diclofenac has been researched along with metoprolol in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.22) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (31.11) | 29.6817 |
| 2010's | 24 (53.33) | 24.3611 |
| 2020's | 6 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Avdeef, A; Tam, KY | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L | 1 |
| Ablad, B; Aurell, M; Kopp, U; Sjölander, M | 1 |
| Casper, H; Scheil, V; Schwaiger, J; Triebskorn, R | 1 |
| Golloch, A; Schmidt, TC; Sein, MM; von Sonntag, C | 1 |
| Bracher, F; Dietrich, S; Laforsch, C; Ploessl, F | 1 |
| Marison, IW; von Stockar, U; Whelehan, M | 1 |
| Montforts, M; van den Brandhof, EJ | 1 |
| Koenen, S; Pinnekamp, J; Tondera, K | 1 |
| Ehrhard, P; Fahlenkamp, H; Jagemann, P; Launer, M; Lyko, S | 1 |
| Faber, H; Frensemeier, L; Karst, U; Lareo, PL; Lutze, H; Schmidt, TC; Vogel, M | 1 |
| Gröner, F; Kloas, W; Ziková, A | 1 |
| Ahnfelt, E; Axén, N; Lennernäs, H; Sjögren, E | 1 |
| Behrendt, J; Beier, S; Gulyas, H; Meyer, W; Otterpohl, R; Reich, M | 1 |
| Baron, MG; Hetheridge, MJ; Jackson, SK; Jha, AN; Mintram, KS; Moody, AJ; Owen, SF; Purcell, WM | 1 |
| Brunsch, AF; Christoffels, E; Rijnaarts, H; Ter Laak, TL | 1 |
| Butkovskyi, A; Hernandez Leal, L; Meulepas, RJW; Rijnaarts, HHM; Sevenou, L; Zeeman, G | 1 |
| Ahmad, S; Baker, D; Gerhard, U; Murnane, D; Spooner, N | 1 |
| Hohrenk-Danzouma, LL; Klein, M; Lutze, HV; Merkus, VI; Schmidt, TC; Wirzberger, V | 1 |
| Fernandes, TV; Langenhoff, A; Rijnaarts, H; Tizzani, R; Wu, K; Zweers, H | 1 |
| Al-Hindi, M; Malli, A; Mansour, F; Mheidli, N | 1 |
| Bhayani, D; Khan, S; Mehta, P; Naik, H; Nathaniel, TN; Patel, M | 1 |
2 review(s) available for diclofenac and metoprolol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Occurrence and risk assessment of pharmaceuticals in surface waters of the Middle East and North Africa: A review.
Topics: Animals; Anti-Bacterial Agents; Carbamazepine; Child; Diclofenac; Drinking Water; Ecosystem; Environmental Monitoring; Estradiol; Humans; Metoprolol; Pharmaceutical Preparations; Risk Assessment; Spiramycin; Thiamphenicol; Water Pollutants, Chemical | 2022 |
43 other study(ies) available for diclofenac and metoprolol
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish | 2020 |
The role of prostaglandins in the alpha- and beta-adrenoceptor mediated renin release response to graded renal nerve stimulation.
Topics: Animals; Diclofenac; Dogs; Drug Combinations; Female; Indomethacin; Kidney; Male; Metoprolol; Phenoxybenzamine; Prostaglandins; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Renin; Stimulation, Chemical | 1981 |
Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio).
Topics: Animals; Carbamazepine; Carps; Clofibric Acid; Diclofenac; Gills; Kidney; Liver; Metoprolol; Microscopy, Electron, Transmission; Oncorhynchus mykiss | 2007 |
Oxidation of some typical wastewater contaminants (tributyltin, clarithromycin, metoprolol and diclofenac) by ozone.
Topics: Clarithromycin; Diclofenac; Kinetics; Metoprolol; Molecular Structure; Oxidation-Reduction; Ozone; Trialkyltin Compounds; Tropical Climate; Waste Disposal, Fluid; Water Pollutants, Chemical | 2009 |
Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna--a multigenerational study.
Topics: Animals; Carbamazepine; Daphnia; Diclofenac; Environmental Exposure; Ethinyl Estradiol; Metoprolol; Pharmaceutical Preparations; Reproduction; Water Pollutants, Chemical | 2010 |
Removal of pharmaceuticals from water: using liquid-core microcapsules as a novel approach.
