamada, M; Yamazaki, Y	1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K	1
Apan, A; Basar, H; Buyukkocak, U; Ozcan, S; Yilmaz, E	1
Beattie, IG; Graham, KS; Riley, RJ; Weaver, R	1
Adedoyin, A; Caserta, KA; Jones, SS; Laws, K; Saraswat, LD; Wei, D	1
DeSante, KA; Gillespie, JS; Jensen, CB; Long, AJ; Petullo, D; Read, HA; Ring, B; Sanburn, NP; Sauer, JM; Smith, BP; VandenBranden, MR; Witcher, JW; Wrighton, SA	1
Wright, GA	1
Carter, GT; Di, L; Kerns, EH; Li, SQ	1
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J	1
Bush, D; Doss, GA; Franklin, RB; Vincent, S; Xu, S; Zhu, B	1
Grime, K; Riley, RJ; Webborn, PJ	1
Jones, BC; Lyons, R; Payne, L; Saunders, K; Youdim, KA	1
Hao, HP; Peng, Y; Roberts, MS; Shang, LL; Sun, JG; Wang, GJ; Wang, XJ; Xia, CH; Xie, L; Zhang, R; Zhang, XX	1
Andersson, TB; Björquist, P; Brolén, G; Ek, M; Eriksson, G; Heins, N; Ingelman-Sundberg, M; Johansson, I; Semb, H; Sivertsson, L	1
Gashi, V; Hasani, A; Maloku, H; Ozgen, SU; Sallahu, F	1
Iwasaki, K; Matsuno, K; Matsushita, A; Nakamura, C; Nakanishi, Y; Uno, Y; Utoh, M	1
Hasani, A; Jakupi, M; Soljakova, M; Ustalar-Ozgen, S	1
Hall, SD; Harrelson, JP; Mao, J; Mohutsky, MA; Wrighton, SA	1
Atzrodt, J; Blankenstein, J; Brasseur, D; Calvo-Vicente, S; Denoux, M; Derdau, V; Lavisse, M; Perard, S; Roy, S; Sandvoss, M; Schofield, J; Zimmermann, J	1
Arakawa, H; Ikeya, T; Inoue, Y; Iwai, H; Jomura, T; Koeda, A; Kusumoto, K; Nagao, T; Naitoh, K; Ogihara, T; Ohkura, T; Ohta, K; Ozeki, E; Takahashi, N; Ueda, T; Wada, K	1
Brown, D; Burke, RS; Carr, BA; Deshmukh, SV; DiMuzio, J; DiPietro, MA; Eisenhandler, R; Fauty, SE; Gibson, C; Gindy, ME; Hamilton, KA; Hochman, JH; Knemeyer, I; Koeplinger, KA; Kwon, HW; Lifsted, TQ; Menzel, K; Patel, M; Prueksaritanont, T; Pudvah, N; Rearden, P; Rudd, DJ; Seitzer, J; Somasuntharam, I; Strapps, WR; Thompson, CD	1
Berben, SA; Doggen, CJ; Gaakeer, MI; IJzerman, MJ; Pierik, JG; van Eenennaam, FL; van Vugt, AB	1
Jilek, JL; Tian, Y; Yu, AM	1
Apers, S; Bijttebier, S; Casteleyn, C; Cos, P; Maes, L; Matheeussen, A; Pype, C; Saad, M; Van Cruchten, S; Van Ginneken, C; Verbueken, E	1
Bedwell, DW; Hall, SD; Mohutsky, MA; Rougée, LRA; Ruterbories, KJ	1
Liu, L; Liu, X; Tang, X; Wang, S; Xu, J; Yang, T; Zhang, J	1
Arakawa, H; Itoh, M; Kojima, H; Koyama, S; Masuda, N; Ogihara, T; Yano, K	1
Murayama, N; Yamazaki, H	1
Andersson, TB; Artursson, P; Christensen, H; Krogstad, V; Matsson, P; Urdzik, J; Wegler, C	1

