diclofenac has been researched along with mefenamic acid in 90 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (10.00) | 18.7374 |
1990's | 13 (14.44) | 18.2507 |
2000's | 16 (17.78) | 29.6817 |
2010's | 40 (44.44) | 24.3611 |
2020's | 12 (13.33) | 2.80 |
Authors | Studies |
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Chalmers, DK; Craik, DJ; Iskander, MN; Kolliniatis, E; Munro, SL; Scholz, GH; Stockigt, JR; Topliss, DJ | 1 |
Chang, TK; Ensom, MH; Kiang, TK | 1 |
Bain, G; Beher, D; Chen, W; Jiang, X; Munoz, B; Peachey, J; Prasit, P; Shearman, MS; St-Jacques, R; Stock, N; Williamson, TL; Wrigley, JD | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Kumar, M; Sinha, VR; Thareja, S | 1 |
Grillo, MP; Tadano Lohr, M; Wait, JC | 1 |
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
Bellman, K; Knegtel, RM; Settimo, L | 1 |
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y | 1 |
Maccari, R; Ottanà, R | 1 |
Kourounakis, PN; Kourti, M; Rekka, EA; Theodosis-Nobelos, P; Tziona, P | 1 |
Bennis, K; Ducki, S; Lesage, F; Vivier, D | 1 |
Gavalas, A; Kourti, M; Rekka, EA; Theodosis-Nobelos, P | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Boa, AN; Chandrabalan, A; McPhillie, MJ; Morice, AH; Sadofsky, LR | 1 |
DeRose, EF; Duff, MR; Gabel, SA; Howell, EE; Krahn, JM; London, RE; Pedersen, LC | 1 |
Barlow, JW; Lim, CF; Raggatt, LE; Stockigt, JR; Topliss, DJ | 1 |
Raineri-Gerber, I; von Felten, A | 1 |
Benvenga, S; Cahnmann, HJ; Gregg, RE; Robbins, J | 1 |
Bhattacharya, SK; Parmar, SS | 1 |
Stewart, I; Thomas, A | 1 |
Fukui, Y; Hirasawa, N; Ohuchi, K; Ozeki, T; Tsurufuji, S; Watanabe, M | 1 |
Benvenga, S; Li Calzi, L; Robbins, J | 1 |
Hamblin, PS; Kolliniatis, E; Lim, CF; Stockigt, JR; Topliss, DJ | 1 |
Güller, R | 1 |
Serfaty, D | 1 |
Aylward, M; Dewland, PM; Lewis, PA; Maddock, J | 1 |
Breeson, AJ; Ezeh, UO; Lamb, MD; Martin, JL; Shoulder, VS; Vellacott, ID | 1 |
Bielecki, JW; Filippini, L; Gebbers, JO | 1 |
Awaya, N; Handa, M; Matsuyama, M; Ogino, M; Okada, H; Saruta, T; Suzuki, H; Toya, S | 1 |
Benvenga, S; Cahnmann, HJ; Robbins, J | 1 |
Cahill, RJ; Gilvarry, J; O'Morain, CA; Sant, SM | 1 |
Curti, C; Jordani, MC; Mingatto, FE; Santos, AC; Uyemura, SA | 2 |
Jalal, IM; Najib, NM; Rawashdeh, NM | 1 |
Curti, C; Mingatto, FE; Pigoso, AA; Rodrigues, T; Santos, AC; Uyemura, SA | 1 |
Karami-Tehrani, F; Mokarram, P; Salami, S | 1 |
Lozano, JJ; Pouplana, R; Ruiz, J | 1 |
Adeli, M; Namazi, H | 1 |
Buylaert, MA; Schifferli, JA | 1 |
Abe, F; Fujimoto, Y; Fukuda, M; Hasegawa, T; Kitaichi, K; Morishima, T; Takagi, K | 1 |
De Alencastro, LF; Grandjean, D; Tarradellas, J; Tauxe-Wuersch, A | 1 |
Cañada-Cañada, F; Espinosa-Mansilla, A; González Gómez, D; Muñoz de la Peña, A | 1 |
Yamamoto, Y; Yokobori, S; Yokota, H | 1 |
Aberer, W; Arbab, E; Grims, R; Komericki, P; Kränke, B | 1 |
Baba, A; Yoshioka, T | 1 |
Atherton, J; Bauman, J; Kohl, C; Lam, W; Lou, Z; Mutlib, A; Reily, M; Walker, GS | 1 |
Nogueira, JM; Portugal, FC; Silva, AR | 1 |
Obach, RS | 1 |
