diclofenac has been researched along with caffeine in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.70) | 18.7374 |
| 1990's | 3 (3.70) | 18.2507 |
| 2000's | 20 (24.69) | 29.6817 |
| 2010's | 35 (43.21) | 24.3611 |
| 2020's | 20 (24.69) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 2 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Campillo, NE; Cañada, FJ; Canales, A; Carvalho, I; Chierrito, TPC; Martinez, A; Martínez-Gonzalez, L; Pedersoli-Mantoani, S; Perez, C; Pérez, DI; Roca, C; Sebastian-Pérez, V | 1 |
| Balliano, TL; Barbosa, G; Carvalho, VF; da Silva, BA; de Souza, ET; Lima, LM; Martins, IRR; Martins, MA; Medeiros, MM; Moraes Junior, MO; Nunes, IKDC; Silva, PMR; Silva, SWD | 1 |
| Balinsky, D; Cayanis, E; Disler, P; Gomperts, ED; Myers, A | 1 |
| Collste, P | 1 |
| Verbov, J | 1 |
| Middleton, RS | 1 |
| Castillo, EF; Chaves, F; Herrera, JE; Medina, R; Reyes, G; Tinajero, J; Valdes, B | 1 |
| Lewis, IA; Palmer, J; Pleasance, S; Scott, RJ | 1 |
| Cox, PJ; Munday, DL | 1 |
| Cannon, JM; Kostoryz, E; Russo, KA; Smith, RE; Yourtee, DM | 1 |
| Dickins, M; Gibson, A; Palmer, JL; Pleasance, S; Scott, RJ | 1 |
| Goldstein, J; Kolodner, K; Lipton, RB; Lyon, JA; Peroutka, SJ; Swarbrick, J | 1 |
| Avdeef, A; Nielsen, PE | 1 |
| Foster, GD; Thomas, PM | 1 |
| Fujimoto, S; Kunimatsu, M; Mori, M; Tsushima, H | 1 |
| Müller-Goymann, C; Savic, M; Savic, S; Tamburic, S; Weber, C | 1 |
| Müller-Goymann, C; Savić, MM; Savić, S; Weber, C | 1 |
| Korber, DR; Lawrence, JR; Roy, J; Swerhone, GD; Topp, E; Tumber, V; Waiser, MJ; Zhu, B | 1 |
| Gersberg, RM; Hua, T; Tan, SK; Tuan, NA; Zhang, DQ; Zhu, J | 1 |
| Betz, G; Ibrić, S; Petrović, J; Đurić, Z | 1 |
| Gersberg, RM; Hua, T; Jinadasa, KB; Tan, SK; Zhang, DQ; Zhu, J | 1 |
| Neubert, RH; Ochalek, M; Podhaisky, H; Ruettinger, HH; Wohlrab, J | 1 |
| Carriquiriborde, P; Elorriaga, Y; Marino, DJ; Ronco, AE | 1 |
| Karadzovska, D; Riviere, JE | 1 |
| Karadzovska, D; Riviere, J | 1 |
| Jiang, JG; Song, GS; Zhang, XR; Zhang, YH | 1 |
| Choi, DJ; Her, N; Kim, SK; Nam, SW; Zoh, KD | 1 |
| Derry, CJ; Derry, S; Moore, RA | 1 |
| Harris, G; Landesmann, B; Mennecozzi, M; Palosaari, T; Whelan, M | 1 |
| do Nascimento, C; Issa, JP; Kurita Varoli, F; Pedrazzi, V; Sato, S; Sucena Pita, M | 1 |
| Cimetière, N; Fallou, H; Giraudet, S; Le Cloirec, P; Wolbert, D | 1 |
| Engesland, A; Flaten, GE; Škalko-Basnet, N | 1 |
| Sintov, AC | 1 |
| Dorrani, M; Goodyear, B; Haq, A; Joshi, V; Michniak-Kohn, B | 1 |
| Chiang, PC; Dang, Z; Gong, B; Huang, CP; Huang, Z; Pan, SY; Wu, P | 1 |
| Alshaikh, RA; El Maghraby, GM; Essa, EA | 1 |
| El-Adl, SM; Mattar, AA; Sebaiy, MM | 1 |
| Carl, P; Gregório, BJR; Hoffmann, K; Lehmann, A; Rurack, K; Sarma, D; Schneider, RJ | 1 |
| Brambila-Souza, G; Branco, GS; Godoi, FGA; Gomes, ADO; Lo Nostro, FL; Moreira, RG; Muñoz-Peñuela, M; Tolussi, CE | 1 |
| Almeida, TS; Carvalho, JPF; Freire, CSR; Mota, JP; Rosado, C; Silva, NHCS; Silvestre, AJD; Vilela, C | 1 |
| Correa-Navarro, YM; Giraldo, L; Moreno-Piraján, JC | 1 |
| Alonso, JD; Chorilli, M; da Silva Barud, H; de Freitas, LAP; de Sousa, PZ; Manieri, KF; Meneguin, AB; Pacheco, G; Sábio, RM | 1 |