Topics: Capsules; Carbamazepine; Clofibric Acid; Diclofenac; Environmental Monitoring; Feasibility Studies; Fresh Water; Furosemide; Kinetics; Metoprolol; Pharmaceutical Preparations; Reproducibility of Results; Sulfamethoxazole; Warfarin; Water Pollutants, Chemical; Water Purification; Water Supply | 2010 |
Fish embryo toxicity of carbamazepine, diclofenac and metoprolol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Antimanic Agents; Carbamazepine; Diclofenac; Dose-Response Relationship, Drug; Metoprolol; Time Factors; Toxicity Tests; Water Pollutants, Chemical; Zebrafish | 2010 |
Survey monitoring results on the reduction of micropollutants, bacteria, bacteriophages and TSS in retention soil filters.
Topics: Bacteria; Bacteriophages; Benzhydryl Compounds; Diclofenac; Filtration; Metoprolol; Phenols; Waste Disposal, Fluid; Water Pollution; Water Purification | 2013 |
Application of CFD modelling at a full-scale ozonation plant for the removal of micropollutants from secondary effluent.
Topics: Diatrizoate; Diclofenac; Hydrodynamics; Metoprolol; Models, Theoretical; Oxidants; Ozone; Waste Disposal, Fluid; Water Pollutants, Chemical | 2013 |
Liquid chromatography/mass spectrometry to study oxidative degradation of environmentally relevant pharmaceuticals by electrochemistry and ozonation.
Topics: Chromatography, Liquid; Diclofenac; Electrochemical Techniques; Electrodes; Metoprolol; Oxidation-Reduction; Ozone; Tandem Mass Spectrometry; Water Purification | 2014 |
Effects of the pharmaceuticals diclofenac and metoprolol on gene expression levels of enzymes of biotransformation, excretion pathways and estrogenicity in primary hepatocytes of Nile tilapia (Oreochromis niloticus).
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cells, Cultured; Cichlids; Cytochrome P-450 CYP1A1; Diclofenac; Estrogens; Gene Expression Regulation; Genes, MDR; Glutathione Transferase; Hepatocytes; Male; Metoprolol; RNA, Messenger; Vitellogenins; Water Pollutants, Chemical | 2015 |
A miniaturized in vitro release method for investigating drug-release mechanisms.
Topics: Carbamazepine; Computer Simulation; Diclofenac; Drug Delivery Systems; Drug Liberation; Humans; Intestinal Absorption; Metoprolol; Miniaturization; Models, Theoretical; Naproxen | 2015 |
Measured and predicted environmental concentrations of carbamazepine, diclofenac, and metoprolol in small and medium rivers in northern Germany.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Diclofenac; Environmental Monitoring; Forecasting; Germany; Metoprolol; Models, Theoretical; Rivers; Solid Phase Extraction; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical | 2016 |
Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance.
Topics: Animals; Atenolol; Biotransformation; Carbamazepine; Diazepam; Diclofenac; Drug Evaluation, Preclinical; Female; Kinetics; Liver; Metoprolol; Models, Animal; Oncorhynchus mykiss; Phenylbutazone; Propranolol; Tandem Mass Spectrometry; Water Pollutants, Chemical; Xenobiotics | 2017 |
Pharmaceutical concentration variability at sewage treatment plant outlets dominated by hydrology and other factors.
Topics: Biodegradation, Environmental; Carbamazepine; Diclofenac; Environmental Monitoring; Germany; Hydrology; Metoprolol; Pharmaceutical Preparations; Rain; Sewage; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2018 |
Micropollutant removal from black water and grey water sludge in a UASB-GAC reactor.
Topics: Anaerobiosis; Benzopyrans; Bioreactors; Carbon; Diclofenac; Ibuprofen; Metoprolol; Sewage; Triclosan; Waste Disposal, Fluid; Water Pollutants, Chemical | 2018 |
Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis.
Topics: Animals; Blood Proteins; Chromatography, Liquid; Dialysis; Diclofenac; Metoprolol; Propranolol; Protein Binding; Rats; Solid Phase Microextraction; Tandem Mass Spectrometry | 2021 |
Bromide strongly influences the formation of reaction products during the ozonation of diclofenac, metoprolol and isoproturon.
Topics: Bromides; Diclofenac; Metoprolol; Ozone; Phenylurea Compounds; Water Pollutants, Chemical; Water Purification | 2022 |
Removal processes of individual and a mixture of organic micropollutants in the presence of Scenedesmus obliquus.
Topics: Carbamazepine; Chlorophyceae; Clarithromycin; Diclofenac; Metoprolol; Microalgae; Scenedesmus; Wastewater; Water Pollutants, Chemical | 2022 |
Ground-based selected ionizing space radiation effects on stability of APIs and their formulations.
Topics: Ciprofloxacin; Diclofenac; Metoprolol; Protons; Radiation, Ionizing; Space Flight; Tablets | 2022 |