Hata, T; Kawai, S; Nishida, T; Okamura, H | 1 |
El-Kabbani, O; Endo, S; Hara, A; Matsunaga, T; Soda, M; Tajima, K; Zhao, HT | 1 |
Sato, K; Takahashi, H; Toriyama, M | 1 |
Bhavsar, R; Dhaneshwar, S; Mahadik, M | 1 |
Commandeur, JN; Elias, NS; Hendriks, DF; Venkataraman, H; Vermeulen, NP; Vos, JC; Vredenburg, G | 1 |
Bondesson, U; Hansson, A; Hedeland, M; Hellqvist, A; Rydevik, A | 1 |
Eguchi, S; Hasegawa, S; Nakano, E; Okada, K; Sunagawa, A; Tanaka, M; Yamamoto, F; Yamamoto, R; Yokota, H | 1 |
Manzo, V; Pereira, E; Richter, P; Rodríguez, I; Ulisse, K | 1 |
Krajewska, J; Laudy, AE; Mrowka, A; Tyski, S | 1 |
Abubakr, NH; Elzaki, WM; Ibrahim, YE; Ziada, HM | 1 |
Choo, YW; Fernández, C; Lim, SH; Mariño, EL; Modamio, P; Ooi, IH; Segarra, I; Tan, SY; Tiew, AL; Wong, MM | 1 |
Asl, YA; Rezazadeh, M; Seidi, S; Yamini, Y | 1 |
Cooper, G; Crichton, S; Eddleston, M; Kamour, A; Lupton, DJ; Thomas, SH; Thompson, JP; Vale, JA | 1 |
Chan, EWL; Raja, I; Yap, JKY; Yee, ZY | 1 |
Arghavani-Beydokhti, S; Asghari, A; Rajabi, M | 1 |
Chang, CH; Dong, YH; Hwang, JS; Toh, S; Wu, LC | 1 |
Caglar, B; Caglar, S; Dilek, E; Erdogan, K; Sahin, O | 1 |
Chang, CC; Chen, YR; Chi, NF; Chiou, HY; Hsieh, FI; Wu, HC | 1 |
Asiabi, H; Shamsayei, M; Yamini, Y | 1 |
Kao Yang, YH; Kubota, K; Lai, EC; Man, KKC; Park, BJ; Pratt, N; Roughead, EE; Setoguchi, S; Shin, JY; Wong, ICK | 1 |
Drewes, JE; Grassmann, J; Grosse, S; Letzel, T; Stadlmair, LF | 1 |
Dimitriou, A; Fotiadou, P; Hatzidimitriou, AG; Papadopoulos, AN; Perontsis, S; Psomas, G | 1 |
Sanàti, SE; Seidi, S | 1 |
Escobedo-Hinojosa, W; Hauer, B; Klenk, JM; Kontny, LH; Nebel, BA | 1 |
Abed, A; Abu-Shalhoob, M; Jarrar, Q; Jarrar, Y; Sha'ban, E | 1 |
Doroudian, M; Seidi, S | 1 |
Ghani, M | 1 |
Abdessayed, N; Ben Salem, C; Ben-Sayed, N; Fathallah, N; Ouni, B; Slim, R | 1 |
Hadjmohammadi, MR; Jafari, Z | 1 |
Brito, NM; Esteves, VI; Freitas, AS; Lima, DLD; Rangel, JHG; Silva, GS; Silva, LK; Sousa, ÉML; Sousa, ER | 1 |
Darvishnejad, F; Ghani, M; Raoof, JB | 1 |
Hall, CD; Jones Lipinski, RA; Katritzky, AR; Morisseau, C; Sebastiano, CS; Smith, BC; Thillier, Y | 1 |
Iqubal, MA; Jayam, C; Nazeer, J; Singh, R; Singh, S | 1 |
Ohkura, K; Tabata, A; Tatematsu, Y | 1 |
Fukushima, T; Hara-Yamamura, H; Nakashima, K; Okabe, S | 1 |
Ikushiro, S; Iwai, Y; Nishikawa, M; Sakaki, T; Sugimoto, H; Takita, T; Yasuda, K; Yasukawa, K; Yogo, Y | 1 |
4 review(s) available for diclofenac and mefenamic acid
Article | Year |
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UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship | 2016 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Side effects of non-steroidal antirheumatic agents in the lower gastrointestinal tract].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diclofenac; Female; Humans; Male; Mefenamic Acid; Middle Aged; Proctitis; Salicylates | 1987 |
6 trial(s) available for diclofenac and mefenamic acid
Article | Year |
---|---|
Mefenamic acid compared with diclofenac sodium in elderly patients with osteoarthritis.
