diclofenac has been researched along with indomethacin in 499 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 138 (27.66) | 18.7374 |
| 1990's | 133 (26.65) | 18.2507 |
| 2000's | 101 (20.24) | 29.6817 |
| 2010's | 104 (20.84) | 24.3611 |
| 2020's | 23 (4.61) | 2.80 |
| Authors | Studies |
|---|---|
| Boettcher, I; Elger, W; Kirsch, G; Siegmund, F; Wachtel, H | 1 |
| Baggiolini, M; Closse, A; Dewald, B; Gubler, HU; Haefliger, W; Hauser, D | 1 |
| Casler, JJ; Collins, PW; Gregory, SA; Isakson, PC; Khanna, IK; Koboldt, CM; Koszyk, FJ; Masferrer, JL; Perkins, WE; Seibert, K; Veenhuizen, AW; Weier, RM; Xu, XD; Yu, Y; Zhang, YY | 1 |
| Graves, P; Kuze, K; Leahy, A; Stuhlmann, H; Wilson, P; You, G | 1 |
| Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S | 1 |
| Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Ethier, D; Evans, JF; Ford-Hutchinson, AW; Gauthier, JY; Gordon, R; Gresser, M; Guay, J; Kargman, S; Kennedy, B; Leblanc, Y; Léger, S; Mancini, J; O'Neill, GP; Ouellet, M; Percival, MD; Perrier, H; Prasit, P; Riendeau, D; Rodger, I; Wang, Z; Zamboni, R | 1 |
| Cha, SH; Endou, H; Kanai, Y; Kim, DK; Kim, JY; Kusuhara, H; Sekine, T; Sugiyama, Y; Yu, E | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Cihlar, T; Ho, ES; Mulato, AS | 1 |
| Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T | 1 |
| Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Beroza, P; Cai, D; Damodaran, K; Gomez, RF; Hsu, N; Keck, JG; Laborde, E; Lum, RT; Macke, TJ; Martin, G; Schow, SR; Simon, RJ; Villar, HO; Wick, MM | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Bain, G; Beher, D; Chen, W; Jiang, X; Munoz, B; Peachey, J; Prasit, P; Shearman, MS; St-Jacques, R; Stock, N; Williamson, TL; Wrigley, JD | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 2 |
| Blobaum, AL; Marnett, LJ | 2 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Barreiro, EJ; Fraga, CA; Lima, LM; Romeiro, NC; Sant'Anna, CM | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Allegretti, M; Aramini, A; Aschi, M; Bertini, R; Bizzarri, C; Cesta, MC; Crucianelli, M; Di Bitondo, R; Di Giacinto, C; Gloaguen, I; Moriconi, A; Sablone, MR | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Bhandari, SV; Bothara, KG; Dangre, SC; Deshmane, BJ; Gore, ST; Khachane, CV; Lokwani, DK; Patil, AA; Raparti, VT; Sarkate, AP | 1 |
| Board, PG; Christ, AN; Clark, AG; Flanagan, JU; Hall, R; Hayes, JD; Hume, DA; Oakley, AJ; Smythe, ML; Weber, JE | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Alcaro, S; Bolasco, A; Cirilli, R; Fioravanti, R; Manna, F; Orallo, F; Ortuso, F; Rossi, F | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Kumar, M; Sinha, VR; Thareja, S | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Furukawa, T; Hosoya, K; Kadono, K; Moriguchi, H; Nakamori, F; Naritomi, Y; Teramura, T; Terashita, S; Tetsuka, K; Yamano, K | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Bhatti, R; Sharma, S; Singh, P | 1 |
| Kourounakis, AP; Matralis, AN | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Bhatti, R; Kaur, M; Sharma, S; Singh, A; Singh, P | 1 |
| Bhatti, R; Dhillon, P; Prasher, P; Singh, P | 1 |
| Blair, A; Boyd, M; Chalmers, AJ; Malviya, G; Pimlott, SL; Sutherland, A; Zmuda, F | 1 |
| Kourounakis, PN; Kourti, M; Rekka, EA; Theodosis-Nobelos, P; Tziona, P | 1 |
| Bennis, K; Ducki, S; Lesage, F; Vivier, D | 1 |
| Gavalas, A; Kourti, M; Rekka, EA; Theodosis-Nobelos, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bhatti, R; Kaur, J; Kaur, S; Singh, G; Singh, P | 1 |
| Arnsmann, M; Elfringhoff, AS; Hanekamp, W; Lehr, M | 1 |
| Abdelall, EKA; Ali, WAM; Azouz, AA; Elshemy, HAH; Moawad, A; Safwat, NM | 1 |
| Katselou, MG; Kourounakis, AP; Matralis, AN | 1 |
| Bernardino, AMR; Boechat, N; Dos Santos, MS; Faria, JV; Miguita, AGC; Vegi, PF | 1 |
| Abdel-Ghany, YS; Alaaeddine, R; Alaeddine, LM; Belal, ASF; El-Yazbi, AF; Hazzaa, A; Ismail, A; Moussa, G; Nassra, R | 1 |
| Alcaro, S; Angeli, A; Angius, R; Bianco, G; Capasso, C; Cottiglia, F; Del Prete, S; Deplano, S; Distinto, S; Fois, B; Gaspari, M; Maccioni, E; Meleddu, R; Melis, C; Ortuso, F; Supuran, CT; Taverna, D; Yanez, M | 1 |
| Abu-Serie, MM; AlFadly, ED; Bakkar, NZ; Bartolini, M; Belal, ASF; El-Yazbi, AF; Elkazaz, S; Elzahhar, PA; Ghareeb, DA; Iriepa, I; Janockova, J; Kobeissy, F; Moraleda, I; Rafeh, RW; Saudi, MNS; Shaltout, H; Soukup, O; Tramarin, A | 1 |
| Alaaeddine, R; Belal, ASF; Bruning, JB; Chua, BSK; El-Yazbi, AF; Elzahhar, PA; Frkic, RL; Ibrahim, TM; Ismail, A; Knape, T; Labib, H; Nassra, R; von Knethen, A; Wallner, N | 1 |
| Abid, OU; Ahmad, A; Ahmad, S; Ayaz, M; Hussain, F; Jan, MS; Mahmood, F; Rashid, U; Sadiq, A; Ullah, F | 1 |
| Bhatti, R; Kaur, J; Kaur, S; Kumari, P; Singh, P | 1 |
| Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K | 1 |
| Neha, K; Wakode, S | 1 |
| Bhatti, R; Kaur, J; Kumari, P; Singh, P | 1 |
| Kawai, K; Kuzuna, S; Morimoto, S | 1 |
| Bhattacharya, SK; Keshary, PR; Sanyal, AK | 1 |
| Dürrigl, T; Miko, M; Pucar, I; Vitaus, M | 1 |
| Fredholm, BB; Granström, E; Jonsson, CE; Oliw, E; Shimizu, Y | 1 |
| Tsvetkova, ES | 2 |
| Adamska-Dyniewska, H; Goch, JH | 1 |
| Mutru, O; Penttilä, M; Pesonen, J; Salmela, P; Sonck, T; Suhonen, O | 1 |
| Bijlsma, A | 1 |
| Baghiris, D; De Candia, O | 1 |
| Burdeĭnyĭ, AP | 2 |
| Gothoni, G; Rejholec, V; Tokola, O; Vapaatalo, H | 1 |
| Chaudri, HA; Ciccolunghi, SN; Schubiger, BI | 2 |
| Anselmo, G; Cascio, F; Trombetta, N | 1 |
| Barnes, CG; Berry, H; Carter, ME; Downie, WW; Fowler, PD; Moll, JM; Perry, JD; Sawaf, MS; Wright, V | 1 |
| Bonomo, I | 1 |
| Cash, HC; McMahon, MF | 1 |
| Kather, H; Simon, B | 1 |
| Ciccolunghi, SN; Reddrop, R; Schubiger, BI | 1 |
| Ohtsuki, H; Okabe, S; Tabata, K | 1 |
| Mörsdorf, K; Wolf, G | 1 |
| Anggärd, E; Lundén, I; Oliw, E | 1 |
| Ahlberg, KF | 1 |
| Anggård, E; Kövér, G; Larsson, C; Oliw, E | 1 |
| Abdel-Halim, MS; Anggård, E; Sjöquist, B | 1 |
| Eberl, R; Tausch, G; Tuschl, P | 1 |
| Ikeda, S; Tanaka, M; Uchiyama, M | 1 |
| Chan, WY | 1 |
| Hofer, M; Holá, J; Pipalová, I; Pospísil, M; Tkadlecek, L; Viklická, S | 1 |
| Beró, T; Jávor, T; Nagy, L; Vincze, A | 1 |
| Huskisson, EC | 1 |
| Asproudis, I; Kalogeropoulos, C; Loucatzicos, E; Petroutsos, G; Psilas, K | 1 |
| Kaasinen, S; Kalso, E; Perttunen, K | 1 |
| Besana, F; De Benedittis, G; Lorenzetti, A | 1 |
| Dimitrakos, SA; Panidou-Kyriakidou, I; Topouzidis, C | 1 |
| Louisot, P; Mathieu, P; Richard, M; Vignon, E | 1 |
| Freudenthal, Y; Karvonen, J; Kiiskilä, EL; Laitinen, J; Nuutinen, L; Ranta, P | 1 |
| Bright, TP; McNulty, CJ | 1 |
| Pellegrini, P | 1 |
| Carrasco, E; Felipe, A; Grau, M; Guasch, J; Juliá, S; Montero, JL | 2 |
| Kozubík, A; Netíková, J; Pospísil, M | 1 |
| Fernandes, G; Flescher, E; Fossum, D; Gray, PJ; Harper, MJ; Talal, N | 1 |
| Broen, JJ; Cafruny, WA; DesJarlais, SE; Hecht, ML; Jaqua, RA | 1 |
| Raineri-Gerber, I; von Felten, A | 1 |
| Boeckh, C; Otten, U; Pfeilschifter, J; Radeke, H; Steiner, P | 1 |
| Fidler, IJ; Utsugi, T | 1 |
| Collier, S; Ghosh, P | 2 |
| Gribnau, F; van 't Hof, M; van de Putte, L; van Riel, P; Wijnands, M | 1 |
| Chu, TM; Lin, TH; Nakajima, I; Ohnishi, H | 1 |
| Hardingham, TE; Rayan, V | 1 |
| Fukushima, T; Sasaki, H; Sekizawa, K; Takishima, T; Yamauchi, K; Yamaya, M; Zayasu, K | 1 |
| Leyck, S; Parnham, MJ | 1 |
| Blomgren, H; Hammarström, S; Petrini, B; Rotstein, S; Wasserman, J | 2 |
| Baici, A; Lang, A | 1 |
| Rechziegler, H; Thebud-Lassak, R | 1 |
| de Man, P; Engberg, I; Linder, H; Svanborg-Edén, C; van Kooten, C | 1 |
| Bacojanis, C; Beldecos, D; Karabelis, A; Karvounis, N; Kosmidis, P; Milonacis, N; Tsavaris, N; Zinelis, A | 1 |
| el-Sherif, AE; Foda, R; Norlen, LJ; Yahia, H | 1 |
| Gostick, N; James, IG; Khong, TK; Miller, AJ; Roy, P; Shepherd, PR | 1 |
| Crowley, B; Hamill, JJ; Lyndon, S; McKellican, JF; Miller, AJ; Williams, P | 1 |
| Brune, K; Dietzel, K; Nuernberg, B; Schneider, HT | 1 |
| Graf, HP; Pataki, A; Witzemann, E | 1 |
| Brune, K; Jurna, I | 1 |
| Biasco, G; Brandi, G; Di Febo, G; Gizzi, G; Paganelli, GM; Villani, V | 1 |
| Czernielewski, J; Duteil, L; Ortonne, JP; Poncet, M; Queille, C | 1 |
| Montenegro, MA; Palomino, H | 1 |
| Brundig, P; Schlichter, A | 1 |
| Hirasawa, N; Kamo, I; Tsurufuji, S | 1 |
| Dahlén, SE; Hedqvist, P; Raud, J; Sydbom, A | 1 |
| Lewis, GP; O'Neill, LA | 1 |
| Collet, P; Gravagna, B; Later, D; Lejeune, E; Llorca, G | 1 |
| Hurault de Ligny, B; Ryckelynck, JP | 1 |
| Baer, GA; Metsä-Ketelä, T; Miralles, J; Palomäki, E; Rorarius, MG; Vapaatalo, H | 1 |
| Masuda, K; Mishima, H; Miyake, K | 1 |
| Kozubík, A; Netíková, J; Pipalová, I; Pospísil, M | 1 |
| Moilanen, E | 1 |
| Mashiah, V; Meyer, FA; Yaron, I; Yaron, M | 1 |
| Paulus, HE; Schlegel, SI | 1 |
| Berradia, N; Humbert, JC; Marchand-Arvier, M; Vigneron, C | 1 |
| Heldt, R; Hertting, G; Okajima, T | 1 |
| Chew, C; Davis, P; Friman, C; Johnston, C | 1 |
| Keller, F; Krause, PH; Mihatsch, MJ; Offermann, G; Schwarz, A | 1 |
| Jávor, T; Nagy, S; Past, T; Tárnok, F | 1 |
| Sallmann, AR | 1 |
| Hirasawa, N; Ohuchi, K; Sugio, K; Tsurufuji, S; Watanabe, M; Yoshino, S | 1 |
| Hambsch, K; Herrmann, F; Löbe, M; Ludewig, R; Müller, P; Sorger, D | 1 |
| Koide, T; Siesjö, BK; Wieloch, TW | 1 |
| Bassenge, E; Holtz, J; Münzel, T; Stewart, DJ | 1 |
| Quintana, A; Quintana, MA; Raczka, E | 1 |
| Dowling, EJ; Parke, DV; Symons, AM | 1 |
| Pillunat, LE; Stodtmeister, R; Wagner, P | 1 |
| Gribnau, FW; Meyboom, RH; Van den Ouweland, FA | 1 |
| Hayaishi, O; Honda, K; Inoué, S; Naito, K; Osama, H; Ueno, R | 1 |
| Cole, RS; Fry, CH; Shuttleworth, KE | 1 |
| Giroud, JP; Hakim, J; Périanin, A | 1 |
| Bray, MA; Hengstler, B; Rich, R; Tomasz, A; Tuomanen, E; Zak, O | 1 |
| Ali, M; Angelo-Khattar, M; Thulesius, O | 1 |
| de Jong, PE; de Zeeuw, D; Donker, AJ; Pratt, JJ; van der Hem, GK; Vriesendorp, R | 1 |
| Zuckner, J | 1 |
| Altman, R | 1 |
| Calabro, JJ | 1 |
| Broggini, M; Garagiola, U; Grossi, E; Marconi, A | 1 |
| Khan, MA | 2 |
| Börner, RH; Brundig, P | 1 |
| Hansson, BG; Hedner, T; Nilsson, G; Petersson, I | 1 |
| Berbatis, CG; Hurley, SF | 1 |
| Brune, K | 2 |
| Bauer, HC; Brosjö, O; Nilsson, OS; Törnkvist, H | 1 |
| Ivlev, AS; Polunina, TE | 1 |
| Allegue, F; Ledo, A; Rocamora, A; Sendagorta, E | 1 |
| Grom, VV | 1 |
| DeLong, RE; Phillis, JW; Towner, JK | 1 |
| Isomäki, H; Laitinen, O; Nissilä, M; Nuotio, P; Nykänen, E; Seppälä, E; Vapaatalo, H | 1 |
| Rainsford, KD | 1 |
| Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D | 1 |
| Arakawa, T; Fukuda, T; Kobayashi, K; Nakamura, H; Satoh, H | 1 |
| Baer, GA; Miralles, J; Palomäki, E; Rorarius, M | 1 |
| Jonsson, O; Kihl, B; Lundstam, S; Pettersson, S | 1 |
| Kimble, EF; Kothari, HV; Ku, EC; Lee, W; Liauw, L; Tjan, J | 1 |
| Jelić-Ivanović, Z; Majkić-Singh, N; Spasić, S; Todorović, P | 1 |
| Bacarelli, MR; Calabria, AA; Fioravanti, A; Lalumera, M; Mazzullo, G; Pucci, G; Renieri, A | 1 |
| Karkashina, NS; Kazakova, LM; Korovchenko, NF; Tkachuk, NN | 1 |
| Macauley, D | 1 |
| Machtey, I | 1 |
| Oglodek, C; Reim, M; Schaffelt, F; Thüne, G; von Kiether, R | 1 |
| Peterson, HI | 1 |
| Hertting, G; Knepel, W; Vlaskovska, M | 1 |
| Minker, E; Végh, A | 1 |
| Ablad, B; Aurell, M; Kopp, U; Sjölander, M | 1 |
| Domnikov, AD; Nikulova, MM; Polozov, KK | 1 |
| Klimov, IuV | 1 |
| Abgarowicz-Miłkowska, T; Dratwianka, B; Grabowska, A; Jedryka, A; Małdykowa, H | 1 |
| Valindas, E; Wafin, F; Wuolijoki, E | 1 |
| Baumüller, A; Esders, K | 1 |
| Carlsson, I; Wennmalm, A | 1 |
| Baumann, J; von Bruchhausen, F; Wurm, G | 1 |
| Drapier, JC; Petit, JF | 1 |
| Guobis, G; Iushenaite, Ia | 1 |
| Cronberg, S; Söderberg, I; Wallmark, E | 1 |
| Mashiah, V; Yaron, I; Yaron, M | 1 |
| Nishikawa, T; Okamoto, H; Terada, H; Tsujimoto, A | 1 |
| Horubała-Bielak, G; Kowalewski, J; Miturzyńska-Stryjecka, H; Szczepański, L | 1 |
| Reinike, K; Wessel, H | 1 |
| Espey, LL | 1 |
| Brendl, K; Bruhn, R; Ganote, DP; Lücker, PW; Scholz, HJ | 2 |
| Isomäki, H; Kaarela, K; Kajander, A; Koota, K; Lehtinen, K; Luukkainen, R; Martio, J; Martio, T; Nissilä, M; Nuotio, P | 1 |
| Schlumpf, U | 1 |
| Obel, AO | 1 |
| Chantharaksri, U; Fuchs, AR | 1 |
| Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM | 1 |
| Hobara, N; Watanabe, A | 1 |
| Aizawa, Y; Hasegawa, N; Inazu, N; Kogo, H; Takeuchi, K; Yamada, K; Yoshida, Y | 1 |
| Baggiolini, M; Dewald, B; Schnyder, J | 1 |
| Bonfiglioli, D; Bott, A; Fasoli, A; Raggi, U; Scarpellini, P; Sommariva, D; Zanaboni, L | 1 |
| Förstermann, U; Heldt, R; Hertting, G; Knappen, F | 1 |
| Kanbarov, GM | 1 |
| Dzhuzenova, BS | 1 |
| Arent, H; Uthgenannt, H | 1 |
| Fenner, H | 1 |
| Sigidin, IaA; Tsvetkova, ES | 1 |
| Ehmann, L; Tyberghein, JM | 1 |
| Bird, HA; Fowler, PD; Leatham, PA; Wright, V | 1 |
| Glasius, E; Noach, EL; Oosterhuis, JA; van Delft, JL; van Haeringen, NJ | 1 |
| Inada, Y; Kato, K; Nishikawa, K; Shibouta, Y; Terashita, ZI | 1 |
| Tympner, F | 1 |
| Anggård, E; Davila, D; Davila, T; Oliw, E | 1 |
| Leardini, G; Mattara, L; Mazzucco, A; Rossetto, G | 1 |
| Hüge, W; Stobbe, H | 1 |
| Lacki, JK; Mackiewicz, SH; Wiktorowicz, KE | 1 |
| Locatelli, L; Panerai, AE; Sacerdote, P | 1 |
| Campanero, MR; del Pozo, MA; Díaz-González, F; González-Alvaro, I; Mollinedo, F; Muñoz, C; Pivel, JP; Sánchez-Madrid, F | 1 |
| Friedman, DI; Schwarz, JS; Weisspapir, M | 1 |
| Schröder, H; Schrör, K | 1 |
| Chemtob, S; Hanna, N; Lachapelle, P; Orquin, J; Roy, MS; Varma, DR | 1 |
| Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K | 1 |
| Abou-Mohamed, G; el-Kashef, HA; Elmazar, MM; Salem, HA | 1 |
| Willburger, RE; Wittenberg, RH | 1 |
| Müller-Peddinghaus, R; Theisen-Popp, P | 1 |
| Capellà, D; Castel, JM; Figueras, A; Laorte, JR | 1 |
| Ito, A; Mori, Y; Nose, T; Takahashi, S | 1 |
| Ferreira, SH; Tonussi, CR | 1 |
| Shastin, NN; Stepanov, VP | 1 |
| Church, DJ; Lang, U; Vallotton, MB; Van der Bent, V | 1 |
| Hessemer, V; Schmitt, K | 1 |
| Bersinic, S; Cuddy, LJ; Riedemann, PJ; Torrance, GW; Tugwell, PX | 1 |
| Atanasova, I; Terziivanov, D | 1 |
| Aldini, G; Carini, M; Macciocchi, A; Maffei Facino, R; Saibene, L | 1 |
| Baeyens, W; Donato, MG; Sandra, P; van den Bossche, W | 1 |
| Bitensky, L; Chayen, J; Dunham, J; Mehdizadeh, S; Older, J | 1 |
| Franco-Cereceda, A; Källner, G; Lundberg, JM | 1 |
| Bacon, P | 1 |
| Baer, GA; Lahti, T; Laippala, P; Rorarius, MG; Siirtola, M | 1 |
| Kleemeyer, KS; Peskar, BA; Willburger, RE; Wittenberg, RH | 1 |
| Giraud, AS; Skeljo, MV; Yeomans, ND | 1 |
| McKnight, GW; Wallace, JL | 1 |
| Avgerinos, A; Karidas, T; Malamataris, S | 1 |
| Ardizzone, S; Bianchi Porro, G; Caruso, I; Montrone, F; Petrillo, M | 1 |
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| Alfredsson, L; Kaufman, DW; Kelly, JP; Koff, RS; Laszlo, A; Shapiro, S; Sheehan, JE; Wiholm, BE | 1 |
| Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K | 1 |
| Fujiwara, T; Nishi, K; Nishi, O; Shirasawa, E | 1 |
| Choi, VM; Chooi, J; Coates, JE; Russell, AS; Thomson, AB | 1 |
| Christiansen, A; Fagertun, HE; Grønseth, JE; Laerum, E; Ommundsen, OE | 2 |
| Cook, GA; Elliott, SL; Giraud, AS; Skeljo, MV; Yeomans, ND | 1 |
| Cahill, RJ; Gilvarry, J; O'Morain, CA; Sant, SM | 1 |
| Barratt, G; Devissaguet, JP; Fessi, H; Guterres, SS; Puisieux, F | 1 |
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| Carrabba, M; Galante, A; Manfredi, B; Panerai, AE; Pisati, R; Sacerdote, P | 1 |
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| Hessemer, V; Jacobi, A; Schmitt, K | 1 |
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| Akatsuka, M; Inamori, K; Nakano, H; Otsuka, M; Rou, N; Tanaka, M; Tanaka, Y; Uda, R | 1 |
| Bowdler, J; Kornasoff, D; Maisenbacher, J; Raber, A | 1 |
| Batlle-Gualda, E; Figueroa, M; Ivorra, J; Raber, A | 1 |
| Alexandrov, VA; Bespalov, VG; Petrov, AS; Troyan, DN | 1 |
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| Okuma, Y; Osumi, Y; Yokotani, K | 1 |
| Danputipong, P; Soparat, K; Waikakul, S | 1 |
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| Akpinar, R; Başdemir, G; Berkan, T; Karan, A; Kocaoğlu, S | 1 |
| Arnaud, B; Trinquand, C | 1 |
| Diestelhorst, M; Konen, W; Mester, U; Schmidl, B | 1 |
| Agut, J; Conejo, L; Márquez, M; Ortiz, JA; Palop, D; Sacristán, A | 1 |
| Alió, JL; Laria, C; Ruiz-Moreno, JM | 1 |
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| Diestelhorst, M; Konen, W; Mester, U; Raj, PS; Schmidl, B | 1 |
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| Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T | 1 |
| Cecchi, E; Failli, P; Giotti, A; Laffi, G; Mugelli, A; Tosti-Guerra, C; Zilletti, L | 1 |
| Arne, JL; Assouline, M; David, T; Lasmolles, C; Malecaze, F; Pouliquen, YJ; Renard, G | 1 |
| Bianchi Porro, G; Caruso, I; Lazzaroni, M; Manzionna, G; Montrone, F; Petrillo, M | 1 |
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| Deby, CM; Deby-Dupont, GP; Henrotin, YE; Lamy, MM; Mouithys-Mickalad, AM; Reginster, JY; Zheng, SX | 1 |
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| Inoue, N; Matsui, M; Tachibana, M; Ukai, Y; Yano, J; Yoshida, E | 1 |