Reviews

1 review(s) available for diclofenac and midazolam

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

4 trial(s) available for diclofenac and midazolam

Article	Year
Oral clonidine premedication reduces vomiting in children after strabismus surgery. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:11 Topics: Administration, Oral; Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Child, Preschool; Clonidine; Diazepam; Diclofenac; Double-Blind Method; Female; Humans; Incidence; Length of Stay; Male; Midazolam; Neuromuscular Nondepolarizing Agents; Pain, Postoperative; Placebos; Postoperative Complications; Preanesthetic Medication; Premedication; Prospective Studies; Strabismus; Vecuronium Bromide; Vomiting	1995
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A). British journal of clinical pharmacology, 2001, Volume: 52, Issue:5 Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Drug Interactions; Female; Humans; Male; Mephenytoin; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating	2001
Comparison of three analgesics for extracorporeal shock wave lithotripsy. Scandinavian journal of urology and nephrology, 2002, Volume: 36, Issue:4 Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Anesthesia, Intravenous; Diclofenac; Drug Administration Schedule; Drug Therapy, Combination; Elective Surgical Procedures; Female; Fentanyl; Follow-Up Studies; Humans; Injections, Intramuscular; Kidney Calculi; Lithotripsy; Male; Midazolam; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Preoperative Care; Tramadol; Treatment Outcome	2002
Preemptive analgesia with midazolam and diclofenac for hernia repair pain. Hernia : the journal of hernias and abdominal wall surgery, 2011, Volume: 15, Issue:3 Topics: Adult; Aged; Anesthesia Recovery Period; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Drug Therapy, Combination; Female; Hernia, Inguinal; Humans; Hypnotics and Sedatives; Hypotension; Male; Midazolam; Middle Aged; Pain Measurement; Pain, Postoperative; Premedication; Time Factors	2011

