diclofenac has been researched along with diclofenac hydroxyethylpyrrolidine in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (33.33) | 18.2507 |
| 2000's | 12 (28.57) | 29.6817 |
| 2010's | 14 (33.33) | 24.3611 |
| 2020's | 2 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Fazio, G; Fini, A; Orienti, I; Rapaport, I; Zecchi, V | 1 |
| Lualdi, P; Maggi, CA; Mautone, G | 1 |
| Castellari, C; Sabatino, P | 1 |
| Galeazzi, M; Marcolongo, R | 1 |
| Dreiser, RL; Tisne-Camus, M | 1 |
| Gremion, G; Jenoure, P; Lühti, U; Segesser, B | 1 |
| Fazio, G; Fini, A; Rapaport, I | 1 |
| Assandri, A; Canali, S; Giachetti, C | 1 |
| Gallacchi, G; Marcolongo, R | 1 |
| Bahous, I; Rosenthal, M | 1 |
| Corrigan, OI; Draper, SM; Ledwidge, MT; Wilcock, DJ | 1 |
| Christ, AD; Speich, R; Stocker, DN | 1 |
| Fazio, G; Fernández-Hervás, MJ; Fini, A; Holgado, MA; Rabasco, AM | 1 |
| Cicero, MR; Fioravanti, A; Manopulo, R; Marcolongo, R; Nerucci, F | 1 |
| Corrigan, OI; O'Connor, KM | 1 |
| Conte, A; Mautone, G; Petrini, M; Ronca, G | 1 |
| Duruz, H; Liguori, V; Mahler, F; Mahler, P; Mautone, G; Ramazzina, M | 1 |
| Fukamachi, K; Kim, CK; Moore, MA; Naito, A; Nomoto, H; Tsuda, H | 1 |
| Solignac, M | 2 |
| Brühlmann, P; de Vathaire, F; Dreiser, RL; Michel, BA | 1 |
| Auclair, E; Buis, J; Le Louarn, C | 1 |
| Ehrlich, GE; Kean, WF; Rainsford, KD | 1 |
| Petersen, B; Rovati, S | 1 |
| Makarem, J; Rahimi, M | 1 |
| Bodie, J; Magelli, M; Rovati, S; Sjogren, J; Yanchick, J | 1 |
| Argoff, CE; McCarberg, BH | 1 |
| Berkes, I; Castellacci, E; Forgacs, A; Klainguti, A | 1 |
| Coudreuse, JM; de Vathaire, F | 1 |
| Costantino, C; Kwarecki, J; Mautone, G; Rovati, S; Samokhin, AV | 1 |
| Brewer, AR; Magelli, M; Pierchala, LA; Rovati, S; Yanchick, JK | 1 |
| Jacobs, D; McGuinness, N; Paterson, CA; Rasmussen, S; Youngberg, SP | 1 |
| Gugliotta, B; Hoffmann, P; Kopačka, P; Rovati, S | 1 |
| Brunner, M; Burian, A; Burian, B; Crevenna, R; Frangione, V; Keilani, M; Leuratti, C; Mautone, G; Rovati, S; Vaccani, A; Zeitlinger, M | 1 |
| Frangione, V; Li, C; Rovati, S; Zheng, Q | 1 |
| Basalious, EB; El-Nabarawi, MA; Fouad, SA; Tayel, SA | 1 |
| Affaitati, G; Costantini, R; Fabrizio, A; Frangione, V; Giamberardino, MA; Lanzarotti, A; Lapenna, D; Lopopolo, M; Tafuri, E | 1 |
| Jones, C; Nencioni, A; Rainsford, KD; Roberts, MS | 1 |
| Arishita, G; Chrysopoulo, M; Garza, R; Ketchum, N; Ledoux, P; Michalek, JE; Nastala, C; Ochoa, O; Pisano, S | 1 |
| Frangione, V; Hoehler, FK; Jones, C; Jones, CA; Ledesma, G; Wisman, PP | 1 |
| Barbaro, B; Giordan, N; Gruber, G; Pabst, H; Picciotto, R | 1 |
6 review(s) available for diclofenac and diclofenac hydroxyethylpyrrolidine
| Article | Year |
|---|---|
Carcinogenesis and its modification by environmental endocrine disruptors: in vivo experimental and epidemiological findings.