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| Brooks, G; Crabbe, MJ; Harper, JV; Shattock, MJ; Wang, Y; Yu, XM | 1 |
| Grosser, N; Schröder, H | 1 |
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| Kennedy, JH; Korn, N; Thurston, RJ | 1 |
| Caruso-Neves, C; Fernandes, MS; Leão-Ferreira, LR; Lopes, AG; Quintana-Gomes, E; Santos, DP; Soares, AC | 1 |
| Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA | 1 |
| Gotoh, T; Hoshino, T; Hwang, HJ; Mima, S; Mizushima, T; Mori, M; Takenaka, H; Tomisato, W; Tsuchiya, T; Tsutsumi, S | 1 |
| Aragona, P; Ferreri, F; Mobrici, M; Stilo, A | 1 |
| Engberg, G; Erhardt, C; Erhardt, S; Schwieler, L | 1 |
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| Caruelle, JP; Cebrian, J; Ferry, A; Martelly, I; Vignaud, A | 1 |
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| Dal Cin, E; Dell'Antonio, G; Ferrero, ME; Foglieni, C; Franzone, JS; Fulgenzi, A; Ticozzi, P | 1 |
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| Lam, PK; Man, SY; Rainer, TH; Woo, WW | 1 |
| Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
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| Chi, YM; Hashimoto, F; Kinjo, J; Nakamura, M; Nohara, T; Sakurada, S; Yan, WM; Yoshizawa, T; Zhao, XY | 1 |
| Baraliakos, X; Bohl-Bühler, MH; Braun, J; Feldtkeller, E; Zochling, J | 1 |
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| Huang, HH; Lin, LH; Zhang, P; Zhong, DF | 1 |
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| Fujiwara, M; Furusawa, S; Kushima, K; Oda, K; Sakuma, S | 1 |
| Abe, N; Hatakeyama, M; Hayashi, Y; Inoue, K; Nakai, Y; Ohta, KY; Otagiri, M; Yuasa, H | 1 |
| Derbot, J; Jung, T; Krammer, G; Kreiss, A; Litschig, S; Mysler, E; Tate, GA; Thurston, H; Willburger, RE | 1 |
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| Fujii, M; Han, HY; Kohno, S; Mizutani, N; Nabe, T; Takenaka, H; Terada, T | 1 |
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| Hakozaki, M; Kikuchi, S; Konno, S; Otani, K; Tajino, T | 1 |
| Díaz-Rodríguez, L; García-Martínez, O; Morales, MA; Rodríguez-Pérez, L; Rubio-Ruiz, B; Ruiz, C | 1 |
| Ortiz, MI | 2 |
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| Finel, M; Hirvonen, J; Rousu, T; Soikkeli, A; Tolonen, A; Zhang, H | 1 |
| Finel, M; Häkli, M; Ketola, RA; Kidron, H; Manevski, N; Urtti, A; Wissel, G; Xhaard, H; Yliperttula, M | 1 |
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| Cela, R; Quintana, JB; Rodil, R; Rodríguez-Álvarez, T; Triñanes, S | 1 |
| Becker, KG; D'Souza, T; Morin, PJ; Valle, BL; Wersto, RP; Wood, WH; Zhang, Y | 1 |
| Boelsterli, UA; Fujimoto, K; Lee, KK; Redinbo, MR; Saitta, KS; Zhang, C | 1 |
| Brown, A; Garud, S; Sethi, N; Sethi, S; Wadhwa, V | 1 |
| Arimitsu, J; Hagihara, K; Hiyama, S; Iijima, H; Inoue, T; Kawai, S; Mukai, A; Nishida, T; Ogata, A; Shinzaki, S; Shiraishi, E; Takehara, T; Tsujii, M | 1 |
| Haeri, G; Haghighi, Z; Hekmatdoust, A; Rezaei, Z | 1 |
| de Graaf, IA; Groothuis, GM; Niu, X; van der Bij, HA | 1 |
| Andriulli, A; Baron, TH; Deviere, J; Dumonceau, JM; Elmunzer, BJ; Hassan, C; Kapral, C; Marek, T; Mariani, A; Meister, T; Testoni, PA | 1 |
| Castilla-Rodríguez, I; Gimeno-García, AZ; Nicolás-Pérez, D; Núñez-Díaz, V; Quintero, E; Romero-García, R | 1 |
| Mocanu, G; Nichifor, M; Stanciu, MC | 1 |
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| De Luna-Bertos, E; García-Martínez, O; Manzano-Moreno, FJ; Ramos-Torrecillas, J; Ruiz, C | 1 |
| Bjerring, PN; Larsen, FS; Pedersen, HR; Rohde, J | 1 |
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| Afshar, K; Eftekhari, A; Jafari, S; MacNeily, AE; Marks, AJ | 1 |
| Klingler, FM; Merk, D; Proschak, E; Schmidt, J; Schubert-Zsilavecz, M; Steinhilber, D | 1 |
| Matteson, EL; Thongprayoon, C; Ungprasert, P | 1 |
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| Cheng, YT; Lu, CC; Yen, GC | 1 |
| Kramulová, B; Marsik, P; Rezek, J; Tauchen, J; Vaněk, T; Židková, M | 1 |
| Agrawal, R; Assaiya, A; Banerjee, T; Jain, N; Kumar, A; Manivannan, E; Mufti, I; Parmar, HS; Tiwari, S | 1 |
| Mohácsi, L; Patai, Á; Patai, ÁV; Solymosi, N | 1 |
| Finšgar, M; Gradišnik, L; Horvat, G; Knez, Ž; Maver, U; Novak, Z; Xhanari, K | 1 |
| Amayem, A; Brown, MD; Ghandour, O; Harrison, N; Lang, E; Lawrenson, AL; Lawrenson, JG; McCormick, R; Quirke, M; Wakai, A; Walsh, CD; Wang, Y | 1 |
| Baev, DS; Dolgikh, MP; Lipeeva, AV; Shults, EE; Tolstikova, TG | 1 |
| Cariño-Cortés, R; Castañeda-Hernández, G; González-García, MP; Ortiz, MI; Ponce-Monter, HA; Salinas-Caballero, M | 1 |
| Chang, SN; Chung, HM; Jung, CR; Kim, CY; Kim, J; Kim, U; Lee, BH; Lee, JM; Lee, S; Oh, H; Park, JH; Ryu, B | 1 |
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| Fujiwara, Y; Higashimori, A; Hosomi, S; Itani, S; Kamata, N; Nadatani, Y; Nagami, Y; Nakata, A; Otani, K; Shiba, M; Shimada, S; Sugimura, N; Taira, K; Tanaka, F; Tanigawa, T; Watanabe, T; Yamagami, H | 1 |
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43 review(s) available for diclofenac and indomethacin
| Article | Year |
|---|---|
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
Structural and functional basis of cyclooxygenase inhibition.
Topics: Animals; Cardiovascular System; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; History, 18th Century; History, 19th Century; History, 20th Century; History, 21st Century; History, Ancient; Humans; Kinetics; Models, Molecular; Protein Conformation; Risk Assessment | 2007 |
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship | 2016 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Recently reported biological activities of pyrazole compounds.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antineoplastic Agents; Antiviral Agents; Humans; Pyrazoles | 2017 |
Contemporary advances of cyclic molecules proposed for inflammation.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Humans; Inflammation; Molecular Structure; Structure-Activity Relationship | 2021 |
[Drug therapy of ankylosing spondyloarthritis (Bechterew's disease)].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Apazone; Butadienes; Cyclophosphamide; Diclofenac; Drug Combinations; Drug Evaluation; Glycolates; Gold; Humans; Ibuprofen; Indomethacin; Ketoprofen; Levamisole; Naproxen; Oxyphenbutazone; Phenylbutazone; Salicylates; Spondylitis, Ankylosing; Sulindac | 1978 |
[Clinical profile of acemetacin].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Indomethacin; Randomized Controlled Trials as Topic; Rheumatic Diseases | 1990 |
[The role of non steroidal anti-inflammatory agents in the treatment of renal colic].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Humans; Indomethacin; Ketoprofen; Kidney Diseases | 1989 |
The putative role of prostaglandins in cystoid macular edema.
Topics: Aqueous Humor; Cataract Extraction; Diclofenac; Fluorescein Angiography; Flurbiprofen; Humans; Indomethacin; Macular Edema; Prostaglandins | 1989 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Diclofenac; Drug Hypersensitivity; Gastrointestinal Diseases; Hematologic Diseases; Humans; Ibuprofen; Indomethacin; Ketoprofen; Kidney Diseases; Kinetics; Naproxen; Phenylbutazone; Piroxicam; Salicylates; Thiazines | 1986 |
Granulomatous interstitial nephritis after nonsteroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Indomethacin; Ketoprofen; Nephritis, Interstitial | 1988 |
[Adjuvant therapy with nonsteroidal antiphlogistics in disease of the urogenital tract].
Topics: Anti-Inflammatory Agents; Aspirin; Diclofenac; Diflunisal; Escin; Flurbiprofen; Humans; Indomethacin; Oxyphenbutazone; Phenylbutazone; Piroxicam; Thiazines; Urologic Diseases | 1984 |
[Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Eruptions; Drug Interactions; Female; Gastrointestinal Diseases; Headache; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Sulindac | 1981 |
[The introduction of non-steroidal antirheumatics: is there a rational therapy].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbazoles; Chronic Disease; Diclofenac; Diflunisal; Humans; Indomethacin; ortho-Aminobenzoates; Osteoarthritis; Phenylbutazone; Piroxicam; Rheumatic Diseases; Salicylates; Thiazines; Tolmetin | 1982 |
Practical therapeutics: the newer nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Diclofenac; Humans; Ibuprofen; Indomethacin; Naproxen; Phenylbutazone; Phenylbutyrates; Piroxicam; Propionates; Sulindac; Thiazines | 1982 |
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Female; Gastric Mucosa; Gout; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Osteoarthritis; Pain; Phenylacetates; Platelet Aggregation; Rheumatic Diseases; Spondylitis, Ankylosing; Ulcer | 1980 |
A study to determine the efficacy and safety of tenoxicam versus piroxicam, diclofenac and indomethacin in patients with osteoarthritis: a meta-analysis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Piroxicam; Random Allocation | 1993 |
The emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Conjunctivitis, Allergic; Diclofenac; Drug Therapy; Edema; Eye Diseases; Humans; Indomethacin; Pain, Postoperative; Postoperative Complications; Pyrazoles | 1996 |
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cohort Studies; Diclofenac; Humans; Incidence; Indomethacin; Liver; Liver Diseases; Naproxen; Oxaprozin; Phenylbutazone; Propionates; Risk Factors; Sulindac | 1996 |
Evidence-based emergency medicine. Update: do ophthalmic nonsteroidal anti-inflammatory drugs reduce the pain associated with simple corneal abrasion without delaying healing?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Corneal Injuries; Diclofenac; Double-Blind Method; Drug Combinations; Emergency Medicine; Evidence-Based Medicine; Eye Foreign Bodies; Eye Injuries; Follow-Up Studies; Gentamicins; Humans; Indomethacin; Ketorolac; Middle Aged; Multicenter Studies as Topic; Ophthalmic Solutions; Pain; Pain Measurement; Pain Threshold; Placebos; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; Wound Healing | 2003 |
[Acute rheumatic fever: problems and outlooks].
Topics: Acute Disease; Adolescent; Adult; Age Factors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Agents; Child; Diagnosis, Differential; Diclofenac; Humans; Indomethacin; Penicillin G Benzathine; Rheumatic Fever; Rheumatic Heart Disease; Streptococcal Infections; Streptococcus pyogenes; Time Factors | 2003 |
Pharmacological treatment of heterotopic ossification following hip and acetabular surgery.
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Diclofenac; Humans; Indomethacin; Naproxen; Ossification, Heterotopic; Postoperative Complications; Pyrazoles; Sulfonamides | 2008 |
Pseudogout of the acromioclavicular joint: report of two cases and review of the literature.
Topics: Acromioclavicular Joint; Aged; Anti-Inflammatory Agents, Non-Steroidal; Calcium Pyrophosphate; Chondrocalcinosis; Dexamethasone; Diclofenac; Drug Therapy, Combination; Glucocorticoids; Humans; Indomethacin; Joint Diseases; Lidocaine; Male; Middle Aged; Synovial Fluid; Tomography, X-Ray Computed | 2011 |
Pharmacogenetics of nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Aspirin; Celecoxib; Cytochrome P-450 CYP2C9; Diclofenac; Humans; Ibuprofen; Indomethacin; Pharmacogenetics; Pyrazoles; Sulfonamides | 2012 |
A meta-analysis on the role of rectal diclofenac and indomethacin in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Humans; Indomethacin; Pancreatitis; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
Repercussions of NSAIDS drugs on bone tissue: the osteoblast.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bone and Bones; Cell Adhesion; Cell Cycle; Cell Differentiation; Cell Movement; Cell Proliferation; Diclofenac; Humans; Indomethacin; Osteoblasts | 2015 |
[Prevention of acute pancreatitis following endoscopic retrograde cholangiopancreatography].
Topics: Acute Disease; Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Cholangiopancreatography, Endoscopic Retrograde; Contraindications; Diclofenac; Humans; Hungary; Indomethacin; Infusions, Intravenous; Pancreatitis; Primary Prevention; Rehydration Solutions; Risk Assessment; Risk Factors; Severity of Illness Index; Stents; Unnecessary Procedures | 2015 |
Efficacy and safety of etoricoxib compared with NSAIDs in acute gout: a systematic review and a meta-analysis.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Gout; Humans; Indomethacin; Pain Measurement; Pyridines; Randomized Controlled Trials as Topic; Sulfones; Treatment Outcome | 2016 |
Nonsteroidal anti-inflammatory drugs (NSAIDs) and non-opioids for acute renal colic.
Topics: Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Indomethacin; Parasympatholytics; Randomized Controlled Trials as Topic; Renal Colic; Scopolamine | 2015 |
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cerebral Hemorrhage; Diclofenac; Humans; Ibuprofen; Incidence; Indomethacin; Lactones; Meloxicam; Naproxen; Observational Studies as Topic; Odds Ratio; Piroxicam; Proportional Hazards Models; Stroke; Sulfones; Thiazines; Thiazoles | 2016 |
Non-steroidal anti-inflammatory drugs for chronic low back pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Diclofenac; Disability Evaluation; Humans; Ibuprofen; Indomethacin; Low Back Pain; Pain Measurement; Piroxicam; Randomized Controlled Trials as Topic | 2016 |
Endoscopic and pharmacological treatment for prophylaxis against postendoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis and systematic review.
Topics: Administration, Intravenous; Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Hormones; Humans; Indomethacin; Odds Ratio; Pancreatic Ducts; Pancreatitis; Postoperative Complications; Somatostatin; Stents | 2016 |
Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa.
Topics: Angiogenesis Inducing Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Aspirin; Diclofenac; Flavonoids; Gastric Mucosa; Gastrointestinal Tract; Humans; Indomethacin; Inflammation; Ketoprofen; Oxidative Stress; Phytochemicals; Protective Agents | 2017 |
Indomethacin and diclofenac in the prevention of post-ERCP pancreatitis: a systematic review and meta-analysis of prospective controlled trials.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Controlled Clinical Trials as Topic; Diclofenac; Humans; Indomethacin; Pancreatitis; Postoperative Complications | 2017 |
Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Corneal Injuries; Diclofenac; Flurbiprofen; Humans; Indomethacin; Ketorolac; Pain Measurement; Randomized Controlled Trials as Topic; Wound Healing | 2017 |
What is impact of nonsteroidal anti-inflammatory drugs in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis of randomized controlled trials.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Drug Administration Routes; Drug Administration Schedule; Humans; Indomethacin; Pancreatitis; Publication Bias; Randomized Controlled Trials as Topic; Risk Factors | 2018 |
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with a combination of pharmacological agents based on rectal non-steroidal anti-inflammatory drugs: A systematic review and network meta-analysis.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Drug Therapy, Combination; Female; Humans; Indomethacin; Male; Nitrates; Pancreatitis; Postoperative Complications; Ringer's Lactate; Treatment Outcome | 2021 |
Rectal NSAIDs-based combination modalities are superior to single modalities for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a network meta-analysis.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Humans; Indomethacin; Network Meta-Analysis; Nitrates; Pancreatitis | 2022 |
Efficacy of Combined Management with Nonsteroidal Anti-inflammatory Drugs for Prevention of Pancreatitis After Endoscopic Retrograde Cholangiography: a Bayesian Network Meta-analysis.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Epinephrine; Humans; Indomethacin; Melatonin; Network Meta-Analysis; Nitrates; Nitroglycerin; Pancreatitis; Somatostatin; Systematic Reviews as Topic | 2022 |
The Incidence and Severity of Post-ERCP Pancreatitis in Patients Receiving Standard Administration of NSAIDs: a Systematic Review and Meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Humans; Hyperplasia; Incidence; Indomethacin; Pancreatitis | 2022 |
Comparison of different nonsteroidal anti-inflammatory drugs for cesarean section: a systematic review and network meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cesarean Section; Diclofenac; Female; Humans; Indomethacin; Ketorolac; Network Meta-Analysis; Pain; Pregnancy | 2023 |
82 trial(s) available for diclofenac and indomethacin
| Article | Year |
|---|---|
Diclofenac sodium (Voltaren): results of a multi-centre comparative trial in adult-onset rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Diclofenac; Female; Humans; Indomethacin; Male | 1975 |
[Diclofenac in the treatment of inflammatory and degenerative diseases of the locomotor system].
