diclofenac and dextromethorphan

diclofenac has been researched along with dextromethorphan in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (12.50)	18.2507
2000's	14 (43.75)	29.6817
2010's	12 (37.50)	24.3611
2020's	2 (6.25)	2.80

Authors

Authors	Studies
Barecki, M; Casciano, CN; Clement, RP; Johnson, WW; Lew, K; Wang, E	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Kanebratt, KP; Sjögren, E; Svanberg, P	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Peng, Y; Welsh, WJ; Zhang, Q	1
Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL	1
Bonnabry, P; Dayer, P; Leemann, T	1
Beaune, P; Dayer, P; Lecoeur, S; Leemann, T; Transon, C	1
Caruso, FS; Frenk, H; Lu, J; Mao, J; Mayer, DJ; Price, DD	1
Kawamata, M; Kawamata, T; Namiki, A; Omote, K	1
Ekins, S; Lawton, MP; Mankowski, DC	1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K	1
Weinbroum, AA	1
Flanagan, JU; McLaughlin, LA; Paine, MJ; Roberts, GC; Sutcliffe, MJ; Wolf, CR	1
Adedoyin, A; Caserta, KA; Jones, SS; Laws, K; Saraswat, LD; Wei, D	1
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y	1
Aoki, T; Kaneko, A; Naito, H; Ota, Y; Shiiki, K; Yamaguchi, H	1
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J	1
Jones, BC; Lyons, R; Payne, L; Saunders, K; Youdim, KA	1
Appiah-Opong, R; Axson, C; Commandeur, JN; Vermeulen, NP	1
Dickinson, PA; Lennernäs, H; Lundahl, A; Schrickx, JA; Thörn, HA	1
Jilek, JL; Tian, Y; Yu, AM	1
Apers, S; Bijttebier, S; Casteleyn, C; Cos, P; Maes, L; Matheeussen, A; Pype, C; Saad, M; Van Cruchten, S; Van Ginneken, C; Verbueken, E	1
Bedwell, DW; Hall, SD; Mohutsky, MA; Rougée, LRA; Ruterbories, KJ	1
Chiang, W; Li, ML; Lin, JH; Liu, YT; Yao, HT	1

Reviews

1 review(s) available for diclofenac and dextromethorphan

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

3 trial(s) available for diclofenac and dextromethorphan

Article	Year
Premedication with oral dextromethorphan reduces postoperative pain after tonsillectomy. Anesthesia and analgesia, 1998, Volume: 86, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Deglutition; Dextromethorphan; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain, Postoperative; Premedication; Tonsillectomy	1998
Dextromethorphan reduces immediate and late postoperative analgesic requirements and improves patients' subjective scorings after epidural lidocaine and general anesthesia. Anesthesia and analgesia, 2002, Volume: 94, Issue:6 Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Dextromethorphan; Diclofenac; Double-Blind Method; Female; Hernia, Inguinal; Humans; Lidocaine; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Preanesthetic Medication	2002
Dextromethorphan premedication reduced postoperative analgesic consumption in patients after oral surgery. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2006, Volume: 102, Issue:5 Topics: Administration, Oral; Adult; Analgesics, Opioid; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Dextromethorphan; Diclofenac; Double-Blind Method; Female; Humans; Male; Mandible; Molar, Third; Pain Measurement; Pain, Postoperative; Premedication; Prospective Studies; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric; Tooth Extraction	2006