| Branco, GS; Dal'Olio Gomes, A; Godoi, FGA; Lo Nostro, FL; Moreira, RG; Muñoz-Peñuela, M; Pinheiro, JPS; Tolussi, CE | 1 |
| Aguiar, MB; Avena, MJ; Onaga Medina, FM; Parolo, ME | 1 |
| de Moura, AA; Gimenes, ML; Moreira, WM; Vieira, MGA; Viotti, PV | 1 |
| Branco, GS; Gomes, ADO; Lo Nostro, FL; Moreira, RG; Muñoz-Peñuela, M; Pinheiro, JPS; Tolussi, CE; Zampieri, RA | 1 |
| Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB | 1 |
| Escher, BI; Müller, RA; Nivala, J; Reemtsma, T; Schlichting, R; Sossalla, NA; van Afferden, M | 1 |
| Correia, AT; de Oliveira, TMN; Guimarães, LL; Pisetta, AM; Roveri, V | 1 |
| Björklund, E; Jankowska, K; Lambropoulou, D; Luczkiewicz, A; Nannou, C; Polkowska, Ż; Potapowicz, J; Svahn, O; Szopińska, M | 1 |
| Correia, AT; Guimarães, LL; Roveri, V; Toma, W | 1 |
| Lau, CI; Wang, YF | 1 |
| Anwar, MM; Laila, IMI | 1 |
| Acosta, S; Andrade, DL; Barrado, M; Cabrera, M; Capparelli, MV; Cipriani-Avila, I; Jara-Negrete, E; Medina-Villamizar, EJ; Mogollón, NGS; Molinero, J; Pinos-Velez, V | 1 |
| Caldas, LL; Espíndola, ELG; Moreira, RA; Novelli, A | 1 |
| Jin, Y; Liu, J; Niu, H; Xie, W; Zhang, Y; Zhang, Z | 1 |
3 review(s) available for diclofenac and caffeine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Diclofenac; Drug Synergism; Dysmenorrhea; Female; Headache; Humans; Ibuprofen; Male; Middle Aged; ortho-Aminobenzoates; Pain, Postoperative; Postpartum Period; Pregnancy; Randomized Controlled Trials as Topic | 2014 |
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Phenothiazines; Sumatriptan; Valproic Acid | 2022 |
4 trial(s) available for diclofenac and caffeine
| Article | Year |
|---|---|
A comparison of two analgesic muscle relaxant combinations in acute back pain.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aspirin; Back Pain; Caffeine; Carisoprodol; Chlormezanone; Clinical Trials as Topic; Diclofenac; Drug Combinations; Female; Humans; Male; Methocarbamol; Middle Aged | 1984 |
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Drug Interactions; Female; Humans; Male; Mephenytoin; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating | 2001 |
Efficacy of diclofenac sodium softgel 100 mg with or without caffeine 100 mg in migraine without aura: a randomized, double-blind, crossover study.
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Cross-Over Studies; Diclofenac; Double-Blind Method; Drug Combinations; Female; Gels; Humans; Male; Middle Aged; Migraine without Aura | 2004 |
Analgesia evaluation of 2 NSAID drugs as adjuvant in management of chronic temporomandibular disorders.
Topics: Acetaminophen; Adult; Aged; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carisoprodol; Chronic Pain; Diclofenac; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pain Management; Pain Measurement; Temporomandibular Joint Disorders | 2015 |
74 other study(ies) available for diclofenac and caffeine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water | 2006 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Determination of log D via automated microfluidic liquid-liquid extraction.
Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Piperidines; Structure-Activity Relationship | 2018 |
Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies.
Topics: Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Design; Enzyme Inhibitors; Humans; Hydrazones; Hypersensitivity; Lung; Male; Mice | 2020 |
G6PD hillbrow: a new variant of glucose-6-phosphate dehydrogenase associated with drug-induced haemolytic anaemia.
Topics: Acetaminophen; Adult; Anemia, Hemolytic; Caffeine; Carisoprodol; Chlormezanone; Diclofenac; Drug Combinations; Erythrocyte Aging; Erythrocytes; Genetic Variation; Glucosephosphate Dehydrogenase; Humans; Male | 1975 |
[Lobak--a case of disinformation?].
Topics: Acetaminophen; Analgesics; Caffeine; Carisoprodol; Chlormezanone; Diclofenac; Drug Combinations; Drug Information Services; Humans; Sweden | 1991 |
Fixed drug eruption due to a drug combination but not to its constituents.
Topics: Acetaminophen; Adult; Analgesics; Caffeine; Carisoprodol; Chlormezanone; Diclofenac; Drug Combinations; Drug Eruptions; Female; Humans | 1985 |
On the analgesic effect of sodium diclofenac in pain-induced functional impairment in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Male; Motor Activity; Pain; Rats; Rats, Wistar; Time Factors; Uric Acid | 1998 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline | 1999 |
Compressed xanthan and karaya gum matrices: hydration, erosion and drug release mechanisms.
Topics: Caffeine; Diclofenac; Drug Carriers; Karaya Gum; Kinetics; Polysaccharides, Bacterial; Solubility | 2000 |
Bisphenol A and its biomaterial monomer derivatives alteration of in vitro cytochrome P450 metabolism in rat, minipig, and human.
Topics: Animals; Benzhydryl Compounds; Caffeine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Diclofenac; Enzyme Inhibitors; Humans; Isoenzymes; Liver; Male; Microsomes, Liver; Phenols; Rats; Rats, Sprague-Dawley; Species Specificity; Swine; Swine, Miniature | 2000 |
PAMPA--a drug absorption in vitro model 8. Apparent filter porosity and the unstirred water layer.
Topics: Adsorption; Algorithms; Caffeine; Desipramine; Diclofenac; Filtration; Hydrogen-Ion Concentration; Lipids; Membranes, Artificial; Models, Chemical; Permeability; Piroxicam; Porosity; Water | 2004 |
Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process.
Topics: Caffeine; Diclofenac; Ibuprofen; Ketoprofen; Meclofenamic Acid; Models, Chemical; Naproxen; Pharmaceutical Preparations; Triclosan; Waste Disposal, Fluid; Water Pollutants, Chemical | 2005 |
Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Apamin; Barium; Benzopyrans; Caffeine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Charybdotoxin; Diclofenac; Dimethyl Sulfoxide; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Nitroarginine; Papaverine; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Protein Serine-Threonine Kinases; Pyrazoles; Receptor, Cannabinoid, CB1; rho-Associated Kinases; Tetraethylammonium; Vasodilator Agents | 2006 |
Topical vehicles based on natural surfactant/fatty alcohols mixed emulsifier: The influence of two polyols on the colloidal structure and in vitro/in vivo skin performance.
Topics: Adult; Caffeine; Colloids; Diclofenac; Emulsions; Fatty Alcohols; Female; Glycerol; Glycolipids; Humans; Pharmaceutical Vehicles; Propylene Glycol; Skin; Skin Absorption; Skin Irritancy Tests; Skin, Artificial; Young Adult | 2009 |
Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance.
Topics: Administration, Cutaneous; Adult; Caffeine; Cell Line; Cell Survival; Cells, Cultured; Colloids; Diclofenac; Drug Compounding; Excipients; Fatty Alcohols; Female; Fibroblasts; Glycolipids; Humans; Hydrogen-Ion Concentration; Keratinocytes; Lipids; Permeability; Skin Irritancy Tests; Skin, Artificial; Solubility; Surface-Active Agents; Young Adult | 2009 |
Molecular and microscopic assessment of the effects of caffeine, acetaminophen, diclofenac, and their mixtures on river biofilm communities.
