diclofenac has been researched along with dinoprostone in 170 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (13.53) | 18.7374 |
| 1990's | 39 (22.94) | 18.2507 |
| 2000's | 65 (38.24) | 29.6817 |
| 2010's | 39 (22.94) | 24.3611 |
| 2020's | 4 (2.35) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Bendele, AM; Benslay, DN; Hom, JT; Lee, SJ; Lindstrom, TD; Naismith, RW; Ruterbories, KJ; Spaethe, SM | 1 |
| Abe, K; Akiu, N; Saito, T; Sato, M; Takeuchi, K; Yasujima, M; Yoshinaga, K | 1 |
| Endo, T; Fukumura, T; Matsui, H; Mizushima, Y; Nakagawa, T; Uemura, H; Yanagawa, A | 1 |
| Alj, AE; Bienkiewicz, A; Cabrol, D; Carbonne, B; Cedard, L; Dallot, E | 1 |
| Pfeilschifter, J; Sallmann, A; Schweizer, A; Wenk, P; Wiesenberg-Boettcher, I | 1 |
| Abe, K; Sato, K; Sato, M; Takeuchi, K; Tanno, M; Yasujima, M; Yoshinaga, K | 1 |
| Fernandes, G; Flescher, E; Fossum, D; Gray, PJ; Harper, MJ; Talal, N | 1 |
| Fidler, IJ; Utsugi, T | 1 |
| Chu, TM; Lin, TH; Nakajima, I; Ohnishi, H | 1 |
| Fukushima, T; Sasaki, H; Sekizawa, K; Takishima, T; Yamauchi, K; Yamaya, M; Zayasu, K | 1 |
| Dahlén, SE; Hedqvist, P; Raud, J; Sydbom, A | 1 |
| Lewis, GP; O'Neill, LA | 1 |
| Baer, GA; Metsä-Ketelä, T; Miralles, J; Palomäki, E; Rorarius, MG; Vapaatalo, H | 1 |
| Hayaishi, O | 1 |
| Heldt, R; Hertting, G; Okajima, T | 1 |
| Kothari, HV; Ku, EC; Lee, W; Scholer, DW | 1 |
| Hirasawa, N; Ohuchi, K; Sugio, K; Tsurufuji, S; Watanabe, M; Yoshino, S | 1 |
| Barrett, PA; Butler, KD; Shand, RA; Wallis, RB | 1 |
| Fukui, Y; Hirasawa, N; Ohuchi, K; Ozeki, T; Tsurufuji, S; Watanabe, M | 1 |
| Cole, RS; Fry, CH; Shuttleworth, KE | 1 |
| Bray, MA; Hengstler, B; Rich, R; Tomasz, A; Tuomanen, E; Zak, O | 1 |
| Levin, DR; Moskovitz, B; Munichor, M | 1 |
| de Jong, PE; de Zeeuw, D; Donker, AJ; Pratt, JJ; van der Hem, GK; Vriesendorp, R | 1 |
| Isomäki, H; Laitinen, O; Nissilä, M; Nuotio, P; Nykänen, E; Seppälä, E; Vapaatalo, H | 1 |
| Arakawa, T; Fukuda, T; Kobayashi, K; Nakamura, H; Satoh, H | 1 |
| Jonsson, O; Kihl, B; Lundstam, S; Pettersson, S | 1 |
| Kimble, EF; Kothari, HV; Ku, EC; Lee, W; Liauw, L; Tjan, J | 1 |
| Aldo-Benson, MA; Benson, MD; Brandt, KD; Chan, K; Ku, E; Lee, W; Liauw, HL; Vyas, K; Waiter, SL | 1 |
| Bhattacharya, SK; Das, N | 1 |
| Hertting, G; Knepel, W; Vlaskovska, M | 1 |
| Drapier, JC; Petit, JF | 1 |
| Baggiolini, M; Dewald, B; Schnyder, J | 1 |
| el-Ghazaly, MA; el-Khatib, AS; Khayyal, MT | 1 |
| Kajiyama, G; Lane, NE; Smith, RL | 1 |
| Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K | 1 |
| Willburger, RE; Wittenberg, RH | 1 |
| Ito, A; Mori, Y; Nose, T; Takahashi, S | 1 |
| Ferreira, SH; Tonussi, CR | 1 |
| de la Cruz, C; de Nicoläs, R; Egido, J; González, E; Herrero-Beaumont, G | 1 |
| Church, DJ; Lang, U; Vallotton, MB; Van der Bent, V | 1 |
| Campos, M; Krueger, RR; McDonnell, PJ; Phillips, AF; Szerenyi, K | 1 |
| Bravo, L; Bulbena, O; Escolar, G; Navarro, C; Pfeiffer, CJ | 1 |
| Itoh, K; Nakao, M; Shichijo, S; Tanaka, H; Tsuboi, I | 1 |
| Bellot, JL; Espí, R; García-Cabanes, C; Hariton, C; Orts, A; Palmero, M | 1 |
| Bieńkiewicz, A; Kuś, E; Welfel, J | 1 |
| Baersch, G; Frölich, JC | 1 |
| Hayashi, S; McDonnell, PJ; Phillips, AF; Seitz, B; Wee, WR | 1 |
| Cortina, P; Diaz-Llopis, M; Gómez-Lechón, MJ; Menezo, JL; Navea, A; Terencio, MC | 1 |
| Andĕrova, E; Jandera, A; Kuchar, M; Panajotova, V | 1 |
| Hashimoto, S; Kaneda, N; Kawai, S; Koshino, T; Matsuzaki, T; Mizushima, Y; Okamoto, R; Yamazaki, R; Yokokura, T | 1 |
| Higaki, M; Inoue, T; Mizushima, Y; Takahashi, S | 1 |
| Ito, S; Ito, Y; Miki, H; Sugatani, J; Ueda, M; Unezaki, S; Uyama, M | 1 |
| Kuznetsova, AA; Natochin, IuV | 1 |
| Kamigata, K; Nasa, Y; Takeo, S; Tsunoda, Y; Uchibayashi, K; Urata, M; Yoshida, H | 1 |
| Doi, T; Ito, A; Kido, H; Kimura, K; Kodera, N; Murakami, N; Naruse, T | 1 |
| Masuda, K; Oshika, T; Shoji, N | 1 |
| Ghosh, D; Nayak, NR; Sengupta, J | 1 |
| Bellot, JL; García-Cabanes, C; Orts, A; Palmero, M | 1 |
| Hashimoto, S; Kawai, S; Koshino, T; Matsumoto, T; Matsuzaki, T; Mizushima, Y; Okamoto, R; Yamazaki, R; Yokokura, T | 1 |
| Giuliano, F; Warner, TD | 1 |
| Fernández, AG; Godessart, N; Palacios, JM; Salcedo, C | 1 |
| Hashimoto, S; Ito, A; Kawai, S; Matsuzaki, T; Mizushima, Y; Yamazaki, R; Yokokura, T | 1 |
| Brady, MT; Gamache, DA; Graff, G; Spellman, JM; Yanni, JM | 1 |
| Lundberg, C; Lundgren, B; Wallentin, N | 1 |
| Arnout, J; Buntinx, A; Dallob, A; De Lepeleire, I; De Schepper, PJ; Depré, M; Ebel, DL; Gertz, BJ; Schwartz, JI; Tanaka, W; Van Hecken, A; Wong, PH; Wynants, K | 1 |
| Edwards, SR; Grace, RF; Lin, Y; Mather, LE; Power, I | 1 |
| Shoyama, Y; Watanabe, S; Yamaguchi, T; Yamamoto, T | 1 |
| Alió y Sanz, J; Honrubia López, FM; Ruiz Moreno, JM; Ruiz Moreno, O; Vélez, P | 1 |
| Bellot, JL; Castillo, M; García-Cabanes, C; Orts, A; Palmero, M | 1 |
| de Leval, X; Deby-Dupont, G; Delarge, J; Dogné, JM; Henrotin, Y; Mathy-Hartet, M; Mouithys-Mickalad, A; Reginster, JY | 1 |
| Abe, M; Hori, T; Oka, T; Takahashi, S | 1 |
| Natochin, IuV; Prutskova, NP; Shakhmatova, EI | 1 |
| Catella-Lawson, F; Cucchiara, AJ; DeMarco, S; FitzGerald, GA; Kapoor, SC; Reilly, MP; Tournier, B; Vyas, SN | 1 |
| Blanco, FJ; Fernández-Sueiro, JL; Galdo, F; Lema, B; López-Armada, MJ; Maneiro, E | 1 |
| Kawai, M; Mashima, Y; Mochizuki, H; Ogata, M; Yamada, M | 1 |
| Athie-Morales, V; Chain, BM; Delves, PJ; Free, P; Kvirkvelia, N; Lund, T; Rademacher, TW; Rayment, N; Roitt, IM; Vojnovic, I; Warner, TD | 1 |
| Côté, CH; Frenette, J; Lapointe, BM | 1 |
| Diez-Ortego, I; Egido, J; Herrero-Beaumont, G; Largo, R; López-Armada, MJ; Palacios, I; Sánchez-Pernaute, O | 1 |
| Kato, S; Kunikata, T; Miyazawa, T; Takeuchi, K; Tanaka, A | 1 |
| Baum, Y; Hoffer, E; Nahir, AM | 1 |
| Brockmöller, J; Kirchheiner, J; Meineke, I; Meisel, C; Roots, I; Steinbach, N | 1 |
| Hattori, T; Itoh, T; Kajikuri, J; Katsuya, H | 1 |
| Bräutigam, L; Frank, S; Geisslinger, G; Kämpfer, H; Pfeilschifter, J | 1 |
| Li, HY; Li, WX; Sun, LG | 1 |
| Belton, O; Bresnihan, B; Duffy, T; FitzGerald, D; FitzGerald, O | 1 |
| Kennedy, JH; Korn, N; Thurston, RJ | 1 |
| Caruso-Neves, C; Fernandes, MS; Leão-Ferreira, LR; Lopes, AG; Quintana-Gomes, E; Santos, DP; Soares, AC | 1 |
| Hashimoto, T; Hoshina, F; Igarashi, A; Kohno, S; Notsu, Y; Toyoda, Y; Yamada, M | 1 |
| Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA | 1 |
| Akaike, A; Banno, Y; Fushimi, K; Nakashima, S; Shimizu, K; Takigawa, M | 1 |
| Cristofoletti, R; Fabricio, AS; Navarra, P; Souza, GE; Veiga, FH | 1 |
| Bretschneider, E; Censarek, P; Fischer, JW; Meyer-Kirchrath, J; Pape, R; Rabausch, K; Sarbia, M; Schrör, K; Weber, AA | 1 |
| Bogolepova, AE; Shakhmatova, EI | 1 |
| Berry, C; Dawson, J; Du, Z; Esser, R; Fox, A; Fujimoto, RA; Haston, W; Kimble, EF; Koehler, J; Marshall, PJ; Peppard, J; Quadros, E; Quintavalla, J; Toscano, K; Urban, L; van Duzer, J; Zhang, X; Zhou, S | 1 |
