diclofenac has been researched along with methotrexate in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.79) | 18.7374 |
| 1990's | 6 (10.71) | 18.2507 |
| 2000's | 21 (37.50) | 29.6817 |
| 2010's | 26 (46.43) | 24.3611 |
| 2020's | 2 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Graves, P; Kuze, K; Leahy, A; Stuhlmann, H; Wilson, P; You, G | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Calin, A; Elswood, J | 1 |
| Balabanova, RM; Bassam, B | 1 |
| Lacki, JK; Mackiewicz, SH; Wiktorowicz, KE | 1 |
| Ciccarelli, A; de Crescenzo, G; de Paulis, A; Marinò, D; Marinò, I; Marone, G | 1 |
| Lacki, JK; Mackiewicz, SH | 1 |
| Gao, F; Hirata, K; Horie, T; Sosogi, A; Tomimatsu, T | 2 |
| Giasi, V; Olivieri, I; Padula, A; Scarano, E | 1 |
| Benesch, M; Dornbusch, HJ; Lackner, H; Moser, A; Raith, J; Schwinger, W; Sovinz, P; Triebl-Roth, K; Urban, C | 1 |
| Branson, JM; Chales, GH; Hartmann, SN; Juvin, RR; Lafforgue, P; Le Parc, JM; Meyer, OC; Milosavljev, S; Rordorf, CM; Tavernier, CG | 1 |
| Kandefer-Szerszeń, M; Majdan, M; Parada-Turska, J; Rzeski, W; Turski, WA | 1 |
| Akar, S; Akkoc, N; Birlik, M; Onen, F; Sari, I; Sis, B | 1 |
| Feng, XH; He, YT; Lin, SQ; Liu, W; Lü, AP; Lü, C; Qian, X; Song, YJ; Su, L; Yan, XP; Zeng, SP; Zha, QL; Zhu, WH | 1 |
| Abe, N; Hatakeyama, M; Hayashi, Y; Inoue, K; Nakai, Y; Ohta, KY; Otagiri, M; Yuasa, H | 1 |
| Feng, X; He, Y; Liu, W; Lu, A; Lu, C; Qian, X; Song, Y; Su, L; Yan, X; Zeng, S; Zha, Y; Zhu, W | 1 |
| He, Y; Lu, A; Tsang, I; Zha, Y | 1 |
| He, Y; Jiang, M; Lu, A; Zha, Q; Zhao, J | 1 |
| Bartsch, MS; Czech, N; Henze, E; Kampen, WU; Möller, B; von Forstner, C | 1 |
| Honjo, H; Iwamoto, K; Uwai, Y | 1 |
| Böttcher, A; Guder, E; Just, T | 1 |
| Aliste, M; Gatica, H; Goecke, IA; Guerrero, J | 1 |
| Chao, PD; Hou, YC; Juang, SH; Tsai, SY; Yang, SY | 1 |
| Bhatia, M; Garg, LN; Gupta, S; Kumar, S | 1 |
| Han, JG; Tao, YL; Wang, ZJ; Wei, P | 1 |
| González-Cortazar, M; Herrera-Ruiz, M; Jiménez-Ferrer, E; Pérez, S; Salinas-Sánchez, DO; Tortoriello, J; Zamilpa, A | 1 |
| Garg, NK; Jain, A; Jain, S; Katare, OP; Sharma, G; Singh, B; Tyagi, RK | 1 |
| Chang, SN; Chung, HM; Jung, CR; Kim, CY; Kim, J; Kim, U; Lee, BH; Lee, JM; Lee, S; Oh, H; Park, JH; Ryu, B | 1 |
| Hagström, M; Kidron, H; Rimpelä, AK; Urtti, A | 1 |
| Biju, IK; Manappallil, RG; Peringat, J; Prasan, D | 1 |
| Hagström, M; Hellinen, L; Knuutila, H; Reinisalo, M; Ruponen, M; Urtti, A | 1 |
| Alanazi, FK; Alshehri, S; Kazi, M; Masum, AA; Shariare, MH; Uddin, J | 1 |
| Alqahtani, SS; Alshahrani, S; Banji, D; Banji, OJF; Rashida, S | 1 |
2 review(s) available for diclofenac and methotrexate
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
8 trial(s) available for diclofenac and methotrexate
| Article | Year |
|---|---|
[The efficacy of immunomodulating therapy in rheumatoid arthritis].
Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Peptides; Randomized Controlled Trials as Topic; Thymus Extracts; Time Factors | 1990 |
Lymphocyte phenotype studies of rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Female; HLA-DR Antigens; Humans; Immunophenotyping; Immunosuppressive Agents; Lymphocyte Count; Lymphocyte Subsets; Male; Methotrexate; Microscopy, Fluorescence; Middle Aged; Receptors, Interleukin-2; Treatment Outcome | 1994 |
[The effect of low dose methotrexate on the course of rheumatoid arthritis--four years of observation].