Topics: Animals; Breast Neoplasms; DDT; Diclofenac; Endocrine System; Environmental Pollutants; Epidemiologic Studies; Female; Glycine max; Gonadal Steroid Hormones; Humans; Insecticides; Isoflavones; Male; Mice; Neoplasms; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Prostatic Neoplasms; Rats; Risk Assessment | 2003 |
[Assessment of a topical NSAIDs in the treatment of pain and inflammation. The example of Flector Plaster, a local bioadhesive plaster containing diclofenac epolamine].
Topics: Administration, Topical; Animals; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Diclofenac; Humans; Inflammation; Osteoarthritis; Pain; Rabbits; Rats; Sprains and Strains | 2004 |
Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Delayed-Action Preparations; Diclofenac; Humans; Inflammation; Muscular Diseases; Pain; Skin | 2008 |
Diclofenac epolamine (Flector) patch: evidence for topical activity.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Musculoskeletal Diseases; Pain; Skin | 2009 |
Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Contusions; Diclofenac; Humans; Pain; Soft Tissue Injuries; Sprains and Strains; Transdermal Patch; Treatment Outcome | 2010 |
Rationale and evidence for the incorporation of heparin into the diclofenac epolamine medicated plaster.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Heparin; Humans; Inflammation; Osteoarthritis, Knee; Pain | 2019 |
20 trial(s) available for diclofenac and diclofenac hydroxyethylpyrrolidine
| Article | Year |
|---|---|
Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man.
Topics: Biological Availability; Diclofenac; Female; Humans; Male; Middle Aged | 1990 |
A placebo-controlled study of the efficacy and tolerability of a nonsteroidal anti-inflammatory drug, DHEP plaster, in inflammatory peri- and extra-articular rheumatological diseases.
Topics: Administration, Cutaneous; Adult; Aged; Arthritis, Rheumatoid; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscular Diseases; Osteoarthritis; Rheumatic Diseases; Tendinopathy | 1993 |
DHEP plasters as a topical treatment of knee osteoarthritis--a double-blind placebo-controlled study.
Topics: Administration, Cutaneous; Aged; Diclofenac; Double-Blind Method; Female; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis | 1993 |
A trial with diclofenac HEP plaster as topical treatment in minor sport injuries.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Athletic Injuries; Child; Diclofenac; Female; Humans; Male; Middle Aged; Pain Measurement | 1993 |
A controlled clinical study on the new topical dosage form of DHEP plasters in patients suffering from localized inflammatory diseases.
Topics: Administration, Cutaneous; Arthritis; Diclofenac; Female; Humans; Male; Middle Aged; Pain Measurement; Tendinopathy | 1993 |
Double-blind controlled clinical study of the efficacy and tolerability of diclofenac-N-(2-hydroxyethyl)-pyrrolidine lecithin gel compared with diclofenac-N-(2-hydroxyethyl)-pyrrolidine gel in patients with peri and extraarticular inflammatory diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Diclofenac; Double-Blind Method; Edema; Female; Gels; Humans; Inflammation; Male; Middle Aged; Pain; Phosphatidylcholines; Rheumatic Diseases | 1999 |
Effect of lecithin on epicutaneous absorption of diclofenac epolamine.
Topics: Adjuvants, Pharmaceutic; Administration, Cutaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chemistry, Pharmaceutical; Chromatography, Gas; Cross-Over Studies; Diclofenac; Female; Forearm; Gels; Humans; Male; Middle Aged; Phosphatidylcholines; Skin Absorption | 2002 |
Double-blind, randomized, controlled study on the efficacy and safety of a novel diclofenac epolamine gel formulated with lecithin for the treatment of sprains, strains and contusions.
Topics: Acetaminophen; Administration, Topical; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Ankle Injuries; Anti-Inflammatory Agents; Contusions; Diclofenac; Double-Blind Method; Female; Gels; Humans; Knee Injuries; Leg Injuries; Male; Middle Aged; Pain Measurement; Phosphatidylcholines; Prospective Studies; Sprains and Strains | 2003 |
[Proof of the pharmacodynamic activity of Flector Plaster in healthy volunteers and patients suffering from osteo-arthritis of the knee].