| Giagoudakis, G; Markantonis, SL | 1 |
| Cramer, JA; Esser, RE; Georgieva, A; Maniara, W; Miserendino-Molteni, R; Porter, W; Ramos, L; Sharr, M; Zhang, X; Zhuang, S | 1 |
| Dietrich, DR; Hitzfeld, B; Hoeger, B; Köllner, B | 1 |
| Aita, T; Ishihata, A; Katano, Y; Ogaki, T | 1 |
| Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Alvarez-Soria, MA; Calvo, E; Egido, J; Hernández, M; Herrero-Beaumont, G; Largo, R; Sánchez-Pernaute, O; Santillana, J | 1 |
| Geisslinger, G; Manderscheid, C; Niederberger, E | 1 |
| Ayoub, SS; Botting, RM; Colville-Nash, PR; Willoughby, DA | 1 |
| Campana, V; Gavotto, A; Moya, M; Palma, J; Simes, J; Soriano, F; Soriano, M; Soriano, R; Spitale, L | 1 |
| Takahira, Y; Takeuchi, K; Tanaka, A; Yokota, A | 1 |
| Chono, K; Funatsu, T; Hirata, T; Keto, Y; Kimoto, A; Sasamata, M | 1 |
| Akkel, A; Hermle, T; Huber, SM; Kempe, DS; Kiedaisch, V; Lang, F; Lang, P; Laufer, S; Shumilina, E; Wieder, T | 1 |
| Aletras, AJ; Andonopoulos, AP; Giannopoulou, E; Gouvousis, PA; Panagiotopoulos, E; Syggelos, SA | 1 |
| Becker, TL; Gambero, A; Maróstica, M; Pedrazzoli, J | 1 |
| Mythilypriya, R; Sachdanandam, P; Shanthi, P | 1 |
| Averbukh, Z; Berman, S; Efrati, S; Golik, A; Lotan, R; Siman-Tov, Y; Weissgarten, J | 1 |
| Gerstberger, R; Greis, A; Hübschle, T; Murgott, J; Rafalzik, S; Roth, J | 1 |
| Bhatia, M; Li, L; Moore, PK; Sidhapuriwala, J; Sparatore, A | 1 |
| Berenguer, B; De la Puerta, R; Martín-Calero, MJ; Miño, P; Quílez, A; Sánchez-Fidalgo, S; Trabadela, C | 1 |
| Fujii, M; Han, HY; Kohno, S; Mizutani, N; Nabe, T; Takenaka, H; Terada, T | 1 |
| Chain, A; Danhof, M; Della Pasqua, O; Huntjens, DR; Metcalf, A; Spalding, DJ; Strougo, A; Summerfield, S | 1 |
| Chu, PY; Hsu, DZ; Li, YH; Liu, MY | 1 |
| Cavanaugh, PF; Chappell, DL; Dallob, AL; Flynn, ME; Hilliard, DA; Larson, PJ; Laterza, OF; Miller, J; Royalty, J; Schwartz, JI; Snyder, KM; Wagner, JA | 1 |
| Alvarez-Soria, MA; Calvo, E; Egido, J; Herrero-Beaumont, G; Largo, R; Moreno-Rubio, J; Santillana, J | 1 |
| Cancedda, FD; Cancedda, R; Ulivi, V | 1 |
| Benyó, Z; Hortobágyi, L; Horváth, B; Hrabák, A; Lenzsér, G; Sándor, P; Schweer, H | 1 |
| Evans, RB; Hyde, WG; Kind, AJ; McClure, SR; Schleining, JA; Wulf, LW | 1 |
| Fujiwara, T; Haruna, T; Higaki, T; Kariya, S; Makihara, S; Nishizaki, K; Okano, M | 1 |
| Bubić-Filipi, L; Samarija, I | 1 |
| Berna, M; Del Soldato, P; Giaccone, G; Jensen, RT; Moody, TW; Ridnour, LA; Roberts, DD; Santana-Flores, W; Sparatore, A; Switzer, C; Thill, M; Wink, DA; Yeh, GC | 1 |
| Barañano, DE; Durairaj, C; Edelhauser, HF; Handa, JT; Kim, SJ; Kompella, UB | 1 |
| Gold, M; Kienzler, JL; Nollevaux, F | 1 |
| Hammond, PT; Leung, A; Riollano, M; Smith, RC | 1 |
| Brochhausen, C; Hofmann, A; Kuhn, S; Mattyasovszky, SG; Müller, LP; Ritz, U; Rommens, PM; Schulze-Koops, H; Watzer, B; Wollstädter, J | 1 |
| Cnubben, NH; Hendriks, HF; Newman, JW; Pedersen, TL; Rubingh, C; Smilde, AK; van der Greef, J; van Erk, MJ; van Ommen, B; van Vliet, T; Verheij, E; Wopereis, S | 1 |
| de Carvalho, PS; Gambero, A; Maróstica, M; Pedrazzoli, J | 1 |
| Desai, DC; Deshattiwar, JJ; Deshmukh, NJ; Dhiman, M; Gaikwad, PP; Karwa, M; Mali, SV; Nemmani, KV; Pamidiboina, V; Pathan, AR; Satyam, A; Sharma, SD; Thanga Mariappan, T | 1 |
| Hamachi, E; Hatori, C; Ishii, N; Iwashita, A; Kumakura, F; Shimizu, Y; Takeshita, N; Terasawa, T; Yoshimi, E | 1 |
| Kaur, J; Sanyal, SN | 1 |
| Gilhotra, RM; Mathurm, M | 1 |
| Cairns, BE; Dong, X; Hakim, AW | 1 |
| Gray, DA; Maloney, SK; Marais, M | 1 |
| Amagase, K; Gyenge, M; Kojo, A; Nukui, K; Takeuchi, K; Tanaka, A | 1 |
| Fujino, H; Kato, T; Kawashima, T; Murayama, T; Oyama, S | 1 |
| Eid, NM; Hassan, GS; Nissan, YM; Ragab, FA | 1 |
| Cairns, BE; Dong, XD; Svensson, P; Wong, H | 1 |
| Arnold, G; de Carvalho, MH; Demeurie, F; Leal-Junior, EC; Lopes-Martins, RÁ; Magdalou, J; Magnenet, V; Marcos, RL; Rahouadj, R; Wang, X | 1 |
| Eberle, J; Fecker, LF; Rodust, PM; Stockfleth, E | 1 |
| Drozdov, VN; Kim, VA; Tkachenko, EV; Varvanina, GG | 1 |
| Guo, HF; Li, P; Liu, L; Liu, XD; Zhang, J | 1 |
| Barbieri, KP; Bosquesi, PL; Campos, ML; Chelucci, RC; Chin, CM; de Castro Souto, PC; Matsubara, MH; Moreira, V; Peccinini, RG; Santos, JL; Teixeira, C | 1 |
| Endo, K; Ito, K; Kageyama, H; Osaka, T; Sakagami, J; Shioda, S; Suzuki, M; Takenoya, F; Wang, LH; Watanabe, J | 1 |
| Aoyama, M; Asai, H; Asai, K; Hussein, MH; Kakita, H; Kato, S; Nagaya, Y; Saitoh, S; Suzuki, M | 1 |
| Brunner, M; Burian, A; Burian, B; Crevenna, R; Frangione, V; Keilani, M; Leuratti, C; Mautone, G; Rovati, S; Vaccani, A; Zeitlinger, M | 1 |
| Galloway-Phillipps, NA; Kirkby, NS; Mitchell, JA; Paul-Clark, MJ; Reed, DM; Wright, WR | 1 |
| Kurup, GM; Mahadevan, R; Mohsin, S | 1 |
| Bullins, KW; Denham, JW; Hanley, AV; Hanley, GA; Harirforoosh, S; Panus, PC; Wood, RC; Wyatt, JE | 1 |
| Abed, A; Britchford, ER; Buttery, LD; Heathman, TR; Rahman, CV; Sidney, LE | 1 |
| Helen, A; Krishnan, K; Mathew, LE; Vijayalakshmi, NR | 1 |
| Dastidar, P; Deb, J; Jana, SS; Roy, R | 1 |
| Fukui, H; Kondo, T; Miwa, H; Okada, H; Oshima, T; Tomita, T; Watari, J | 1 |
| Bakhteeva, VT; Fedorova, EV; Fok, EM; Lavrova, EA; Parnova, RG | 1 |
| Castor, MG; Duarte, ID; Navarro, LC; Romero, TR; Silva, LC | 1 |
| Che Ahmad Tantowi, NA; Hussin, P; Lau, SF; Mohamed, S | 1 |
| Adefisayo, MA; Akomolafe, RO; Alabi, QK; Fasanya, MK; Nafiu, AO; Oladele, AA; Olukiran, OS | 1 |
| Fukuda, K; Haginiwa, S; Ieda, M; Isomi, M; Kojima, H; Kurotsu, S; Miyamoto, K; Muraoka, N; Nara, K; Okano, H; Osakabe, R; Sadahiro, T; Shimizu, S; Sugimoto, Y; Tamura, F; Tani, H; Torii, S; Yamakawa, H | 1 |
| Abdullah, ST; Bhatt, S; Dogra, A; Gour, A; Koul, S; Malik, TA; Nandi, U; Rath, SK; Sangwan, PL; Sharma, A; Singh, G | 1 |
| Addobbati, R; Agostinis, C; Cecchini, P; Cirigliano, G; D'Aloisio, R; De Giacinto, C; Di Martino, G; Di Nicola, M; Pastore, MR; Radillo, O; Tognetto, D | 1 |
| Afşar, E; Aslan, M; Çeker, T; Kırımlıoğlu, E; Yılmaz, Ç | 1 |
| Ahmed, EM; El-Dash, Y; Hassan, MSA; Khalil, NA | 1 |
| Gorbach, T; Koiro, O; Kudina, O; Shtrygol, S; Tovchiga, O; Yudkevich, T | 1 |
18 trial(s) available for diclofenac and dinoprostone
| Article | Year |
|---|---|
Possible mechanisms of gastroduodenal mucosal damage in volunteers treated with nonsteroidal antiinflammatory drugs--the usefulness of prodrugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Digestive System; Dinoprostone; Double-Blind Method; Duodenal Diseases; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Gastrointestinal Diseases; Hexosamines; Humans; Hydrogen-Ion Concentration; Incidence; Indoleacetic Acids; Intestinal Mucosa; Japan; Male; Microcirculation; Phenylpropionates; Prodrugs; Regional Blood Flow | 1992 |
No adverse effect of non-steroidal anti-inflammatory drugs, sulindac and diclofenac sodium, on blood pressure control with a calcium antagonist, nifedipine, in elderly hypertensive patients.
