diclofenac and cyclosporine

diclofenac has been researched along with cyclosporine in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (15.56)	18.2507
2000's	17 (37.78)	29.6817
2010's	21 (46.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chang, TK; Ensom, MH; Kiang, TK	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Dai, R; Liu, Y; She, M; Wu, Z	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Goetz, GH; Philippe, L; Shapiro, MJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Hitzenberger, G; Johnston, A; Koelle, EU; Kovarik, JM; Merdjan, H; Mueller, EA	1
Alten, R; Genth-Stolzenburg, S; Guerret, M; Kovarik, JM; Kurki, P; Markert, E; Mueller, E; Zeidler, H	1
Ciccarelli, A; de Crescenzo, G; de Paulis, A; Marinò, D; Marinò, I; Marone, G	1
Cortina, P; Diaz-Llopis, M; Gómez-Lechón, MJ; Menezo, JL; Navea, A; Terencio, MC	1
Curti, C; Jordani, MC; Mingatto, FE; Santos, AC; Uyemura, SA	1
Curti, C; Mingatto, FE; Pigoso, AA; Rodrigues, T; Santos, AC; Uyemura, SA	1
Constantopoulos, A	1
Horie, T; Masubuchi, Y; Nakayama, S	1
Liu, SC; Tsai, TH	1
Aoki, MS; Miyabara, EH; Moriscot, AS; Salvini, TF; Selistre de Araújo, HS; Tostes, RC	1
Alberti, LR; Chaves, DN; Pereira, WA; Petroianu, A	1
Fujita, H; Inoue, A; Kanno, T; Muranaka, S; Tamai, H; Utsumi, K	1
Doblinger, A; Fischer-Colbrie, R; Kieselbach, G; Kirchmair, R; Kralinger, M; Pallhuber, J; Stemberger, K; Troger, J	1
Boorsma, DM; Bruynzeel, DP; Gibbs, S; Moed, H; Rustemeyer, T; Scheper, RJ; Stoof, TJ; von Blomberg, BM	1
Baiza-Durán, L; Cruz-Olmos, E; González, JR; Hernández-Santoyo, A; López-Sánchez, MI; Mondragón-Flores, R; Quintana-Hau, JD; Sánchez-Castellanos, V	1
Boelsterli, UA; Gupta, R; Lim, MS; Lim, PL	1
Hu, J; Liu, H; Liu, X; Wang, G; Xie, L	1
Boelsterli, UA; Latchoumycandane, C; Pun, PB; Siu, WP	1
Boelsterli, UA; Gavillet, B; LoGuidice, A; Proli, A; Ramirez-Alcantara, V	1
Kilic, S; Kulualp, K	1
Boisseaux, P; Garric, J; Noury, P; Thomas, H	1
Honda, H; Ito, Y; Kawamoto, T; Morita, O	1
El-Gowelli, HM; El-Mas, MM; El-Yazbi, AF; Ibrahim, KS	1

Reviews

3 review(s) available for diclofenac and cyclosporine

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

3 trial(s) available for diclofenac and cyclosporine

Article	Year
Pharmacokinetics of cyclosporine and multiple-dose diclofenac during coadministration. Journal of clinical pharmacology, 1993, Volume: 33, Issue:10 Topics: Administration, Oral; Adult; Cyclosporine; Diclofenac; Drug Administration Schedule; Drug Interactions; Humans; Male; Models, Biological; Time Factors	1993
Diclofenac combined with cyclosporine in treatment refractory rheumatoid arthritis: longitudinal safety assessment and evidence of a pharmacokinetic/dynamic interaction. The Journal of rheumatology, 1996, Volume: 23, Issue:12 Topics: Adult; Aged; Arthritis, Rheumatoid; Cyclosporine; Diclofenac; Drug Combinations; Drug Interactions; Female; Humans; Kidney; Longitudinal Studies; Male; Middle Aged	1996
Characterization of the novel ophthalmic drug carrier Sophisen in two of its derivatives: 3A Ofteno and Modusik-A Ofteno. Drug development and industrial pharmacy, 2005, Volume: 31, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cyclosporine; Diclofenac; Drug Carriers; Dry Eye Syndromes; Female; Humans; Immunosuppressive Agents; Ophthalmic Solutions; Rabbits	2005