Topics: Aged; Aged, 80 and over; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Mefenamic Acid; Middle Aged; Osteoarthritis | 1988 |
A comparative crossover study of piroxicam vs. mefenamic acid and diclofenac in France.
Topics: Adult; Clinical Trials as Topic; Diclofenac; Dysmenorrhea; Female; Humans; Mefenamic Acid; Piroxicam | 1986 |
Mefenamic acid and diclofenac sodium in osteoarthritis of the weight bearing joints: a double blind comparison.
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Humans; Male; Mefenamic Acid; Middle Aged; Osteoarthritis; Phenylacetates | 1985 |
Local anaesthetic on Filshie clips for pain relief after tubal sterilisation: a randomised double-blind controlled trial.
Topics: Adult; Cyclizine; Diclofenac; Double-Blind Method; Female; Gels; Humans; Laparoscopy; Lidocaine; Mefenamic Acid; Morphine; Nausea; Pain Measurement; Pain, Postoperative; Patient Discharge; Pelvic Pain; Placebos; Sterilization, Tubal; Surface Properties; Vomiting | 1995 |
Comparative bioavailability of two capsule formulations of mefenamic acid.
Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Diclofenac; Humans; Male; Mefenamic Acid; Regression Analysis; Therapeutic Equivalency; Time Factors | 1997 |
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Humans; Ibuprofen; Lidocaine; Male; Mefenamic Acid; Pain; Pain Measurement; Pain, Postoperative; Placebos; Pulpitis; Root Canal Preparation; Root Canal Therapy | 2016 |
80 other study(ies) available for diclofenac and mefenamic acid
Article | Year |
---|---|
Thyroid hormone uptake by hepatocytes: structure-activity relationships of phenylanthranilic acids with inhibitory activity.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Flufenamic Acid; Liver; Liver Neoplasms, Experimental; Meclofenamic Acid; Mefenamic Acid; Molecular Structure; ortho-Aminobenzoates; Rats; Structure-Activity Relationship; Triiodothyronine; Tumor Cells, Cultured | 1993 |
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Flurbiprofen; Mice; Peptide Fragments | 2006 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship | 2012 |
Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat.
Topics: Animals; Biotransformation; Chromatography, Liquid; Glutathione; Hepatocytes; Humans; In Vitro Techniques; Mefenamic Acid; Rats; Tandem Mass Spectrometry | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2014 |
Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Diabetes Complications; Diabetes Mellitus; Enzyme Inhibitors; Humans; Inflammation | 2015 |
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine max; Hyperlipidemias; Indoleacetic Acids; Lipoxygenase Inhibitors; Polyethylene Glycols; Propanols; Propionates; Rats; Thioctic Acid | 2015 |
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hyperlipidemias; Hypolipidemic Agents; Morpholines; Rats; Triglycerides | 2016 |
N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.
Topics: Animals; Calcium Signaling; Cinnamates; Guinea Pigs; HEK293 Cells; Humans; Male; Molecular Docking Simulation; ortho-Aminobenzoates; Structure-Activity Relationship; TRPA1 Cation Channel | 2019 |
The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Crystallography, X-Ray; Drug Design; Folic Acid; Folic Acid Antagonists; Humans; Models, Molecular; Tetrahydrofolate Dehydrogenase | 2020 |
Characterization of cytoplasmic T3 binding sites by adsorption to hydroxyapatite: effects of drug inhibitors of T3 and relationship to glutathione-S-transferases.
Topics: Amiodarone; Animals; Binding Sites; Binding, Competitive; Cytosol; Diclofenac; Dithiothreitol; Dose-Response Relationship, Drug; Durapatite; Furosemide; Glutathione Transferase; Hydrocortisone; Hydroxyapatites; In Vitro Techniques; Iopanoic Acid; Liver; Macaca fascicularis; Mefenamic Acid; Sulfobromophthalein; Taurocholic Acid; Triiodothyronine | 1992 |
[Inhibition of thrombocyte function by non-steroidal anti-rheumatic agents: a comparative study between diclofenac, acemetacin, mefenamic acid and ibuprofen].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Indomethacin; Malondialdehyde; Mefenamic Acid; Platelet Aggregation; Thromboxanes | 1991 |
Characterization of the binding of thyroxine to high density lipoproteins and apolipoproteins A-I.