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Drug Evaluation; Humans; Indomethacin; Inflammation; Middle Aged; Pain; Phenylacetates; Rheumatic Diseases | 1977 |
Diclofenac sodium (Voltaren) and indomethacin in the ambulatory treatment of rheumatoid arthritis: a double-blind multicentre study.
Topics: Adult; Aged; Ambulatory Care; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged; Phenylacetates | 1978 |
The long-term efficacy and tolerability of Voltaren (diclofenac sodium) and indomethacin in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Central Nervous System; Clinical Trials as Topic; Diclofenac; Digestive System; Double-Blind Method; Drug Evaluation; Female; Follow-Up Studies; Humans; Indomethacin; Male; Phenylacetates; Time Factors | 1978 |
[Comparative effectiveness of voltaren and indomethacin in rheumatoid arthritis (according to the data of a double-blind study)].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Evaluation; Female; Humans; Indomethacin; Middle Aged; Phenylacetates; Placebos | 1978 |
[Sodium dichlorophenylacetate in the treatment of rheumatoid arthritis in the aged].
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Drug Evaluation; Female; Humans; Indomethacin; Male; Phenylacetates; Regression Analysis | 1978 |
Tolfenamic acid in the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Drug Evaluation; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; ortho-Aminobenzoates; Phenylbutazone; Prednisone; Time Factors | 1979 |
How long should long be? Long-term trials in rheumatic diseases.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Drug Evaluation; Humans; Indomethacin; Osteoarthritis; Phenylacetates; Research Design; Rheumatic Diseases; Time Factors | 1979 |
[Comparative study of the efficacy of diclofenac sodium and indomethacin in post-operative inflammation following varicose vein surgery].
Topics: Adult; Clinical Trials as Topic; Diclofenac; Humans; Indomethacin; Inflammation; Middle Aged; Phenylacetates; Postoperative Complications; Varicose Veins | 1979 |
The value and results of long-term studies with diclofenac sodium (Voltarol).
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Tolerance; Hematologic Tests; Humans; Indomethacin; Liver Function Tests; Naproxen; Phenylacetates; Time Factors | 1979 |
Diclofenac sodium (Voltarol) and indomethacin: a multicentre comparative study in rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Hemoglobins; Humans; Indomethacin; Kidney Function Tests; Liver Function Tests; Osteoarthritis; Phenylacetates; Time Factors | 1979 |
Analysis of the Brazilian literature on diclofenac sodium (Voltarol).
Topics: Arthritis, Rheumatoid; Brazil; Clinical Trials as Topic; Diclofenac; Drug Tolerance; Female; Humans; Ibuprofen; Indomethacin; Male; Osteoarthritis; Time Factors | 1979 |
An open assessment of the efficacy and tolerability of diclofenac sodium (Voltarol) in patients with rheumatic disease and a comparative study of diclofenac sodium (Voltarol) with indomethacin in patients with osteoarthritis and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Drug Evaluation; Drug Tolerance; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Phenylacetates | 1979 |
[Clinical experiences and results of clinical experimental studies with Voltaren in rheumatic diseases].
Topics: Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Diclofenac; DNA Repair; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged; Phenylacetates; Vertigo; Vomiting | 1976 |
Four commonly prescribed non-steroidal anti-inflammatory drugs for rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Cross-Over Studies; Delayed-Action Preparations; Diclofenac; Humans; Indomethacin; Naproxen; Pain; Piroxicam; Single-Blind Method; Surveys and Questionnaires | 1991 |
The effect of indomethacin, diclofenac and flurbiprofen on the maintenance of mydriasis during extracapsular cataract extraction.
Topics: Aged; Aged, 80 and over; Cataract Extraction; Diclofenac; Flurbiprofen; Humans; Indomethacin; Intraoperative Complications; Lens Capsule, Crystalline; Middle Aged; Miosis; Ophthalmic Solutions; Premedication; Pupil; Treatment Outcome | 1992 |
A new topical treatment for acute herpetic neuralgia and post-herpetic neuralgia: the aspirin/diethyl ether mixture. An open-label study plus a double-blind controlled clinical trial.
Topics: Acute Disease; Administration, Topical; Adult; Aged; Aspirin; Diclofenac; Double-Blind Method; Drug Combinations; Ether; Female; Follow-Up Studies; Herpes Zoster; Humans; Indomethacin; Male; Middle Aged; Neuralgia; Skin Diseases | 1992 |
[Prevention of peroperative miosis: comparison between prostaglandin inhibitors. Sodium diclofenac and indomethacin in local application].
Topics: Cataract Extraction; Diclofenac; Humans; Indomethacin; Intraoperative Complications; Miosis; Ophthalmic Solutions | 1992 |
Comparison of intravenous diclofenac, indomethacin and oxycodone as post-operative analgesics in patients undergoing knee surgery.
Topics: Adult; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Injections, Intravenous; Knee Joint; Male; Middle Aged; Oxycodone; Pain, Postoperative | 1992 |
Longterm treatment with nonsteroidal antiinflammatory drugs in rheumatoid arthritis: a prospective drug survival study.
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen; Prospective Studies; Sex Factors; Time Factors | 1991 |
[Clinical profile of acemetacin].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Indomethacin; Randomized Controlled Trials as Topic; Rheumatic Diseases | 1990 |
A randomized trial of the effect of three non-steroid anti-inflammatory agents in ameliorating cancer-induced fever.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Fever; Humans; Indomethacin; Male; Naproxen; Neoplasms; Paraneoplastic Syndromes | 1990 |
Treatment of renal colic by prostaglandin synthetase inhibitors and avafortan (analgesic antispasmodic).
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Dipyrone; Drug Combinations; Female; Glycine; Humans; Indomethacin; Injections, Intramuscular; Injections, Intravenous; Kidney Diseases; Male; Middle Aged; Phenylacetates; Prospective Studies | 1990 |
Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of osteoarthritis: a comparative controlled clinical trial in general practice.
Topics: Adult; Aged; Delayed-Action Preparations; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Male; Medical Records; Middle Aged; Osteoarthritis; Pain; Pain Measurement | 1990 |
Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of rheumatoid arthritis: a comparative controlled clinical trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Delayed-Action Preparations; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Male; Medical Records; Middle Aged; Pain; Pain Measurement | 1990 |
Effects of peri-operatively administered diclofenac and indomethacin on blood loss, bleeding time and plasma prostanoids in man.
Topics: Adult; Aged; Bleeding Time; Blood Volume Determination; Diclofenac; Dinoprostone; Double-Blind Method; Female; Genital Diseases, Female; Humans; Indomethacin; Middle Aged; Platelet Function Tests; Randomized Controlled Trials as Topic; Thromboxane B2 | 1989 |
[Comparison of locally applied prostaglandin synthesis inhibitors in Nd:YAG laser surgery--initial results].
Topics: Aged; Cataract Extraction; Clinical Trials as Topic; Diclofenac; Humans; Indomethacin; Intraocular Pressure; Laser Therapy; Ophthalmic Solutions; Premedication; Random Allocation | 1987 |
International experience with diclofenac in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Humans; Ibuprofen; Indomethacin; Naproxen; Phenylbutazone | 1986 |
International experiences with diclofenac in osteoarthritis.
Topics: Aspirin; Clinical Trials as Topic; Diclofenac; Diflunisal; Double-Blind Method; Gastrointestinal Diseases; Humans; Ibuprofen; Indomethacin; Naproxen; Osteoarthritis; Random Allocation; Sulindac | 1986 |
Efficacy of diclofenac in ankylosing spondylitis.
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Gastrointestinal Diseases; Headache; Humans; Indomethacin; Male; Middle Aged; Pain; Random Allocation; Spondylitis, Ankylosing | 1986 |
[New etiopathologic and therapeutic perspectives in ureteral colic. Evaluation of clinical experience with diclofenac sodium and indomethacin].
Topics: Clinical Trials as Topic; Diclofenac; Double-Blind Method; Humans; Indomethacin; Narcotics; Pain; Parasympatholytics; Pentazocine; Prostaglandins; Ureteral Diseases | 1986 |
A double blind comparison of diclofenac and indomethacin in the treatment of ankylosing spondylitis.
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Random Allocation; Spondylitis, Ankylosing | 1987 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration Schedule; Humans; Indomethacin; Indoprofen; Ketoprofen; Middle Aged; Naproxen; Osteoarthritis; Pain; Patient Compliance; Piroxicam; Thiazines | 1985 |
Diclofenac versus indomethacin given as intravenous infusions: their effect on haemodynamics and bleeding time, and side-effects in healthy subjects.
Topics: Adult; Bleeding Time; Blood Coagulation; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Hemodynamics; Humans; Indomethacin; Infusions, Parenteral; Male; Middle Aged; Random Allocation | 1985 |
Diclofenac in the treatment of ankylosing spondylitis: review of worldwide clinical experience and report of a double-blind comparison with indomethacin.
Topics: Adolescent; Adult; Aged; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Pain; Spondylitis, Ankylosing | 1985 |
[Role of non-steroid preparations (voltaren and indomethacin) in the present-day treatment of rheumatism in children].
Topics: Adolescent; Anti-Inflammatory Agents; Child; Child, Preschool; Clinical Trials as Topic; Diclofenac; Humans; Indomethacin; Phenylacetates; Rheumatic Fever; Rheumatic Heart Disease | 1983 |
[Results of treatment of patients with rheumatoid arthritis with Voltaren SR and Metindol].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Humans; Indomethacin; Middle Aged; Phenylacetates | 1983 |
Comparison of diclofenac and indomethacin suppositories in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Tolerance; Humans; Indomethacin; Pain; Phenylacetates; Suppositories | 1984 |
Effect of different prostaglandin synthesis inhibitors on post-occlusive blood flow in human forearm.
Topics: Adolescent; Adult; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Female; Forearm; Humans; Hyperemia; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Piroxicam; Regional Blood Flow; Thiazines | 1983 |
[Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Eruptions; Drug Interactions; Female; Gastrointestinal Diseases; Headache; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Sulindac | 1981 |
Comparison of the analgesic effect of ten nonsteroidal anti-inflammatory drugs.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Female; Humans; Ibuprofen; Indomethacin; Ketoprofen; Male; Middle Aged; Naproxen; ortho-Aminobenzoates; Quinazolines | 1984 |
[Effect of 3-(4-chlorphenyl-) 1-phenyl-1H-pyrazole-4-acetic acid (lonazolac-Ca), diclofenac-Na and indomethacin on the gastrointestinal blood loss].
Topics: Anti-Inflammatory Agents; Diclofenac; Digestive System; Gastrointestinal Hemorrhage; Humans; Indomethacin; Male; Phenylacetates; Pyrazoles | 1982 |
[Stomach tolerance of non-steroid anti-rheumatic agents. Studies on gastric irritation caused by carprofen in comparison with acetylsalicyclic acid, indomethacin, piroxicam, and diclofenac].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbazoles; Diclofenac; Gastric Mucosa; Humans; Indomethacin; Male; Phenylacetates; Piroxicam; Thiazines | 1982 |
[Comparative effectiveness of new antirheumatic drugs].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Flufenamic Acid; Humans; Indomethacin; Naproxen | 1980 |
Diclofenac suppositories in osteoarthrosis. A double-blind comparison with indomethacin.
Topics: Aged; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Male; Osteoarthritis; Phenylacetates; Suppositories | 1981 |
[Double-blind trial of the therapeutic efficacy of voltaren and indomethacin in Bechterew's disease].
Topics: Adult; Clinical Trials as Topic; Dermatitis, Atopic; Diclofenac; Dizziness; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Nausea; Phenylacetates; Spondylitis, Ankylosing | 1981 |
The run-in period in trial design: a comparison of two non-steroidal anti-inflammatory agents in psoriatic arthropathy.
Topics: Adult; Anti-Inflammatory Agents; Arthritis; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Humans; Indomethacin; Psoriasis; Research Design | 1982 |
[Anti-inflammatory effect of a local combination therapy with diclofenac and prednisolone vs. indomethacin and prednisolone. A laser flare cell photometry study].
Topics: Aged; Aqueous Humor; Diclofenac; Dose-Response Relationship, Drug; Drug Administration Schedule; Endophthalmitis; Female; Humans; Indomethacin; Lenses, Intraocular; Male; Ophthalmic Solutions; Ophthalmoscopes; Photometry; Postoperative Complications; Prednisolone; Premedication | 1994 |
Worldwide experience with etodolac (Lodine) 300 mg b.i.d. in the treatment of osteoarthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Diclofenac; Double-Blind Method; Etodolac; Global Health; Hip Joint; Humans; Indomethacin; Knee Joint; Middle Aged; Naproxen; Osteoarthritis; Pain; Piroxicam; Time Factors | 1993 |
Effect of intravenous diclofenac or indomethacin on the emergence from anaesthesia for tonsillectomy.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, General; Arousal; Attention; Awareness; Blood Loss, Surgical; Diclofenac; Double-Blind Method; Hemorrhage; Humans; Indomethacin; Injections, Intravenous; Memory; Memory, Short-Term; Middle Aged; Motor Skills; Oxycodone; Placebos; Premedication; Tonsillectomy | 1993 |
Sulglycotide in the prevention of nonsteroidal anti-inflammatory drug-induced gastroduodenal mucosal injury. A controlled double-blind, double-dummy, randomized endoscopic study versus placebo in rheumatic patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Diclofenac; Double-Blind Method; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Indomethacin; Intestinal Mucosa; Male; Middle Aged; Osteoarthritis; Sialoglycoproteins; Stomach Ulcer; Time Factors | 1993 |
Nonsteroidal anti-inflammatory drug use in relation to major upper gastrointestinal bleeding.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Diclofenac; Female; Gastrointestinal Hemorrhage; Humans; Hungary; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Piroxicam; Risk Factors; Sweden; United States | 1993 |
Oral diclofenac in the prophylactic treatment of recurrent renal colic. A double-blind comparison with placebo.
Topics: Administration, Oral; Adult; Analysis of Variance; Colic; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Kidney Calculi; Male; Placebos; Recurrence | 1995 |
Plasma and synovial fluid interleukin-1, interleukin-6 and substance P concentrations in rheumatoid arthritis patients: effect of the nonsteroidal anti inflammatory drugs indomethacin, diclofenac and naproxen.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Female; Humans; Indomethacin; Interleukin-1; Interleukin-6; Male; Middle Aged; Naproxen; Substance P; Synovial Fluid | 1995 |
[Anti-inflammatory effects and aqueous humor concentration of various nonsteroidal anti-inflammatory drugs in extracapsular cataract surgery].
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Blood-Retinal Barrier; Cataract Extraction; Chromatography, High Pressure Liquid; Diclofenac; Dose-Response Relationship, Drug; Drug Administration Schedule; Endophthalmitis; Female; Flurbiprofen; Humans; Indomethacin; Lenses, Intraocular; Male; Middle Aged; Ophthalmic Solutions; Postoperative Complications | 1996 |
[The relief of postoperative pain by suppositories of buprenorphine or NSAID].
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Buprenorphine; Diclofenac; Female; Humans; Indomethacin; Middle Aged; Pain, Postoperative; Suppositories | 1996 |
The efficacy and tolerability of aceclofenac compared to indomethacin in patients with rheumatoid arthritis.
Topics: Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Elasticity; Female; Hand Strength; Heartburn; Humans; Indomethacin; Joints; Male; Middle Aged; Pain Measurement; Statistics, Nonparametric; Treatment Outcome; Vertigo | 1996 |
The efficacy and tolerability of aceclofenac in the treatment of patients with ankylosing spondylitis: a multicenter controlled clinical trial. Aceclofenac Indomethacin Study Group.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Multivariate Analysis; Patient Compliance; Patient Participation; Spondylitis, Ankylosing; Time Factors | 1996 |
Topical aspirin/diethyl ether mixture versus indomethacin and diclofenac/diethyl ether mixtures for acute herpetic neuralgia and postherpetic neuralgia: a double-blind crossover placebo-controlled study.
Topics: Acute Disease; Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Double-Blind Method; Ether; Female; Herpes Zoster Oticus; Humans; Indomethacin; Male; Middle Aged; Neuralgia; Pain Measurement; Solvents | 1996 |
Topical analgesics, indomethacin plaster and diclofenac emulgel for low back pain: a parallel study.
Topics: Administration, Cutaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Gels; Humans; Indomethacin; Low Back Pain; Male; Middle Aged; Pain Measurement; Single-Blind Method | 1996 |
Intramuscular diclofenac versus intravenous indomethacin in the treatment of acute renal colic.
Topics: Acute Disease; Adult; Analgesics, Opioid; Colic; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Indomethacin; Injections, Intramuscular; Injections, Intravenous; Kidney Diseases; Male; Meperidine; Single-Blind Method | 1996 |
[Double-blind study on 3 parallel groups of 2 formulations of 0.1% indomethacin and 0.1% diclofenac in preventing and controlling inflammation after cataract surgery].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Inflammation; Male; Middle Aged; Postoperative Period; Premedication; Prospective Studies | 1997 |
[Laser flare measurement with 3 different nonsteroidal anti-inflammatory drugs after phacoemulsification with posterior chamber lens implantation].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Endophthalmitis; Female; Flurbiprofen; Humans; Indomethacin; Lenses, Intraocular; Male; Middle Aged; Ophthalmic Solutions; Phacoemulsification; Postoperative Complications; Prospective Studies | 1997 |
Efficacy and tolerance of diclofenac sodium 0.1%, flurbiprofen 0.03%, and indomethacin 1.0% in controlling postoperative inflammation.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Endophthalmitis; Female; Flurbiprofen; Follow-Up Studies; Humans; Indomethacin; Lenses, Intraocular; Male; Ophthalmic Solutions; Phacoemulsification; Postoperative Complications; Prospective Studies; Treatment Outcome | 1996 |
[Heterotopic ossifications].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthrography; Arthroplasty, Replacement, Hip; Aspirin; Combined Modality Therapy; Diclofenac; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indomethacin; Male; Middle Aged; Ossification, Heterotopic; Postoperative Complications; Prospective Studies; Radiotherapy Dosage; Risk Factors | 1997 |
A prospective randomized trial of topical soluble 0.1% indomethacin versus 0.1% diclofenac versus placebo for the control of pain following excimer laser photorefractive keratectomy.
Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cornea; Diclofenac; Double-Blind Method; Female; Follow-Up Studies; Humans; Indomethacin; Lasers, Excimer; Male; Myopia; Ophthalmic Solutions; Pain Threshold; Pain, Postoperative; Photorefractive Keratectomy; Prospective Studies; Safety; Treatment Outcome; Wound Healing | 1998 |
Prevention of gastroduodenal damage with omeprazole in patients receiving continuous NSAIDs treatment. A double blind placebo controlled study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Double-Blind Method; Endoscopy, Digestive System; Female; Follow-Up Studies; Gastric Mucosa; Humans; Indomethacin; Intestinal Mucosa; Ketoprofen; Male; Middle Aged; Omeprazole; Peptic Ulcer; Rheumatic Diseases; Safety; Treatment Outcome | 1998 |
Double-blind, placebo-controlled study on effects of diclofenac sodium and indomethacin on postprandial gastric motility in man.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Gastrointestinal Motility; Humans; Indomethacin; Male; Postprandial Period | 1998 |
[The effect of diclofenac sodium and indomethacin used locally for maintenance of pupillary dilatation during cataract surgery].