Topics: Aged; Blood Pressure; Diclofenac; Dinoprostone; Drug Therapy, Combination; Female; Humans; Hypertension; Kidney; Nifedipine; Sulindac | 1991 |
Effects of peri-operatively administered diclofenac and indomethacin on blood loss, bleeding time and plasma prostanoids in man.
Topics: Adult; Aged; Bleeding Time; Blood Volume Determination; Diclofenac; Dinoprostone; Double-Blind Method; Female; Genital Diseases, Female; Humans; Indomethacin; Middle Aged; Platelet Function Tests; Randomized Controlled Trials as Topic; Thromboxane B2 | 1989 |
Long-term effect of nonsteroidal anti-inflammatory drugs on the production of cytokines and other inflammatory mediators by blood cells of patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Diclofenac; Dinoprostone; Double-Blind Method; Female; Humans; Interleukin-1; Interleukin-6; Knee Joint; Leukotriene B4; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osteoarthritis; Platelet Activating Factor; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 1994 |
Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.
Topics: Adolescent; Adult; Bleeding Time; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Lipopolysaccharides; Meloxicam; Membrane Proteins; Middle Aged; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfones; Thiazines; Thiazoles; Thromboxane B2 | 2000 |
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Interactions; Drug Therapy, Combination; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sulfones; Thromboxane B2 | 2001 |
Inhibition of PGE2 production by nimesulide compared with diclofenac in the acutely inflamed joint of patients with arthritis.
Topics: Acute Disease; Administration, Oral; Arthralgia; Arthritis; Cyclooxygenase 1; Cyclooxygenase 2; Diclofenac; Dinoprostone; Double-Blind Method; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Synovial Fluid | 2003 |
Relationships between the concentrations of prostaglandins and the nonsteroidal antiinflammatory drugs indomethacin, diclofenac, and ibuprofen.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Cross-Over Studies; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Ibuprofen; Indomethacin; Male; Tablets; Time Factors | 2005 |
Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blotting, Western; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Depression, Chemical; Diclofenac; Dinoprostone; Female; Gene Expression; Humans; Interleukin-1; Knee Joint; Male; Membrane Proteins; Osteoarthritis, Knee; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Synovial Membrane; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Photobiomodulation of pain and inflammation in microcrystalline arthropathies: experimental and clinical results.
Topics: Animals; Arthralgia; Arthritis, Experimental; Biomarkers; Calcium Pyrophosphate; Diclofenac; Dinoprostone; Durapatite; Female; Fibrinogen; Gout; Humans; Laser Therapy; Middle Aged; Rats; Tumor Necrosis Factor-alpha; Uric Acid | 2006 |
Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 versus COX-1 in healthy subjects.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Double-Blind Method; Etoricoxib; Female; Humans; Male; Middle Aged; Pyrazoles; Pyridines; Sulfonamides; Sulfones; Thromboxane B2 | 2008 |
Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Celecoxib; Chondrocytes; Cyclooxygenase 2; Diclofenac; Dinoprostone; Down-Regulation; Female; Humans; Interleukin-1; Male; Nitric Oxide; Osteoarthritis, Knee; Pyrazoles; Sulfonamides; Synovial Membrane | 2008 |
Systemic bioavailability of topical diclofenac sodium gel 1% versus oral diclofenac sodium in healthy volunteers.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Cross-Over Studies; Diclofenac; Dinoprostone; Female; Humans; Male; Middle Aged; Platelet Aggregation; Tablets, Enteric-Coated; Thromboxane B2 | 2010 |
Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study.
Topics: Adult; Annexin A1; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Caspase 8; Diclofenac; Dinoprostone; Gene Expression Profiling; Humans; Inflammation; Inflammation Mediators; Male; Metabolomics; Middle Aged; Multivariate Analysis; Obesity; Overweight; Proteomics; Tumor Necrosis Factor-alpha | 2010 |
Influence of a specific ginger combination on gastropathy conditions in patients with osteoarthritis of the knee or hip.
Topics: Abdominal Pain; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprost; Dinoprostone; Dyspepsia; Endoscopy, Digestive System; Female; Gastric Mucosa; Gastrins; Hip; Hip Joint; Humans; Knee; Knee Joint; Male; Middle Aged; Osteoarthritis, Hip; Osteoarthritis, Knee; Pain Measurement; Phytotherapy; Plant Extracts; Severity of Illness Index; Zingiber officinale | 2012 |
An exploratory microdialysis study investigating the effect of repeated application of a diclofenac epolamine medicated plaster on prostaglandin concentrations in skeletal muscle after standardized physical exercise.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Exercise; Healthy Volunteers; Humans; Male; Microdialysis; Quadriceps Muscle; Transdermal Patch; Young Adult | 2013 |
The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Dinoprostone; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Esophagoscopy; Esophagus; Healthy Volunteers; Heartburn; Histocytochemistry; Humans; Male; Placebos; Prospective Studies | 2015 |
VITREOUS PROSTAGLANDIN E2 CHANGES AFTER TOPICAL ADMINISTRATION OF DICLOFENAC 0.1%, INDOMETHACIN 0.5%, NEPAFENAC 0.3%, AND BROMFENAC 0.09.
Topics: Administration, Ophthalmic; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Benzophenones; Bromobenzenes; Chromatography, High Pressure Liquid; Diclofenac; Dinoprostone; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Epiretinal Membrane; Female; Humans; Indomethacin; Male; Middle Aged; Ophthalmic Solutions; Phenylacetates; Prospective Studies; Retinal Perforations; Vitrectomy; Vitreous Body | 2020 |
152 other study(ies) available for diclofenac and dinoprostone
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors | 2003 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Collagen; Diamines; Diclofenac; Dinoprostone; Disease Models, Animal; Female; Interleukin-1; Leukotriene B4; Male; Naproxen; Oxazines; Phenols; Piroxicam; Rats; Rats, Inbred Lew; Thromboxane B2 | 1992 |
Effect of sulindac on prostaglandin synthesis in human and in cultured rat renal and vascular smooth muscle cells.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Animals; Arachidonic Acids; Cells, Cultured; Creatinine; Diclofenac; Dinoprostone; Female; Humans; Ibuprofen; Kidney; Kidney Glomerulus; Male; Middle Aged; Muscle, Smooth, Vascular; Prostaglandins; Rats; Rats, Sprague-Dawley; Sulindac | 1992 |
Induction of labor and cervical maturation using mifepristone (RU 486) in the late pregnant rat. Influence of a cyclooxygenase inhibitor (Diclofenac).