Topics: Apolipoprotein A-I; Apolipoproteins A; Autoradiography; Binding Sites; Diclofenac; Furosemide; Lipoproteins, HDL; Lipoproteins, VLDL; Mefenamic Acid; Temperature; Thyroid Hormones; Thyroxine; Thyroxine-Binding Proteins; Time Factors | 1989 |
Stress by restraining potentiates morphine catalepsy in rats.
Topics: 5,6-Dihydroxytryptamine; Animals; Benserazide; Catalepsy; Diclofenac; Ditiocarb; Drug Interactions; Fenclonine; Hemicholinium 3; Levodopa; Male; Mefenamic Acid; Morphine; Naloxone; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Physiological | 1985 |
The effect of diphenylamine derivatives on arachidonic acid metabolism in rat peritoneal macrophages.
Topics: Aniline Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Chromatography, High Pressure Liquid; Diclofenac; Dinoprostone; Diphenylamine; Macrophages; Male; Mefenamic Acid; ortho-Aminobenzoates; Peritoneal Cavity; Prostaglandins E; Radioimmunoassay; Rats; Rats, Inbred Strains | 1987 |
Effect of free fatty acids and nonlipid inhibitors of thyroid hormone binding in the immunoradiometric assay of thyroxin-binding globulin.
Topics: Binding, Competitive; Diclofenac; False Negative Reactions; Fatty Acids, Nonesterified; Furosemide; Humans; Mefenamic Acid; Phenylacetates; Radioimmunoassay; Reagent Kits, Diagnostic; Thyroxine; Thyroxine-Binding Proteins | 1987 |
Furosemide, fenclofenac, diclofenac, mefenamic acid and meclofenamic acid inhibit specific T3 binding in isolated rat hepatic nuclei.
Topics: Amiodarone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Nucleus; Diclofenac; Furosemide; In Vitro Techniques; Liver; Male; Meclofenamic Acid; Mefenamic Acid; Phenylacetates; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Thyroid Hormone | 1988 |
[Segmental small intestine lesions after taking non-steroidal antirheumatic drugs].
Topics: Abdominal Pain; Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Diclofenac; Humans; Intestinal Diseases; Intestine, Small; Jejunal Diseases; Jejunum; Laparoscopy; Male; Mefenamic Acid; Middle Aged; Time Factors; Tomography, X-Ray Computed; Ulcer | 1995 |
Serious adverse effects induced by simultaneous administration of two nonsteroidal anti-inflammatory drugs.
Topics: Acute Kidney Injury; Agranulocytosis; Anemia, Hemolytic; Diclofenac; Drug Therapy, Combination; Female; Headache; Humans; Mefenamic Acid; Middle Aged | 1993 |
Characterization of thyroid hormone binding to apolipoprotein-E: localization of the binding site in the exon 3-coded domain.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Apolipoproteins E; Binding Sites; Blood Proteins; Diclofenac; Exons; Furosemide; Isoelectric Focusing; Mefenamic Acid; Mice; Molecular Sequence Data; Mutation; Photochemistry; Thyroxine | 1993 |
Do non-steroidal anti-inflammatory drugs have an effect on gastric cell turnover?
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Bromodeoxyuridine; Cell Division; Diclofenac; Gastric Mucosa; Gastroscopy; Humans; Ibuprofen; Immunohistochemistry; Indomethacin; Mefenamic Acid; Naproxen; Pyloric Antrum | 1995 |
In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat kidney mitochondria: respiration and ATP synthesis.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dipyrone; Kidney Cortex; Kinetics; Male; Mefenamic Acid; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Piroxicam; Rats; Rats, Wistar; Uncoupling Agents | 1996 |
Diclofenac sodium and mefenamic acid: potent inducers of the membrane permeability transition in renal cortex mitochondria.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclosporine; Diclofenac; Kidney Cortex; Lipid Peroxidation; Male; Mefenamic Acid; Mitochondria; Mitochondrial Swelling; Oxidation-Reduction; Permeability; Rats; Rats, Wistar; Salicylates; Salicylic Acid; Sulfhydryl Compounds | 1997 |
Premature closure of the fetal ductus arteriosus after maternal use of non-steroidal anti-inflammatory drugs. Adverse Drug Reactions Advisory Committee.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Australia; Diclofenac; Ductus Arteriosus; Female; Fetal Diseases; Humans; Indomethacin; Mefenamic Acid; Pregnancy | 1998 |
Influence of nonsteroidal anti-inflammatory drugs on calcium efflux in isolated rat renal cortex mitochondria and aspects of the mechanisms involved.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclosporine; Diclofenac; Dipyrone; Ibuprofen; In Vitro Techniques; Ion Transport; Kidney Cortex; Male; Mefenamic Acid; Mitochondria; NAD; NADP; Oxidation-Reduction; Piroxicam; Rats; Rats, Wistar; Salicylic Acid | 1998 |
Competition of tamoxifen with thyroxine for TBG binding: ligand binding assay and computational data.