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclofenac; Female; Humans; Indomethacin; Intraoperative Period; Male; Middle Aged; Miosis; Mydriasis; Preoperative Care | 1998 |
Comparative study of two non-steroidal anti-inflammatory eyedrops, 0.1% indomethacin versus 0.1% diclofenac in pain control post photorefractive keratectomy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Lasers, Excimer; Male; Ophthalmic Solutions; Pain, Postoperative; Photorefractive Keratectomy | 1997 |
The effects of the topical administration of non-steroidal anti-inflammatory drugs on corneal epithelium and corneal sensitivity in normal subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Corneal Diseases; Diclofenac; Double-Blind Method; Epithelium, Corneal; Female; Flurbiprofen; Humans; Indomethacin; Ketorolac; Male; Middle Aged; Paresthesia; Procaine | 2000 |
[Indomethacin (indocollyre) versus diclofenac (voltarene) for the control of pain following excimer photoablation].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Indomethacin; Lasers, Excimer; Male; Pain Measurement; Pain, Postoperative; Photorefractive Keratectomy; Prospective Studies | 2000 |
Effects of the topical treatment with NSAIDs on corneal sensitivity and ocular surface of Sjögren's syndrome patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cornea; Diclofenac; Dry Eye Syndromes; Epithelium, Corneal; Eye Diseases; Female; Fluorescein; Humans; Indomethacin; Male; Middle Aged; Ophthalmic Solutions; Sensation; Single-Blind Method; Sjogren's Syndrome; Statistics, Nonparametric; Treatment Outcome | 2005 |
Relationships between the concentrations of prostaglandins and the nonsteroidal antiinflammatory drugs indomethacin, diclofenac, and ibuprofen.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Cross-Over Studies; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Ibuprofen; Indomethacin; Male; Tablets; Time Factors | 2005 |
Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness; Female; Humans; Indomethacin; Male; Musculoskeletal Diseases; Nausea; Pain; Pain Measurement; Patient Satisfaction; Treatment Outcome; Vomiting; Wounds and Injuries | 2005 |
Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout.
Topics: Abdominal Pain; Acute Disease; Administration, Oral; Adult; Aged; Analysis of Variance; Argentina; Diclofenac; Double-Blind Method; Drug Administration Schedule; Female; Germany; Gout; Headache; Humans; Indomethacin; Joints; Logistic Models; Male; Middle Aged; Pain Measurement; Treatment Outcome; Vertigo | 2007 |
Comparison of the efficacy of diclofenac and indomethacin suppositories in treating perineal pain after episiotomy or laceration: a prospective, randomized, double-blind clinical trial.
Topics: Administration, Rectal; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Episiotomy; Female; Humans; Indomethacin; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Prospective Studies; Statistics, Nonparametric; Suppositories | 2009 |
Comparison of diclofenac sodium with indomethacin suppositories for mediolateral episiotomies.
Topics: Adult; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Episiotomy; Female; Humans; Indomethacin; Pain, Postoperative; Pregnancy; Prospective Studies; Young Adult | 2012 |
Amelioration of small bowel injury by switching from nonselective nonsteroidal anti-inflammatory drugs to celecoxib in rheumatoid arthritis patients: a pilot study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Capsule Endoscopy; Celecoxib; Cytokines; Diclofenac; Drug Substitution; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Middle Aged; Phenylpropionates; Pilot Projects; Prospective Studies; Pyrazoles; Severity of Illness Index; Single-Blind Method; Sulfonamides | 2014 |
A comparative study on relieving post-episiotomy pain with diclofenac and indomethacin suppositories or placebo.
Topics: Administration, Rectal; Adolescent; Adult; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Episiotomy; Female; Humans; Indomethacin; Pain, Postoperative; Pregnancy; Young Adult | 2014 |
Comparison of rectal indomethacin, diclofenac, and naproxen for the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis.
Topics: Administration, Rectal; Adult; Aged; Amylases; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Double-Blind Method; Eicosapentaenoic Acid; Female; Humans; Incidence; Indomethacin; Iran; Lipase; Lipoxins; Male; Middle Aged; Naproxen; Pancreatitis; Risk Factors; Time Factors; Treatment Outcome | 2017 |
VITREOUS PROSTAGLANDIN E2 CHANGES AFTER TOPICAL ADMINISTRATION OF DICLOFENAC 0.1%, INDOMETHACIN 0.5%, NEPAFENAC 0.3%, AND BROMFENAC 0.09.
Topics: Administration, Ophthalmic; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Benzophenones; Bromobenzenes; Chromatography, High Pressure Liquid; Diclofenac; Dinoprostone; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Epiretinal Membrane; Female; Humans; Indomethacin; Male; Middle Aged; Ophthalmic Solutions; Phenylacetates; Prospective Studies; Retinal Perforations; Vitrectomy; Vitreous Body | 2020 |
376 other study(ies) available for diclofenac and indomethacin
| Article | Year |
|---|---|
Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Indans; Indenes; Male; Rats; Rats, Inbred Strains | 1984 |
2,3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzofurans; Cattle; Chemical Phenomena; Chemistry; Depression, Chemical; Edema; In Vitro Techniques; Male; Prostaglandins; Rats; Stomach Ulcer; Structure-Activity Relationship | 1981 |
1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Gastrointestinal Diseases; Humans; Imidazoles; Isoenzymes; Membrane Proteins; Mice; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship; Sulfonamides; Sulfones | 1997 |
Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; COS Cells; Glycosylation; Histidine; In Situ Hybridization; Kidney; Kinetics; Mice; p-Aminohippuric Acid; Probenecid; Protein Processing, Post-Translational; Renal Agents; Substrate Specificity; Tunicamycin | 1999 |
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis | 1999 |
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
Topics: Administration, Oral; Animals; Biological Availability; CHO Cells; Cricetinae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Sulfones | 1999 |
Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.
Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Cloning, Molecular; Dehydroepiandrosterone Sulfate; Estrone; Humans; Kidney; Kinetics; Membrane Proteins; Molecular Sequence Data; Ochratoxins; Oocytes; Placenta; RNA, Messenger; Sequence Alignment; Sulfates; Xenopus | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship | 2000 |
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis | 2001 |
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors | 2003 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Ibuprofen; Inhibitory Concentration 50; Isoenzymes; Models, Molecular; Models, Theoretical; Molecular Structure; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Quantitative Structure-Activity Relationship | 2004 |
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism | 2005 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Flurbiprofen; Mice; Peptide Fragments | 2006 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water | 2006 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
Topics: Amino Acid Substitution; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Humans; Kinetics; Male; Membrane Proteins; Mice; Models, Molecular; Mutation, Missense; Protein Binding; Protein Structure, Tertiary; Sheep; Time Factors | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Catalytic Domain; Computational Biology; Drug Design; Ligands; Models, Molecular; PPAR gamma; Protein Conformation; Software | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Topics: Allosteric Regulation; Allosteric Site; Chemistry, Organic; Chemistry, Pharmaceutical; Chemotaxis; Humans; Inhibitory Concentration 50; Models, Chemical; Models, Molecular; Molecular Conformation; Mutagenesis; Mutation; Receptors, Interleukin-8A; Structure-Activity Relationship | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Edema; Female; Male; Mice; Models, Molecular; Molecular Structure; Nitric Oxide; Pain Measurement; Protein Binding; Pyrazoles; Rats; Rats, Wistar; Stomach; Ulcer; Vasodilator Agents | 2009 |
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
Topics: Binding Sites; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutathione Transferase; Hematopoiesis; Humans; Intramolecular Oxidoreductases; Lipocalins; Models, Molecular; Molecular Conformation; Nocodazole | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors.
Topics: Animals; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Insecta; Models, Molecular; Molecular Structure; Pyrazoles; Stereoisomerism; Structure-Activity Relationship | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Quantitative prediction of human intestinal glucuronidation effects on intestinal availability of UDP-glucuronosyltransferase substrates using in vitro data.
Topics: Administration, Oral; Biotransformation; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Glucuronides; Glucuronosyltransferase; Humans; Intestinal Absorption; Intestines; Isoenzymes; Kinetics; Metabolic Clearance Rate; Microsomes; Models, Biological; Pharmaceutical Preparations; Recombinant Proteins; Substrate Specificity | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Female; Male; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2014 |
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; Carrageenan; Cholesterol, Dietary; Cyclooxygenase Inhibitors; Diet, High-Fat; Drug Design; Edema; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hypolipidemic Agents; In Vitro Techniques; Indicators and Reagents; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Mice; Microsomes; Phenothiazines; Picrates; Rats | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chromones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Indoles; Mice; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Pyrazoles; Structure-Activity Relationship | 2014 |
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Crystallography, X-Ray; Cyclooxygenase 2 Inhibitors; Hyperalgesia; Indoles; Inhibitory Concentration 50; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Molecular Structure; Peptidomimetics | 2015 |
Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo.
Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Glioblastoma; Humans; Iodine Radioisotopes; Mice; Mice, Nude; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2015 |
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine max; Hyperlipidemias; Indoleacetic Acids; Lipoxygenase Inhibitors; Polyethylene Glycols; Propanols; Propionates; Rats; Thioctic Acid | 2015 |
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hyperlipidemias; Hypolipidemic Agents; Morpholines; Rats; Triglycerides | 2016 |
Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.
Topics: Animals; Anti-Inflammatory Agents; Calorimetry; Carbon-13 Magnetic Resonance Spectroscopy; Cyclooxygenase 2 Inhibitors; Drug Design; Female; Humans; Male; Mice; Peptides; Proton Magnetic Resonance Spectroscopy; Quantitative Structure-Activity Relationship; Spectrometry, Mass, Electrospray Ionization | 2016 |
Structure-activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A
Topics: Animals; Blood Platelets; Carboxylic Acids; Group IV Phospholipases A2; Humans; Indoles; Liver; Mice; Phospholipase A2 Inhibitors; Rats; Solubility; Structure-Activity Relationship | 2017 |
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclization; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Male; Molecular Docking Simulation; Protein Conformation; Pyrazoles; Rats; Stereoisomerism; Structure-Activity Relationship; Triazines; Ulcer | 2017 |
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
Topics: Animals; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hypolipidemic Agents; Male; Mice; Mice, Hairless; Molecular Structure; Morpholines; Oxidative Stress; Rats; Structure-Activity Relationship; Thiazines | 2017 |
Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Cell Differentiation; Click Chemistry; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Female; Humans; Lipoxygenase Inhibitors; Macrophages; Molecular Docking Simulation; Molecular Structure; Quinazolinones; Rats; Rats, Wistar; Structure-Activity Relationship; Sulfhydryl Compounds; Tumor Cells, Cultured | 2018 |
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides.
Topics: | 2018 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Neurons; PC12 Cells; Rats; Semicarbazides; Triazoles | 2019 |
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 15-Lipoxygenase; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Ligands; Molecular Docking Simulation; PPAR gamma; Protein Binding; Thiazolidinediones | 2019 |
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Design; Edema; Enzyme Inhibitors; Female; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Molecular Structure; Pyrrolidines; Structure-Activity Relationship | 2020 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Formaldehyde; Humans; Hyperalgesia; Inflammation; Molecular Docking Simulation; Molecular Structure; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship; Triazines; Tryptophan | 2020 |
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry | 2020 |
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Humans; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Tartrates | 2021 |
Effects of some anti-rheumatic agents on copper-catalyzed thermal aggregation of gamma globulin.
Topics: Anti-Inflammatory Agents; Aspirin; Copper; Dexamethasone; Diclofenac; Flufenamic Acid; gamma-Globulins; Gold Sodium Thiomalate; Hot Temperature; Humans; Ibuprofen; Indans; Indomethacin; Penicillamine; Phenylbutazone; Prednisolone | 1979 |
Immobilisation stress-induced antinociception in rats: possible role of serotonin and prostaglandins.
Topics: 5,6-Dihydroxytryptamine; Analgesia; Animals; Diclofenac; Female; Fenclonine; Humans; Indomethacin; Male; Prostaglandins; Rats; Restraint, Physical; Serotonin; Stress, Psychological; Time Factors | 1978 |
Efflux of cyclic AMP, prostaglandin E2 and F2 alpha and thromboxane B2 in leg lymph of rabbits after scalding injury.
Topics: Animals; Burns; Cyclic AMP; Diclofenac; Hindlimb; Indomethacin; Lymph; Prostaglandins E; Prostaglandins F; Rabbits; Thromboxane B2; Thromboxanes; Time Factors | 1979 |
[Current anti-rheumatism agents].
Topics: Allopurinol; Anti-Inflammatory Agents; Diclofenac; Glucocorticoids; Humans; Indomethacin; Rheumatic Diseases | 1978 |
Prostaglandin-sensitive adenylate cyclase in human gastric mucosa. Inhibition by nonsteroid anti-inflammatory agents.
Topics: Adenylyl Cyclases; Anti-Inflammatory Agents; Diclofenac; Gastric Mucosa; Humans; Indomethacin; ortho-Aminobenzoates; Prostaglandin Antagonists; Prostaglandins E | 1979 |
Comparisons of tolerability findings in international clinical trials.
Topics: Arthritis, Rheumatoid; Aspirin; Cardiovascular System; Clinical Trials as Topic; Diclofenac; Drug Tolerance; Follow-Up Studies; Gastrointestinal Diseases; Hematologic Tests; Humans; Ibuprofen; Indomethacin; International Cooperation; Naproxen; Phenylacetates; Time Factors | 1979 |
[Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)].
Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Digestive System; Ibuprofen; Indomethacin; Irritants; Male; Phenylbutazone; Rats; Stomach Ulcer; Thiazoles | 1979 |
[On the efficiency of new antiinflammatory agents. A comparative study (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Carrageenan; Diclofenac; Edema; Fenoprofen; In Vitro Techniques; Indenes; Indomethacin; Ketoprofen; Naproxen; Phenylbutazone; Protease Inhibitors; Rats | 1977 |
In vivo inhibition of prostaglandin synthesis in rabbit kidney by non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Dose-Response Relationship, Drug; Indomethacin; Injections, Intravenous; Kidney; Kidney Medulla; Male; Naproxen; Prostaglandins E; Prostaglandins F; Rabbits; Time Factors | 1978 |
Dose-dependent inhibition of sensory nerve activity in the feline dental pulp by anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Cats; Dental Pulp; Diclofenac; Dose-Response Relationship, Drug; Hot Temperature; Indomethacin; Injections, Intravenous; Methysergide; Naproxen; Nerve Endings; Sensory Receptor Cells | 1978 |
Indomethacin and diclofenac sodium increase sodium and water excretion after extracellular volume expansion in the rabbit.
Topics: Animals; Blood Pressure; Body Water; Diclofenac; Extracellular Space; Hematocrit; Indomethacin; Inulin; Male; p-Aminohippuric Acid; Phenylacetates; Prostaglandins; Rabbits; Renin; Sodium; Time Factors | 1978 |
Inhibition of prostaglandin synthesis in rat brain.
Topics: Acetaminophen; Animals; Aspirin; Brain; Diclofenac; Dose-Response Relationship, Drug; Indomethacin; Male; Naproxen; Prostaglandin Antagonists; Prostaglandins E; Prostaglandins F; Rats; Time Factors | 1978 |
Duodenal mucosal damage associated with chronic use of anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents; Aspirin; Diclofenac; Duodenal Ulcer; Endoscopy; Female; Fiber Optic Technology; Gastritis; Humans; Ibuprofen; Indomethacin; Intestinal Mucosa; Male; Middle Aged | 1977 |
Relationship between the uterotonic action of oxytocin and prostaglandins: oxytocin action and release of PG-activity in isolated nonpregnant and pregnant rat uteri.
Topics: Animals; Diclofenac; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indomethacin; Oxytocin; Pregnancy; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Uterine Contraction; Uterus | 1977 |
Low survival of mice following lethal gamma-irradiation after administration of inhibitors of prostaglandin synthesis.
Topics: Animals; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Gamma Rays; Hematopoietic System; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Prostaglandin Antagonists; Prostaglandins; Survival Rate; Whole-Body Irradiation | 1992 |
Measurement of non-steroid antiinflammatory drugs induced gastric microbleeding.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Diclofenac; Gastric Juice; Gastrointestinal Hemorrhage; Humans; Indomethacin; Middle Aged; Naproxen | 1992 |
Pain after thoracic surgery.
Topics: Acute Disease; Anesthesia Recovery Period; Anesthesia, Conduction; Anesthesia, Epidural; Benzilates; Benzophenones; Chronic Disease; Diclofenac; Dipyrone; Drug Combinations; Female; Finland; Humans; Incidence; Indomethacin; Male; Middle Aged; Oxycodone; Pain Measurement; Pain, Postoperative; Parasympatholytics; Thoracotomy; Time Factors | 1992 |
In vitro effect of nonsteroidal antiinflammatory drugs on proteoglycanase and collagenase activity in human osteoarthritic cartilage.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Diclofenac; Endopeptidases; Female; Humans; Indomethacin; Ketoprofen; Male; Metalloendopeptidases; Microbial Collagenase; Middle Aged; Osteoarthritis, Hip; Piroxicam; Salicylates; Salicylic Acid | 1991 |
Suspected central nervous system toxicity from inadvertent nonsteroidal antiinflammatory drug overdose.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Diseases; Diclofenac; Drug Overdose; Female; Humans; Ibuprofen; Indomethacin; Middle Aged; Poisoning | 1991 |
Clinical experiences in the treatment of pain in rheumatology.
Topics: Adult; Aged; Diclofenac; Female; Humans; Indomethacin; Male; Meclofenamic Acid; Middle Aged; Oxyphenbutazone; Pain; Rheumatic Diseases | 1991 |
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoquinones; Capillary Permeability; Carrageenan; Diclofenac; Edema; Female; Granuloma; Indomethacin; Male; Mice; Naproxen; Pain; Phenylbutazone; Pleurisy; Rats; Rats, Inbred Strains; Silver Nitrate; Stomach Ulcer; Synovitis | 1991 |
Possibilities of the combined use of non-steroidal anti-inflammatory drugs and sulfhydryl compounds in radioprotection.
Topics: Amifostine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cystamine; Diclofenac; Drug Combinations; Drug Evaluation; Drug Synergism; Hematopoiesis; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Radiation Dosage; Radiation-Protective Agents; Sulfhydryl Compounds; Time Factors; Whole-Body Irradiation | 1991 |
Aspirin-like drugs prime human T cells. Modulation of intracellular calcium concentrations.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation, T-Lymphocyte; Arachidonic Acid; Arachidonic Acids; Calcium; CD8 Antigens; Cell Division; Chromatography, High Pressure Liquid; Diclofenac; Dinoprostone; Drug Synergism; Female; Flow Cytometry; Flurbiprofen; Humans; Indomethacin; Interleukin-2; Lymphocyte Activation; Male; Middle Aged; Phytohemagglutinins; Radioimmunoassay; T-Lymphocytes | 1991 |
Enhancement of murine susceptibility to oral lactate dehydrogenase-elevating virus infection by non-steroidal anti-inflammatory agents, and antagonism by misoprostol.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Aspirin; Diclofenac; Female; Indomethacin; Lactate dehydrogenase-elevating virus; Mice; Mice, Inbred Strains; Misoprostol; Virus Diseases | 1991 |
[Inhibition of thrombocyte function by non-steroidal anti-rheumatic agents: a comparative study between diclofenac, acemetacin, mefenamic acid and ibuprofen].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Indomethacin; Malondialdehyde; Mefenamic Acid; Platelet Aggregation; Thromboxanes | 1991 |
Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor synthesis in rat mesangial cells.
Topics: Alkaloids; Analysis of Variance; Animals; Cells, Cultured; Clone Cells; Diclofenac; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glomerular Mesangium; Indomethacin; Interleukin-1; Kinetics; Male; Masoprocol; Nerve Growth Factors; Protein Kinase C; Rats; Rats, Inbred Strains; Recombinant Proteins; RNA, Messenger; Staurosporine; Tumor Necrosis Factor-alpha | 1991 |
Prostaglandin E2 does not inhibit tumoricidal activity of mouse macrophages against adherent tumor cells.
Topics: Animals; Cytotoxicity, Immunologic; Diclofenac; Dinoprostone; Indomethacin; Macrophages; Mice; Mice, Inbred C57BL; Peritoneal Cavity; Thioglycolates; Tumor Cells, Cultured | 1991 |
Comparison of the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on proteoglycan synthesis by articular cartilage explant and chondrocyte monolayer cultures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cells, Cultured; Culture Techniques; Diclofenac; Indomethacin; Ketoprofen; Piroxicam; Propionates; Proteoglycans; Rabbits; Time Factors | 1991 |
Prostaglandin E2 from macrophages of murine splenocyte cultures inhibits the generation of lymphokine-activated killer cell activity.
Topics: Adenocarcinoma; Animals; Cells, Cultured; Diclofenac; Dinoprostone; Down-Regulation; Female; Immune Sera; Indomethacin; Killer Cells, Lymphokine-Activated; Macrophages; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Protein Kinase C; Spleen | 1991 |
The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dogs; Female; Indomethacin; Male; Mice; Naproxen; Phenylbutazone; Rats; Rats, Inbred Strains; Stomach Ulcer | 1991 |
Proteoglycan metabolism in chondrocytes of young pig articular cartilage and its modulation by therapeutic agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cells, Cultured; Dexamethasone; Diclofenac; Indomethacin; Organ Culture Techniques; Proteoglycans; Swine | 1990 |
Mechanisms of decrease in cytoplasmic motility of alveolar macrophages during immediate asthmatic response in dogs.