Topics: Acetaminophen; Archaea; Bacteria; Biodiversity; Biofilms; Biomass; Caffeine; Carbon; Cyanobacteria; Diclofenac; Rivers; Water Microbiology; Water Pollutants, Chemical | 2012 |
Pharmaceutical removal in tropical subsurface flow constructed wetlands at varying hydraulic loading rates.
Topics: Caffeine; Carbamazepine; Clofibric Acid; Diclofenac; Ecosystem; Environmental Restoration and Remediation; Ketoprofen; Models, Chemical; Pharmaceutical Preparations; Rhizosphere; Tropical Climate; Waste Disposal, Fluid; Water Movements; Water Pollutants, Chemical; Wetlands | 2012 |
Optimization of matrix tablets controlled drug release using Elman dynamic neural networks and decision trees.
Topics: Artificial Intelligence; Caffeine; Chemistry, Pharmaceutical; Decision Trees; Delayed-Action Preparations; Diclofenac; Diglycerides; Drug Compounding; Hydrophobic and Hydrophilic Interactions; Neural Networks, Computer; Polyethylene Glycols; Porosity; Solubility; Tablets; Tensile Strength | 2012 |
Batch versus continuous feeding strategies for pharmaceutical removal by subsurface flow constructed wetland.
Topics: Biodegradation, Environmental; Caffeine; Carbamazepine; Clofibric Acid; Diclofenac; Ibuprofen; Ketoprofen; Kinetics; Pharmaceutical Preparations; Waste Disposal, Fluid; Water Movements; Water Pollutants, Chemical; Wetlands | 2012 |
SC lipid model membranes designed for studying impact of ceramide species on drug diffusion and permeation, part III: influence of penetration enhancer on diffusion and permeation of model drugs.
Topics: Caffeine; Diclofenac; Diffusion; Hydrophobic and Hydrophilic Interactions; Lipids; Membranes, Artificial; Permeability; Urea | 2012 |
Human pharmaceuticals in wastewaters from urbanized areas of Argentina.
Topics: Argentina; Atenolol; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Cities; Diclofenac; Environmental Monitoring; Humans; Ibuprofen; Mass Spectrometry; Pharmaceutical Preparations; Wastewater; Water Pollutants, Chemical | 2013 |
Assessing vehicle effects on skin absorption using artificial membrane assays.
Topics: Animals; Biological Assay; Caffeine; Cortisone; Diclofenac; Ethanol; In Vitro Techniques; Mannitol; Membranes, Artificial; Propylene Glycol; Quantitative Structure-Activity Relationship; Salicylic Acid; Skin; Skin Absorption; Swine; Testosterone; Water | 2013 |
Assessing vehicle effects on skin absorption of non-volatile compounds using membrane-coated fiber arrays.
Topics: Acrylic Resins; Caffeine; Cortisone; Diclofenac; Dimethylpolysiloxanes; Ethanol; Mannitol; Membranes, Artificial; Polyethylene Glycols; Salicylic Acid; Skin Absorption; Testosterone; Volatilization; Water | 2013 |
[Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS].
Topics: Acetaminophen; Acetanilides; Amantadine; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Antipyrine; Caffeine; Chlorpheniramine; Chromatography, Liquid; Diclofenac; Diphenhydramine; Drug Contamination; Drug Stability; Ephedrine; Guaifenesin; Promethazine; Pseudoephedrine; Reproducibility of Results; Salicylates; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Adsorption characteristics of selected hydrophilic and hydrophobic micropollutants in water using activated carbon.
Topics: 2,4-Dichlorophenoxyacetic Acid; Acetaminophen; Adsorption; Atrazine; Caffeine; Carbanilides; Carbon; Diclofenac; Endocrine Disruptors; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Naproxen; Pesticides; Pharmaceutical Preparations; Sulfamethazine; Sulfamethoxazole; Temperature; Waste Disposal, Fluid; Water Pollutants, Chemical; Water Purification | 2014 |
Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Calcium; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Chlorpromazine; Diclofenac; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Omeprazole; Primary Cell Culture; Sex Characteristics; Verapamil | 2015 |
Adsorption of pharmaceuticals onto activated carbon fiber cloths - Modeling and extrapolation of adsorption isotherms at very low concentrations.