Topics: Administration, Topical; Adult; Diclofenac; Double-Blind Method; Female; Humans; Knee Joint; Male; Osteoarthritis; Pain; Pain Measurement; Placebos; Treatment Outcome | 2004 |
Effects of diclofenac epolamine patch on postoperative sore throat in parturients after cesarean delivery under endotracheal general anesthesia.
Topics: Administration, Topical; Adult; Anesthesia, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Cesarean Section; Diclofenac; Dosage Forms; Female; Humans; Intubation, Intratracheal; Pharyngitis; Postoperative Complications; Pregnancy | 2009 |
A plaster containing DHEP and heparin for mild to moderate contusions and sprains with haematoma: a double-blind randomized study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Casts, Surgical; Contusions; Diclofenac; Double-Blind Method; Female; Hematoma; Heparin; Humans; Male; Middle Aged; Muscular Diseases; Placebos; Severity of Illness Index; Sprains and Strains; Young Adult | 2010 |
Effect of a plaster containing DHEP and heparin in acute ankle sprains with oedema: a randomized, double-blind, placebo-controlled, clinical study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Casts, Surgical; Diclofenac; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Heparin; Humans; Joint Diseases; Male; Middle Aged; Placebos; Sprains and Strains; Young Adult | 2010 |
Diclofenac epolamine plus heparin plaster versus diclofenac epolamine plaster in mild to moderate ankle sprain: a randomized, double-blind, parallel-group, placebo-controlled, multicentre, phase III trial.
Topics: Adolescent; Adult; Aged; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Diclofenac; Double-Blind Method; Drug Combinations; Edema; Female; Heparin; Humans; Male; Middle Aged; Placebos; Sprains and Strains; Transdermal Patch | 2011 |
Randomized, open-label, 5-way crossover study to evaluate the pharmacokinetic/pharmacodynamic interaction between furosemide and the non-steroidal anti-inflammatory drugs diclofenac and ibuprofen in healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cross-Over Studies; Diclofenac; Diuretics; Drug Interactions; Female; Furosemide; Humans; Ibuprofen; Male; Middle Aged; Transdermal Patch; Young Adult | 2011 |
Efficacy and tolerability of DHEP-heparin plaster in reducing pain in mild-to-moderate muscle contusions: a double-blind, randomized trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Antifibrinolytic Agents; Casts, Surgical; Contusions; Diclofenac; Double-Blind Method; Female; Heparin; Humans; Male; Middle Aged; Muscular Diseases; Pain; Placebos; Severity of Illness Index; Treatment Outcome; Young Adult | 2012 |
An exploratory microdialysis study investigating the effect of repeated application of a diclofenac epolamine medicated plaster on prostaglandin concentrations in skeletal muscle after standardized physical exercise.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Exercise; Healthy Volunteers; Humans; Male; Microdialysis; Quadriceps Muscle; Transdermal Patch; Young Adult | 2013 |
Diclofenac epolamine medicated plaster in the treatment of minor soft tissue injuries: a multicenter randomized controlled trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Follow-Up Studies; Humans; Male; Middle Aged; Retrospective Studies; Soft Tissue Injuries; Time Factors; Wounds and Injuries | 2013 |
Effects of topical diclofenac plus heparin (DHEP+H plaster) on somatic pain sensitivity in healthy subjects with a latent algogenic condition of the lower limb.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Diclofenac; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Healthy Volunteers; Heparin; Humans; Hyperalgesia; Male; Middle Aged; Nociceptive Pain; Pain Threshold; Prospective Studies; Quadriceps Muscle; Skin; Thigh; Ultrasonography | 2015 |
Safety and Efficacy of the FLECTOR (Diclofenac Epolamine) Topical System in Children with Minor Soft Tissue Injuries: A Phase IV Non-randomized Clinical Trial.
Topics: Acute Pain; Administration, Topical; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Diclofenac; Humans; Pyrrolidines; Soft Tissue Injuries | 2022 |
Efficacy and safety of Diclofenac sodium plaster in patients with acute pain of the limbs: a randomized, placebo and active-controlled, double-blind, parallel-group trial.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Soft Tissue Injuries; Treatment Outcome | 2023 |
16 other study(ies) available for diclofenac and diclofenac hydroxyethylpyrrolidine
| Article | Year |
|---|---|
Chemical properties-dissolution relationship. IV. Behaviour in solution of the diclofenac/N-(2-hydroxyethyl) pyrrolidine salt (DHEP).