Topics: Animals; Arachidonic Acids; Cervix Uteri; Diclofenac; Dinoprostone; Electrophoresis, Cellulose Acetate; Female; Glycosaminoglycans; Labor, Induced; Leukotriene B4; Mifepristone; Pregnancy; Radioimmunoassay; Rats; Rats, Inbred Strains | 1991 |
Pharmacological properties of five diclofenac metabolites identified in human plasma.
Topics: Animals; Arthritis, Experimental; Diclofenac; Dinoprostone; Edema; Humans; In Vitro Techniques; Macrophages; Mice; Pain; Rats; Rats, Inbred Strains; SRS-A | 1991 |
Aspirin-like drugs prime human T cells. Modulation of intracellular calcium concentrations.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation, T-Lymphocyte; Arachidonic Acid; Arachidonic Acids; Calcium; CD8 Antigens; Cell Division; Chromatography, High Pressure Liquid; Diclofenac; Dinoprostone; Drug Synergism; Female; Flow Cytometry; Flurbiprofen; Humans; Indomethacin; Interleukin-2; Lymphocyte Activation; Male; Middle Aged; Phytohemagglutinins; Radioimmunoassay; T-Lymphocytes | 1991 |
Prostaglandin E2 does not inhibit tumoricidal activity of mouse macrophages against adherent tumor cells.
Topics: Animals; Cytotoxicity, Immunologic; Diclofenac; Dinoprostone; Indomethacin; Macrophages; Mice; Mice, Inbred C57BL; Peritoneal Cavity; Thioglycolates; Tumor Cells, Cultured | 1991 |
Prostaglandin E2 from macrophages of murine splenocyte cultures inhibits the generation of lymphokine-activated killer cell activity.
Topics: Adenocarcinoma; Animals; Cells, Cultured; Diclofenac; Dinoprostone; Down-Regulation; Female; Immune Sera; Indomethacin; Killer Cells, Lymphokine-Activated; Macrophages; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Protein Kinase C; Spleen | 1991 |
Mechanisms of decrease in cytoplasmic motility of alveolar macrophages during immediate asthmatic response in dogs.
Topics: Aerosols; Alprostadil; Animals; Antigens, Helminth; Ascaris; Asthma; Carbon Dioxide; Cytoplasm; Diclofenac; Dinoprostone; Dogs; In Vitro Techniques; Indomethacin; Macrophages; Oxygen; Partial Pressure; Pulmonary Alveoli; Respiration | 1990 |
Prostaglandin E2 prevents diclofenac-induced enhancement of histamine release and inflammation evoked by in vivo challenge with compound 48/80 in the hamster cheek pouch.
Topics: Animals; Cheek; Diclofenac; Dinoprostone; Guinea Pigs; Histamine Release; Indomethacin; Inflammation; Leukocytes; Microcirculation; p-Methoxy-N-methylphenethylamine; Vasodilation | 1989 |
Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release. A novel effect on free arachidonic acid levels in human synovial cells.
Topics: Acute-Phase Reaction; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Diclofenac; Dinoprostone; Humans; Indomethacin; Interleukin-1; Synovial Membrane | 1989 |
Prostaglandin D2 and sleep.
Topics: Animals; Circadian Rhythm; Diclofenac; Dinoprostone; Electroencephalography; Electromyography; Macaca mulatta; Prostaglandin D2; Rats; Reference Values; Sleep; Sleep, REM | 1989 |
Functional compartmentalization of arginine-vasopressin-activated cyclic AMP in anterior pituitary gland: the presence of a compartment activated by prostaglandin E2.
Topics: Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Cyclic AMP; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Indomethacin; Male; Pituitary Gland, Anterior; Prostaglandins E; Rats; Rats, Inbred Strains | 1986 |
Effect of diclofenac sodium on the arachidonic acid cascade.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Leukocytes; Lipoxygenase Inhibitors; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Naproxen; Phospholipids; Piroxicam; Prostaglandins E; Rats; SRS-A; Thiazines; Triglycerides | 1986 |
Vascular permeability responses and the role of prostaglandin E2 in an experimental allergic inflammation of air pouch type in rats.
Topics: Animals; Capillary Permeability; Diclofenac; Dinoprostone; Hypersensitivity; Indomethacin; Inflammation; Male; Propionates; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Intrathoracic platelet accumulation in the guinea-pig induced by intravenous administration of arachidonic acid--effect of cyclooxygenase and thromboxane synthetase inhibitors.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Chromium Radioisotopes; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Fibrinogen; Guinea Pigs; Injections, Intravenous; Iodine Radioisotopes; Platelet Aggregation; Prostaglandin D2; Prostaglandins D; Prostaglandins E; Pulmonary Circulation; Thorax; Thromboxane B2; Thromboxane-A Synthase | 1986 |
The effect of diphenylamine derivatives on arachidonic acid metabolism in rat peritoneal macrophages.
Topics: Aniline Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Chromatography, High Pressure Liquid; Diclofenac; Dinoprostone; Diphenylamine; Macrophages; Male; Mefenamic Acid; ortho-Aminobenzoates; Peritoneal Cavity; Prostaglandins E; Radioimmunoassay; Rats; Rats, Inbred Strains | 1987 |
The action of the prostaglandins on isolated human ureteric smooth muscle.
Topics: Diclofenac; Dinoprost; Dinoprostone; Humans; In Vitro Techniques; Indomethacin; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Prostaglandins; Prostaglandins E; Prostaglandins F; Ureter | 1988 |
Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis.
Topics: Ampicillin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteriolysis; Cell Wall; Cerebrospinal Fluid; Diclofenac; Dinoprostone; Indenes; Indomethacin; Leukocytosis; Male; Masoprocol; Meningitis, Pneumococcal; Methylprednisolone; Prostaglandins E; Rabbits; Streptococcus pneumoniae | 1987 |
Effect of diclofenac sodium (Voltaren) and prostaglandin E2 on spermatogenesis in mature dogs.
Topics: Animals; Diclofenac; Dinoprostone; Dogs; Male; Prostaglandins E; Prostaglandins E, Synthetic; Seminiferous Tubules; Sperm Count; Spermatids; Spermatogenesis | 1987 |
Reduction of urinary protein and prostaglandin E2 excretion in the nephrotic syndrome by non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Diclofenac; Dinoprostone; Flurbiprofen; Glomerular Filtration Rate; Humans; Indomethacin; Male; Middle Aged; Nephrotic Syndrome; Prostaglandins E; Proteinuria; Renin; Sulindac | 1986 |
Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Dinoprostone; Guanidines; Humans; Indomethacin; Naproxen; ortho-Aminobenzoates; Prednisolone; Prostaglandins; Prostaglandins E; Quinazolines; Synovial Fluid; Thromboxane B2 | 1985 |
Effect of indomethacin, tiaprofenic acid and dicrofenac on rat gastric mucosal damage and content of prostacyclin and prostaglandin E2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Gastric Fundus; Gastric Mucosa; Indomethacin; Male; Propionates; Prostaglandins E; Radioimmunoassay; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
Prostaglandin synthetase inhibition of renal pelvic smooth muscle in the rabbit.
Topics: Animals; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Kidney Pelvis; Muscle Contraction; Muscle, Smooth; Prostaglandins E; Prostaglandins E, Synthetic; Prostaglandins F; Rabbits | 1985 |
The effects of diclofenac sodium on arachidonic acid metabolism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indomethacin; Leukocytes; Lipoxygenase; Naproxen; Phospholipases A; Phospholipases A2; Phospholipids; Piroxicam; Prostaglandins E; SRS-A; Thiazines; Triglycerides | 1985 |
Effects of Voltaren on arachidonic acid metabolism in arthritis patients.
Topics: Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Diclofenac; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Metabolic Clearance Rate; Osteoarthritis; Prostaglandins E; Synovial Fluid; Thromboxane B2 | 1985 |
Effect of central prostaglandins on carrageenan-induced pedal oedema in rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Carrageenan; Diclofenac; Dinoprost; Dinoprostone; Edema; Female; Injections, Intraventricular; Male; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats | 1984 |
Adrenocorticotropin and beta-endorphin release from rat adenohypophysis in vitro: inhibition by prostaglandin E2 formed locally in response to vasopressin and corticotropin-releasing factor.
Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Endorphins; Flurbiprofen; Indomethacin; Male; Pituitary Gland, Anterior; Potassium; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains | 1984 |
Involvement of prostaglandins in LPS-mediated regulation of plasminogen activator synthesis by inflammatory macrophages.
Topics: Animals; Bacterial Toxins; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Endotoxins; Enterotoxins; Indomethacin; Inflammation; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred Strains; Plasminogen Activators; Prostaglandins E | 1984 |
Effects of cyclooxygenase inhibitors and prostaglandin E2 on macrophage activation in vitro.