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Disease Progression; Drug Therapy, Combination; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Prednisone; Radiography; Treatment Outcome | 1997 |
Lumiracoxib does not affect methotrexate pharmacokinetics in rheumatoid arthritis patients.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Over Studies; Cyclooxygenase 2; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Isoenzymes; Male; Membrane Proteins; Methotrexate; Middle Aged; Organic Chemicals; Prostaglandin-Endoperoxide Synthases | 2004 |
[Predictive role of diagnostic information in treatment efficacy of rheumatoid arthritis based on neural network model analysis].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Drugs, Chinese Herbal; Female; Humans; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Neural Networks, Computer; Phytotherapy; Sulfasalazine; Treatment Outcome | 2007 |
Correlations between symptoms as assessed in traditional chinese medicine (TCM) and ACR20 efficacy response: a comparison study in 396 patients with rheumatoid arthritis treated with TCM or Western medicine.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Single-Blind Method; Sulfasalazine; Treatment Outcome | 2007 |
Differential effect on symptoms treated with traditional Chinese medicine and western combination therapy in RA patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Drugs, Chinese Herbal; Endpoint Determination; Female; Humans; Male; Methotrexate; Middle Aged; Single-Blind Method; Sulfasalazine | 2008 |
Does gastrointestinal adverse drug reaction influence therapeutic effect in the treatment of rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Drugs, Chinese Herbal; Gastrointestinal Diseases; Humans; Methotrexate; Sulfasalazine; Treatment Outcome | 2010 |
46 other study(ies) available for diclofenac and methotrexate
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; COS Cells; Glycosylation; Histidine; In Situ Hybridization; Kidney; Kinetics; Mice; p-Aminohippuric Acid; Probenecid; Protein Processing, Post-Translational; Renal Agents; Substrate Specificity; Tunicamycin | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis | 2001 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A prospective nationwide cross-sectional study of NSAID usage in 1331 patients with ankylosing spondylitis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Cross-Sectional Studies; Diclofenac; Female; Gold; Humans; Ibuprofen; Male; Methotrexate; Middle Aged; Naproxen; Penicillamine; Piroxicam; Prednisolone; Prospective Studies; Spondylitis, Ankylosing; Sulfasalazine; United Kingdom | 1990 |
Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs.
Topics: Adenosine; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chymases; Cyclosporine; Diclofenac; Histamine Release; Humans; Immunoglobulin E; Immunosuppressive Agents; Leukotriene C4; Mast Cells; Methotrexate; Middle Aged; Polyenes; Prostaglandins D; Rheumatic Diseases; Serine Endopeptidases; Sirolimus; Substance P; Sulfonamides; Synovial Membrane; Tacrolimus; Tryptases | 1997 |
Effects of non-steroidal anti-inflammatory drugs on the methotrexate transport in rat small intestine.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport, Active; Diclofenac; Flufenamic Acid; Folic Acid Antagonists; Indomethacin; Intestine, Small; Male; Methotrexate; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase | 2003 |
Non-steroidal anti-inflammatory drugs affect the methotrexate transport in IEC-6 cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Coloring Agents; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flufenamic Acid; Hydrogen-Ion Concentration; Indomethacin; Intestine, Small; Intestines; Methotrexate; Phosphorylation; Rats; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
Dactylitis of the thumb extending to the radial bursa.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Psoriatic; Bursa, Synovial; Bursitis; Diclofenac; Finger Joint; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Radiography; Radius; Tenosynovitis; Thumb | 2003 |
Multimodal treatment of children with unresectable or recurrent desmoid tumors: an 11-year longitudinal observational study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Diclofenac; Female; Fibromatosis, Aggressive; Humans; Infant; Longitudinal Studies; Magnetic Resonance Imaging; Male; Methotrexate; Neoplasm Recurrence, Local; Surgical Procedures, Operative; Tamoxifen; Vinblastine | 2004 |
Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro.
Topics: Animals; Antirheumatic Agents; Benzodiazepines; Benzodiazepinones; Celecoxib; Cell Line; Cell Proliferation; Cell Survival; Diclofenac; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Methotrexate; Naproxen; Pyrazoles; Quinoxalines; Sulfasalazine; Sulfonamides; Synovial Membrane | 2006 |
Anti-tumor necrosis factor-alpha-induced psoriasis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Methotrexate; Prednisone; Psoriasis; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2006 |
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Biological Transport, Active; Cell Line; Cell Membrane; Diclofenac; Dose-Response Relationship, Drug; Folic Acid; Green Fluorescent Proteins; Humans; Hydrogen-Ion Concentration; Indomethacin; Kinetics; Membrane Transport Proteins; Methotrexate; Microscopy, Confocal; Nigericin; Proton-Coupled Folate Transporter; Sulfasalazine; Transfection | 2007 |
Radiosynoviorthesis of the temporomandibular joint--initial clinical application.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Diclofenac; Female; Gamma Cameras; Humans; Methotrexate; Middle Aged; Prednisolone; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Synovitis; Temporomandibular Joint Disorders | 2009 |
Inhibitory effect of selective cyclooxygenase-2 inhibitor lumiracoxib on human organic anion transporters hOAT1 and hOAT3.