Topics: Diclofenac; Excipients; Solubility | 1991 |
Anti-inflammatory drugs: 1-(2-hydroxyethyl)pyrrolidinium salt of diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Crystallography, X-Ray; Diclofenac; Hydrogen Bonding | 1994 |
Diclofenac/N-(2-hydroxyethyl)pyrrolidine: a new salt for an old drug.
Topics: Diclofenac; Micelles; Salts; Solubility | 1993 |
Local tolerability and pharmacokinetic profile of a new transdermal delivery system, diclofenac hydroxyethylpyrrolidine plaster.
Topics: Administration, Cutaneous; Animals; Diclofenac; Female; Humans; Male; Patch Tests; Rabbits; Skin Absorption | 1993 |
Pharmacokinetics of diclofenac hydroxyethylpyrrolidine (DHEP) plasters in patients with monolateral knee joint effusion.
Topics: Administration, Cutaneous; Adult; Aged; Diclofenac; Female; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis; Synovial Fluid | 1993 |
Physicochemical characterization of diclofenac N-(2-hydroxyethyl)pyrrolidine: anhydrate and dihydrate crystalline forms.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Crystallization; Diclofenac; Hydrogen Bonding; Molecular Structure; Spectrophotometry, Infrared; Thermodynamics; Water; X-Ray Diffraction | 1996 |
[Ulcer + ulcer].
Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Bandages; Diclofenac; Duodenal Ulcer; Female; Humans; Peptic Ulcer Hemorrhage; Varicose Ulcer | 1998 |
Effect of the temperature on a hydrate diclofenac salt.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Crystallization; Diclofenac; Drug Stability; Heating; Image Processing, Computer-Assisted; Microscopy, Electron, Scanning; Surface Properties; Temperature; Time Factors; Water | 1999 |
Comparison of the physicochemical properties of the N-(2-hydroxyethyl) pyrrolidine, diethylamine and sodium salt forms of diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Diclofenac; Hydrogen-Ion Concentration; Solubility; X-Ray Diffraction | 2001 |
Short-term treatment with topical diclofenac epolamine plaster in patients with symptomatic knee osteoarthritis: pooled analysis of two randomised clinical studies.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged; Osteoarthritis, Knee; Randomized Controlled Trials as Topic | 2006 |
A diclofenac patch (Flector) for pain.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Administration Schedule; Drug Costs; Humans; Pain; Pain Measurement; Treatment Outcome | 2008 |
Flector tissugel used to treat capsular contracture after breast augmentation surgery.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Breast; Breast Implants; Calcinosis; Contracture; Diclofenac; Female; Gels; Humans; Time Factors | 2008 |
Time to significant pain reduction following DETP application vs placebo for acute soft tissue injuries.
Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Aged; Ankle Joint; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Male; Middle Aged; Pain; Placebos; Randomized Controlled Trials as Topic; Retrospective Studies; Soft Tissue Injuries; Sprains and Strains; Treatment Outcome; Young Adult | 2010 |
Gastrointestinal tolerability of diclofenac epolamine topical patch 1.3%: a pooled analysis of 14 clinical studies.
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Gastrointestinal Tract; Humans; Male; Middle Aged; Pain; Randomized Controlled Trials as Topic; Sex Factors; Transdermal Patch | 2011 |
Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation.
Topics: Administration, Cutaneous; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Delayed-Action Preparations; Diclofenac; Drug Delivery Systems; Edema; Emulsions; Gels; In Vitro Techniques; Male; Poloxamer; Rats; Rats, Wistar; Skin; Skin Absorption | 2013 |
Prospective Longitudinal Patient-Reported Satisfaction and Health-Related Quality of Life following DIEP Flap Breast Reconstruction: Relationship with Body Mass Index.
Topics: Adult; Body Mass Index; Breast Neoplasms; Diclofenac; Disease-Free Survival; Epigastric Arteries; Female; Graft Survival; Humans; Longitudinal Studies; Mammaplasty; Mastectomy; Middle Aged; Patient Reported Outcome Measures; Perforator Flap; Prospective Studies; Quality of Life; Rectus Abdominis; Risk Assessment; Survival Rate; Treatment Outcome; United States | 2019 |