diclofenac and gabapentin

diclofenac has been researched along with gabapentin in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (29.03)29.6817
2010's19 (61.29)24.3611
2020's3 (9.68)2.80

Authors

AuthorsStudies
Jolivette, LJ; Ward, KW1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Adair, RM; Altenbach, RJ; Bettencourt, BM; Brioni, JD; Cowart, MD; Drizin, I; Esbenshade, TA; Fix-Stenzel, SR; Honore, P; Hsieh, GC; Liu, H; Marsh, KC; McPherson, MJ; Milicic, I; Miller, TR; Sullivan, JP; Wetter, JM; Wishart, N; Witte, DG1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Peng, Y; Welsh, WJ; Zhang, Q1
Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I1
Castañeda-Hernández, G; Ortiz, MI; Picazo, A1
Biyik, I; Ergene, O; Gülcüler, M; Karabiga, M; Tayyar, N1
Bhattacharya, D; Chakrabarti, J; Chakraborty, S; Chowdhury, L; Mandals, M1
Bannon, AW; Decker, MW; Gauvin, D; Hsieh, GC; Joshi, SK; Lee, CH; Lewis, LG; Mikusa, J; Mills, CD; Rueter, LE; Zhong, C; Zhu, CZ1
Imamachi, N; Narai, Y; Saito, Y1
Choy, WS; Lee, JW; Lee, SK; Yang, DS1
Bannon, AW; Gauvin, DM; Gomez, EJ; Mikusa, J; Mills, CD; Nguyen, T; Salyers, AK; Tanga, FY; Zhong, C1
Agalave, NM; Baharpoor, A; Bas, DB; Codeluppi, S; Holmdahl, R; Lundberg, J; Nandakumar, KS; Sandor, K; Su, J; Svensson, CI1
Ammendolia, C; Furlan, AD; Kennedy, CA; Rampersaud, YR; Schneider, M; Stuber, K; Tomkins-Lane, C1
Al Taher, WM; Bekawi, MS; El Wakeel, LM; Mageed, WM1
Bannon, AW; Joshi, SK; Zhu, CZ1
Bremer, N; Dizdarevic, A1
Abdelwahab, S; Abdelzaher, WY; Ibrahim, MA; Rofaeil, RR1
Chenu, C; Chessell, IP; Luiz, AP; Santana-Varela, S; Ter Heegde, F; Welsh, F; Wood, JN1
England, D; Ralph, C; Thai, KJ1
Acton, EK; Bilker, WB; Brensinger, CM; Chen, C; Chung, SP; Dawwas, GK; Dublin, S; Hennessy, S; Horn, JR; Leonard, CE; Miano, TA; Pham Nguyen, TP; Soprano, SE1

Reviews

2 review(s) available for diclofenac and gabapentin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
What interventions improve walking ability in neurogenic claudication with lumbar spinal stenosis? A systematic review.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2014, Volume: 23, Issue:6

    Topics: Acetaminophen; Amines; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation Agents; Calcitonin; Cyclohexanecarboxylic Acids; Decompression, Surgical; Diclofenac; Gabapentin; gamma-Aminobutyric Acid; Humans; Intermittent Claudication; Lumbar Vertebrae; Physical Therapy Modalities; Prostaglandins; Spinal Stenosis; Walking

2014

Trials

4 trial(s) available for diclofenac and gabapentin

ArticleYear
Efficacy of gabapentin versus diclofenac in the treatment of chest pain and paresthesia in patients with sternotomy.
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2009, Volume: 9, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chest Pain; Cyclohexanecarboxylic Acids; Diclofenac; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Paresthesia; Severity of Illness Index; Sternotomy; Treatment Outcome

2009
Analgesic effect of low gynaecological surgery under general anaesthesia.
    Journal of the Indian Medical Association, 2010, Volume: 108, Issue:11

    Topics: Administration, Oral; Adult; Amines; Analgesics; Analysis of Variance; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; Diclofenac; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Gynecologic Surgical Procedures; Humans; Middle Aged; Pain Measurement; Pain, Postoperative; Placebos

2010
Four treatment strategies for complex regional pain syndrome type 1.
    Orthopedics, 2012, Volume: 35, Issue:6

    Topics: Administration, Oral; Adult; Aged; Amines; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; Dexamethasone; Diclofenac; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Mannitol; Middle Aged; Pain Measurement; Reflex Sympathetic Dystrophy; Treatment Outcome

2012
Clinical study evaluating pregabalin efficacy and tolerability for pain management in patients undergoing laparoscopic cholecystectomy.
    The Clinical journal of pain, 2014, Volume: 30, Issue:11