Topics: Acetaminophen; Adsorption; Caffeine; Carbamazepine; Carbon; Carbon Fiber; Charcoal; Diclofenac; Models, Theoretical; Reproducibility of Results; Water Purification | 2016 |
In vitro models to estimate drug penetration through the compromised stratum corneum barrier.
Topics: Administration, Cutaneous; Animals; Caffeine; Diclofenac; Epidermis; Humans; Hydrophobic and Hydrophilic Interactions; Permeability; Pharmacokinetics; Phospholipids; Skin Absorption; Swine | 2016 |
Cumulative evidence of the low reliability of frozen/thawed pig skin as a model for in vitro percutaneous permeation testing.
Topics: Administration, Cutaneous; Animals; Caffeine; Cryopreservation; Diclofenac; Freezing; In Vitro Techniques; Levodopa; Permeability; Reproducibility of Results; Skin; Skin Absorption; Swine | 2017 |
Membrane properties for permeability testing: Skin versus synthetic membranes.
Topics: Caffeine; Cellulose; Diclofenac; Humans; Hydrocortisone; Membranes, Artificial; Polymers; Skin; Skin Absorption; Sulfones | 2018 |
Performance evaluation of integrated adsorption-nanofiltration system for emerging compounds removal: Exemplified by caffeine, diclofenac and octylphenol.
Topics: Adsorption; Caffeine; Diclofenac; Phenols; Water Pollutants, Chemical; Water Purification | 2019 |
Eutexia for enhanced dissolution rate and anti-inflammatory activity of nonsteroidal anti-inflammatory agents: Caffeine as a melting point modulator.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carrageenan; Diclofenac; Drug Liberation; Edema; Flurbiprofen; Male; Meloxicam; Powder Diffraction; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Transition Temperature; X-Ray Diffraction | 2019 |
Different techniques for overlapped UV spectra resolution of some co-administered drugs with paracetamol in their combined pharmaceutical dosage forms.
Topics: Acetaminophen; Caffeine; Diclofenac; Linear Models; Models, Chemical; Orphenadrine; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2020 |
Wash-Free Multiplexed Mix-and-Read Suspension Array Fluorescence Immunoassay for Anthropogenic Markers in Wastewater.
Topics: Biomarkers; Caffeine; Carbamazepine; Chromatography, Liquid; Diclofenac; Environmental Monitoring; Fluorescence; Humans; Immunoassay; Limit of Detection; Suspensions; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical | 2019 |
Endocrine disruptive action of diclofenac and caffeine on Astyanax altiparanae males (Teleostei: Characiformes: Characidae).
Topics: Animals; Caffeine; Characidae; Diclofenac; Endocrine Disruptors; Estradiol; Liver; Male; Testis; Testosterone; Water Pollutants, Chemical | 2020 |
Topical Drug Delivery Systems Based on Bacterial Nanocellulose: Accelerated Stability Testing.
Topics: Administration, Topical; Bacteria; Biocompatible Materials; Caffeine; Cellulose; Diclofenac; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Stability; Humans; Ibuprofen; Lidocaine; Nanoparticles | 2020 |
Biochar from Fique Bagasse for Remotion of Caffeine and Diclofenac from Aqueous Solution.
Topics: Adsorption; Caffeine; Cellulose; Charcoal; Chromatography, High Pressure Liquid; Diclofenac; Hydrogen-Ion Concentration; Kinetics; Solutions; Water Pollutants, Chemical | 2020 |
Spray-dried bacterial cellulose nanofibers: A new generation of pharmaceutical excipient intended for intestinal drug delivery.
Topics: Animals; Bacteria; Caffeine; Cellulose; Diclofenac; Drug Compounding; Drug Delivery Systems; Drug Liberation; Excipients; Fibroblasts; Gastrointestinal Tract; Mice; Nanofibers; Polymers | 2020 |
Diclofenac and caffeine inhibit hepatic antioxidant enzymes in the freshwater fish Astyanax altiparanae (Teleostei: Characiformes).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Caffeine; Catalase; Central Nervous System Stimulants; Characiformes; Diclofenac; Fresh Water; Gills; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Lipid Peroxidation; Liver; Male; Oxidative Stress; Superoxide Dismutase; Water Pollutants, Chemical | 2021 |
Insights of competitive adsorption on activated carbon of binary caffeine and diclofenac solutions.