Topics: Animals; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Hexosephosphates; In Vitro Techniques; Indomethacin; Macrophages; Male; Mice; Phagocytosis; Phenylacetates; Plasminogen Activators; Prostaglandins E; Zymosan | 1981 |
Mechanisms involved in the antiinflammatory effect of propolis extract.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Edema; Guinea Pigs; Histamine Release; In Vitro Techniques; Inflammation; Leukotriene D4; Lung; Male; Propolis; Prostaglandins; Rats | 1993 |
Nonsteroidal antiinflammatory drugs: effects on normal and interleukin 1 treated human articular chondrocyte metabolism in vitro.
Topics: Cartilage, Articular; Cell Division; Cells, Cultured; Collagenases; Diclofenac; Dinoprostone; Extracellular Matrix; Humans; Ibuprofen; Interleukin-1; Interleukin-6; Naproxen; Reference Values; Salicylates | 1995 |
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depression, Chemical; Diclofenac; Dinoprostone; Dogs; Etodolac; Gastric Mucosa; Guinea Pigs; Indomethacin; Interleukin-1; Ketoprofen; Kidney; Naproxen; Oxygen; Pain; Piroxicam; Rabbits; Rats | 1994 |
Prostaglandin release from lumbar disc and facet joint tissue.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Cartilage, Articular; Diclofenac; Dinoprostone; Humans; In Vitro Techniques; Indomethacin; Intervertebral Disc; Leukotriene C4; Lumbar Vertebrae; Radioimmunoassay | 1994 |
Cyclooxygenase inhibitors augment the production of pro-matrix metalloproteinase 9 (progelatinase B) in rabbit articular chondrocytes.
Topics: Alprostadil; Animals; Cartilage, Articular; Cells, Cultured; Collagenases; Diclofenac; Dinoprostone; Enzyme Precursors; Gelatinases; Indomethacin; Matrix Metalloproteinase 9; Metalloendopeptidases; Rabbits; Synovial Membrane | 1995 |
Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization.
Topics: Analgesia; Animals; Arginine; Carrageenan; Diclofenac; Dinoprostone; Drug Interactions; Enzyme Activation; Guanylate Cyclase; Hyperalgesia; Indomethacin; Inflammation; Injections, Intra-Articular; Knee Injuries; Male; Methylene Blue; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Pain Measurement; Rats; Rats, Wistar | 1994 |
Role of prostaglandin-mediated cyclic AMP formation in protein kinase C-dependent secretion of atrial natriuretic peptide in rat cardiomyocytes.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Atrial Natriuretic Factor; Bucladesine; Cells, Cultured; Cyclic AMP; Diclofenac; Dinoprost; Dinoprostone; Epoprostenol; Heart; Heart Ventricles; Indomethacin; Kinetics; Myocardial Contraction; Myocardium; Nifedipine; Prostaglandins; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Thionucleotides | 1994 |
Arachidonic acid metabolites after excimer laser corneal surgery.
Topics: Animals; Cornea; Diclofenac; Dinoprostone; Fluorometholone; Immunoenzyme Techniques; Laser Therapy; Leukocyte Count; Leukotriene B4; Neutrophils; Ophthalmic Solutions; Rabbits; Random Allocation | 1993 |
Gastroprotective effect of zinc acexamate against damage induced by nonsteroidal antiinflammatory drugs. A morphological study.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Dinoprostone; Drug Evaluation, Preclinical; Female; Gastric Mucosa; Indomethacin; Microscopy, Electron, Scanning; Necrosis; Piroxicam; Rats; Rats, Wistar; Surface Properties | 1993 |
Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cells, Cultured; Clone Cells; Diclofenac; Dinoprostone; Gene Expression Regulation; HTLV-I Infections; Humans; Indomethacin; Interferon-gamma; Interleukin-2; Interleukin-6; Ketoprofen; Leukemia-Lymphoma, Adult T-Cell; Leukocytes, Mononuclear; Lymphocyte Activation; Molecular Sequence Data; Polymerase Chain Reaction; RNA, Messenger; Sarcoidosis, Pulmonary; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uveitis | 1995 |
Additive effect of nitric oxide and prostaglandin-E2 synthesis inhibitors in endotoxin-induced uveitis in the rabbit.
Topics: Administration, Topical; Animals; Aqueous Humor; Arginine; Ciliary Body; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Lipopolysaccharides; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Rabbits; Random Allocation; Uveitis; Vitreous Body | 1996 |
Prostaglandin-induced changes and the influence of cyclo-and lipoxygenase inhibitors on the uterine collagen concentration in late pregnancy in rats.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Collagen; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Female; Lipoxygenase Inhibitors; Pregnancy; Rats; Rats, Wistar; Uterus | 1996 |
A new bioassay to study contractile and relaxant effects of PGE2 on perfused guinea pig trachea.
Topics: Analysis of Variance; Animals; Biological Assay; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Interactions; Female; Guinea Pigs; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxytocics; Reproducibility of Results; Trachea | 1996 |
Effect of diclofenac, ketorolac, and fluorometholone on arachidonic acid metabolites following excimer laser corneal surgery.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Chemotaxis, Leukocyte; Cornea; Diclofenac; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Fluorometholone; Ketorolac; Lasers, Excimer; Leukotriene B4; Neutrophils; Ophthalmic Solutions; Photorefractive Keratectomy; Rabbits; Tolmetin | 1996 |
Diclofenac sodium and cyclosporin A inhibit human lens epithelial cell proliferation in culture.
Topics: Aged; Animals; Cell Division; Cell Survival; Cells, Cultured; Chlorocebus aethiops; Cyclooxygenase Inhibitors; Cyclosporine; Diclofenac; Dinoprostone; Epithelial Cells; Epithelium; Humans; Immunosuppressive Agents; Lens, Crystalline; Middle Aged; Vero Cells | 1997 |
Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid.
Topics: Abdominal Pain; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Butyrates; Carrageenan; Diclofenac; Dinoprostone; Edema; Female; Graft vs Host Reaction; Leukotriene B4; Male; Mice; Mice, Inbred C57BL; Phagocytosis; Phenylbutyrates; Pleurisy; Rats; Rats, Inbred Lew; Stomach Ulcer | 1997 |
Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Chromatography, Thin Layer; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Monocytes; Neutrophils; Prostaglandin-Endoperoxide Synthases; Synovial Membrane | 1997 |
Cyclooxygenase inhibitors enhance the production of tissue inhibitor-1 of metalloproteinases (TIMP-1) and pro-matrix metalloproteinase 1 (proMMP-1) in human rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Collagenases; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Enzyme Precursors; Fibroblasts; Humans; Indomethacin; Interleukin-1; Matrix Metalloproteinase 1; Recombinant Proteins; Synovial Membrane; Tissue Inhibitor of Metalloproteinase-1 | 1997 |
Involvement of prostaglandin E2 in rabbit corneal injury by anterior segment ischaemia.
Topics: Alprostadil; Animals; Anterior Eye Segment; Aqueous Humor; Cornea; Corneal Diseases; Corneal Edema; Cyclic AMP; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Ischemia; Male; Organ Culture Techniques; Prostaglandins; Proteins; Rabbits | 1997 |
[Nocturnal enuresis as a manifestation of autocoidosis].
Topics: Adolescent; Body Water; Calcium; Child; Creatinine; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Diuresis; Eicosanoids; Enuresis; Humans; Loop of Henle; Magnesium; Nephrons; Sodium; Vasopressins | 1997 |
Effects of the antihypertensive agent, cicletanine, on noradrenaline release and vasoconstriction in perfused mesenteric artery of SHR.
Topics: Animals; Antihypertensive Agents; Diclofenac; Dinoprostone; Electric Stimulation; Male; Mesenteric Arteries; Norepinephrine; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstriction | 1998 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Dinoprostone; Edema; Erythema; Fever; Gastric Mucosa; Guinea Pigs; Hindlimb; Hyperalgesia; Indomethacin; Intestinal Mucosa; Ketoprofen; Male; Phenylpropionates; Rats; Species Specificity; Stomach Ulcer; Ultraviolet Rays | 1998 |
Inflammatory reaction via arachidonic acid cascade after intravitreal injection of endothelin-1.
Topics: Administration, Topical; Animals; Anterior Chamber; Aqueous Humor; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Endothelin-1; Eye Proteins; Female; Inflammation; Injections; Leukotriene B4; Male; Rabbits; Radioimmunoassay; Uveitis, Anterior; Vitreous Body | 1998 |
Antinidatory effect of luteal phase administration of mifepristone (RU486) is associated with changes in endometrial prostaglandins during the implantation window.