Topics: Aerosols; Alprostadil; Animals; Antigens, Helminth; Ascaris; Asthma; Carbon Dioxide; Cytoplasm; Diclofenac; Dinoprostone; Dogs; In Vitro Techniques; Indomethacin; Macrophages; Oxygen; Partial Pressure; Pulmonary Alveoli; Respiration | 1990 |
Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Diclofenac; Edema; Elapid Venoms; Female; Gastric Mucosa; Indomethacin; Isoindoles; Levamisole; Male; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium | 1990 |
In vitro capacity of various cyclooxygenase inhibitors to revert immune suppression caused by radiation therapy for breast cancer.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Immune Tolerance; In Vitro Techniques; Indomethacin; Ketoprofen; Lymphocyte Activation; Lysine; Meclofenamic Acid; Middle Aged; Phytohemagglutinins | 1990 |
Effect of interleukin-1 beta on the production of cathepsin B by rabbit articular chondrocytes.
Topics: Animals; Cartilage, Articular; Cathepsin B; Cells, Cultured; Dexamethasone; Diclofenac; Gels; In Vitro Techniques; Indomethacin; Interleukin-1; Microbial Collagenase; Rabbits | 1990 |
Effects of anti-inflammatory agents on mucosal inflammation induced by infection with gram-negative bacteria.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colony Count, Microbial; Dexamethasone; Diclofenac; Escherichia coli; Gram-Negative Bacteria; Indomethacin; Interleukin-6; Kidney; Kinetics; Leukocyte Count; Mice; Mice, Inbred C3H; Mucous Membrane; Urinary Bladder; Urine | 1990 |
Biliary elimination of non-steroidal anti-inflammatory drugs in patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Bile; Cholestasis; Common Bile Duct Diseases; Diclofenac; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged | 1990 |
Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Indomethacin; Joints; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Prednisone; Radiography | 1990 |
Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Diclofenac; Dose-Response Relationship, Drug; Female; Ibuprofen; Indomethacin; Male; Nerve Fibers; Neurons; Rats; Rats, Inbred Strains; Thalamus | 1990 |
Ano-rectal lesions in patients taking suppositories containing non-steroidal anti-inflammatory drugs (NSAID).
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anus Diseases; Diclofenac; Endoscopy; Female; Gastrointestinal Hemorrhage; Humans; Indomethacin; Male; Middle Aged; Rectal Diseases; Suppositories | 1990 |
Objective assessment of topical corticosteroids and non-steroidal anti-inflammatory drugs in methyl-nicotinate-induced skin inflammation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Bufexamac; Clobetasol; Dermatitis, Contact; Diclofenac; Humans; Hydrocortisone; Ibuprofen; Indomethacin; Male; Nicotinic Acids; Niflumic Acid; Phenylbutazone; Regional Blood Flow; Skin | 1990 |
Induction of cleft palate in mice by inhibitors of prostaglandin synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cleft Palate; Diclofenac; Female; Indomethacin; Injections, Intramuscular; Maternal-Fetal Exchange; Mice; Microscopy; Naproxen; Organ Culture Techniques; Palate; Pregnancy; Sulindac | 1990 |
[Urinary calculus protective side effects of anti-rheumatic therapy].
Topics: Arthritis, Rheumatoid; Calcium; Calcium Oxalate; Diclofenac; Follow-Up Studies; Humans; Indomethacin; Magnesium; Uric Acid; Urinary Calculi | 1990 |
Evaluation of the effect of antiarthritic drugs on the secretion of proteoglycans by lapine chondrocytes using a novel assay procedure.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cells, Cultured; Diclofenac; Glycosaminoglycans; Indomethacin; Ketoprofen; Methods; Pentosan Sulfuric Polyester; Propionates; Proteoglycans; Rabbits | 1989 |
Analysis of the effects of cyclooxygenase and lipoxygenase inhibitors on leukocyte accumulation in the inflammatory site.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Cimetidine; Cyclooxygenase Inhibitors; Diclofenac; Histamine Release; Indomethacin; Inflammation; Leukocytes; Lipoxygenase Inhibitors; Propionates; Pyrilamine | 1989 |
Prostaglandin E2 prevents diclofenac-induced enhancement of histamine release and inflammation evoked by in vivo challenge with compound 48/80 in the hamster cheek pouch.
Topics: Animals; Cheek; Diclofenac; Dinoprostone; Guinea Pigs; Histamine Release; Indomethacin; Inflammation; Leukocytes; Microcirculation; p-Methoxy-N-methylphenethylamine; Vasodilation | 1989 |
Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release. A novel effect on free arachidonic acid levels in human synovial cells.
Topics: Acute-Phase Reaction; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Diclofenac; Dinoprostone; Humans; Indomethacin; Interleukin-1; Synovial Membrane | 1989 |
Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors.
Topics: Breast Neoplasms; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Immune Tolerance; Indomethacin; Monocytes; Prognosis; Prospective Studies; Prostaglandins; Random Allocation; T-Lymphocytes | 1989 |
[Evolution of enzymuria in the course of acute renal insufficiency caused by non-steroidal anti-inflammatory agents].
Topics: Acetylglucosaminidase; Acute Kidney Injury; Aged; Aged, 80 and over; Aminopeptidases; Anti-Inflammatory Agents, Non-Steroidal; CD13 Antigens; Diclofenac; Female; gamma-Glutamyltransferase; Hexosaminidases; Humans; Indomethacin; Middle Aged; Naproxen | 1989 |
Effect of indomethacin, diclofenac sodium and sodium salicylate on peripheral blood cell counts in sublethally gamma-irradiated mice.
Topics: Animals; Blood Cell Count; Diclofenac; Dose-Response Relationship, Drug; Hematopoiesis; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Radiation Injuries, Experimental; Sodium Salicylate; Time Factors | 1989 |
Effects of diclofenac, indomethacin, tolfenamic acid and hydrocortisone on prostanoid production in healthy and rheumatic synovial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Humans; Hydrocortisone; Indomethacin; Kinetics; Knee Joint; ortho-Aminobenzoates; Prostaglandin Antagonists; Prostaglandins; Reference Values; Synovial Fluid | 1989 |
Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin-1.
Topics: Diclofenac; Fibroblasts; Humans; Hyaluronic Acid; Hydrocortisone; Indomethacin; Interleukin-1; Prostaglandins E; Stimulation, Chemical; Synovial Fluid | 1989 |
Effects of indomethacin and diclofenac on some functions of polymorphonuclear neutrophils.
Topics: Cell Adhesion; Chemotaxis, Leukocyte; Cytochrome c Group; Diclofenac; Humans; In Vitro Techniques; Indomethacin; Neutrophils; Nitroblue Tetrazolium; Superoxides | 1988 |
Functional compartmentalization of arginine-vasopressin-activated cyclic AMP in anterior pituitary gland: the presence of a compartment activated by prostaglandin E2.
Topics: Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Cyclic AMP; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Indomethacin; Male; Pituitary Gland, Anterior; Prostaglandins E; Rats; Rats, Inbred Strains | 1986 |
Effect of diclofenac sodium, tolfenamic acid and indomethacin on the production of superoxide induced by N-formyl-methionyl-leucyl-phenylalanine in normal human polymorphonuclear leukocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Depression, Chemical; Diclofenac; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; ortho-Aminobenzoates; Superoxide Dismutase; Superoxides; Tritium | 1986 |
Cytoprotective effect of free radical scavengers against mucosal damage produced by different antirheumatic drugs.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Ascorbic Acid; Aspirin; Diclofenac; Female; Free Radicals; Gastric Mucosa; Indomethacin; Male; Penicillamine; Quinolines; Rats; Solubility; Thioctic Acid; Vitamin A; Vitamin E | 1986 |
The history of diclofenac.
Topics: Chemical Phenomena; Chemistry; Diclofenac; Humans; Hydrogen-Ion Concentration; Ibuprofen; Indenes; Indomethacin; Ketoprofen; Naproxen; Phenylbutazone; Piroxicam; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Thiazines | 1986 |
Vascular permeability responses and the role of prostaglandin E2 in an experimental allergic inflammation of air pouch type in rats.
Topics: Animals; Capillary Permeability; Diclofenac; Dinoprostone; Hypersensitivity; Indomethacin; Inflammation; Male; Propionates; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; Rats, Inbred Strains; Time Factors | 1986 |
[Unwanted modification of the thyroid gland by drugs with special reference to nonsteroidal antirheumatic agents].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Female; Goiter; Humans; Indomethacin; Long-Term Care; Male; Middle Aged; Retrospective Studies; Thyroid Gland; Thyroid Hormones | 1986 |
Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis.
Topics: Animals; Blood Glucose; Brain Chemistry; Brain Ischemia; Cyclooxygenase Inhibitors; Dexamethasone; Diclofenac; Electroencephalography; Energy Metabolism; Fatty Acids, Nonesterified; Glycogen; Indomethacin; Male; Necrosis; Neurons; Rats; Rats, Inbred Strains | 1986 |
Preferential venoconstriction by cyclooxygenase inhibition in vivo without attenuation of nitroglycerin venodilation.
Topics: Animals; Cardiac Output; Compliance; Cyclooxygenase Inhibitors; Diclofenac; Indomethacin; Models, Cardiovascular; Nitroglycerin; Norepinephrine; Time Factors; Vasoconstriction; Veins | 1988 |
Effects of indomethacin and diclofenac on cerebral blood flow in hypercapnic conscious rats.
Topics: Animals; Carbon Dioxide; Cerebrovascular Circulation; Diclofenac; Hypercapnia; Indomethacin; Male; Rats; Rats, Inbred Strains | 1988 |
Lipid peroxidation, free radicals and experimental inflammation.
Topics: Animals; Diclofenac; Disease Models, Animal; Edema; Free Radicals; Indomethacin; Inflammation; Lipid Peroxidation; Luminescent Measurements; Male; Malondialdehyde; Piroxicam; Prednisolone; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Congestive heart failure due to nonsteroidal anti-inflammatory drugs in the elderly.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Heart Failure; Humans; Indomethacin; Male; Retrospective Studies | 1988 |
Suppression of sleep by prostaglandin synthesis inhibitors in unrestrained rats.
Topics: Administration, Oral; Animals; Diclofenac; Dose-Response Relationship, Drug; Indomethacin; Injections, Intravenous; Injections, Intraventricular; Male; Prostaglandins; Rats; Rats, Inbred Strains; Sleep | 1988 |
The action of the prostaglandins on isolated human ureteric smooth muscle.
Topics: Diclofenac; Dinoprost; Dinoprostone; Humans; In Vitro Techniques; Indomethacin; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Prostaglandins; Prostaglandins E; Prostaglandins F; Ureter | 1988 |
Nonsteroidal anti-inflammatory drug as tools for analysis of neutrophil functions.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Diclofenac; Humans; Indomethacin; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phenylbutazone | 1987 |
Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis.
Topics: Ampicillin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteriolysis; Cell Wall; Cerebrospinal Fluid; Diclofenac; Dinoprostone; Indenes; Indomethacin; Leukocytosis; Male; Masoprocol; Meningitis, Pneumococcal; Methylprednisolone; Prostaglandins E; Rabbits; Streptococcus pneumoniae | 1987 |
The effect of prostaglandin synthesis inhibition on motility of the sheep ureter.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Diclofenac; Dinoprost; Humans; Indomethacin; Muscle Contraction; Muscle, Smooth; Prostaglandins F; Sheep; Thromboxane B2; Ureter | 1987 |
Reduction of urinary protein and prostaglandin E2 excretion in the nephrotic syndrome by non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Diclofenac; Dinoprostone; Flurbiprofen; Glomerular Filtration Rate; Humans; Indomethacin; Male; Middle Aged; Nephrotic Syndrome; Prostaglandins E; Proteinuria; Renin; Sulindac | 1986 |
Clinical results in the treatment of therapy-resistant calcium-stone formers with non-steroidal anti-inflammatory drugs.
Topics: Adult; Aged; Calcium Oxalate; Diclofenac; Drug Therapy, Combination; Female; Humans; Indomethacin; Male; Middle Aged; Retrospective Studies; Urinary Calculi | 1987 |
Water intoxication associated with non-steroidal anti-inflammatory drug therapy.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Female; Humans; Hyponatremia; Indomethacin; Piroxicam; Water Intoxication | 1987 |
Drug-bone marrow interactions.
Topics: Anemia, Aplastic; Australia; Bone Marrow Diseases; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Humans; Indomethacin; Product Surveillance, Postmarketing | 1987 |
Clinical relevance of nonsteroidal anti-inflammatory drug pharmacokinetics.
Topics: Absorption; Biological Availability; Diclofenac; Drug Interactions; Humans; Indomethacin; Kinetics; Piroxicam; Tablets, Enteric-Coated | 1987 |
A comparison of indomethacin and diclofenac in the inhibition of experimental heterotopic new bone formation.
Topics: Animals; Bone Development; Diclofenac; Indomethacin; Male; Rats; Rats, Inbred Strains | 1987 |
[Drug-induced lesion of the liver].
Topics: Adult; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; Drug Combinations; Drug Therapy, Combination; Humans; Indomethacin; Male; Middle Aged; Phenylbutazone; Sulfadimethoxine | 1987 |
Generalized pustular psoriasis precipitated by diclofenac and indomethacin.
Topics: Adult; Diclofenac; Humans; Indomethacin; Male; Psoriasis | 1987 |
[Changes in the filtration and reabsorption barrier of the kidneys of the rat after administration of nonsteroidal anti-inflammatory preparations].
Topics: Animals; Anti-Inflammatory Agents; Diclofenac; Epithelium; Indomethacin; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Microscopy, Electron; Mitochondria; Rats; Rats, Inbred Strains | 1986 |
Indomethacin and ibuprofen enhance anoxia-induced hyperemia in rat brain.
Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Diclofenac; Extracorporeal Circulation; Hyperemia; Hypoxia, Brain; Ibuprofen; Indomethacin; Male; Rats; Rats, Inbred Strains | 1986 |
Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Dinoprostone; Guanidines; Humans; Indomethacin; Naproxen; ortho-Aminobenzoates; Prednisolone; Prostaglandins; Prostaglandins E; Quinazolines; Synovial Fluid; Thromboxane B2 | 1985 |
Effects of anti-inflammatory drugs on catabolin-induced cartilage destruction in vitro.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Cattle; Culture Techniques; Diclofenac; Hydroxychloroquine; Indomethacin; Interleukin-1; Interleukin-1beta; Phenylacetates | 1985 |
Pharmacokinetic factors as causes of variability in response to non-steroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Bile; Biological Availability; Diclofenac; Humans; Indomethacin; Kinetics; Liver Circulation; Metabolic Clearance Rate; Piroxicam; Rheumatic Diseases; Thiazines; Tissue Distribution | 1985 |
Effect of indomethacin, tiaprofenic acid and dicrofenac on rat gastric mucosal damage and content of prostacyclin and prostaglandin E2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Gastric Fundus; Gastric Mucosa; Indomethacin; Male; Propionates; Prostaglandins E; Radioimmunoassay; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
Prostaglandin synthetase inhibition of renal pelvic smooth muscle in the rabbit.
Topics: Animals; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Kidney Pelvis; Muscle Contraction; Muscle, Smooth; Prostaglandins E; Prostaglandins E, Synthetic; Prostaglandins F; Rabbits | 1985 |
The effects of diclofenac sodium on arachidonic acid metabolism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indomethacin; Leukocytes; Lipoxygenase; Naproxen; Phospholipases A; Phospholipases A2; Phospholipids; Piroxicam; Prostaglandins E; SRS-A; Thiazines; Triglycerides | 1985 |
Effects of some anti-inflammatory drugs on 12 blood constituents: protocol for the study of in vivo effects of drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Chemical Analysis; Blood Urea Nitrogen; Cholesterol; Creatinine; Diclofenac; Humans; Ibuprofen; Indomethacin; Iron; Ketoprofen; Prospective Studies; Retrospective Studies; Serum Albumin; Time Factors; Triglycerides; Uric Acid | 1985 |
[In vitro effects of non-steroidal anti-inflammatory drugs on production of oxygen radicals evaluated by the chemiluminescent response of polymorphonuclear leukocytes].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Cell Membrane; Diclofenac; Free Radicals; Humans; Indomethacin; Luminescent Measurements; Neutrophils; Oxygen; Piroxicam; Thiazines; Zymosan | 1985 |
[Clinico-paraclinical characteristics of Wissler-Fanconi subsepsis].
Topics: Child; Child, Preschool; Diagnosis, Differential; Diclofenac; Drug Therapy, Combination; Humans; Indomethacin; Infant; Prednisolone; Wissler's Syndrome | 1985 |
Worldwide experience with diclofenac in rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Humans; Indomethacin; Naproxen; Osteoarthritis; Sulindac; Tolmetin | 1985 |
Diclofenac in the treatment of painful joints and traumatic tendinitis (including strains and sprains): a brief review.
Topics: Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Joint Diseases; Ketoprofen; Naproxen; Pain; Sprains and Strains; Tendinopathy | 1985 |
[Effect of inhibitors of prostaglandin synthesis on the eye].
Topics: Animals; Burns, Chemical; Diclofenac; Eye; Eye Burns; Eye Diseases; Humans; Indomethacin; Inflammation; Neovascularization, Pathologic; Phenylacetates; Postoperative Care; Preoperative Care; Prostaglandin Antagonists; Rabbits | 1983 |
Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
Topics: Animals; Aspirin; Diclofenac; Fibrosarcoma; Indomethacin; Liver Neoplasms, Experimental; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Prostaglandin Antagonists; Rats; Rats, Inbred Strains; Sarcoma, Experimental | 1983 |
Adrenocorticotropin and beta-endorphin release from rat adenohypophysis in vitro: inhibition by prostaglandin E2 formed locally in response to vasopressin and corticotropin-releasing factor.
Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Endorphins; Flurbiprofen; Indomethacin; Male; Pituitary Gland, Anterior; Potassium; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains | 1984 |
Ganglionic blocking effect of indomethacin and other prostaglandin synthetase inhibitors.
Topics: Animals; Cats; Diclofenac; Fenoprofen; Ganglia, Sympathetic; In Vitro Techniques; Indomethacin; Niflumic Acid; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Rana esculenta; Sulindac; Synaptic Transmission | 1980 |
The role of prostaglandins in the alpha- and beta-adrenoceptor mediated renin release response to graded renal nerve stimulation.
Topics: Animals; Diclofenac; Dogs; Drug Combinations; Female; Indomethacin; Kidney; Male; Metoprolol; Phenoxybenzamine; Prostaglandins; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Renin; Stimulation, Chemical | 1981 |
[Effect of indocide and voltaren on blood coagulability in surgical interventions on rheumatology patients].
Topics: Adult; Aged; Blood Coagulation; Diclofenac; Humans; Indomethacin; Middle Aged; Phenylacetates; Preoperative Care; Rheumatic Diseases; Time Factors | 1984 |
Decreasing inhibitory potency of prostaglandin synthetase inhibitors during their cooxidative metabolism. Studies on aminophenols, pyrazolon derivatives and 1,3-diphenylisobenzofuran.
Topics: Acetaminophen; Aminophenols; Aminopyrine; Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Cyclooxygenase Inhibitors; Diclofenac; Indomethacin; Kidney Medulla; Lipoxygenase Inhibitors; Male; Peroxides; Phenacetin; Phenylbutazone; Rats; Rats, Inbred Strains | 1983 |
Involvement of prostaglandins in LPS-mediated regulation of plasminogen activator synthesis by inflammatory macrophages.
Topics: Animals; Bacterial Toxins; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Endotoxins; Enterotoxins; Indomethacin; Inflammation; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred Strains; Plasminogen Activators; Prostaglandins E | 1984 |
Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Diclofenac; Diflunisal; Epinephrine; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Oxyphenbutazone; Piroxicam; Platelet Aggregation; Thiazines; Time Factors | 1984 |
Inhibition of prostaglandin E synthesis by steroidal and nonsteroidal antiinflammatory drugs in human synovial fibroblast cultures.
Topics: Anti-Inflammatory Agents; Cells, Cultured; Diclofenac; Fibroblasts; Humans; Hyaluronic Acid; Hydrocortisone; Ibuprofen; Indomethacin; Poly I-C; Prostaglandins E; Synovial Membrane | 1984 |
Inhibitory effect of a new nonsteroidal anti-inflammatory drug, 6-methoxy-4-phenyl-1-(2,2,2-trifluoroethyl)-2-(1H)-quinazolinone, on prostaglandin biosynthesis.