Other Studies

39 other study(ies) available for diclofenac and cyclosporine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3 Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides. ACS medicinal chemistry letters, 2014, Oct-09, Volume: 5, Issue:10 Topics:	2014
Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. Arthritis and rheumatism, 1997, Volume: 40, Issue:3 Topics: Adenosine; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chymases; Cyclosporine; Diclofenac; Histamine Release; Humans; Immunoglobulin E; Immunosuppressive Agents; Leukotriene C4; Mast Cells; Methotrexate; Middle Aged; Polyenes; Prostaglandins D; Rheumatic Diseases; Serine Endopeptidases; Sirolimus; Substance P; Sulfonamides; Synovial Membrane; Tacrolimus; Tryptases	1997
Diclofenac sodium and cyclosporin A inhibit human lens epithelial cell proliferation in culture. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1997, Volume: 235, Issue:3 Topics: Aged; Animals; Cell Division; Cell Survival; Cells, Cultured; Chlorocebus aethiops; Cyclooxygenase Inhibitors; Cyclosporine; Diclofenac; Dinoprostone; Epithelial Cells; Epithelium; Humans; Immunosuppressive Agents; Lens, Crystalline; Middle Aged; Vero Cells	1997
Diclofenac sodium and mefenamic acid: potent inducers of the membrane permeability transition in renal cortex mitochondria. Archives of biochemistry and biophysics, 1997, Jun-15, Volume: 342, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclosporine; Diclofenac; Kidney Cortex; Lipid Peroxidation; Male; Mefenamic Acid; Mitochondria; Mitochondrial Swelling; Oxidation-Reduction; Permeability; Rats; Rats, Wistar; Salicylates; Salicylic Acid; Sulfhydryl Compounds	1997
Influence of nonsteroidal anti-inflammatory drugs on calcium efflux in isolated rat renal cortex mitochondria and aspects of the mechanisms involved. The international journal of biochemistry & cell biology, 1998, Volume: 30, Issue:9 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclosporine; Diclofenac; Dipyrone; Ibuprofen; In Vitro Techniques; Ion Transport; Kidney Cortex; Male; Mefenamic Acid; Mitochondria; NAD; NADP; Oxidation-Reduction; Piroxicam; Rats; Rats, Wistar; Salicylic Acid	1998
Colitis induced by interaction of cyclosporine A and non-steroidal anti-inflammatory drugs. Pediatrics international : official journal of the Japan Pediatric Society, 1999, Volume: 41, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Child; Colitis; Cyclosporine; Diclofenac; Drug Interactions; Female; Humans; Immunosuppressive Agents; Indomethacin	1999
Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclosporine; Diclofenac; Hepatocytes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; NADP; Permeability; Rats; Rats, Wistar; Sulfhydryl Compounds; Verapamil	2002
Determination of diclofenac in rat bile and its interaction with cyclosporin A using on-line microdialysis coupled to liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Apr-05, Volume: 769, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Cyclosporine; Diclofenac; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results	2002
Cutaneous drug reaction case reports: from the world literature. American journal of clinical dermatology, 2003, Volume: 4, Issue:5 Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Benzamides; Clozapine; Cyclosporine; Diclofenac; Drug Eruptions; Female; Humans; Imatinib Mesylate; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Nimodipine; Paroxetine; Piperazines; Polyethylene Glycols; Prednisolone; Pyrimidines; Recombinant Proteins; Salicylamides; Spironolactone; Thioridazine; Vinblastine; Vinorelbine	2003
Cyclosporin A attenuates skeletal muscle damage induced by crotoxin in rats. Toxicon : official journal of the International Society on Toxinology, 2004, Volume: 43, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcineurin Inhibitors; Crotoxin; Cyclosporine; Diclofenac; Drug Antagonism; Enzyme Inhibitors; Muscle, Skeletal; Necrosis; Rats; Rats, Wistar	2004
Effects of thalidomide, cyclosporine, and diclofenac on skin allograft survival in rabbits. Transplantation proceedings, 2004, Volume: 36, Issue:4 Topics: Animals; Cyclosporine; Diclofenac; Disease Models, Animal; Graft Survival; Immunosuppressive Agents; Rabbits; Skin Transplantation; Thalidomide; Time Factors	2004
Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway. Free radical biology & medicine, 2004, Oct-15, Volume: 37, Issue:8 Topics: 2-Methoxyestradiol; Acetylcysteine; Amino Acid Chloromethyl Ketones; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspases; Chromones; Cyclic AMP; Cyclosporine; Cysteine Proteinase Inhibitors; Cytochromes c; Diclofenac; DNA Fragmentation; DNA, Neoplasm; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Estradiol; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase	2004
Secretoneurin in the human aqueous humor and the absence of an effect of frequently used eye drops on the levels. Peptides, 2004, Volume: 25, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Aqueous Humor; Cyclosporine; Diclofenac; Drug Combinations; Female; Humans; Male; Middle Aged; Neuropeptides; Ophthalmic Solutions; Pregnadienes; Secretogranin II; Tobramycin; Uveitis, Anterior	2004
Identification of anti-inflammatory drugs according to their capacity to suppress type-1 and type-2 T cell profiles. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004, Volume: 34, Issue:12 Topics: Anti-Inflammatory Agents; Cells, Cultured; Cholecalciferol; Cyclosporine; Dermatitis, Allergic Contact; Diclofenac; Dimethyl Fumarate; Flow Cytometry; Fumarates; Humans; Hydrocortisone; Interleukin-12; Interleukin-4; Interleukin-7; Lactoferrin; Lymphocyte Activation; Nickel; Patch Tests; Th1 Cells; Th2 Cells	2004
Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes. Toxicology and applied pharmacology, 2006, Dec-15, Volume: 217, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aryl Hydrocarbon Hydroxylases; Calcium; Cell Line, Transformed; Cyclosporine; Cytochrome P-450 CYP2C9; Cytosol; Diclofenac; Dose-Response Relationship, Drug; Drug Antagonism; Egtazic Acid; Hepatocytes; Humans; Membrane Potentials; Mitochondria, Liver; Mitochondrial Membranes; Oxidation-Reduction; Permeability; Sulfaphenazole; Superoxides; Uncoupling Agents	2006
Possible multiple transporters were involved in hepatobiliary excretion of antofloxacin in rats. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:6 Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bile; Biological Transport; Cimetidine; Cyclosporine; Diclofenac; Enzyme Inhibitors; Erythromycin; Liver; Male; Membrane Transport Proteins; Ofloxacin; Probenecid; Rats; Rats, Sprague-Dawley; Uricosuric Agents	2007
Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A. Toxicology and applied pharmacology, 2008, Mar-15, Volume: 227, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Calcium; Cell Line; Chelating Agents; Cyclophilins; Cyclosporine; Cytoprotection; Diclofenac; Egtazic Acid; Hepatocytes; Humans; MAP Kinase Kinase Kinase 5; Mitochondria, Liver; Mitochondrial Membranes; Mitochondrial Proteins; Permeability; RNA, Small Interfering; Thioredoxins	2008
Pharmacologic targeting or genetic deletion of mitochondrial cyclophilin D protects from NSAID-induced small intestinal ulceration in mice. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclophilins; Cyclosporine; Diclofenac; Disease Models, Animal; Enterocytes; Intestinal Diseases; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Peptidyl-Prolyl Isomerase F; Ulcer	2010
Efficacy of Several Therapeutic Agents in a Murine Model of Dry Eye Syndrome. Comparative medicine, 2016, Volume: 66, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Blinking; Cyclosporine; Diclofenac; Disease Models, Animal; Dry Eye Syndromes; Female; Mice; Mice, Inbred BALB C; Ophthalmic Solutions; Tears	2016
Immune responses in the aquatic gastropod Lymnaea stagnalis under short-term exposure to pharmaceuticals of concern for immune systems: Diclofenac, cyclophosphamide and cyclosporine A. Ecotoxicology and environmental safety, 2017, Volume: 139 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Cell Count; Cell Survival; Cyclophosphamide; Cyclosporine; Diclofenac; Hemocytes; Immunosuppressive Agents; Lymnaea; Phagocytosis; Water Pollutants, Chemical	2017
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. The Journal of toxicological sciences, 2017, Volume: 42, Issue:4 Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; Dose-Response Relationship, Drug; Flutamide; Gene Expression; Humans; Imipramine; Inflammation; Ketoconazole; Liver; Methyltestosterone; Oxidative Stress; Rats; Risk Assessment; Sulindac; Tamoxifen; Toxicogenetics	2017
Heme oxygenase byproducts variably influences myocardial and autonomic dysfunctions induced by the cyclosporine/diclofenac regimen in female rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 101 Topics: Animals; Autonomic Nervous System; Baroreflex; Carbon Monoxide; Cyclosporine; Diclofenac; Female; Heart Rate; Heart Ventricles; Heme Oxygenase (Decyclizing); Hemodynamics; Myocardium; Rats, Wistar	2018