Topics: Animals; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Embryo Implantation; Endometrium; Female; Hydroxyprostaglandin Dehydrogenases; Luteal Phase; Luteolytic Agents; Macaca mulatta; Male; Mifepristone; Misoprostol; Oxytocics; Prostaglandin-Endoperoxide Synthases; Prostaglandins | 1998 |
PGE2 synthesis by corneal endothelial cells: effect of glucocorticoids and NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Cattle; Cells, Cultured; Dexamethasone; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Endothelium, Corneal; Glucocorticoids; Indomethacin; Ionophores; Lipopolysaccharides; Prednisolone; Salmonella typhimurium | 1999 |
Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydrolysis; Immunoenzyme Techniques; Isoenzymes; Membrane Proteins; Microsomes; Prostaglandin-Endoperoxide Synthases; Synovial Membrane | 1999 |
Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Blood Pressure; Carcinoma; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indans; Isoenzymes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salicylates; Substrate Specificity; Sulfonamides; Sulindac; Thromboxane B2; Tumor Cells, Cultured | 1999 |
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Indomethacin; Isoenzymes; Ketorolac; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides; Time Factors; Wound Healing | 1999 |
A major metabolite of aceclofenac, 4'-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Dinoprostone; Enzyme Precursors; Extracellular Space; Humans; Interleukin-1; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Protease Inhibitors; RNA, Messenger; Synovial Membrane; Tissue Inhibitor of Metalloproteinase-1 | 2000 |
Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Evaluation, Preclinical; Eye Diseases; Inflammation; Isoenzymes; Phenylacetates; Prodrugs; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rabbits | 2000 |
Lack of correlation between intraocular inflammation and after-cataract formation in the rabbit eye.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Cataract Extraction; Dexamethasone; Diclofenac; Dinoprostone; Endotoxins; Glucocorticoids; Leukocytes; Ophthalmic Solutions; Ovalbumin; Pilot Projects; Rabbits; Uveitis, Anterior | 2000 |
Effects of diclofenac in the rat tail ischaemia--reperfusion injury model of acute hyperalgesia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain Chemistry; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Hyperalgesia; Injections, Subcutaneous; Male; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Tail; Thromboxane B2 | 2001 |
Behavioral suppression induced by cannabinoids is due to activation of the arachidonic acid cascade in rats.
Topics: Animals; Arachidonic Acid; Behavior, Animal; Cannabinoids; Conditioning, Operant; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Dronabinol; Hallucinogens; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Second Messenger Systems | 2001 |
[Effect of tobramycin with topical diclofenac on arachidonic acid in endotoxin-induced uveitis].
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Bacterial Toxins; Diclofenac; Dinoprostone; Drug Interactions; Drug Therapy, Combination; Endotoxins; Leukotriene B4; Rabbits; Tobramycin; Uveitis | 2001 |
Inhibition of COX in ocular tissues: an in vitro model to identify selective COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Endothelium, Corneal; Isoenzymes; Lipopolysaccharides; Nitrobenzenes; Pigment Epithelium of Eye; Piroxicam; Prostaglandin-Endoperoxide Synthases; Salmonella typhimurium; Sulfonamides | 2001 |
In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chondrocytes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Dinoprostone; DNA; Humans; In Vitro Techniques; Inflammation Mediators; Interleukin-1; Isoenzymes; Membrane Proteins; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction | 2001 |
Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats.
Topics: Animals; Bacterial Infections; Body Temperature; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Hypothalamus; Isoenzymes; Lipopolysaccharides; Male; Membrane Proteins; Nitrobenzenes; Pain Measurement; Pain Threshold; Preoptic Area; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Reaction Time; Septal Nuclei; Sulfonamides | 2001 |
[Increase of water permeability and recovery of water impermeability of the frog urinary bladder].
Topics: Animals; Biological Transport; Cyclic AMP; Deamino Arginine Vasopressin; Diclofenac; Dinoprostone; Enzyme Inhibitors; Osmosis; Permeability; Phospholipases A; Phospholipases A2; Quinacrine; Rana temporaria; Receptors, Vasopressin; Urinary Bladder; Vasotocin; Water | 2001 |
Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cartilage, Articular; Cells, Cultured; Chondrocytes; Culture Media, Conditioned; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Humans; Insulin-Like Growth Factor I; Interleukin 1 Receptor Antagonist Protein; Lipopolysaccharides; Middle Aged; Nitric Oxide; Osteoarthritis, Knee; Piroxicam; Sialoglycoproteins; Tumor Necrosis Factor-alpha | 2001 |
Topical diclofenac sodium decreases the substance P content of tears.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Eye Proteins; Female; Humans; Immunoenzyme Techniques; Male; Ophthalmic Solutions; Substance P; Tears | 2002 |
Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells.
Topics: Animals; Benzene Derivatives; Cell Division; Chorionic Villi; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Female; Furans; Humans; Immune Tolerance; Indomethacin; Interleukin-2; Isoenzymes; Membrane Proteins; Mice; Pregnancy; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; T-Lymphocytes | 2002 |
Lengthening contraction-induced inflammation is linked to secondary damage but devoid of neutrophil invasion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Collagenases; Diclofenac; Dinoprostone; Disease Progression; Female; Immunohistochemistry; Inflammation; Isometric Contraction; Macrophages; Muscle Contraction; Muscle, Skeletal; Neutrophil Infiltration; Neutrophils; Rats; Rats, Wistar; Recovery of Function | 2002 |
Modulation of cell recruitment by anti-inflammatory agents in antigen-induced arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemokine CCL2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Gene Expression Regulation; Interleukin-8; Leukocytes; Meloxicam; Neutrophil Infiltration; Ovalbumin; Rabbits; Thiazines; Thiazoles | 2002 |
Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Naproxen; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley | 2002 |
N-Acetylcysteine enhances the action of anti-inflammatory drugs as suppressors of prostaglandin production in monocytes.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Drug Synergism; Expectorants; Humans; In Vitro Techniques; Lactones; Lipopolysaccharides; Monocytes; Sulfones | 2002 |
Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Diclofenac; Dinoprostone; Genotype; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Polymorphism, Genetic; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 2003 |
Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzoquinones; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Hydrogen Peroxide; In Vitro Techniques; Leukotriene C4; Leukotriene D4; Lipoxygenase Inhibitors; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channel Blockers; Rabbits; Vasodilator Agents | 2003 |
Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair.
Topics: 3T3 Cells; Animals; Blotting, Western; Chromatography, Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Isoenzymes; Mass Spectrometry; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Chemical; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Ribonucleases; Skin; Wound Healing | 2003 |
[Influence of prostaglandin E2 on proliferation of melanocytes in full-thickness skin graft].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cell Proliferation; Diclofenac; Dinoprostone; Epidermis; Guinea Pigs; Melanocytes; Skin; Skin Transplantation; Time Factors | 2003 |
Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility.
Topics: Alprostadil; Animals; Aspirin; Cell Membrane; Cryopreservation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Resveratrol; Semen; Semen Preservation; Sperm Motility; Spermatozoa; Stilbenes; Sulfonamides; Tolmetin; Turkeys | 2003 |
PLA2/PGE2 are involved in the inhibitory effect of bradykinin on the angiotensin-(1-7)-stimulated Na(+)-ATPase activity of the proximal tubule.
Topics: Angiotensin I; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Cell Membrane; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Kidney Tubules, Proximal; Peptide Fragments; Phospholipases A; Phospholipases A2; Quinacrine; Receptor, Bradykinin B2; Sodium-Potassium-Exchanging ATPase; Swine | 2004 |
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Benzophenones; Benzopyrans; Bromobenzenes; Conjunctivitis, Allergic; Diclofenac; Dinoprostone; Disease Models, Animal; Evans Blue; Exudates and Transudates; Eye; Guinea Pigs; Histamine; Histamine Release; Immunization; Injections, Intraperitoneal; Injections, Subcutaneous; Ketotifen; Male; Ovalbumin; Propionates; Prostaglandin D2; Pruritus; Therapeutic Irrigation | 2003 |
Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hyperalgesia; Indomethacin; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 2004 |
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Calpain; Cell Line, Tumor; Chondrocytes; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Diclofenac; Dinoprostone; Humans; Nitrobenzenes; Phenylpropionates; Prostaglandin Antagonists; Sulfonamides; Tumor Necrosis Factor-alpha; Up-Regulation; Xanthones | 2004 |
The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Endothelin-1; Fever; Indomethacin; Injections, Intraperitoneal; Injections, Intraventricular; Intubation, Gastrointestinal; Lipopolysaccharides; Male; Organic Chemicals; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2005 |
Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandins.
Topics: Alprostadil; Blood Coagulation; Bucladesine; Carotid Artery Diseases; Carotid Artery, Internal; Cells, Cultured; Colforsin; Coronary Vessels; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Epoprostenol; Etoricoxib; Gene Expression Profiling; Gene Expression Regulation; Humans; Iloprost; Isoquinolines; Mammary Arteries; Membrane Proteins; Models, Biological; Myocytes, Smooth Muscle; Oligonucleotide Array Sequence Analysis; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; RNA, Messenger; Saphenous Vein; Second Messenger Systems; Sulfonamides; Sulfones; Tetradecanoylphorbol Acetate; Thrombomodulin; Thrombophilia; Vasodilator Agents | 2005 |
[Role of prostaglandin E2 in regulation of urine excretion in saluresis, water and osmotic diuresis in rat].
Topics: Animals; Celecoxib; Chlorides; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Diuresis; Diuretics; Furosemide; Male; Natriuresis; Osmosis; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Urination; Water | 2004 |
Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Availability; Blood Platelets; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Edema; Female; Fever; Fibroblasts; Humans; Hyperalgesia; Male; Membrane Proteins; Organic Chemicals; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Skin; Thromboxane B2 | 2005 |
Pharmacodynamic behaviour of the selective cyclooxygenase-2 inhibitor lumiracoxib in the lipopolysaccharide-stimulated rat air pouch model.
Topics: Animals; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Female; Lipopolysaccharides; Organic Chemicals; Rats; Rats, Inbred Lew | 2005 |
Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario).
