diclofenac has been researched along with metformin in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (18.42) | 29.6817 |
| 2010's | 25 (65.79) | 24.3611 |
| 2020's | 6 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Darvesh, AS; Geldenhuys, WJ; Leeper, TC; Morris, DL; Sullivan, PG; Yonutas, HM | 1 |
| Miao, GX; Wang, YD; Yan, ZW; Zhang, LY | 1 |
| DeRose, EF; Duff, MR; Gabel, SA; Howell, EE; Krahn, JM; London, RE; Pedersen, LC | 1 |
| Akeson, J; Christensson, A; Schmidt, A | 1 |
| Xu, W; Yang, Y | 3 |
| Hosoi, Y; Kanamaru, T; Konno, T; Nakagami, H; Tajiri, S; Yada, S; Yoshida, K | 1 |
| Ortiz, MI | 1 |
| Fey, SJ; Wrzesinski, K | 1 |
| Alsudir, S; Iqbal, Z; Lai, EP | 1 |
| Karthikeyan, K; Korrapati, PS; Vijayalakshmi, E | 1 |
| Alenazi, NA; Lai, EP; Manthorpe, JM | 2 |
| Kumar, VL; Pandey, A | 1 |
| Dettmer, K; Gerthofer, V; Hau, P; Jachnik, B; Kreutz, M; Oefner, P; Proescholdt, M; Renner, K; Riemenschneider, MJ; Seliger, C; Vollmann-Zwerenz, A | 1 |
| Abolhassani, M; da Veiga Moreira, J; Hamraz, M; Jolicœur, M; Peres, S; Schwartz, L | 1 |
| Alieva, T; Arroyave Ospina, JC; Buist-Homan, M; Cheng, X; Geng, Y; Lezoualc'h, F; Mora, FAA; Moshage, H; Musheshe, N; Rodrigo, JA; Schmidt, M; Soto, JM | 1 |
| Abbas, HAA; Abdel-Karim, SAM; El-Ganiny, AMA; El-Sayed, MA | 1 |
| Kassie, GM; Kerr, M; Moffat, A; Pratt, N; Roughead, EE | 1 |
| Aminzadeh, A; Darijani, MH; Heidari, MR; Jafari, E; Karami-Mohajeri, S; Mandegary, A; Rahimi, HR | 1 |
2 review(s) available for diclofenac and metformin
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
36 other study(ies) available for diclofenac and metformin
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs | 2013 |
Identification of small molecules that bind to the mitochondrial protein mitoNEET.
Topics: Hypoglycemic Agents; Ligands; Mitochondrial Proteins; Protein Binding; Small Molecule Libraries; Thiazolidinediones | 2016 |
Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors.
Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Glycogen Phosphorylase; Hep G2 Cells; Hepatocytes; Humans; Hypoglycemic Agents; Indoles; Mice; Molecular Structure; Rats; Structure-Activity Relationship | 2020 |
The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Crystallography, X-Ray; Drug Design; Folic Acid; Folic Acid Antagonists; Humans; Models, Molecular; Tetrahydrofolate Dehydrogenase | 2020 |
Intensive care treatment of severe mixed metabolic acidosis.
Topics: Abdominal Abscess; Acidosis; Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blood Gas Analysis; Cholecystitis; Critical Care; Diabetes Mellitus, Type 2; Diclofenac; Female; Humans; Hypoglycemic Agents; Laparoscopy; Metformin; Renal Replacement Therapy; Sepsis; Severity of Illness Index | 2005 |
Drug sorption onto and release from soy protein fibers.
Topics: Biocompatible Materials; Diclofenac; Fluorouracil; Metformin; Pharmacokinetics; Soybean Proteins; Thermodynamics | 2009 |
Drug release and its relationship with kinetic and thermodynamic parameters of drug sorption onto starch acetate fibers.
Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Diclofenac; Diffusion; Fluorouracil; Hypoglycemic Agents; Kinetics; Metformin; Pharmaceutical Preparations; Starch; Thermodynamics | 2010 |
Relationship between drug release and some physical parameters of drug sorption onto PLA fibers.