    Topics: Adult; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cholecystectomy, Laparoscopic; Cyclohexanecarboxylic Acids; Diclofenac; Dizziness; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Meperidine; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Postoperative Nausea and Vomiting; Pregabalin; Prospective Studies; Young Adult

2014

Other Studies

25 other study(ies) available for diclofenac and gabapentin

ArticleYear
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
    Journal of medicinal chemistry, 2008, Oct-23, Volume: 51, Issue:20

    Topics: Amines; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Histamine Antagonists; Ligands; Mice; Molecular Structure; Pain; Pyrimidines; Rats; Receptors, Histamine

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
    Journal of medicinal chemistry, 2021, 01-14, Volume: 64, Issue:1

    Topics: Animals; Binding Sites; Blood-Brain Barrier; Drug Design; Guinea Pigs; Half-Life; Humans; Microsomes, Liver; Molecular Dynamics Simulation; Neuralgia; Pain Management; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship; Rats; Receptors, sigma; Sigma-1 Receptor; Triazoles

2021
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
    Japanese journal of pharmacology, 2000, Volume: 83, Issue:4

    Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Herpes Simplex; Herpesvirus 1, Human; Hyperalgesia; Mice; Mice, Inbred BALB C; Morphine; Neuralgia; Neurons, Afferent; Pain

2000
Examination of the interaction between peripheral diclofenac and gabapentin on the 5% formalin test in rats.
    Life sciences, 2006, Nov-10, Volume: 79, Issue:24

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Female; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Pain Measurement; Rats; Rats, Wistar

2006
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
    European journal of pain (London, England), 2012, Volume: 16, Issue:6

    Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Central Nervous System Stimulants; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ibuprofen; Lameness, Animal; Male; Morphine; Motor Activity; Neuritis; Rats; Rats, Sprague-Dawley; Thiophenes

2012
Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:1

    Topics: Amines; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Spinal; Neural Pathways; Pain Measurement; Pain Threshold; Pain, Postoperative; Rats; Spinal Cord; Time Factors

2012
Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats.
    European journal of pain (London, England), 2013, Volume: 17, Issue:4

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Nerve Growth Factor; Pain Threshold; Physical Stimulation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thiophenes; TRPV Cation Channels

2013
Collagen antibody-induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency.
    Arthritis and rheumatism, 2012, Volume: 64, Issue:12

    Topics: Amines; Analgesics; Animals; Arthralgia; Arthritis, Experimental; Buprenorphine; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Neuroglia; Prostaglandins; Spine; Time Factors; Treatment Outcome

2012
Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats.
    European journal of pain (London, England), 2015, Volume: 19, Issue:10

    Topics: Adjuvants, Immunologic; Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; Ibuprofen; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley

2015
Cervical Spinal Cord Stimulation with Concomitant Serotonin Norepinephrine Reuptake Inhibitor Therapy Leading to the Serotonin Syndrome.
    Pain medicine (Malden, Mass.), 2017, 06-01, Volume: 18, Issue:6

    Topics: Adult; Analgesics; Cervical Vertebrae; Clonidine; Complex Regional Pain Syndromes; Diclofenac; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; Humans; Lamotrigine; Male; Oxycodone; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Spinal Cord Stimulation

2017
Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 100

    Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Male; Neuralgia; Oxidative Stress; Pain Measurement; Pain Threshold; Rats, Wistar; Treatment Outcome

2018
Noninvasive Mechanical Joint Loading as an Alternative Model for Osteoarthritic Pain.
    Arthritis & rheumatology (Hoboken, N.J.), 2019, Volume: 71, Issue:7

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Behavior, Animal; Cartilage, Articular; Diclofenac; Disease Models, Animal; Gabapentin; Hyperesthesia; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Osteoarthritis, Knee; Weight-Bearing

2019
Treatment of Cabozantinib-Related Palmar-Plantar Erythrodysesthesia With Topical Sildenafil, Diclofenac, and Gabapentin Cream: A Case Report.
    JCO oncology practice, 2020, Volume: 16, Issue:3

    Topics: Administration, Cutaneous; Aged; Anilides; Carcinoma, Renal Cell; Diclofenac; Gabapentin; Hand-Foot Syndrome; Humans; Male; Pyridines; Sildenafil Citrate; Skin Cream

2020
Skeletal muscle relaxant drug-drug-drug interactions and unintentional traumatic injury: Screening to detect three-way drug interaction signals.
    British journal of clinical pharmacology, 2022, Volume: 88, Issue:11

    Topics: Aged; Alprazolam; Diclofenac; Drug Interactions; Gabapentin; Humans; Medicare; Neuromuscular Agents; Omeprazole; United States

2022