Topics: Animals; Anti-Inflammatory Agents; Diclofenac; Female; Indomethacin; Male; Prostaglandin Antagonists; Prostaglandins; Quinazolines; Quinazolinones; Rabbits | 1983 |
[Effect of indomethacin and diclofenac on plasma and synovial prostaglandins in patients with rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Diclofenac; Dinoprost; Humans; Indomethacin; Phenylacetates; Prostaglandin Antagonists; Prostaglandins E; Prostaglandins F; Synovial Fluid | 1983 |
[Interactions of antirheumatic and anti-inflammatory agents].
Topics: Aluminum Hydroxide; Aminopyrine; Anti-Inflammatory Agents; Biotransformation; Diclofenac; Drug Interactions; Humans; Indomethacin; Kinetics; Liver; Pyrimidinones; Rheumatic Diseases | 1983 |
Comparison of the effect of nonsteroidal and steroidal antiinflammatory agents on prostaglandin production during ovulation in the rabbit.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Dexamethasone; Diclofenac; Female; Fenoprofen; Indomethacin; Ovulation; Prostaglandins; Rabbits | 1983 |
[Imadyl: gastric irritation in comparison with acetylsalicylic acid, indomethacin, piroxicam and diclofenac-Na].
Topics: Anti-Inflammatory Agents; Aspirin; Carbazoles; Diclofenac; Humans; Indomethacin; Male; Membrane Potentials; Piroxicam; Stomach; Thiazines | 1983 |
PGF2 alpha regulation of LH action on testicular testosterone production.
Topics: Animals; Antigen-Antibody Reactions; Cyclooxygenase Inhibitors; Diclofenac; Indomethacin; Luteinizing Hormone; Male; Prostaglandins E; Prostaglandins F; Testis; Testosterone | 1980 |
Altered pharmacodynamics of 1-(2-tetrahydrofuryl)-5-fluorouracil by pretreatment of rats with phenobarbital, indomethacin, diclofenac sodium and carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Diclofenac; Female; Fluorouracil; Indomethacin; Microsomes, Liver; Phenobarbital; Phenylacetates; Rats; Tegafur; Time Factors | 1980 |
[Inhibitory action of non-steroidal anti-flammatory drugs on prostaglandin synthesis and release (author's transl)].
Topics: Acetates; Animals; Anti-Inflammatory Agents; Aspirin; Depression, Chemical; Diclofenac; Flurbiprofen; Indomethacin; Male; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; Synovial Membrane; Synovitis; Thiazoles | 1980 |
Effects of cyclooxygenase inhibitors and prostaglandin E2 on macrophage activation in vitro.
Topics: Animals; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Hexosephosphates; In Vitro Techniques; Indomethacin; Macrophages; Male; Mice; Phagocytosis; Phenylacetates; Plasminogen Activators; Prostaglandins E; Zymosan | 1981 |
Influence of two non-steroidal anti-inflammatory drugs on lipolysis and on plasma post-heparin lipoprotein lipase activity in normal man.
Topics: Adult; Aged; Blood Glucose; Cholesterol; Cyclooxygenase Inhibitors; Diclofenac; Fatty Acids, Nonesterified; Female; Heparin; Humans; Indomethacin; Lipolysis; Lipoprotein Lipase; Lipoproteins; Male; Middle Aged; Phenylacetates; Triglycerides | 1981 |
Potential anticonvulsive properties of endogenous prostaglandins formed in mouse brain.
Topics: Animals; Brain; Diclofenac; Electroshock; Flurbiprofen; Indomethacin; Kinetics; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Prostaglandin-Endoperoxide Synthases; Prostaglandins | 1982 |
[Effect of antirheumatic preparations on myocardial contractile function].
Topics: Adolescent; Adult; Aspirin; Dexamethasone; Diclofenac; Drug Evaluation; Drug Therapy, Combination; Humans; Indomethacin; Male; Myocardial Contraction; Prednisolone; Rheumatic Diseases; Time Factors | 1981 |
[Comparative efficacy of prednisolone and modern nonsteroid anti-inflammatory agents (voltaren and indomethacin) in the therapy of acute rheumatism].
Topics: Acute Disease; Adolescent; Adult; Diclofenac; Hemodynamics; Humans; Indomethacin; Male; Phenylacetates; Prednisolone; Rheumatic Diseases; Time Factors | 1981 |
[Transsynovial kinetics and correlation of dosage and effect of non-steroidal anti-rheumatic agents].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Humans; Indomethacin; Kinetics; Piroxicam; Synovial Fluid; Thiazines | 1982 |
A comparison of the effects of non-steroidal compounds on the disruption of the blood-aqueous barrier.
Topics: Animals; Anti-Inflammatory Agents; Aqueous Humor; Diclofenac; Eye; Eye Proteins; Flurbiprofen; Hydrogen-Ion Concentration; Indomethacin; Rabbits | 1982 |
Renal effects of pinane-thromboxane A2 and indomethacin in saline volume-expanded spontaneously hypertensive rats.
Topics: Animals; Bicyclic Monoterpenes; Blood Pressure; Diclofenac; Hypertension; Indomethacin; Kidney; Male; Potassium; Prostaglandins; Rats; Rats, Inbred Strains; Sodium; Thromboxane A2; Thromboxanes | 1982 |
[Influence of various non-steroid antirheumatic drugs on the electric potential between the gastric serosa and mucosa (author's transl)].
Topics: Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Diclofenac; Female; Gastric Mucosa; Humans; Indomethacin; Male; Membrane Potentials; Middle Aged; Phenylbutazone | 1981 |
Renal prostaglandins and sodium balance in the rabbit: lack of effect of aspirin-like drugs.
Topics: Aldosterone; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Diet, Sodium-Restricted; Female; Indomethacin; Kidney; Mineralocorticoid Receptor Antagonists; Naproxen; Potassium; Prostaglandins E; Prostaglandins F; Rabbits; Sodium | 1980 |
[Therapy of degenerative arthropathies with sodium diclofenac].
Topics: Adult; Aged; Bone Diseases; Diclofenac; Female; Humans; Indomethacin; Joint Diseases; Male; Middle Aged; Osteoarthritis; Phenylacetates | 1980 |
[Hematotoxic lesions caused by non-steroidal antirheumatic agents].
Topics: Adult; Aged; Agranulocytosis; Anemia, Aplastic; Arthritis, Rheumatoid; Aspirin; Diclofenac; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Penicillamine; Phenylbutazone; Thrombocytopenia | 1980 |
Contrasting effect of oral and intravenous cyclophosphamide treatment on phenotypes of human peripheral blood lymphocytes.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Diclofenac; Female; HLA-DR Antigens; Humans; Immunophenotyping; Immunosuppressive Agents; Indomethacin; Injections, Intravenous; Lymphocyte Count; Lymphocyte Subsets; Male; Middle Aged; Receptors, Interleukin-2 | 1994 |
Inhibitory effect of NSAIDs on the chemotaxis induced by substance P on human monocytes and polymorphonuclear cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Chemotaxis, Leukocyte; Diclofenac; Humans; Ibuprofen; Indomethacin; Leukocytes; Monocytes; Neutrophils; Piroxicam; Substance P | 1993 |
Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Aspirin; Cell Adhesion; Cell Adhesion Molecules; Cytoplasmic Granules; Diclofenac; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzymes; Humans; Indomethacin; Inflammation; Intercellular Adhesion Molecule-1; L-Selectin; Neutrophils; Piroxicam | 1995 |
Submicron emulsion vehicle for enhanced transdermal delivery of steroidal and nonsteroidal antiinflammatory drugs.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Indomethacin; Naproxen; Piroxicam; Rats; Rats, Sprague-Dawley; Skin; Steroids; Time Factors | 1995 |
Prostacyclin-dependent cyclic AMP formation in endothelial cells.
Topics: Animals; Cell Line; Cells, Cultured; Cyclic AMP; Diclofenac; Endothelium, Vascular; Epoprostenol; Iloprost; Indomethacin; Swine | 1993 |
Alterations in the electroretinogram of newborn piglets by propionic acid-derivative nonsteroidal antiinflammatory drugs but not by indomethacin and diclofenac.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Electroretinography; Flurbiprofen; Ibuprofen; Indomethacin; Naproxen; Photoreceptor Cells; Propionates; Prostaglandins; Retina; Swine | 1995 |
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depression, Chemical; Diclofenac; Dinoprostone; Dogs; Etodolac; Gastric Mucosa; Guinea Pigs; Indomethacin; Interleukin-1; Ketoprofen; Kidney; Naproxen; Oxygen; Pain; Piroxicam; Rabbits; Rats | 1994 |
Effect of zinc on the anti-inflammatory and ulcerogenic activities of indometacin and diclofenac.
Topics: Analysis of Variance; Animals; Diclofenac; Drug Interactions; Indomethacin; Male; Rats; Stomach Ulcer; Zinc | 1995 |
Prostaglandin release from lumbar disc and facet joint tissue.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Cartilage, Articular; Diclofenac; Dinoprostone; Humans; In Vitro Techniques; Indomethacin; Intervertebral Disc; Leukotriene C4; Lumbar Vertebrae; Radioimmunoassay | 1994 |
Antirheumatic drug profiles evaluated in the adjuvant arthritis of rats by multiparameter analysis.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Diclofenac; Drug Evaluation, Preclinical; Foot; Freund's Adjuvant; Immunosuppressive Agents; Indomethacin; Male; Organ Size; Rats; Rats, Inbred Lew; Steroids | 1994 |
Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs. A report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations.
Topics: Administration, Cutaneous; Administration, Oral; Adverse Drug Reaction Reporting Systems; Age Distribution; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Formularies, Hospital as Topic; Humans; Indomethacin; Male; Sex Distribution; Sex Factors; Spain | 1994 |
Cyclooxygenase inhibitors augment the production of pro-matrix metalloproteinase 9 (progelatinase B) in rabbit articular chondrocytes.
Topics: Alprostadil; Animals; Cartilage, Articular; Cells, Cultured; Collagenases; Diclofenac; Dinoprostone; Enzyme Precursors; Gelatinases; Indomethacin; Matrix Metalloproteinase 9; Metalloendopeptidases; Rabbits; Synovial Membrane | 1995 |
Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization.
Topics: Analgesia; Animals; Arginine; Carrageenan; Diclofenac; Dinoprostone; Drug Interactions; Enzyme Activation; Guanylate Cyclase; Hyperalgesia; Indomethacin; Inflammation; Injections, Intra-Articular; Knee Injuries; Male; Methylene Blue; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Pain Measurement; Rats; Rats, Wistar | 1994 |
[The treatment of temporal arteritis].
Topics: Aged; Anti-Inflammatory Agents; Diclofenac; Female; Giant Cell Arteritis; Humans; Indomethacin; Methylprednisolone; Methylprednisolone Acetate; Remission Induction | 1994 |
Role of prostaglandin-mediated cyclic AMP formation in protein kinase C-dependent secretion of atrial natriuretic peptide in rat cardiomyocytes.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Atrial Natriuretic Factor; Bucladesine; Cells, Cultured; Cyclic AMP; Diclofenac; Dinoprost; Dinoprostone; Epoprostenol; Heart; Heart Ventricles; Indomethacin; Kinetics; Myocardial Contraction; Myocardium; Nifedipine; Prostaglandins; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Thionucleotides | 1994 |
Utilization of some NSAID's and a H2-blocker in two hospitals.
Topics: Bulgaria; Diclofenac; Drug Utilization; Hospitals, University; Hospitals, Urban; Humans; Indomethacin; Random Allocation; Ranitidine; Seasons | 1994 |
Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Diclofenac; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Indomethacin; Liposomes; Membranes, Artificial; Models, Biological; Phosphatidylcholines; Sulfonamides | 1993 |
The determination of non-steroidal antiinflammatory drugs in pharmaceuticals by capillary zone electrophoresis and micellar electrokinetic capillary chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Buffers; Calibration; Chemistry, Pharmaceutical; Chromatography; Diclofenac; Dosage Forms; Electrophoresis; Ibuprofen; Indomethacin; Ketoprofen; Micelles; Piroxicam; Reference Standards; Regression Analysis; Reproducibility of Results | 1994 |
Testing drugs on human osteoarthritic articular cartilage.
Topics: Aged; Aged, 80 and over; Alcian Blue; Birefringence; Cartilage, Articular; Diclofenac; Female; Hip Joint; Humans; Indomethacin; Male; Middle Aged; Organ Culture Techniques; Osteoarthritis, Hip; Proteoglycans; Reproducibility of Results; Uridine Diphosphate Glucose Dehydrogenase | 1994 |
Cyclo-oxygenase products released by low pH have capsaicin-like actions on sensory nerves in the isolated guinea pig heart.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Diclofenac; Epoprostenol; Guinea Pigs; Heart; Hydrogen-Ion Concentration; Indomethacin; Lactates; Lactic Acid; Neurons, Afferent; Perfusion; Receptors, Drug | 1994 |
In vitro release of prostaglandins and leukotrienes from synovial tissue, cartilage, and bone in degenerative joint diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Bone and Bones; Cartilage, Articular; Chondrocalcinosis; Culture Techniques; Diclofenac; Eicosanoids; Humans; Indomethacin; Leukotrienes; Osteoarthritis; Prostaglandins; Synovial Membrane | 1993 |
Gastric mucosal damage induced by nonsalicylate nonsteroidal antiinflammatory drugs in rats is mediated systemically.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Gastric Mucosa; Indomethacin; Male; Naproxen; Rats; Rats, Wistar | 1993 |
Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Indomethacin; Male; Misoprostol; Pyloric Antrum; Rabbits; Ranitidine; Stomach Ulcer | 1993 |
Extractionless high-performance liquid chromatographic method for the determination of diclofenac in human plasma and urine.
Topics: Chromatography, High Pressure Liquid; Diclofenac; Humans; Indomethacin; Spectrophotometry, Ultraviolet | 1993 |
Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia?
Topics: Acetazolamide; Acidosis; Animals; Carbon Dioxide; Cerebrovascular Circulation; Diclofenac; Extracellular Space; Hypercapnia; Indomethacin; Male; Rats; Rats, Wistar | 1993 |
Motor effects of indomethacin, morphine or vagal nerve stimulation on the feline small intestine in vivo.
Topics: Animals; Aspirin; Autonomic Nervous System; Cats; Diclofenac; Electric Stimulation; Female; Gastrointestinal Motility; Indomethacin; Jejunum; Male; Morphine; Muscle Contraction; Neuroeffector Junction; Vagus Nerve | 1993 |
Gastroprotective effect of zinc acexamate against damage induced by nonsteroidal antiinflammatory drugs. A morphological study.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Dinoprostone; Drug Evaluation, Preclinical; Female; Gastric Mucosa; Indomethacin; Microscopy, Electron, Scanning; Necrosis; Piroxicam; Rats; Rats, Wistar; Surface Properties | 1993 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygenase Inhibitors; Diclofenac; Edema; Fever; Ibuprofen; In Vitro Techniques; Indomethacin; Male; Nitrobenzenes; Pain; Phenylpropionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides | 1993 |
Effects of diclofenac sodium and indomethacin on proliferation and collagen synthesis of lens epithelial cells in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cataract; Cell Division; Cells, Cultured; Collagen; Cyclooxygenase Inhibitors; Diclofenac; DNA Replication; Epithelium; Humans; Indomethacin; Lens, Crystalline; Proline; Thymidine | 1995 |
Small bowel permeability--a variable effect of NSAIDS.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromium Radioisotopes; Diclofenac; Edetic Acid; Female; Humans; Indomethacin; Intestinal Absorption; Intestine, Small; Male; Mannitol; Middle Aged; Permeability; Piroxicam | 1995 |
Gastric mucosal adaptation to diclofenac injury.
Topics: Adaptation, Physiological; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dose-Response Relationship, Drug; Drug Tolerance; Ethanol; Gastric Mucosa; Indomethacin; Male; Membrane Potentials; Piroxicam; Rats; Rats, Inbred Strains; Time Factors | 1996 |
Do non-steroidal anti-inflammatory drugs have an effect on gastric cell turnover?
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Bromodeoxyuridine; Cell Division; Diclofenac; Gastric Mucosa; Gastroscopy; Humans; Ibuprofen; Immunohistochemistry; Indomethacin; Mefenamic Acid; Naproxen; Pyloric Antrum | 1995 |
Poly(D,L-lactide) nanocapsules containing non-steroidal anti-inflammatory drugs: gastrointestinal tolerance following intravenous and oral administration.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Diclofenac; Drug Carriers; Indomethacin; Infusions, Intravenous; Intestine, Small; Male; Polyesters; Rats; Rats, Wistar; Stomach | 1995 |
Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cells, Cultured; Clone Cells; Diclofenac; Dinoprostone; Gene Expression Regulation; HTLV-I Infections; Humans; Indomethacin; Interferon-gamma; Interleukin-2; Interleukin-6; Ketoprofen; Leukemia-Lymphoma, Adult T-Cell; Leukocytes, Mononuclear; Lymphocyte Activation; Molecular Sequence Data; Polymerase Chain Reaction; RNA, Messenger; Sarcoidosis, Pulmonary; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uveitis | 1995 |
[A case of drug-induced immune hemolytic anemia during alpha-interferon therapy for renal cell carcinoma].
Topics: Anemia, Hemolytic, Autoimmune; Carcinoma, Renal Cell; Diclofenac; Female; Humans; Indomethacin; Interferon-alpha; Kidney Neoplasms; Middle Aged; Prednisolone | 1996 |
Study of post-natal effect of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. III. Inhibitory action of indomethacin, voltaren, theophylline and epsilon-aminocaproic acid.
Topics: Aminocaproic Acid; Animals; Anticarcinogenic Agents; Brain Neoplasms; Carcinogens; Central Nervous System Neoplasms; Diclofenac; Ethylnitrosourea; Female; Indomethacin; Kidney Neoplasms; Maternal-Fetal Exchange; Neoplasms, Experimental; Peripheral Nervous System Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Spinal Cord Neoplasms; Theophylline | 1996 |
Brain prostaglandins mediate the bombesin-induced increase in plasma levels of catecholamines.
Topics: Animals; Bombesin; Brain; Diclofenac; Epinephrine; Indomethacin; Injections, Intraventricular; Kinetics; Male; Norepinephrine; Prostaglandins; Rats; Rats, Wistar; Thyrotropin-Releasing Hormone | 1996 |
Modelling of indometacin and diclofenac sodium binding to the molecule of human serum albumin.
Topics: Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Hydrogen-Ion Concentration; Indomethacin; Models, Chemical; Molecular Sequence Data; Protein Binding; Serum Albumin; Spectrophotometry, Infrared; Urea | 1996 |
Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Enzyme Activation; gamma-Glutamyltransferase; Indomethacin; Kidney; Male; Piroxicam; Rats; Rats, Inbred Strains | 1997 |
Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Diclofenac; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastrins; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Pentagastrin; Ranitidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiazoles | 1997 |
Combined non-steroidal therapy in experimental corneal injury.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns, Chemical; Cornea; Corneal Injuries; Dexamethasone; Diclofenac; Disease Models, Animal; Drug Therapy, Combination; Eye Burns; Free Radical Scavengers; Glucocorticoids; Indomethacin; Ophthalmic Solutions; Rabbits; Thiourea; Wound Healing | 1997 |
Vasospastic angina induced by nonsteroidal anti-inflammatory drugs.
Topics: Aged; Angina Pectoris; Anti-Inflammatory Agents, Non-Steroidal; Coronary Angiography; Coronary Vasospasm; Diagnosis, Differential; Diclofenac; Drug Hypersensitivity; Electrocardiography; Female; Humans; Indomethacin; Male | 1997 |
Cyclooxygenase inhibitors enhance the production of tissue inhibitor-1 of metalloproteinases (TIMP-1) and pro-matrix metalloproteinase 1 (proMMP-1) in human rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Collagenases; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Enzyme Precursors; Fibroblasts; Humans; Indomethacin; Interleukin-1; Matrix Metalloproteinase 1; Recombinant Proteins; Synovial Membrane; Tissue Inhibitor of Metalloproteinase-1 | 1997 |
Diclofenac and indomethacin influence the healing of normal and ischaemic incisional wounds in skin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Indomethacin; Male; Rats; Rats, Wistar; Skin; Surgical Flaps; Tensile Strength; Time Factors; Wound Healing | 1997 |
Reduction by antiinflammatory drugs of the response of corneal sensory nerve fibers to chemical irritation.
Topics: Acetic Acid; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Carbon Dioxide; Cats; Cornea; Cyclooxygenase Inhibitors; Diclofenac; Diltiazem; Electrophysiology; Female; Flurbiprofen; Indomethacin; Male; Nerve Fibers; Nociceptors; Pain; Trigeminal Nerve | 1997 |
Mechanisms and sites of pyrogenic action exerted by staphylococcal enterotoxin A in rabbits.