Topics: Animals; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Environmental Exposure; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Genes, MHC Class II; Germany; Gills; Granulocytes; Immunohistochemistry; Kidney; Muramidase; Rivers; Trout; Water Pollutants, Chemical | 2005 |
Role of prostaglandins in urotensin II-induced vasodilatation in the coronary arteries of aged rats.
Topics: Aging; Analysis of Variance; Animals; Coronary Circulation; Coronary Vessels; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Inbred F344; Time Factors; Urotensins; Vasodilation; Vasodilator Agents | 2005 |
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2 | 2006 |
Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib.
Topics: Animals; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Etoricoxib; Gene Expression Regulation; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Organic Chemicals; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Sulfones; Transcription Factor AP-1 | 2006 |
The involvement of a cyclooxygenase 1 gene-derived protein in the antinociceptive action of paracetamol in mice.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Aminopyrine; Analgesics, Non-Narcotic; Animals; Antipyrine; Behavior, Animal; Blotting, Western; Brain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Spinal Cord | 2006 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lactones; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones; Time Factors; Up-Regulation | 2006 |
Mucosal acid causes gastric mucosal microcirculatory disturbance in nonsteroidal anti-inflammatory drug-treated rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Diclofenac; Dinoprostone; Endothelin-1; Gastric Acid; Gastric Mucosa; Male; Microcirculation; Pyrazoles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sulfonamides | 2007 |
Stimulation of suicidal erythrocyte death by lipoxygenase inhibitor Bay-Y5884.
Topics: Aspirin; Biological Transport; Calcium; Cell Death; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Erythrocytes; Humans; Lipoxygenase Inhibitors; Patch-Clamp Techniques; Phosphatidylserines; Potassium Channels, Calcium-Activated | 2006 |
In vitro effects of non-steroidal anti-inflammatory drugs on cytokine, prostanoid and matrix metalloproteinase production by interface membranes from loose hip or knee endoprostheses.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Cytokines; Diclofenac; Dinoprostone; Female; Hip Prosthesis; Humans; Indomethacin; Knee Prosthesis; Matrix Metalloproteinases; Middle Aged; Piroxicam; Tissue Inhibitor of Metalloproteinases | 2007 |
Effect of different cyclooxygenase inhibitors on gastric adaptive cytoprotection induced by 20% ethanol.
Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytoprotection; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gastric Acid; Gastric Mucosa; Ibuprofen; Irritants; Male; Meloxicam; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyrazoles; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides; Thiazines; Thiazoles | 2007 |
Analgesic, antipyretic and Ulcerogenic properties of an indigenous formulation--Kalpaamruthaa.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Arthritis, Rheumatoid; Diclofenac; Dinoprostone; Female; Fruit; Gastric Mucosa; Male; Mice; Phyllanthus emblica; Plant Extracts; Rats; Rats, Wistar; Semecarpus; Stomach Ulcer; Time Factors | 2007 |
N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytoprotection; Diclofenac; Dinoprostone; Hydrogen Peroxide; Kidney; Kidney Cortex; Kidney Medulla; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Renal Circulation; Renal Insufficiency; Tissue Distribution | 2007 |
Characterization of the febrile response induced by fibroblast-stimulating lipopeptide-1 in guinea pigs.
Topics: Animals; Body Temperature; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Diglycerides; Dinoprostone; Dose-Response Relationship, Drug; Fever; Guinea Pigs; Interleukin-6; Lipopolysaccharides; Male; Oligopeptides; Polyethylene Glycols; Prostaglandin-Endoperoxide Synthases; Telemetry; TNF Receptor-Associated Factor 1 | 2007 |
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hindlimb; Hydrogen Sulfide; Injections; Male; Neutrophils; Nitrates; Nitrites; Peroxidase; Rats; Rats, Wistar; Thiones | 2007 |
The aerial parts of Guazuma ulmifolia Lam. protect against NSAID-induced gastric lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Dinoprostone; Female; Flowers; Gastric Mucosa; Glutathione; Glutathione Peroxidase; Leukocytes; Lipid Peroxidation; Male; Malvaceae; Neutrophil Infiltration; Omeprazole; Peroxidase; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Stomach Ulcer; Sulfhydryl Compounds; Superoxide Dismutase | 2007 |
Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Diclofenac; Dinoprostone; Disease Models, Animal; Guinea Pigs; Indomethacin; Male; Nasal Obstruction; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2007 |
Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats.
Topics: Administration, Oral; Animals; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Enterohepatic Circulation; Infusions, Intravenous; Injections, Intraperitoneal; Lactones; Male; Models, Biological; Nonlinear Dynamics; Rats; Rats, Sprague-Dawley; Species Specificity; Sulfones; Time Factors | 2008 |
Sesamol attenuates diclofenac-induced acute gastric mucosal injury via its cyclooxygenase-independent antioxidative effect in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzodioxoles; Diclofenac; Dinoprostone; Gastric Mucosa; Hydroxyl Radical; Lipid Peroxidation; Male; Oxidative Stress; Phenols; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach | 2008 |
15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation.
Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cartilage; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Diclofenac; Dinoprostone; Down-Regulation; Enzyme Induction; Enzyme Repression; Imidazoles; Inflammation; Intramolecular Oxidoreductases; Lipocalin-2; Lipocalins; Lipopolysaccharides; Mice; NF-kappa B; Oncogene Proteins; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; PPAR alpha; PPAR gamma; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Time Factors; Tyrosine | 2008 |
Carbon monoxide-prostaglandin E2 interaction in the hypothalamic circulation.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Gas Analysis; Blood Pressure; Carbon Monoxide; Cyclooxygenase Inhibitors; Deuteroporphyrins; Diclofenac; Dinoprost; Dinoprostone; Enzyme Inhibitors; Heart Rate; Heme Oxygenase (Decyclizing); Hypothalamus; Injections, Intraperitoneal; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar | 2008 |
Liposome-based diclofenac for the treatment of inflammation in an acute synovitis model in horses.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Female; Horse Diseases; Horses; Inflammation; Lameness, Animal; Liposomes; Male; Synovitis | 2008 |
Prostaglandin E(2) suppresses staphylococcal enterotoxin-induced eosinophilia-associated cellular responses dominantly through an E-prostanoid 2-mediated pathway in nasal polyps.
Topics: Adult; Aged; Cells, Cultured; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Dinoprostone; Enterotoxins; Eosinophilia; Female; Humans; Male; Middle Aged; Nasal Polyps; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype | 2009 |
[Renal impairment induced by nonselective prostaglandin inhibitor].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Diclofenac; Dinoprostone; Electrophysiology; In Vitro Techniques; Kidney Tubules, Proximal; Membrane Potentials; Prostaglandin Antagonists; Rats; Rats, Wistar | 2008 |
Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.
Topics: Anethole Trithione; Animals; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Pyrazoles; Sulfones; Valproic Acid | 2010 |
Efficacy and pharmacokinetics of intravitreal non-steroidal anti-inflammatory drugs for intraocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diclofenac; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Injections; Ketorolac; Lipopolysaccharides; Male; Rabbits; Treatment Outcome; Uveitis; Vitreous Body | 2009 |
Layer-by-layer platform technology for small-molecule delivery.
Topics: Cell Line, Tumor; Cyclodextrins; Cyclooxygenase 2; Diclofenac; Dinoprostone; Drug Carriers; Humans; Hydrophobic and Hydrophilic Interactions; Interleukin-1beta; Ions; Nanostructures | 2009 |
The effect of the pro-inflammatory cytokine tumor necrosis factor-alpha on human joint capsule myofibroblasts.
Topics: Actins; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Blotting, Western; Cell Proliferation; Cells, Cultured; Collagen Type I; Contracture; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Diclofenac; Dinoprost; Dinoprostone; Elbow Joint; Extracellular Matrix; Female; Fibroblasts; Fluorescent Antibody Technique; Gene Expression; Hip Joint; Humans; Immunohistochemistry; Inflammation Mediators; Infliximab; Joint Capsule; Male; Middle Aged; Prostaglandins F; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2010 |
Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Carrageenan; Cyclooxygenase 2; Diclofenac; Dinoprostone; Edema; Humans; Intestinal Mucosa; Male; Nitric Oxide; Rats; Rats, Wistar; Ulcer | 2010 |
Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Availability; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Evaluation, Preclinical; Epoprostenol; Gastric Mucosa; Inflammation; Male; Nitrates; Nitric Oxide; Nitric Oxide Donors; Prodrugs; Rats; Rats, Sprague-Dawley; Stomach; Stomach Ulcer | 2010 |
Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Behavior, Animal; Blood Pressure; Chronic Disease; Diclofenac; Dinoprostone; Enzyme Inhibitors; Freund's Adjuvant; Inflammation; Iodoacetates; Male; Motor Activity; Phenylurea Compounds; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Stomach Ulcer; Tramadol | 2010 |
PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; beta Catenin; Caspase 3; Caspase 9; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Wnt Proteins | 2010 |
Glycerogelatin-based ocular inserts of aceclofenac: physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Chemistry, Pharmaceutical; Cross-Linking Reagents; Delayed-Action Preparations; Diclofenac; Diffusion; Dinoprostone; Eye Diseases; Gelatin; Glycerol; Inflammation; Ophthalmic Solutions; Polymers; Rabbits; Vision, Ocular | 2011 |
TNFα mechanically sensitizes masseter muscle nociceptors by increasing prostaglandin E2 levels.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Glutamic Acid; Male; Masseter Muscle; Models, Animal; Nerve Growth Factor; Nociceptors; Rats; Rats, Sprague-Dawley; Receptor, trkA; Receptors, N-Methyl-D-Aspartate; Tumor Necrosis Factor-alpha | 2011 |
Brain IL-6- and PG-dependent actions of IL-1β and lipopolysaccharide in avian fever.