Topics: Binding, Competitive; Diclofenac; Furosemide; Humans; Mefenamic Acid; Models, Molecular; Molecular Conformation; Tamoxifen; Thyroxine; Thyroxine-Binding Proteins | 2001 |
Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Graphics; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Energy Transfer; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Ketoprofen; Meclofenamic Acid; Mefenamic Acid; Membrane Proteins; Models, Molecular; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
Dendrimers of citric acid and poly (ethylene glycol) as the new drug-delivery agents.
Topics: Biocompatible Materials; Citric Acid; Delayed-Action Preparations; Diclofenac; Diffusion; Drug Carriers; Drug Delivery Systems; Drug Stability; Materials Testing; Mefenamic Acid; Mesalamine; Polyethylene Glycols; Polymers; Pyridines | 2005 |
[Acute renal failure--"a well meant present from a friend"].
Topics: Acute Kidney Injury; Administration, Cutaneous; Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Cross Reactions; Diclofenac; Drug Hypersensitivity; Female; Humans; Kidney; Mefenamic Acid; Nephritis, Interstitial; Recurrence | 2004 |
Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood-Brain Barrier; Brain; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Male; Mefenamic Acid; Mice; Organic Anion Transporters, Sodium-Independent; Probenecid; Protein Binding; Shiga Toxin 2 | 2005 |
Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Clofibric Acid; Diclofenac; Environmental Monitoring; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Mefenamic Acid; No-Observed-Adverse-Effect Level; Risk Assessment; Sewage; Switzerland; Waste Disposal, Fluid; Water Pollutants, Chemical | 2005 |
Determinations of fluoroquinolones and nonsteroidal anti-inflammatory drugs in urine by extractive spectrophotometry and photoinduced spectrofluorimetry using multivariate calibration.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Analytical; Ciprofloxacin; Diclofenac; Fluoroquinolones; Humans; Least-Squares Analysis; Mefenamic Acid; Ofloxacin; Photochemistry; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet | 2005 |
Pediatric posterior reversible leukoencephalopathy syndrome and NSAID-induced acute tubular interstitial nephritis.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Back Injuries; Back Pain; Cerebral Cortex; Child; Diclofenac; Drug Therapy, Combination; Follow-Up Studies; Humans; Hypertensive Encephalopathy; Image Enhancement; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Mefenamic Acid; Nephritis, Interstitial; Occipital Lobe; Parietal Lobe; Remission, Spontaneous; Wounds, Nonpenetrating | 2006 |
Tryptase as severity marker in drug provocation tests.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Diclofenac; Drug Hypersensitivity; Female; Humans; Lidocaine; Male; Mefenamic Acid; Middle Aged; Ofloxacin; Penicillins; Prospective Studies; Serine Endopeptidases; Tryptases | 2006 |
Synthesis of 1-beta-O-acyl glucuronides of diclofenac, mefenamic acid and (S)-naproxen by the chemo-selective enzymatic removal of protecting groups from the corresponding methyl acetyl derivatives.
Topics: Acylation; Carbohydrate Conformation; Chromatography, High Pressure Liquid; Diclofenac; Glucuronides; Hydrolysis; Kinetics; Mefenamic Acid; Methylation; Models, Molecular; Naproxen | 2006 |
Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy.
Topics: Acylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Chromatography, Liquid; Cyclooxygenase Inhibitors; Diclofenac; Drug Stability; Flufenamic Acid; Glucuronides; Half-Life; Ibuprofen; Indomethacin; Kinetics; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mefenamic Acid; Molecular Structure; Rats; Rats, Sprague-Dawley; Stereoisomerism; Technology, Pharmaceutical; Tolmetin | 2007 |
Advances in stir bar sorptive extraction for the determination of acidic pharmaceuticals in environmental water matrices Comparison between polyurethane and polydimethylsiloxane polymeric phases.