Topics: Animals; Anisomycin; Cyclooxygenase Inhibitors; Dexamethasone; Diclofenac; Enterotoxins; Enzyme Inhibitors; Guanidines; Indomethacin; Injections, Intraventricular; Male; Nitric Oxide Synthase; Protein Synthesis Inhibitors; Pyrogens; Rabbits; Staphylococcus aureus; Superantigens | 1997 |
Bone marrow infection caused by Actinobacillus ureae in a rheumatoid arthritis patient.
Topics: Actinobacillus; Actinobacillus Infections; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy, Needle; Bone Marrow; Diclofenac; Drug Therapy, Combination; Fever; Humans; Indomethacin; Male; Neurologic Examination; Penicillin G; Penicillins; Physical Examination | 1997 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Dinoprostone; Edema; Erythema; Fever; Gastric Mucosa; Guinea Pigs; Hindlimb; Hyperalgesia; Indomethacin; Intestinal Mucosa; Ketoprofen; Male; Phenylpropionates; Rats; Species Specificity; Stomach Ulcer; Ultraviolet Rays | 1998 |
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Female; Ileum; Indans; Indomethacin; Intestinal Diseases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Ulcer | 1998 |
Effect of some cyclooxygenase inhibitors on the increase in guanosine 3':5'-cyclic monophosphate induced by NO-donors in human whole platelets.
Topics: Acetophenones; Aspirin; Blood Platelets; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Humans; Indomethacin; Indoprofen; Nitric Oxide; Nitroprusside; Penicillamine; Phospholipases A; Thromboxane B2 | 1998 |
Influence of acute uraemia on percutaneous absorption of nonsteroidal anti-inflammatory drugs.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ibuprofen; Indomethacin; Male; Rats; Rats, Wistar; Skin Absorption; Uremia | 1998 |
Premature closure of the fetal ductus arteriosus after maternal use of non-steroidal anti-inflammatory drugs. Adverse Drug Reactions Advisory Committee.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Australia; Diclofenac; Ductus Arteriosus; Female; Fetal Diseases; Humans; Indomethacin; Mefenamic Acid; Pregnancy | 1998 |
PGE2 synthesis by corneal endothelial cells: effect of glucocorticoids and NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Cattle; Cells, Cultured; Dexamethasone; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Endothelium, Corneal; Glucocorticoids; Indomethacin; Ionophores; Lipopolysaccharides; Prednisolone; Salmonella typhimurium | 1999 |
Allergic contact dermatitis due to diclofenac and indomethacin.
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Dermatitis, Allergic Contact; Diclofenac; Eyelids; Female; Humans; Indomethacin; Ophthalmic Solutions; Patch Tests | 1998 |
Protein binding of some nonsteroidal anti-inflammatory drugs studied by high-performance liquid affinity chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Chromatography, High Pressure Liquid; Diclofenac; Indomethacin; Protein Binding; Serum Albumin; Sulindac | 1999 |
The structural and electronical factors that contribute affinity for the time-dependent inhibition of PGHS-1 by indomethacin, diclofenac and fenamates.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Diclofenac; Indomethacin; Isoenzymes; Models, Molecular; Molecular Structure; ortho-Aminobenzoates; Prostaglandin-Endoperoxide Synthases; Sheep; Static Electricity | 1999 |
Colitis induced by interaction of cyclosporine A and non-steroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Child; Colitis; Cyclosporine; Diclofenac; Drug Interactions; Female; Humans; Immunosuppressive Agents; Indomethacin | 1999 |
The effect of some anti-inflammatory drugs on histamine and serotonin release from rat peritoneal mast cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Aspirin; Auranofin; Diclofenac; Histamine Release; Indomethacin; Mast Cells; p-Methoxy-N-methylphenethylamine; Rats; Serotonin | 1999 |
Study of the solid-phase extraction of diclofenac sodium, indomethacin and phenylbutazone for their analysis in human urine by liquid chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diclofenac; Humans; Indomethacin; Phenylbutazone; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1999 |
Cyclooxygenase inhibitors increase Na-K-2Cl cotransporter abundance in thick ascending limb of Henle's loop.
Topics: Animals; Carrier Proteins; Cyclooxygenase Inhibitors; Diclofenac; Indomethacin; Loop of Henle; Male; Misoprostol; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Sodium-Potassium-Chloride Symporters | 1999 |
Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cortical Spreading Depression; Cyclooxygenase Inhibitors; Dexamethasone; Diclofenac; Disease Susceptibility; Dizocilpine Maleate; Enzyme Induction; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Indomethacin; Isoenzymes; Male; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Parietal Lobe; Phospholipases A; Phospholipases A2; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-delta; Quinacrine; Quinoxalines; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Transcriptional Activation | 1999 |
Mechanisms of protection afforded by cyclooxygenase inhibitors to endothelial function against ischemic injury in rat isolated hearts.
Topics: Animals; Arachidonic Acid; Cardiotonic Agents; Coronary Circulation; Coronary Vessels; Cyclooxygenase Inhibitors; Diclofenac; Endothelium, Vascular; Imidazoles; In Vitro Techniques; Indomethacin; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Random Allocation; Rats; Rats, Sprague-Dawley; Vascular Resistance | 1999 |
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Indomethacin; Isoenzymes; Ketorolac; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides; Time Factors; Wound Healing | 1999 |
The pyrrole moiety as a template for COX-1/COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Humans; Indomethacin; Isoenzymes; Leukocytes, Mononuclear; Membrane Proteins; Molecular Structure; Monocytes; Neutrophils; Prostaglandin-Endoperoxide Synthases; Pyrroles; Sulfones; Thiophenes | 2000 |
Allergic contact dermatitis due to indomethacin and diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cross Reactions; Dermatitis, Allergic Contact; Diagnosis, Differential; Diclofenac; Drug Hypersensitivity; Humans; Indomethacin; Male; Middle Aged; Patch Tests; Tennis Elbow | 2000 |
[Approaches to prediction of gastropathy development risk due to non-steroidal antiinflammatory drugs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Gastric Acid; Gastric Mucosa; Gastroscopy; Humans; Hydrogen-Ion Concentration; Indomethacin; Prognosis; Retrospective Studies; Risk Factors; Stomach Diseases | 2000 |
In vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Chlorine; Diclofenac; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; In Vitro Techniques; Indicators and Reagents; Indomethacin; Iron; Kinetics; Lipid Peroxidation; Luminescent Measurements; Neutrophil Activation; Neutrophils; Nitrates; Reactive Oxygen Species; Sodium Hypochlorite; Spectrophotometry, Ultraviolet; Sulfonamides; Tetradecanoylphorbol Acetate | 2000 |
Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chromatography, High Pressure Liquid; Diclofenac; Flufenamic Acid; Indomethacin; Ketoprofen; Mass Spectrometry; Sensitivity and Specificity; Tablets | 2001 |
In vitro effect of different non-steroidal anti-inflammatory drugs on human polymorphonuclear leukocyte activity measured by luminol-dependent chemiluminescence of the whole blood.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Barium Sulfate; Blood Group Antigens; Contrast Media; Diclofenac; Drug Evaluation, Preclinical; Erythrocyte Indices; Female; Hemoglobins; Humans; Ibuprofen; Indicators and Reagents; Indomethacin; Leukocyte Count; Luminescent Measurements; Luminol; Male; Middle Aged; Neutrophils | 2001 |
Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Culture Techniques; Diclofenac; Female; Glycosaminoglycans; Humans; Indomethacin; Male; Middle Aged; Naproxen; Tendons; Wound Healing | 2001 |
Effects of some nonsteroidal anti-inflammatory drugs on articular cartilage of rats in an experimental model of osteoarthritis.
Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Diclofenac; Disease Models, Animal; Indomethacin; Iodoacetates; Knee Joint; Male; Osteoarthritis, Knee; Propionates; Rats; Rats, Sprague-Dawley | 2001 |
Identification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase.
Topics: 15-Oxoprostaglandin 13-Reductase; Alcohol Oxidoreductases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Humans; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Niflumic Acid | 2001 |
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Etodolac; Humans; Ibuprofen; Indomethacin; Ketorolac; Lactones; Nabumetone; Naproxen; Pain, Postoperative; Piroxicam; Pyrazoles; Sulfonamides; Sulfones; Time Factors | 2001 |
Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Graphics; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Energy Transfer; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Ketoprofen; Meclofenamic Acid; Mefenamic Acid; Membrane Proteins; Models, Molecular; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells.
Topics: Animals; Benzene Derivatives; Cell Division; Chorionic Villi; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Female; Furans; Humans; Immune Tolerance; Indomethacin; Interleukin-2; Isoenzymes; Membrane Proteins; Mice; Pregnancy; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; T-Lymphocytes | 2002 |
Effect of inflammatory mediators on the physiology of the human Fallopian tube.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Diclofenac; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; Epithelial Cells; Fallopian Tubes; Female; Histamine; Humans; Ibuprofen; Indomethacin; Inflammation Mediators; Muscle Contraction; Muscle, Smooth; Naproxen; Pelvic Pain; Platelet Activating Factor | 2002 |
Differential effects of nonsteroidal antiinflammatory drugs on the IL-1 altered expression of plasminogen activators and plasminogen activator inhibitor-1 by articular chondrocytes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Cells, Cultured; Chondrocytes; Diclofenac; Dose-Response Relationship, Drug; Gene Expression Regulation; Indomethacin; Interleukin-1; Meloxicam; Naproxen; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Propionates; RNA, Messenger; Thiazines; Thiazoles | 2002 |
Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Camphanes; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Indomethacin; Kinetics; Male; Mice; Mice, Inbred ICR; Pain; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug | 2002 |
Rat retinal tissue releases a vasorelaxing factor.
Topics: Acute Disease; Animals; Calcium-Transporting ATPases; Carotid Arteries; Cyclooxygenase Inhibitors; Diclofenac; Endothelium, Vascular; Enzyme Inhibitors; Female; Guanylate Cyclase; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Retina; Sarcoplasmic Reticulum; Thapsigargin; Vasodilation; Vasodilator Agents | 2002 |
Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies.
Topics: Adenosine; Animals; Aorta; Cyclooxygenase Inhibitors; Diclofenac; Hypoxia; In Vitro Techniques; Indomethacin; Male; Muscle, Skeletal; Nitric Oxide; Prostaglandins; Rats; Rats, Wistar; Theophylline; Vasodilation | 2002 |
Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Naproxen; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley | 2002 |
Study of the anti-inflammatory effect of Sedum praealtum (Siempreviva) in the rat: dose-dependent response.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Diclofenac; Dose-Response Relationship, Drug; Female; Granuloma; Indomethacin; Leukocyte Count; Mast Cells; Plant Extracts; Rats; Rats, Wistar; Sedum; Skin | 2002 |
Effects of non-steroidal anti-inflammatory drugs on the methotrexate transport in rat small intestine.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport, Active; Diclofenac; Flufenamic Acid; Folic Acid Antagonists; Indomethacin; Intestine, Small; Male; Methotrexate; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase | 2003 |
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cyclooxygenase Inhibitors; Diclofenac; Edema; Etodolac; Gastric Mucosa; Indomethacin; Male; Meloxicam; Mice; Peptic Ulcer; Rats; Species Specificity; Thiazines; Thiazoles | 2003 |
Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Female; Indomethacin; Intracellular Membranes; Isoenzymes; Membrane Potentials; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Thymus Gland | 2003 |
Non-steroidal anti-inflammatory drugs affect the methotrexate transport in IEC-6 cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Coloring Agents; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flufenamic Acid; Hydrogen-Ion Concentration; Indomethacin; Intestine, Small; Intestines; Methotrexate; Phosphorylation; Rats; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit vascular smooth muscle cell proliferation via differential effects on the cell cycle.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Cell Division; Cell Line; Diclofenac; Dose-Response Relationship, Drug; Flow Cytometry; Ibuprofen; Indomethacin; Muscle, Smooth, Vascular; Rats; Sodium Salicylate; Sulindac | 2003 |
Aspirin protects endothelial cells from oxidant damage via the nitric oxide-cGMP pathway.
Topics: Animals; Aspirin; Cattle; Cell Survival; Cells, Cultured; Citrulline; Cyclic GMP; Cyclic N-Oxides; Cytoprotection; Diclofenac; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hydrogen Peroxide; Imidazoles; Indomethacin; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Swine | 2003 |
[Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenal Ulcer; Duodenoscopy; Esophageal Diseases; Esophagoscopy; Female; Gastric Mucosa; Gastroscopy; Humans; Ibuprofen; Indomethacin; Male; Peptic Ulcer Hemorrhage; Retrospective Studies; Stomach Ulcer | 2003 |
Therapeutic effect of cyclo-oxygenase inhibitors with different isoform selectivity in lipopolysaccharide-induced preterm birth in mice.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Female; Indomethacin; Isoenzymes; Kidney Diseases; Lipopolysaccharides; Meloxicam; Mice; Mice, Inbred ICR; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome; Prostaglandin-Endoperoxide Synthases; Stomach Diseases; Thiazines; Thiazoles | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Disease Models, Animal; Drug Therapy, Combination; Glucosamine; Ibuprofen; Indomethacin; Ketoprofen; Mice; Pain; Piroxicam | 2003 |
Interaction of allopurinol and non-steroidal anti-inflammatory drugs on the carrageenan-induced rat paw edema.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Edema; Free Radical Scavengers; Hindlimb; Indomethacin; Male; Random Allocation; Rats; Rats, Wistar; Treatment Outcome | 2003 |
The NO-cGMP-K+ channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin.
Topics: Analgesics; Animals; Cyclic GMP; Diclofenac; Dose-Response Relationship, Drug; Female; Indomethacin; Nitric Oxide; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Signal Transduction | 2003 |
Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility.
Topics: Alprostadil; Animals; Aspirin; Cell Membrane; Cryopreservation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Resveratrol; Semen; Semen Preservation; Sperm Motility; Spermatozoa; Stilbenes; Sulfonamides; Tolmetin; Turkeys | 2003 |
PLA2/PGE2 are involved in the inhibitory effect of bradykinin on the angiotensin-(1-7)-stimulated Na(+)-ATPase activity of the proximal tubule.
Topics: Angiotensin I; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Cell Membrane; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Kidney Tubules, Proximal; Peptide Fragments; Phospholipases A; Phospholipases A2; Quinacrine; Receptor, Bradykinin B2; Sodium-Potassium-Exchanging ATPase; Swine | 2004 |
Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hyperalgesia; Indomethacin; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 2004 |
Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis.
Topics: Activating Transcription Factor 4; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Northern; Celecoxib; Cell Line; Cell Survival; Cells, Cultured; Diclofenac; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Gastric Mucosa; Genes, Reporter; Guinea Pigs; Heat-Shock Proteins; Hydrogen Peroxide; Ibuprofen; Immunoblotting; Indomethacin; Luciferases; Macrophages; Microscopy, Fluorescence; Molecular Chaperones; Plasmids; Pyrazoles; Regulatory Factor X Transcription Factors; RNA, Messenger; Sulfonamides; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; X-Box Binding Protein 1 | 2004 |
Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms.
Topics: Animals; Brain; Diclofenac; Enzyme Inhibitors; Indomethacin; Isoxazoles; Kynurenic Acid; Male; Meloxicam; Prostaglandins; Protein Isoforms; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles | 2005 |
The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Endothelin-1; Fever; Indomethacin; Injections, Intraperitoneal; Injections, Intraventricular; Intubation, Gastrointestinal; Lipopolysaccharides; Male; Organic Chemicals; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2005 |
Recombinant human lactoferrin prevents NSAID-induced intestinal bleeding in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gastrointestinal Hemorrhage; Humans; Indomethacin; Lactoferrin; Male; Naproxen; Pain Measurement; Protein Binding; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2005 |
Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cell Line; Cyclooxygenase Inhibitors; Diclofenac; Enzyme Activation; Humans; Ibuprofen; Indomethacin; Lactones; Lung; Naproxen; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Sulfones; tert-Butylhydroperoxide; Transcription, Genetic | 2005 |
[Inflammation, nonsteroidal anti-inflammatory drugs and Alzheimer disease].
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Indomethacin; Inflammation; Inflammation Mediators; Lactones; Risk Factors; Sulfones | 2004 |
Effect of anti-inflammatory and antioxidant drugs on the long-term repair of severely injured mouse skeletal muscle.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blotting, Western; Curcumin; Cyclooxygenase Inhibitors; Diclofenac; Dimethyl Sulfoxide; Electrophoresis, Polyacrylamide Gel; Indomethacin; Male; Mice; Muscle Contraction; Muscle, Skeletal; NF-kappa B; Pyrrolidines; Regeneration; Thiocarbamates | 2005 |
Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP.
Topics: Adenosine Triphosphate; Administration, Cutaneous; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemokine CCL2; Chemokine CXCL10; Chemokines; Chemokines, CXC; Diclofenac; Disease Models, Animal; Hindlimb; Hot Temperature; Hyperalgesia; Indomethacin; Injections, Intravenous; Interleukin-8; Macrophages; Male; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Single-Blind Method | 2005 |
Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzimidazoles; Diclofenac; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Glutathione; Indomethacin; Ligation; Lipoproteins, LDL; Male; Malondialdehyde; Omeprazole; Oxidation-Reduction; Pantoprazole; Peroxidase; Piroxicam; Proton Pump Inhibitors; Pylorus; Rats; Rats, Wistar; Sulfoxides | 2005 |
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2 | 2006 |
Hydrophilic absorbable copolyester exhibiting zero-order drug release.
Topics: Absorption; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Diclofenac; Excipients; Hydrolysis; Indicators and Reagents; Indomethacin; Ketoprofen; Lactic Acid; Lactones; Polyethylenes; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Water | 2006 |
Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colitis, Ulcerative; Crohn Disease; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Indomethacin; Inflammatory Bowel Diseases; Male; Middle Aged; Nabumetone; Naproxen; Prevalence; Recurrence; Sulfonamides | 2006 |
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; Indomethacin; Inflammation; Male; Mutagenicity Tests; Pain Measurement; Phenylpropionates; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Stomach Ulcer; Uric Acid | 2006 |
Nonsteroidal anti-inflammatory drug use in ankylosing spondylitis--a population-based survey.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cohort Studies; Cross-Sectional Studies; Diclofenac; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen; Pain; Pain Measurement; Patient Satisfaction; Pyrazoles; Retreatment; Spondylitis, Ankylosing; Sulfonamides; Surveys and Questionnaires; Treatment Outcome | 2006 |
Anti-inflammatory, anti-nociceptive and antipyretic effects of extracts of Phrygilanthus acutifolius flowers.
Topics: Acetic Acid; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Argentina; Carrageenan; Diclofenac; Dose-Response Relationship, Drug; Edema; Female; Fever; Flowers; Formaldehyde; Indomethacin; Loranthaceae; Male; Medicine, Traditional; Neuralgia; Pain Measurement; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Water | 2006 |
The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction.
Topics: Animals; Convulsants; Cyclooxygenase Inhibitors; Diclofenac; Escherichia coli; Indomethacin; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Motor Activity; Pentylenetetrazole; Pyrazoles; Salicylates; Seizures; Sulfonamides; Time Factors | 2006 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lactones; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones; Time Factors; Up-Regulation | 2006 |
[The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910].
Topics: Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Cunninghamella; Cytochrome P-450 CYP2C9; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Fungal Proteins; Indomethacin; Isoenzymes; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfaphenazole; Tolbutamide; Valproic Acid | 2006 |
In vitro effects of non-steroidal anti-inflammatory drugs on cytokine, prostanoid and matrix metalloproteinase production by interface membranes from loose hip or knee endoprostheses.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Cytokines; Diclofenac; Dinoprostone; Female; Hip Prosthesis; Humans; Indomethacin; Knee Prosthesis; Matrix Metalloproteinases; Middle Aged; Piroxicam; Tissue Inhibitor of Metalloproteinases | 2007 |
Effect of prenatal administration of NSAIDs on the immune response in juvenile and adult rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Aspirin; Diclofenac; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Hemocyanins; Immunoglobulin G; Immunoglobulin M; Immunophenotyping; Indomethacin; Lymphocytes; Male; Maternal Exposure; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Spleen | 2007 |
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Biological Transport, Active; Cell Line; Cell Membrane; Diclofenac; Dose-Response Relationship, Drug; Folic Acid; Green Fluorescent Proteins; Humans; Hydrogen-Ion Concentration; Indomethacin; Kinetics; Membrane Transport Proteins; Methotrexate; Microscopy, Confocal; Nigericin; Proton-Coupled Folate Transporter; Sulfasalazine; Transfection | 2007 |
Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy.