Other Studies

51 other study(ies) available for diclofenac and midazolam

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3 Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2011
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results	2011
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Quantitative prediction of human intestinal glucuronidation effects on intestinal availability of UDP-glucuronosyltransferase substrates using in vitro data. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:9 Topics: Administration, Oral; Biotransformation; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Glucuronides; Glucuronosyltransferase; Humans; Intestinal Absorption; Intestines; Isoenzymes; Kinetics; Metabolic Clearance Rate; Microsomes; Models, Biological; Pharmaceutical Preparations; Recombinant Proteins; Substrate Specificity	2012
Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Kinetics; Microsomes, Liver; Research Design; Tandem Mass Spectrometry	2012
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14 Topics: Animals; Antimalarials; Female; Ferrous Compounds; Heterocyclic Compounds, 1-Ring; Malaria; Mice; Peroxides; Plasmodium berghei; Plasmodium falciparum; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship	2017
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors. Bioorganic & medicinal chemistry letters, 2018, 11-15, Volume: 28, Issue:21 Topics: Administration, Oral; Animals; Blood Glucose; Deoxyglucose; Diabetes Mellitus, Experimental; Drug Design; Humans; Hypoglycemic Agents; Macaca fascicularis; Male; Mice; Microsomes, Liver; Molecular Structure; Rats, Sprague-Dawley; Rats, Zucker; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship	2018
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management. Journal of medicinal chemistry, 2021, 01-14, Volume: 64, Issue:1 Topics: Animals; Binding Sites; Blood-Brain Barrier; Drug Design; Guinea Pigs; Half-Life; Humans; Microsomes, Liver; Molecular Dynamics Simulation; Neuralgia; Pain Management; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship; Rats; Receptors, sigma; Sigma-1 Receptor; Triazoles	2021
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. European journal of medicinal chemistry, 2021, Mar-05, Volume: 213 Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Development; Enzyme Inhibitors; Freund's Adjuvant; Humans; Lipopolysaccharides; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Structure-Activity Relationship	2021
Selective inhibition of major drug metabolizing cytochrome P450 isozymes in human liver microsomes by carbon monoxide. Life sciences, 1994, Volume: 54, Issue:14 Topics: Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating	1994
Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes. European journal of clinical pharmacology, 1996, Volume: 51, Issue:1 Topics: Adult; Age Factors; Anesthetics, Intravenous; Animals; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Female; Humans; Hydroxylation; Isoenzymes; Male; Methylation; Mice; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Rabbits; Regression Analysis; Sex Factors; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; White People	1996
Cold urticaria associated with intraoperative hypotension and facial edema. Anesthesiology, 1999, Volume: 90, Issue:3 Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anesthetics, General; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Atracurium; Atropine; Diclofenac; Down Syndrome; Drug Therapy, Combination; Face; Fentanyl; Hip; Humans; Hypotension; Intraoperative Complications; Legg-Calve-Perthes Disease; Male; Midazolam; Thiopental	1999
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 1999, Volume: 13, Issue:23 Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline	1999
Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase. Environmental and molecular mutagenesis, 2001, Volume: 38, Issue:4 Topics: Alkylating Agents; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Ethanolamines; Genetic Engineering; Humans; Midazolam; Mixed Function Oxygenases; Mutagenicity Tests; NADP; NADPH-Ferrihemoprotein Reductase; Nitrosamines; Recombinant Proteins; Salmonella typhimurium; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	2001
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochemical pharmacology, 2002, Mar-01, Volume: 63, Issue:5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured	2002
Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Drug Design; Drug Industry; Drug Interactions; Drugs, Investigational; Escherichia coli; Ethanolamines; Evaluation Studies as Topic; Kinetics; Mass Spectrometry; Mephenytoin; Microsomes, Liver; Midazolam; Molecular Probes; Phenacetin; Recombinant Proteins; Substrate Specificity	2003
A high-throughput method for enzyme kinetic studies. Journal of biomolecular screening, 2003, Volume: 8, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Evaluation, Preclinical; Enzyme Inhibitors; Enzymes; Half-Life; Humans; Kinetics; Mass Spectrometry; Midazolam; Molecular Biology; Sensitivity and Specificity; Testosterone; Warfarin	2003
Atomoxetine hydrochloride: clinical drug-drug interaction prediction and outcome. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Atomoxetine Hydrochloride; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Diclofenac; Drug Interactions; Ethanolamines; Humans; Hydroxylation; Microsomes, Liver; Midazolam; Phenacetin; Propylamines	2004
Diclofenac pretreatment for propofol. Anaesthesia and intensive care, 2005, Volume: 33, Issue:4 Topics: Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fentanyl; Humans; Midazolam; Pain; Propofol	2005
Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS. International journal of pharmaceutics, 2007, Apr-20, Volume: 335, Issue:1-2 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Drug Design; Drug Interactions; Enzyme Inhibitors; Ethanolamines; Fluorescent Dyes; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Liver; Microsomes, Liver; Midazolam; Recombinant Proteins; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Substrate Specificity; Tandem Mass Spectrometry	2007
Effect of methamphetamine on cytochrome P450 activity. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12 Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide	2007
Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:2 Topics: Animals; Central Nervous System Agents; Diclofenac; Glucuronides; Glucuronosyltransferase; Humans; Male; Microsomes, Liver; Midazolam; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sapogenins; Uridine Diphosphate Glucuronic Acid	2008
Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:8 Topics: Animals; Atorvastatin; Cells, Cultured; Culture Media; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Estrone; Hepatocytes; Heptanoic Acids; Humans; Hydroxylation; Liver; Midazolam; Pyrroles; Quinolines; Rats; Recombinant Proteins; Tritium	2008
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point. Journal of pharmaceutical and biomedical analysis, 2008, Sep-10, Volume: 48, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Biological Assay; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Interactions; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Midazolam; Miniaturization; Oxidoreductases, N-Demethylating; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Tacrine; Tandem Mass Spectrometry; Time Factors	2008
Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats. Planta medica, 2010, Volume: 76, Issue:3 Topics: Animals; Area Under Curve; Chlorzoxazone; Cytochrome P-450 Enzyme System; Diclofenac; Drug Combinations; Drugs, Chinese Herbal; Herb-Drug Interactions; Inactivation, Metabolic; Inhibitory Concentration 50; Injections; Liver; Male; Midazolam; Ophiopogon; Panax; Plant Roots; Rats; Rats, Sprague-Dawley; Theophylline	2010
Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage. Journal of biotechnology, 2010, Feb-01, Volume: 145, Issue:3 Topics: Bone Morphogenetic Protein 4; Cell Differentiation; Cell Line; Cell Separation; Cell Shape; Diclofenac; Embryonic Stem Cells; Endoderm; Fibroblast Growth Factor 2; Hepatocytes; Humans; Midazolam; Phenacetin	2010
Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys. Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Chlorzoxazone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diclofenac; Duodenum; Ileum; Intestine, Small; Jejunum; Kinetics; Liver; Macaca fascicularis; Male; Mephenytoin; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Paclitaxel; Pharmaceutical Preparations; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide	2011
Preemptive analgesic effects of midazolam and diclofenac in rat model. Bosnian journal of basic medical sciences, 2011, Volume: 11, Issue:2 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Formaldehyde; Hot Temperature; Injections, Intraperitoneal; Male; Midazolam; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley	2011
Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Cell Culture Techniques; Cells, Cultured; Chromatography, High Pressure Liquid; Cryopreservation; Culture Media; Culture Media, Serum-Free; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ethanolamines; Hepatocytes; Humans; Hydroxylation; Midazolam; Plasma; Predictive Value of Tests; Substrate Specificity; Tandem Mass Spectrometry	2012
Synthesis of stable isotope labelled internal standards for drug-drug interaction (DDI) studies. Bioorganic & medicinal chemistry, 2012, Sep-15, Volume: 20, Issue:18 Topics: Cytochrome P-450 Enzyme System; Deuterium Exchange Measurement; Diclofenac; Isotope Labeling; Microwaves; Midazolam; Molecular Structure; Pharmaceutical Preparations; Reference Standards	2012
Evaluation of human hepatocytes cultured by three-dimensional spheroid systems for drug metabolism. Drug metabolism and pharmacokinetics, 2014, Volume: 29, Issue:5 Topics: Acetaminophen; Albuterol; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Diclofenac; Glucuronosyltransferase; Hepatocytes; Humans; Lamotrigine; Midazolam; Pharmaceutical Preparations; Propranolol; Spheroids, Cellular; Tandem Mass Spectrometry; Triazines	2014
siRNA-mediated knockdown of P450 oxidoreductase in rats: a tool to reduce metabolism by CYPs and increase exposure of high clearance compounds. Pharmaceutical research, 2014, Volume: 31, Issue:12 Topics: Animals; Chemistry, Pharmaceutical; Cytochrome P-450 Enzyme System; Diclofenac; Gene Knockdown Techniques; In Vitro Techniques; Male; Microsomes; Microsomes, Liver; Midazolam; Nanoparticles; Protein Binding; Rats; RNA, Small Interfering	2014
A nurse-initiated pain protocol in the ED improves pain treatment in patients with acute musculoskeletal pain. International emergency nursing, 2016, Volume: 27 Topics: Acetaminophen; Adult; Analgesics; Diclofenac; Emergency Service, Hospital; Female; Fentanyl; Follow-Up Studies; Guidelines as Topic; Humans; Male; Midazolam; Middle Aged; Morphine; Musculoskeletal Pain; Netherlands; Pain Management; Patient Satisfaction; Time Factors; Tramadol	2016
Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:5 Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Interactions; Male; Mice; MicroRNAs; Midazolam; Pharmacokinetics; Phenacetin	2017
In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds. Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 42 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Embryo, Nonmammalian; Female; Humans; Male; Microsomes, Liver; Midazolam; Testosterone; Zebrafish	2017
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:9 Topics: Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Drug Interactions; Female; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Midazolam; Plasma; Testosterone; Warfarin	2017
Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2 Topics: Atorvastatin; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Kinetics; Microsomes, Liver; Midazolam; Protein Isoforms; Testosterone; Tolbutamide; Verapamil; Warfarin	2019
Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates. Biopharmaceutics & drug disposition, 2018, Volume: 39, Issue:4 Topics: Acetaminophen; Adenosine Triphosphate; Arylsulfotransferase; Cell Culture Techniques; Cells, Cultured; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Diclofenac; Glucuronosyltransferase; Hepatocytes; Humans; Lamotrigine; Midazolam; Omeprazole; Rifampin; RNA, Messenger; Triazines	2018
Cytochrome P450-dependent drug oxidation activities in commercially available hepatocytes derived from human induced pluripotent stem cells cultured for 3 weeks. The Journal of toxicological sciences, 2018, Volume: 43, Issue:4 Topics: Cells, Cultured; Cytochrome P-450 Enzyme System; Diclofenac; Hepatocytes; Humans; Hydroxylation; Induced Pluripotent Stem Cells; Isoenzymes; Midazolam; Omeprazole; Pregnane X Receptor; Receptors, Steroid; Time Factors	2018
Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes. Molecular pharmaceutics, 2021, 04-05, Volume: 18, Issue:4 Topics: Bupropion; Cytochrome P-450 Enzyme System; Diclofenac; Drug Evaluation, Preclinical; Ethanolamines; Hepatobiliary Elimination; Hepatocytes; Humans; Liver; Microsomes, Liver; Midazolam; Omeprazole; Proteome; Proteomics	2021