Topics: Chromatography, High Pressure Liquid; Diclofenac; Dimethylpolysiloxanes; Gemfibrozil; Ibuprofen; Mefenamic Acid; Naproxen; Polyurethanes; Reproducibility of Results; Water Pollutants, Chemical; Water Purification | 2008 |
Glycerolysis of acyl glucuronides as an artifact of in vitro drug metabolism incubations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Artifacts; Biological Assay; Biotransformation; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Diclofenac; Glucuronates; Glucuronides; Glycerol; Humans; In Vitro Techniques; Mass Spectrometry; Mefenamic Acid; Microsomes, Liver; Naproxen; Propionates; Tolmetin; Uridine Diphosphate Glucuronic Acid | 2009 |
Removal of diclofenac and mefenamic acid by the white rot fungus Phanerochaete sordida YK-624 and identification of their metabolites after fungal transformation.
Topics: Biodegradation, Environmental; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Diclofenac; Enzyme Inhibitors; Mefenamic Acid; Phanerochaete; Triazoles | 2010 |
Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Amino Acids; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Diclofenac; Enzyme Inhibitors; Fenamates; Flavonoids; Glycyrrhetinic Acid; Humans; Mefenamic Acid; Mutation; NADP; Plant Extracts; Substrate Specificity | 2010 |
Depigmenting mechanism of NSAIDs on B16F1 melanoma cells.
Topics: alpha-MSH; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Intramolecular Oxidoreductases; Mefenamic Acid; Melanins; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Oxidoreductases; Pigmentation Disorders; Skin Pigmentation; Sulfonamides | 2011 |
A high performance liquid chromatography-tandem mass spectrometric method for the determination of mefenamic acid in human plasma: application to pharmacokinetic study.
Topics: Acetates; Anticoagulants; Area Under Curve; Chromatography, High Pressure Liquid; Diclofenac; Drug Stability; Humans; Hydrogen-Ion Concentration; Linear Models; Liquid-Liquid Extraction; Male; Mefenamic Acid; Methanol; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.
Topics: Activation, Metabolic; Catalysis; Cell Line; Diclofenac; Glutathione; Glutathione S-Transferase pi; Humans; Imines; Mefenamic Acid; NAD(P)H Dehydrogenase (Quinone); Quinones | 2014 |
A novel trapping system for the detection of reactive drug metabolites using the fungus Cunninghamella elegans and high resolution mass spectrometry.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cunninghamella; Diclofenac; Humans; Mefenamic Acid; Microsomes, Liver; Tandem Mass Spectrometry | 2015 |
Assessment of in vitro antiovulatory activities of nonsteroidal anti-inflammatory drugs and comparison with in vivo reproductive toxicities of medaka (Oryzias latipes).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Female; Humans; Ketoprofen; Mefenamic Acid; Oryzias; Ovary; Ovulation; Ovum; Reproduction; Salicylic Acid; Water Pollutants, Chemical | 2016 |
A molecularly imprinted polymer as the sorptive phase immobilized in a rotating disk extraction device for the determination of diclofenac and mefenamic acid in wastewater.
Topics: Acetamides; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Limit of Detection; Mefenamic Acid; Molecular Imprinting; Organosilicon Compounds; Polymers; Solid Phase Extraction; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2015 |
The Influence of Efflux Pump Inhibitors on the Activity of Non-Antibiotic NSAIDS against Gram-Negative Rods.
Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Escherichia coli; Gram-Negative Bacteria; Ibuprofen; Mefenamic Acid; Microbial Sensitivity Tests; Naproxen | 2016 |
Sunitinib DDI with paracetamol, diclofenac, mefenamic acid and ibuprofen shows sex-divergent effects on the tissue uptake and distribution pattern of sunitinib in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrier Proteins; Diclofenac; Drug Interactions; Female; Ibuprofen; Indoles; Male; Mefenamic Acid; Mice; Mice, Inbred ICR; Pyrroles; Sex Characteristics; Sunitinib; Tissue Distribution | 2016 |
Simultaneous extraction of acidic and basic drugs via on-chip electromembrane extraction.