Topics: Animals; Binding, Competitive; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Estrone; Etoricoxib; Humans; Inhibitory Concentration 50; Isoxazoles; Kinetics; Lactones; Methotrexate; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Pyrazoles; Pyridines; RNA, Complementary; Sulfonamides; Sulfones; Xenopus laevis | 2010 |
[Unilateral odynophagia in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cooperative Behavior; Deglutition Disorders; Diagnosis, Differential; Diclofenac; Drug Therapy, Combination; Dysphonia; Endoscopy; Female; Folic Acid; Humans; Interdisciplinary Communication; Lymphopenia; Methotrexate; Middle Aged; Misoprostol; Opportunistic Infections; Oral Ulcer; Pain; Pharyngitis; Prednisolone | 2011 |
Effects of methotrexate on the expression of the translational isoforms of glucocorticoid receptors α and β: correlation with methotrexate efficacy in rheumatoid arthritis patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blotting, Western; Chile; Diclofenac; Female; Glucocorticoids; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Prednisolone; Protein Isoforms; Receptors, Glucocorticoid; Treatment Outcome | 2011 |
St. John's wort significantly increased the systemic exposure and toxicity of methotrexate in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Interactions; Hypericum; Immunosuppressive Agents; Male; Methotrexate; Plant Extracts; Rats; Rats, Sprague-Dawley | 2012 |
Acute and chronic inflammation studies of Strobilanthes callosus leaves extract on rat model.
Topics: Acanthaceae; Acute Disease; Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents; Carrageenan; Chronic Disease; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Methotrexate; Plant Extracts; Plant Leaves; Prednisolone; Rats; Rats, Wistar; Solvents | 2013 |
Inflammatory myofibroblastic tumor successfully treated with chemotherapy and nonsteroidals: a case report.
Topics: Abdominal Neoplasms; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Biopsy; Cisplatin; Diclofenac; Female; Fibroblasts; Humans; Inflammation; Methotrexate; Retroperitoneal Neoplasms; Tomography, X-Ray Computed; Treatment Outcome | 2012 |
Effect of Hautriwaic Acid Isolated from Dodonaea viscosa in a Model of Kaolin/Carrageenan-Induced Monoarthritis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Diclofenac; Diterpenes; Dose-Response Relationship, Drug; Edema; Female; Interleukin-10; Kaolin; Methotrexate; Mice, Inbred Strains; Sapindaceae; Tumor Necrosis Factor-alpha | 2015 |
Functionalized Lipid-Polymer Hybrid Nanoparticles Mediated Codelivery of Methotrexate and Aceclofenac: A Synergistic Effect in Breast Cancer with Improved Pharmacokinetics Attributes.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Diclofenac; Female; Humans; Interleukin-1beta; Interleukin-6; Lipids; Matrix Metalloproteinase 1; MCF-7 Cells; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles; Polymers; Tumor Necrosis Factor-alpha | 2017 |
Development of an alternative zebrafish model for drug-induced intestinal toxicity.
Topics: Animal Testing Alternatives; Animals; Caco-2 Cells; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Humans; Indomethacin; Intestinal Mucosa; Lethal Dose 50; Methotrexate; Rats, Sprague-Dawley; Toxicity Tests; Zebrafish | 2018 |
Melanin targeting for intracellular drug delivery: Quantification of bound and free drug in retinal pigment epithelial cells.
Topics: Animals; Biological Transport; Cell Line; Chloroquine; Diclofenac; Epithelial Cells; Humans; Melanins; Methotrexate; Molecular Targeted Therapy; Propranolol; Retinal Pigment Epithelium; Swine; Timolol | 2018 |
Severe bone marrow suppression due to methotrexate toxicity following aceclofenac-induced acute kidney injury.
Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Cells; Bone Marrow Diseases; Diclofenac; Drug Therapy, Combination; Fatal Outcome; Female; Humans; Methotrexate; Oral Ulcer | 2018 |
Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model.
Topics: Animals; Biological Transport; Cell Line; Chloroquine; Diclofenac; Humans; Melanins; Melanosomes; Methotrexate; Phagocytosis; Pigmentation; Propranolol; Retina; Retinal Pigment Epithelium; Retinal Pigments; Swine | 2019 |
Preparation and Optimization of PEGylated Nano Graphene Oxide-Based Delivery System for Drugs with Different Molecular Structures Using Design of Experiment (DoE).
Topics: Acetaminophen; Calorimetry, Differential Scanning; Diclofenac; Drug Carriers; Drug Delivery Systems; Graphite; Methotrexate; Microscopy, Electron, Scanning; Molecular Structure; Nanoparticles; Particle Size; Polyethylene Glycols; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2021 |
Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Bilirubin; Biological Availability; Boswellia; Diclofenac; Disease Models, Animal; Malondialdehyde; Methotrexate; Plant Extracts; Triterpenes | 2022 |