Other Studies

28 other study(ies) available for diclofenac and dextromethorphan

Article	Year
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chemical research in toxicology, 2001, Volume: 14, Issue:12 Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Mice; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Substrate Specificity	2001
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Kinetics; Microsomes, Liver; Research Design; Tandem Mass Spectrometry	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells). Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4 Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles	2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management. Journal of medicinal chemistry, 2021, 01-14, Volume: 64, Issue:1 Topics: Animals; Binding Sites; Blood-Brain Barrier; Drug Design; Guinea Pigs; Half-Life; Humans; Microsomes, Liver; Molecular Dynamics Simulation; Neuralgia; Pain Management; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship; Rats; Receptors, sigma; Sigma-1 Receptor; Triazoles	2021
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. European journal of medicinal chemistry, 2021, Mar-05, Volume: 213 Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Development; Enzyme Inhibitors; Freund's Adjuvant; Humans; Lipopolysaccharides; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Structure-Activity Relationship	2021
Selective inhibition of major drug metabolizing cytochrome P450 isozymes in human liver microsomes by carbon monoxide. Life sciences, 1994, Volume: 54, Issue:14 Topics: Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating	1994
Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes. European journal of clinical pharmacology, 1996, Volume: 51, Issue:1 Topics: Adult; Age Factors; Anesthetics, Intravenous; Animals; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Female; Humans; Hydroxylation; Isoenzymes; Male; Methylation; Mice; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Rabbits; Regression Analysis; Sex Factors; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; White People	1996
Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats. Pain, 1996, Volume: 68, Issue:1 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Behavior, Animal; Dextromethorphan; Diclofenac; Drug Interactions; Drug Therapy, Combination; Etodolac; Ibuprofen; Injections, Intraperitoneal; Male; Naproxen; Pain; Piroxicam; Rats; Rats, Sprague-Dawley	1996
Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:8 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Intestines; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Obese; Mice, Transgenic; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Testosterone	2000
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochemical pharmacology, 2002, Mar-01, Volume: 63, Issue:5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured	2002
Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity. The Biochemical journal, 2003, Mar-15, Volume: 370, Issue:Pt 3 Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Aspartic Acid; Cytochrome P-450 CYP2C9; Dextromethorphan; Diclofenac; Humans; Hypoglycemic Agents; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; NADPH-Ferrihemoprotein Reductase; Protein Binding; Protein Structure, Secondary; Rabbits; Sequence Alignment; Substrate Specificity; Tolbutamide	2003
A high-throughput method for enzyme kinetic studies. Journal of biomolecular screening, 2003, Volume: 8, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Evaluation, Preclinical; Enzyme Inhibitors; Enzymes; Half-Life; Humans; Kinetics; Mass Spectrometry; Midazolam; Molecular Biology; Sensitivity and Specificity; Testosterone; Warfarin	2003
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:9 Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone	2004
Effect of methamphetamine on cytochrome P450 activity. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12 Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide	2007
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point. Journal of pharmaceutical and biomedical analysis, 2008, Sep-10, Volume: 48, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Biological Assay; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Interactions; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Midazolam; Miniaturization; Oxidoreductases, N-Demethylating; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Tacrine; Tandem Mass Spectrometry; Time Factors	2008
Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Enzyme Inhibitors; Ghana; Glutathione Transferase; Hydroxylation; In Vitro Techniques; Indicators and Reagents; Membranes; Plant Extracts; Plants, Medicinal; Plasmids; Rats	2008
Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Jun-14, Volume: 43, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP-Binding Cassette Transporters; Biotransformation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Gene Expression; Glucuronosyltransferase; Humans; Jejunum; Ketoconazole; Liver; Male; Microsomes, Liver; RNA, Messenger; Species Specificity; Swine; Testosterone; Verapamil	2011
Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:5 Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Interactions; Male; Mice; MicroRNAs; Midazolam; Pharmacokinetics; Phenacetin	2017
In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds. Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 42 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Embryo, Nonmammalian; Female; Humans; Male; Microsomes, Liver; Midazolam; Testosterone; Zebrafish	2017
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:9 Topics: Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Drug Interactions; Female; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Midazolam; Plasma; Testosterone; Warfarin	2017
Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats. Nutrients, 2019, Oct-15, Volume: 11, Issue:10 Topics: Administration, Intravenous; Administration, Oral; Animals; Capsaicin; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Diltiazem; Food-Drug Interactions; Intestinal Absorption; Intestines; Liver; Male; Plant Oils; Rats, Sprague-Dawley; Risk Assessment; Theophylline	2019