Topics: Betaxolol; Diclofenac; Electrochemical Techniques; Mefenamic Acid; Microfluidic Analytical Techniques; Molecular Structure | 2016 |
Central nervous system toxicity of mefenamic acid overdose compared with other NSAIDs: an analysis of cases reported to the United Kingdom National Poisons Information Service.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Diclofenac; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Ibuprofen; Infant; Infant, Newborn; Logistic Models; Male; Mefenamic Acid; Middle Aged; Multivariate Analysis; Naproxen; Neurotoxicity Syndromes; Poison Control Centers; Sex Factors; United Kingdom; Young Adult | 2017 |
Synergistic effect of non-steroidal anti-inflammatory drugs (NSAIDs) on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cefuroxime; Chloramphenicol; Diclofenac; Drug Combinations; Drug Interactions; Drug Resistance, Multiple, Bacterial; Drug Synergism; Ibuprofen; Mefenamic Acid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Staphylococcus aureus | 2017 |
Coupling of two centrifugeless ultrasound-assisted dispersive solid/liquid phase microextractions as a highly selective, clean, and efficient method for determination of ultra-trace amounts of non-steroidal anti-inflammatory drugs in complicated matrices.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Hydrogen-Ion Concentration; Hydroxides; Ibuprofen; Limit of Detection; Liquid Phase Microextraction; Mefenamic Acid; Nanotubes, Carbon; Solid Phase Microextraction; Solvents; Ultrasonic Waves; Wastewater | 2018 |
Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular System; Celecoxib; Cyclooxygenase 2 Inhibitors; Databases, Pharmaceutical; Diclofenac; Female; Hospitalization; Humans; Hypertension; Ibuprofen; Male; Mefenamic Acid; Middle Aged; Naproxen; Risk Factors | 2018 |
Synthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1-(2-aminoethyl)pyrrolidine, diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity.
Topics: Aryldialkylphosphatase; Coordination Complexes; Diclofenac; Humans; Mefenamic Acid; Palladium; Platinum; Pyrrolidines | 2018 |
Effect on Risk of Stroke and Acute Myocardial Infarction of Nonselective Nonsteroidal Anti-Inflammatory Drugs in Patients With Rheumatoid Arthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Diclofenac; Female; Humans; Ibuprofen; Logistic Models; Male; Mefenamic Acid; Meloxicam; Middle Aged; Myocardial Infarction; Odds Ratio; Risk Factors; Stroke | 2018 |
Development of electrochemically controlled packed-in-tube solid phase microextraction method for sensitive analysis of acidic drugs in biological samples.
Topics: Diclofenac; Electrochemical Techniques; Humans; Mefenamic Acid; Particle Size; Solid Phase Microextraction | 2018 |
Comparative safety of NSAIDs for gastrointestinal events in Asia-Pacific populations: A multi-database, international cohort study.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Australia; Celecoxib; Databases, Factual; Diclofenac; Female; Follow-Up Studies; Gastrointestinal Diseases; Hong Kong; Hospitalization; Humans; Incidence; Japan; Male; Mefenamic Acid; Phenylpropionates; Republic of Korea; Taiwan | 2018 |
Comprehensive MS-based screening and identification of pharmaceutical transformation products formed during enzymatic conversion.
Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Laccase; Mass Spectrometry; Mefenamic Acid; Molecular Structure; Peroxidase; Sotalol | 2019 |
Cobalt(II) complexes with the non-steroidal anti-inflammatory drug diclofenac and nitrogen-donor ligands.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cobalt; Coordination Complexes; Diclofenac; Intercalating Agents; Ligands; Mefenamic Acid; Molecular Structure; Nitrogen | 2019 |
Nickel-iron layered double hydroxide nanostructures for micro solid phase extraction of nonsteroidal anti-inflammatory drugs, followed by quantitation by HPLC-UV.