Topics: Acylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Chromatography, Liquid; Cyclooxygenase Inhibitors; Diclofenac; Drug Stability; Flufenamic Acid; Glucuronides; Half-Life; Ibuprofen; Indomethacin; Kinetics; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mefenamic Acid; Molecular Structure; Rats; Rats, Sprague-Dawley; Stereoisomerism; Technology, Pharmaceutical; Tolmetin | 2007 |
Rate-modulating PHBHV/PCL microparticles containing weak acid model drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Capsules; Diclofenac; Drug Compounding; Half-Life; Indomethacin; Kinetics; Microscopy, Electron, Scanning; Models, Chemical; Models, Statistical; Particle Size; Polyesters; Porosity; Solubility; Spectrophotometry, Infrared; Surface Properties; Water | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Depression, Chemical; Diastole; Diclofenac; Disease Models, Animal; Glyburide; In Vitro Techniques; Indomethacin; Myocardial Contraction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nitrobenzenes; Perfusion; Potassium Channel Blockers; Potassium Channels; Rats; Reperfusion Injury; Research Design; Sulfonamides; Systole; Time Factors | 2007 |
Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Diclofenac; Dinoprostone; Disease Models, Animal; Guinea Pigs; Indomethacin; Male; Nasal Obstruction; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2007 |
Intracellular effects of NSAIDs/ASA in oxidatively stressed human lens epithelial cells in culture.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cell Size; Cells, Cultured; Diclofenac; Epithelial Cells; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Indomethacin; Intracellular Membranes; Lens, Crystalline; Membrane Potential, Mitochondrial; Mitochondria; Oxidants; Oxidative Stress; Peroxides; Pyrazoles; Reactive Oxygen Species; Sulfonamides; Superoxides | 2008 |
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles | 2008 |
Removal of selected pharmaceuticals by chlorination, coagulation-sedimentation and powdered activated carbon treatment.
Topics: Antipyrine; Charcoal; Clofibric Acid; Diclofenac; Fenoprofen; Gemfibrozil; Halogenation; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Water Pollutants, Chemical; Water Purification; Water Supply | 2008 |
Pharmaceutical residues in wastewater treatment works effluents and their impact on receiving river water.
Topics: Carbamazepine; Diclofenac; Indomethacin; Pharmaceutical Preparations; Propranolol; Rivers; Sulfamethoxazole; United Kingdom; Water Pollutants, Chemical | 2009 |
Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.
Topics: 3T3-L1 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cyclooxygenase Inhibitors; Diclofenac; Drug Design; Indomethacin; Insulin; Insulin Resistance; Mice; PPAR gamma; Rats | 2009 |
Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts.
Topics: Annexin A5; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Celecoxib; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dexamethasone; Diclofenac; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Indomethacin; Ketorolac; L-Lactate Dehydrogenase; Osteoblasts; Piroxicam; Propidium; Pyrazoles; RNA, Messenger; Sulfonamides; Thymidine | 2009 |
Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Caenorhabditis elegans; Diclofenac; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Ibuprofen; Indomethacin; Microscopy, Confocal; Thiazoles | 2009 |
Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Chronic Disease; Diclofenac; Disease Models, Animal; Indomethacin; Inflammation; Lichens; Lipid Peroxidation; Male; Neutrophil Infiltration; Plant Extracts; Rats; Rats, Sprague-Dawley | 2010 |
Colloids as a sink for certain pharmaceuticals in the aquatic environment.
Topics: Carbamazepine; Colloids; Diclofenac; Environmental Restoration and Remediation; Fresh Water; Indomethacin; Meclofenamic Acid; Pharmaceutical Preparations; Phenethylamines; Propranolol; Sewage; Sulfamethoxazole; Tamoxifen; Thioridazine; Water Pollutants, Chemical | 2010 |
Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonate 5-Lipoxygenase; Arthritis; C-Reactive Protein; Carrageenan; Cartilage, Articular; Catalase; Ceruloplasmin; Chromatography, High Pressure Liquid; Complex Mixtures; Diclofenac; Edema; Foot; Freund's Adjuvant; Glutathione; Glutathione Peroxidase; Hindlimb; Indomethacin; Inflammation; Lethal Dose 50; Male; Medicine, Ayurvedic; Monocytes; Peroxidase; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamins | 2010 |
Hypertrophic cranial pachymeningitis induced by long-term administration of nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain; Diclofenac; Dura Mater; Headache; Humans; Indomethacin; Magnetic Resonance Imaging; Male; Meningitis; Tomography, X-Ray Computed; Young Adult | 2010 |
Functional inhibition of erectile process in rats by indomethacin.
Topics: Animals; Blood Pressure; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Electric Stimulation; Indomethacin; Male; Models, Animal; Nitrates; Nitrites; Penile Erection; Rats; Rats, Wistar | 2011 |
Synthesis, characterization and pharmacological evaluation of 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one: a new anti-inflammatory compound with reduced gastric ulceration properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Movement; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Stability; Female; Gastric Mucosa; Hydrogen-Ion Concentration; Indoles; Indomethacin; Lactams; Male; Mice; Prodrugs; Rats; Rats, Wistar; Stomach Ulcer | 2010 |
Assessment of the efficacy of pamidronate in ankylosing spondylitis: an open prospective trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood Sedimentation; C-Reactive Protein; Cyclooxygenase 2 Inhibitors; Diclofenac; Diphosphonates; Etodolac; Female; Health Status Indicators; Humans; Indomethacin; Male; Pamidronate; Prospective Studies; Spondylitis, Ankylosing; Treatment Failure; Tumor Necrosis Factor-alpha; Young Adult | 2010 |
Effects of indomethacin, nimesulide, and diclofenac on human MG-63 osteosarcoma cell line.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Diclofenac; Flow Cytometry; Humans; Indomethacin; Osteocalcin; Osteosarcoma; Sulfonamides | 2012 |
Blockade of the antinociception induced by diclofenac, but not of indomethacin, by sulfonylureas and biguanides.
Topics: Animals; Biguanides; Diclofenac; Drug Interactions; Drug Therapy, Combination; Indomethacin; Male; Pain Measurement; Psychomotor Performance; Rats; Rats, Wistar; Sulfonylurea Compounds | 2011 |
Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antidepressive Agents, Tricyclic; Antioxidants; Diclofenac; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Paroxetine; Peroxidase; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Stomach Ulcer; Sulfhydryl Compounds; Superoxide Dismutase | 2011 |
Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect.
Topics: Anticarcinogenic Agents; Aspirin; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromans; Collagen Type IV; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Epithelial-Mesenchymal Transition; Humans; Indomethacin; Lung Neoplasms; Matrix Metalloproteinase 9; PPAR gamma; Thiazolidinediones; Troglitazone | 2011 |
Metformin and phenformin block the peripheral antinociception induced by diclofenac and indomethacin on the formalin test.
Topics: Animals; Diclofenac; Dose-Response Relationship, Drug; Indomethacin; KATP Channels; Male; Metformin; Pain Measurement; Phenformin; Rats; Rats, Wistar | 2012 |
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts | 2012 |
Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases.
Topics: Anti-Inflammatory Agents; Diclofenac; Glucuronides; Glucuronosyltransferase; Humans; Hydrogen-Ion Concentration; Hymecromone; Indomethacin; Inhibitory Concentration 50; Naphthols | 2012 |
Impact of probe compound in MRP2 vesicular transport assays.
Topics: Acetaminophen; Animals; Baculoviridae; Biological Assay; Biological Transport; Budesonide; Cell Membrane; Cells, Cultured; Diclofenac; Disopyramide; Estradiol; Estrone; Fluoresceins; Genetic Vectors; Humans; Indomethacin; Inhibitory Concentration 50; Leukotriene C4; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Quercetin; Recombinant Proteins; Spodoptera; Statistics as Topic; Thioridazine; Transfection | 2012 |
Suppressive effects of nonsteroidal anti-inflammatory drugs diclofenac sodium, salicylate and indomethacin on delayed rectifier K+-channel currents in murine thymocytes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Indomethacin; Kv1.3 Potassium Channel; Male; Membrane Potentials; Mice; Sodium Salicylate; Thymocytes | 2012 |
Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caco-2 Cells; Diclofenac; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electron Transport Complex I; Humans; Ibuprofen; Indomethacin; Mitochondria; Multienzyme Complexes; NAD; Piroxicam; Protective Agents; Quercetin; Rats; Ubiquinone | 2012 |
Therapy: can rectal NSAIDs prevent post-ERCP pancreatitis?
Topics: Acute Disease; Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Humans; Indomethacin; Pancreatitis; Sphincter of Oddi Dysfunction | 2012 |
Diclofenac enhances proinflammatory cytokine-induced aquaporin-4 expression in cultured astrocyte.
Topics: Animals; Aquaporin 4; Astrocytes; Blotting, Western; Cells, Cultured; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Gene Expression Regulation; Ibuprofen; Immunohistochemistry; Indomethacin; Inflammation Mediators; NF-kappa B; Rats; Rats, Wistar | 2013 |
How safe is Celecoxib for Asian-Indian patients with rheumatic diseases?
Topics: Adult; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Drug Substitution; Female; Humans; Hypertension; India; Indomethacin; Male; Naproxen; Pyrazoles; Retrospective Studies; Rheumatic Diseases; Sulfonamides; Tertiary Care Centers | 2013 |
Oxidation of non-steroidal anti-inflammatory drugs with aqueous permanganate.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Diclofenac; Indomethacin; Kinetics; Manganese Compounds; Mass Spectrometry; Oxidation-Reduction; Oxides; Time Factors; Water | 2013 |
Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; E2F1 Transcription Factor; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Mice; Mice, Nude; Ovarian Neoplasms; Xenograft Model Antitumor Assays | 2013 |
Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Diclofenac; Enzyme Inhibitors; Glucuronidase; Hepatocytes; Indomethacin; Intestinal Diseases; Intestine, Small; Ketoprofen; Male; Mice; Mice, Inbred C57BL; Quinolones; Statistics, Nonparametric; Tandem Mass Spectrometry; Thiourea | 2014 |
Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caspase 9; Cell Survival; Diclofenac; Diflunisal; Endoplasmic Reticulum Stress; Gene Expression; Glutathione; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Indomethacin; Jejunum; Male; Naproxen; Rats, Wistar; Tissue Culture Techniques | 2014 |
Prophylaxis of post-ERCP pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - updated June 2014.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Hormones; Humans; Indomethacin; Nitroglycerin; Pancreatitis; Preoperative Period; Risk Assessment; Somatostatin; Stents; Vasodilator Agents | 2014 |
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a cost-effectiveness analysis.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Combined Modality Therapy; Cost-Benefit Analysis; Decision Support Techniques; Decision Trees; Diclofenac; Drug Costs; Female; Hospital Costs; Humans; Indomethacin; Male; Middle Aged; Models, Economic; Monte Carlo Method; Odds Ratio; Pancreatitis; Risk Factors; Stents; Time Factors; Treatment Outcome | 2015 |
New shell crosslinked micelles from dextran with hydrophobic end groups and their interaction with bioactive molecules.
Topics: alpha-Tocopherol; Anti-Inflammatory Agents; Biocompatible Materials; Cations; Cross-Linking Reagents; Dextrans; Diclofenac; Ergocalciferols; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Indomethacin; Micelles; Microscopy, Electron, Transmission; Sulfones | 2015 |
Sorption and release of drugs in/from cross-linked poly(ethyleneimine) multilayer films deposited onto silica microparticles.
Topics: Adsorption; Cross-Linking Reagents; Diclofenac; Drug Liberation; Indomethacin; Molecular Structure; Nanoparticles; Polyethyleneimine; Silicon Dioxide; Surface Properties | 2015 |
Effects of dexamethasone and cox inhibitors on intracranial pressure and cerebral perfusion in the lipopolysaccharide treated rats with hyperammonemia.
Topics: 6-Ketoprostaglandin F1 alpha; Ammonium Compounds; Animals; Blood Gas Analysis; Blood Pressure; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Dexamethasone; Diclofenac; Hemodynamics; Hyperammonemia; Indomethacin; Intracranial Pressure; Lipopolysaccharides; Male; Rats; Regional Blood Flow; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
NSAIDs and spontaneous abortions - true effect or an indication bias?
Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Ibuprofen; Indomethacin; Israel; Middle Aged; Naproxen; Pregnancy; Retrospective Studies; Time Factors; Young Adult | 2015 |
NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Diclofenac; Gene Expression; Gene Expression Regulation; Genes, Reporter; Humans; Ibuprofen; Indomethacin; Ligands; Protein Binding; Protein Interaction Domains and Motifs; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Reproducibility of Results; Time Factors | 2015 |
Heterotopic Ossification following acetabular fixation: Incidence and risk factors: 10-year experience of a tertiary centre.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Child; Diclofenac; Female; Follow-Up Studies; Fracture Fixation, Internal; Fractures, Bone; Humans; Incidence; Indomethacin; Ireland; Male; Middle Aged; Ossification, Heterotopic; Postoperative Complications; Prognosis; Radiography; Retrospective Studies; Risk Factors; Treatment Outcome; Young Adult | 2016 |
Effect of non-steroidal anti-inflammatory drugs on biological properties of Acanthamoeba castellanii belonging to the T4 genotype.
Topics: Acanthamoeba castellanii; Acanthamoeba Keratitis; Acetaminophen; Amebicides; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Genotype; Indomethacin; Parasite Encystment; Prostaglandins | 2016 |
(1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; Ibuprofen; Indomethacin; Least-Squares Analysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metabolomics; Piroxicam; Rats; Rats, Sprague-Dawley | 2016 |
Synthesis, characterization and drug release properties of 3D chitosan/clinoptilolite biocomposite cryogels.
Topics: Carbohydrate Conformation; Chitosan; Cryogels; Diclofenac; Diffusion; Drug Carriers; Drug Liberation; Hydrogen-Ion Concentration; Indomethacin; Porosity; Water; Zeolites | 2016 |
NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cyclooxygenase 2; Diclofenac; E-Selectin; Heart; Human Umbilical Vein Endothelial Cells; Humans; Indomethacin; Intercellular Adhesion Molecule-1; Meloxicam; Myocardial Infarction; Myocardium; NF-kappa B; Nitriles; Risk Factors; Sulfones; Thiazines; Thiazoles; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2016 |
Non-steroidal anti-inflammatory drugs in the watercourses of Elbe basin in Czech Republic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Czech Republic; Diclofenac; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Rivers; Water Pollutants, Chemical | 2017 |
Inhibition of Aβ(1-42)Oligomerization, Fibrillization and Acetylcholinesterase Activity by Some Anti-Inflammatory Drugs: An in vitro Study.
Topics: Acetylcholinesterase; Amyloid; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Butylated Hydroxyanisole; Celecoxib; Dexamethasone; Diclofenac; Indomethacin; Methylene Blue; Nitric Oxide; Peptide Fragments; Piroxicam; Rivastigmine; Singlet Oxygen | 2017 |
Novel ethanol-induced pectin-xanthan aerogel coatings for orthopedic applications.
Topics: Cells, Cultured; Coated Materials, Biocompatible; Corrosion; Diclofenac; Drug Carriers; Ethanol; Gels; Humans; Indomethacin; Materials Testing; Osteoblasts; Pectins; Polysaccharides, Bacterial | 2017 |
Rapid Access to Oxazine Fused Furocoumarins and in vivo and in silico Studies of theirs Biological Activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalytic Domain; Cyclic Nucleotide Phosphodiesterases, Type 4; Diclofenac; Drug Evaluation, Preclinical; Furocoumarins; Indomethacin; Mice; Molecular Docking Simulation; Oxazines; Rolipram | 2017 |
Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan-Induced Paw Inflammation in Rats.
Topics: Animals; Carrageenan; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Inflammation; Male; Matricaria; Plant Extracts; Rats; Rats, Wistar; Treatment Outcome | 2017 |
Development of an alternative zebrafish model for drug-induced intestinal toxicity.
Topics: Animal Testing Alternatives; Animals; Caco-2 Cells; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Humans; Indomethacin; Intestinal Mucosa; Lethal Dose 50; Methotrexate; Rats, Sprague-Dawley; Toxicity Tests; Zebrafish | 2018 |
["Indomethacin and diclofenac in the prevention of post-ERCP pancreatitis: a systematic review and meta-analysis of prospective controlled trials"].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Humans; Indomethacin; Pancreatitis; Prospective Studies | 2018 |
A magnetic adsorbent grafted with pendant naphthyl polymer brush for enrichment of the nonsteroidal anti-inflammatory drugs indomethacin and diclofenac.
Topics: Adsorption; Analytic Sample Preparation Methods; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diclofenac; Indomethacin; Magnetite Nanoparticles; Naphthalenes; Polymers; Silicon Dioxide; Solid Phase Extraction | 2018 |
In vitro and in silico study of the biological activity of manganese(III) inverse-[9-MC-3]-metallacrowns and manganese(II) complexes with the anti-inflammatory drugs diclofenac or indomethacin.
Topics: A549 Cells; Coordination Complexes; Cytotoxins; Diclofenac; Estrogen Receptor alpha; HeLa Cells; Humans; Indomethacin; Manganese; MCF-7 Cells; Molecular Docking Simulation; Molecular Structure; Serum Albumin, Human | 2018 |
Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Diclofenac; Etoricoxib; Female; Humans; Indomethacin; Ketorolac; Lactones; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Risk Factors; Sulfones | 2018 |
Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celiac Disease; Diclofenac; Diet, Gluten-Free; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gliadin; Glutens; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Permeability; Phosphorylation; Protein Kinase Inhibitors; Triticum | 2019 |
Natural polyphenols prevent indomethacin-induced and diclofenac-induced Caco-2 cell death by reducing endoplasmic reticulum stress regardless of their direct reactive oxygen species scavenging capacity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; bcl-2-Associated X Protein; Caco-2 Cells; Cell Death; Cell Line, Tumor; Cytoprotection; Diclofenac; Endoplasmic Reticulum Stress; Humans; Indomethacin; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Polyphenols; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Transcription Factor CHOP | 2020 |
Mitigating the risk of post-ERCP pancreatitis: Science and clinical practice.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Evidence-Based Medicine; Humans; Indomethacin; Pancreas; Pancreatitis; Ringer's Lactate; Risk; Stents | 2020 |
Modulation of non-steroidal anti-inflammatory drug-induced, ER stress-mediated apoptosis in Caco-2 cells by different polyphenolic antioxidants: a mechanistic study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Caco-2 Cells; Catechin; Diclofenac; Endoplasmic Reticulum Stress; Humans; Indomethacin; Intestinal Mucosa; Lignans; Mitochondria; Oxidative Stress; Signal Transduction; Thapsigargin; Tunicamycin; Unfolded Protein Response | 2020 |
Molecular recognizable ion-paired complex formation between diclofenac/indomethacin and famotidine/cimetidine regulates their aqueous solubility.
Topics: Cimetidine; Diclofenac; Famotidine; Indomethacin; Solubility; Water | 2020 |
New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Computer Simulation; Cyclooxygenase 1; Cyclooxygenase 2; Diclofenac; Drug Design; Free Radical Scavengers; Humans; Indomethacin; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Nitric Oxide Donors; Serum Albumin, Bovine; Structure-Activity Relationship; Thiazolidines | 2021 |
A 25 mg rectal dose of diclofenac for prevention of post-ERCP pancreatitis in elderly patients.
Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Humans; Indomethacin; Pancreatitis; Retrospective Studies | 2021 |
Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Cardiac Electrophysiology; Diclofenac; Dose-Response Relationship, Drug; Electrocardiography; Female; Ibuprofen; Indomethacin; Isolated Heart Preparation; Rabbits; Tachycardia, Ventricular | 2022 |
Water Mediated One-Pot, Stepwise Green Synthesis, Anti-Inflammatory and Analgesic Activities of (3-Amino-1-Phenyl-1H-Benzo[f]Chromen-2-yl) (1H-Indol-3-yl) Methanone Catalysed by L-Proline.
Topics: Analgesics; Animals; Anthocyanins; Anti-Inflammatory Agents; Benzopyrans; Carrageenan; Catalysis; Diclofenac; Edema; Indomethacin; Mice; Proline; Water | 2022 |
Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer Cells.
Topics: Apoptosis; Biomarkers, Tumor; Cell Cycle; Cell Proliferation; Cyclooxygenase Inhibitors; Diclofenac; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Oleanolic Acid; Oximes; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured | 2022 |
Topics: Apoptosis; Coumaric Acids; Diclofenac; Endoplasmic Reticulum Stress; Humans; Indomethacin; MCF-7 Cells | 2022 |
Ficus vogelii methanol leaf extract ameliorates inflammation and arthritis by modulating osmotic fragility in C57BL/6J mice.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Diclofenac; Edema; Ficus; Granuloma; Indomethacin; Inflammation; Methanol; Mice; Mice, Inbred C57BL; Osmotic Fragility; Plant Extracts | 2021 |
Lipid nanocapsules enhance the transdermal delivery of drugs regardless of their physico-chemical properties.
Topics: Administration, Cutaneous; Diclofenac; Drug Carriers; Indomethacin; Lipids; Nanocapsules; Particle Size | 2022 |