Topics: Diclofenac; Diffusion; Fluorouracil; Lactic Acid; Metformin; Models, Chemical; Pharmaceutical Preparations; Polyesters; Polymers; Solvents; Temperature; Thermodynamics | 2010 |
The relationship between the drug concentration profiles in plasma and the drug doses in the colon.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Area Under Curve; Biological Availability; Colon; Delayed-Action Preparations; Diclofenac; Diltiazem; Dogs; Dose-Response Relationship, Drug; Hypoglycemic Agents; Metformin; Muscarinic Agonists; Quinuclidines; Terfenadine; Thiophenes; Verapamil | 2010 |
Metformin and phenformin block the peripheral antinociception induced by diclofenac and indomethacin on the formalin test.
Topics: Animals; Diclofenac; Dose-Response Relationship, Drug; Indomethacin; KATP Channels; Male; Metformin; Pain Measurement; Phenformin; Rats; Rats, Wistar | 2012 |
Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.
Topics: Acetaminophen; Adenosine Triphosphate; Amiodarone; Bioreactors; Diclofenac; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Lethal Dose 50; Metformin; Phenformin; Proteins; Reproducibility of Results; Risk Assessment; Spheroids, Cellular; Toxicity Tests; Valproic Acid | 2012 |
Competitive CE-UV binding tests for selective recognition of bisphenol A by molecularly imprinted polymer particles.
Topics: Benzhydryl Compounds; Binding, Competitive; Diclofenac; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Metformin; Molecular Imprinting; Particle Size; Phenols; Sensitivity and Specificity | 2012 |
Selective interactions of zein microspheres with different class of drugs: an in vitro and in silico analysis.
Topics: Amino Acid Sequence; Catalytic Domain; Chemistry, Pharmaceutical; Computer Simulation; Diclofenac; Drug Compounding; Ligands; Metformin; Microspheres; Models, Molecular; Particle Size; Pharmaceutical Preparations; Promethazine; Receptors, Drug; Zein | 2014 |
Enhanced selectivity of a molecularly imprinted polymer toward the target molecule via esterification of non-specific binding sites with diazomethane.
Topics: Benzhydryl Compounds; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Carboxylic Acids; Diazomethane; Diclofenac; Electrophoresis, Capillary; Esterification; Metformin; Methylation; Molecular Imprinting; Phenols; Polymers; Polymethyl Methacrylate | 2014 |
Protective Effect of Metformin against Acute Inflammation and Oxidative Stress in Rat.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Catalase; Diclofenac; Disease Models, Animal; Edema; Female; Glutathione; Hypoglycemic Agents; Inflammation; Inflammation Mediators; Male; Metformin; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2016 |
Selectivity Enhancement in Molecularly Imprinted Polymers for Binding of Bisphenol A.
Topics: Baclofen; Benzhydryl Compounds; Diclofenac; Electrophoresis, Capillary; Metformin; Molecular Imprinting; Phenols; Polymers; Water Pollutants, Chemical | 2016 |
Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; Diclofenac; Drug Synergism; Glioma; Glycolysis; Humans; Hypoglycemic Agents; Metformin; Signal Transduction | 2018 |
Metabolic therapies inhibit tumor growth in vivo and in silico.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon; Carcinogenesis; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Proliferation; Citrates; Diclofenac; Energy Metabolism; Glucose; Heterografts; Humans; Lactic Acid; Metformin; Mice; Thioctic Acid | 2019 |
Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclic AMP; Cyclooxygenase Inhibitors; Diclofenac; Guanine Nucleotide Exchange Factors; Hepatocytes; Male; Metformin; Mitochondria, Liver; Oxidative Stress; Primary Cell Culture; Rats, Wistar; Reactive Oxygen Species; Signal Transduction | 2021 |
Promising FDA-approved drugs with efflux pump inhibitory activities against clinical isolates of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Diclofenac; Domperidone; Humans; Metformin; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Nitroglycerin; Staphylococcal Infections; Staphylococcus aureus | 2022 |
Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care.
Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Amlodipine; Amphotericin B; Australia; Case-Control Studies; Ciprofloxacin; Diclofenac; Furosemide; Humans; Ibuprofen; Metformin; Naproxen; Omeprazole; Primary Health Care; Ramipril; Simvastatin; Spironolactone; Sulfamethoxazole; Telmisartan; Trimethoprim; Valacyclovir; Zoledronic Acid | 2022 |
Evaluating the protective effect of metformin against diclofenac-induced oxidative stress and hepatic damage: In vitro and in vivo studies.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diclofenac; Liver; Male; Metformin; Oxidative Stress; Rats; Rats, Wistar | 2023 |