Topics: Adsorption; Alloys; Anti-Inflammatory Agents, Non-Steroidal; Biosensing Techniques; Chromatography, High Pressure Liquid; Diclofenac; Humans; Hydroxides; Ibuprofen; Iron; Limit of Detection; Mefenamic Acid; Metal Nanoparticles; Naproxen; Nickel; Reproducibility of Results; Solid Phase Microextraction; Surface Properties | 2019 |
Oxyfunctionalization of nonsteroidal anti-inflammatory drugs by filamentous-fungi.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Basidiomycota; Cytochrome P-450 Enzyme System; Diclofenac; Fungi; Ibuprofen; Mefenamic Acid; Mucor; Naproxen; Proteomics | 2019 |
Relative Expression of Mouse Udp-glucuronosyl Transferase 2b1 Gene in the Livers, Kidneys, and Hearts: The Influence of Nonsteroidal Anti-inflammatory Drug Treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Glucuronosyltransferase; Ibuprofen; Kidney; Liver; Male; Mefenamic Acid; Meloxicam; Mice, Inbred BALB C; Myocardium | 2019 |
Electrospun NiFe layered double hydroxide/Nylon 6 composite nanofibers as a sorbent for micro solid phase extraction by packed sorbent of non-steroidal anti-inflammatory drugs in human blood.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Caprolactam; Chromatography, High Pressure Liquid; Diclofenac; Humans; Hydroxides; Iron; Limit of Detection; Mefenamic Acid; Nanofibers; Naproxen; Nickel; Polymers; Solid Phase Microextraction | 2020 |
Nanocrystalline cellulose as a biotemplate for preparation of porous titania thin film as a sorbent for thin film microextraction of ketorolac, meloxicam, diclofenac and mefenamic acid.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Chromatography, High Pressure Liquid; Diclofenac; Female; Humans; Ketorolac; Limit of Detection; Male; Mefenamic Acid; Meloxicam; Membranes, Artificial; Middle Aged; Nanoparticles; Porosity; Solid Phase Microextraction; Titanium | 2020 |
Fixed drug eruption (FDE) induced by mefenamic acid with unusually cross-reactivity to diclofenac: A case report.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Eruptions; Humans; Mefenamic Acid | 2021 |
A banana peel/silicon glue coated stir bar for extraction of aspirin, diclofenac, ibuprofen and mefenamic acid followed by high performance liquid chromatography-UV detection.
Topics: Aspirin; Chromatography, High Pressure Liquid; Diclofenac; Humans; Ibuprofen; Mefenamic Acid; Musa; Reproducibility of Results; Silicon; Spectrophotometry, Ultraviolet | 2020 |
Solidified floating organic drop microextraction (SFODME) for the simultaneous analysis of three non-steroidal anti-inflammatory drugs in aqueous samples by HPLC.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Organic; Chromatography, High Pressure Liquid; Diclofenac; Dodecanol; Hydrogen-Ion Concentration; Ions; Limit of Detection; Linear Models; Liquid Phase Microextraction; Mefenamic Acid; Methanol; Naproxen; Osmolar Concentration; Pharmaceutical Preparations; Reproducibility of Results; Seawater; Solvents; Temperature; Water; Water Pollutants, Chemical | 2021 |
In-situ synthesis of nanocubic cobalt oxide @ graphene oxide nanocomposite reinforced hollow fiber-solid phase microextraction for enrichment of non-steroidal anti-inflammatory drugs from human urine prior to their quantification via high-performance liqu
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cobalt; Diclofenac; Female; Graphite; Humans; Ibuprofen; Limit of Detection; Male; Mefenamic Acid; Nanocomposites; Oxides; Solid Phase Microextraction; Ultraviolet Rays | 2021 |
Molecular docking-guided synthesis of NSAID-glucosamine bioconjugates and their evaluation as COX-1/COX-2 inhibitors with potentially reduced gastric toxicity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Drug Design; Glucosamine; Glycoconjugates; Mefenamic Acid; Molecular Docking Simulation; Protein Binding; Protein Conformation; Stomach; Structure-Activity Relationship | 2021 |
Assessment of C-reactive Protein Level and Efficacy of Diclofenac Sodium and Mefenamic Acid in Relieving Pain in Mandibular Impacted Third Molar Surgery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; C-Reactive Protein; Diclofenac; Double-Blind Method; Humans; Mefenamic Acid; Molar, Third; Pain, Postoperative; Tooth Extraction; Tooth, Impacted; Treatment Outcome | 2021 |
Construction of a Drug Release Evaluation System: Application of Mitochondrial Respiration to Monitor Drug Release.
Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Respiration; Diclofenac; Drug Carriers; Drug Liberation; Mefenamic Acid; Mitochondria, Liver; Nitriles; Oxygen; Rats; Uncoupling Agents | 2021 |
Transcriptomic response of HepG2 cells exposed to three common anti-inflammatory drugs: Ketoprofen, mefenamic acid, and diclofenac in domestic wastewater effluents.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Hep G2 Cells; Humans; Ketoprofen; Mefenamic Acid; Pharmaceutical Preparations; Transcriptome; Wastewater; Water Pollutants, Chemical | 2022 |
Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Proteins; Cytochrome P-450 Enzyme System; Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Meclofenamic Acid; Mefenamic Acid; Streptomyces | 2022 |