Topics: Analysis of Variance; Animals; Antibodies; Body Temperature Regulation; Brain; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Ducks; Female; Fever; Inflammation Mediators; Injections, Intraventricular; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Poultry Diseases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Reaction Time; Recombinant Proteins; Time Factors | 2011 |
Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antidepressive Agents, Tricyclic; Antioxidants; Diclofenac; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Paroxetine; Peroxidase; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Stomach Ulcer; Sulfhydryl Compounds; Superoxide Dismutase | 2011 |
Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect.
Topics: Anticarcinogenic Agents; Aspirin; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromans; Collagen Type IV; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Epithelial-Mesenchymal Transition; Humans; Indomethacin; Lung Neoplasms; Matrix Metalloproteinase 9; PPAR gamma; Thiazolidinediones; Troglitazone | 2011 |
Synthesis and anti-inflammatory activity of some benzofuran and benzopyran-4-one derivatives.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Benzopyrans; Binding Sites; Carrageenan; Catalytic Domain; Computer Simulation; Cyclooxygenase 2; Diclofenac; Dinoprostone; Disease Models, Animal; Edema; Gene Expression Regulation; Male; Rats; Rats, Wistar | 2012 |
Intramuscular ketorolac inhibits activation of rat peripheral NMDA receptors.
Topics: Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Excitatory Amino Acid Agonists; Female; Injections, Intramuscular; Ketorolac; Male; Naproxen; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin; Trigeminal Nerve | 2012 |
Low-level laser therapy in collagenase-induced Achilles tendinitis in rats: analyses of biochemical and biomechanical aspects.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biochemistry; Biomechanical Phenomena; Collagenases; Cyclooxygenase 2; Diclofenac; Dinoprostone; Inflammation; Low-Level Light Therapy; Male; Matrix Metalloproteinases; Rats; Rats, Wistar; Tendinopathy; Tumor Necrosis Factor-alpha | 2012 |
Activation of mitochondrial apoptosis pathways in cutaneous squamous cell carcinoma cells by diclofenac/hyaluronic acid is related to upregulation of Bad as well as downregulation of Mcl-1 and Bcl-w.
Topics: Apoptosis; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; bcl-Associated Death Protein; Carcinoma, Squamous Cell; Celecoxib; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytochromes c; Diclofenac; Dinoprostone; Down-Regulation; Humans; Hyaluronic Acid; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Skin Neoplasms; Sulfonamides; Up-Regulation | 2012 |
Pharmacokinetic-pharmacodynamic modeling of diclofenac in normal and Freund's complete adjuvant-induced arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Dinoprostone; Disease Models, Animal; Freund's Adjuvant; Immunoenzyme Techniques; Lipopolysaccharides; Male; Models, Biological; Rats; Rats, Sprague-Dawley | 2012 |
Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Diclofenac; Dinoprostone; Disease Models, Animal; Edema; Leukocytes; Male; Mice; Molecular Structure; Peritoneal Cavity; Prodrugs; Rats; Stomach Ulcer | 2012 |
Galanin-like peptide (GALP) facilitates thermogenesis via synthesis of prostaglandin E2 by astrocytes in the periventricular zone of the third ventricle.
Topics: Animals; Astrocytes; Body Temperature; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cytosol; Diclofenac; Dinoprostone; Galanin-Like Peptide; Heart Rate; Homeostasis; Intramolecular Oxidoreductases; Membrane Proteins; Microsomes; Oxygen Consumption; Prostaglandin-E Synthases; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thermogenesis; Third Ventricle; Transcription, Genetic | 2013 |
Diclofenac enhances proinflammatory cytokine-induced phagocytosis of cultured microglia via nitric oxide production.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Diseases; Cells, Cultured; Cytokines; Diclofenac; Dinoprostone; Humans; Influenza, Human; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Rats; Rats, Wistar | 2013 |
Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Dinoprostone; Fibroblasts; Host-Pathogen Interactions; Humans; Idiopathic Pulmonary Fibrosis; Immunity, Innate; Lipopolysaccharides; Lung; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Poly I-C; Toll-Like Receptors | 2013 |
Effect of ascophyllan from brown algae Padina tetrastromatica on inflammation and oxidative stress in carrageenan-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Diclofenac; Dinoprostone; Edema; Inflammation; Interleukin-6; Male; Oxidative Stress; Peroxidase; Phaeophyceae; Plant Extracts; Polysaccharides; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha | 2013 |
Effects of rebamipide on nephrotoxicity associated with selected NSAIDs in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Cell Adhesion Molecules; Creatinine; Diclofenac; Dinoprostone; Drug Interactions; Kidney; Kidney Diseases; Male; Nitric Oxide; Potassium; Pyrazoles; Quinolones; Rats; Rats, Sprague-Dawley; Sodium; Sulfonamides | 2013 |
Investigation of localized delivery of diclofenac sodium from poly(D,L-lactic acid-co-glycolic acid)/poly(ethylene glycol) scaffolds using an in vitro osteoblast inflammation model.
Topics: Animals; Cell Survival; Cells, Cultured; Diclofenac; Dinoprostone; Drug Delivery Systems; Humans; Inflammation; Interferon-gamma; Interleukin-1beta; Mice; Models, Biological; Nitric Oxide; Osteoblasts; Polyethylene Glycols; Polyglactin 910; Skull; Tissue Scaffolds; Tumor Necrosis Factor-alpha | 2015 |
Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Diclofenac; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; India; Inflammation; Interleukin-6; Leukocytes, Mononuclear; Male; Medicine, Traditional; NF-kappa B; Oleanolic Acid; Plant Leaves; Rats; Rats, Sprague-Dawley | 2014 |
Exploiting supramolecular synthons in designing gelators derived from multiple drugs.
Topics: Amantadine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Materials; Cell Line; Diclofenac; Dinoprostone; Gels; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Rheology; Salicylates; Salts | 2014 |
[Deposition of exogenous and endogenously generated unsaturated fatty acids in lipid droplets triacylglycerol as a mechanism of its sequestration in epithelial cells].
Topics: Animals; Arachidonic Acid; Biological Transport; Carnitine O-Palmitoyltransferase; Cholesterol Esters; Cyclooxygenase 1; Cyclooxygenase 2; Diclofenac; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Epoxy Compounds; Lipid Droplets; Lipid Metabolism; Oleic Acid; Primary Cell Culture; Rana temporaria; Triglycerides; Tritium; Urinary Bladder; Urothelium | 2014 |
κ-Opioid receptor participates of NSAIDs peripheral antinociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dipyrone; Hindlimb; Hyperalgesia; Male; Naloxone; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2016 |
Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apigenin; Cartilage; Collagen Type II; Diclofenac; Dinoprostone; Disease Models, Animal; Down-Regulation; Female; Ficus; Inflammation; Interleukin-1beta; Matrix Metalloproteinase 1; Osteoarthritis; Ovariectomy; Peptide Fragments; Phytotherapy; Plant Extracts; Plant Leaves; Postmenopause; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E | 2017 |
Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats.
Topics: Acute Kidney Injury; Animals; Diclofenac; Dinoprostone; Flavonoids; Garcinia kola; Kidney; Male; Oxidative Stress; Rats, Wistar; Seeds | 2018 |
Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cellular Reprogramming; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Diclofenac; Dinoprostone; Fibroblasts; GATA4 Transcription Factor; Humans; Inflammation; Interleukin-1beta; MEF2 Transcription Factors; Mice; Mice, Transgenic; Myocytes, Cardiac; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; T-Box Domain Proteins | 2019 |
Effect of IS01957, a para-coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytochrome P-450 CYP2C9; Diclofenac; Dinoprostone; Drug Interactions; Drug Synergism; Female; Gastric Mucosa; Hydroxylation; Male; MAP Kinase Signaling System; Mice; Microsomes, Liver; Morpholines; Permeability; Propionates; Rats | 2019 |
Increased PUFA levels in kidney epithelial cells in the course of diclofenac toxicity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cell Line; Cell Survival; Cyclooxygenase 1; Cytosol; Diclofenac; Dinoprostone; Epithelial Cells; Fatty Acids, Unsaturated; Humans; Kidney; Phospholipases A2 | 2020 |
Synthesis and biological evaluation of new nicotinate derivatives as potential anti-inflammatory agents targeting COX-2 enzyme.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Binding Sites; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Dinoprostone; Drug Design; Edema; Male; Molecular Docking Simulation; Niacin; Rats; Stomach Ulcer; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2021 |
The effect of non-steroidal anti-inflammatory drugs with different mechanisms of action on the body temperature and cyclooxygenase pathway of the arachidonic acid cascade on the model of acute general cooling (air hypothermia) in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Body Temperature; Cyclooxygenase 2; Diclofenac; Dinoprost; Dinoprostone; Etoricoxib; Hypothermia; Rats | 2022 |