Topics: Adsorption; Caffeine; Charcoal; Diclofenac; Hydrogen-Ion Concentration; Kinetics; Solutions; Spectroscopy, Fourier Transform Infrared; Water Pollutants, Chemical | 2021 |
Synthesis of a biobased resin and its screening as an alternative adsorbent for organic and inorganic micropollutant removal.
Topics: 2,4-Dichlorophenoxyacetic Acid; Acetaminophen; Adsorption; Atrazine; Biocompatible Materials; Caffeine; Carbon; Diclofenac; Diuron; Flame Retardants; Kinetics; Lead; Methylene Blue; Oxidants; Phenols; Proanthocyanidins; Water; Water Pollutants, Chemical; Water Purification | 2022 |
Neurotoxic, biotransformation, oxidative stress and genotoxic effects in Astyanax altiparanae (Teleostei, Characiformes) males exposed to environmentally relevant concentrations of diclofenac and/or caffeine.
Topics: Acetylcholinesterase; Animals; Biotransformation; Caffeine; Characiformes; Diclofenac; DNA Damage; Male; Oxidative Stress; Water Pollutants, Chemical | 2022 |
Impact of various aeration strategies on the removal of micropollutants and biological effects in aerated horizontal flow treatment wetlands.
Topics: Biological Oxygen Demand Analysis; Caffeine; Diclofenac; Escherichia coli; Naproxen; Nitrogen; Oxygen; Waste Disposal, Fluid; Wastewater; Wetlands | 2022 |
First report on the occurrence of pharmaceuticals and cocaine in the coastal waters of Santa Catarina, Brazil, and its related ecological risk assessment.
Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Cosmetics; Diclofenac; Ecosystem; Environmental Monitoring; Humans; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Sewage; Solid Waste; Tandem Mass Spectrometry; Water; Water Pollutants, Chemical | 2022 |
Pharmaceuticals and other contaminants of emerging concern in Admiralty Bay as a result of untreated wastewater discharge: Status and possible environmental consequences.
Topics: Caffeine; Cosmetics; Diclofenac; Environmental Monitoring; Humans; Ibuprofen; Ketoconazole; Pharmaceutical Preparations; Wastewater; Water Pollutants, Chemical | 2022 |
Occurrence, ecological risk assessment and prioritization of pharmaceuticals and abuse drugs in estuarine waters along the São Paulo coast, Brazil.
Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Diclofenac; Ecosystem; Environmental Monitoring; Furosemide; Illicit Drugs; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Rivers; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2022 |
2022 Taiwan Guidelines for Acute Treatment of Migraine.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Caffeine; Calcitonin Gene-Related Peptide Receptor Antagonists; Child; Diclofenac; Female; Headache; Humans; Ibuprofen; Migraine Disorders; Morphine Derivatives; Naproxen; Nasal Sprays; Pregnancy; Prochlorperazine; Taiwan; Tramadol; Tryptamines | 2022 |
Mitigative effect of caffeine against diclofenac-induced hepato-renal damage and chromosomal aberrations in male albino rats.
Topics: Animals; Anti-Inflammatory Agents; Caffeine; Chromosome Aberrations; Diclofenac; Liver; Male; Rats | 2022 |
Occurrence of emerging contaminants in surface water bodies of a coastal province in Ecuador and possible influence of tourism decline caused by COVID-19 lockdown.
Topics: Caffeine; Communicable Disease Control; COVID-19; Diclofenac; Ecosystem; Ecuador; Environmental Monitoring; Humans; Pandemics; Pharmaceutical Preparations; Tourism; Water; Water Pollutants, Chemical | 2023 |
Environmental Risk Assessment of Drugs in Tropical Freshwaters Using Ceriodaphnia silvestrii as Test Organism.
Topics: Acetaminophen; Animals; Caffeine; Cladocera; Diclofenac; Fresh Water; Ketoprofen; Risk Assessment; Salicylic Acid; Water Pollutants, Chemical | 2023 |
Evaluation of the impact of vindoline, an active components of Catharanthus roseus, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs.
Topics: Animals; Caffeine; Catharanthus; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Rats; Tandem Mass Spectrometry | 2023 |