diclofenac has been researched along with acetylcysteine in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (52.17) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Baillie, TA; Braun, MP; Chen, Q; Doss, GA; Evans, DC; Freeden, C; Griffin, PR; Ngui, JS; Poon, GK; Stearns, RA; Tang, W; Teffera, Y | 1 |
| Baum, Y; Hoffer, E; Nahir, AM | 1 |
| Barelli, D; Cantoni, L; Castell, JV; Hauri, L; Mangolini, A; Ponsoda, X; Rizzardini, M; Valaperta, R; Villa, P | 1 |
| Curtin, WA; Given, HF; Mulhall, KJ | 1 |
| Fujita, H; Inoue, A; Kanno, T; Muranaka, S; Tamai, H; Utsumi, K | 1 |
| Averbukh, Z; Berman, S; Efrati, S; Golik, A; Lotan, R; Siman-Tov, Y; Weissgarten, J | 1 |
| Baillie, TA; Braun, MP; Dean, DC; Doss, GA; Li, Y; Slatter, JG; Stearns, RA; Tang, W; Zhang, Z | 1 |
| Endo, T; Harada, H; Kusama, H; Momose, Y | 1 |
| Jian, W; Yao, M; Zhang, D; Zhu, M | 1 |
| Farshid, AA; Tamaddonfard, E; Yahyaee, F | 1 |
| Balbontín-Ayala, F; Cañigral, A; Carlos, Fd; Cobo, T; Fernández-González, FJ; Fernández-Vázquez, JP; Gonzalo-Orden, JM; Sánchez-Lasheras, F; Vega, JA | 1 |
| Sadeghi-Maleki, MR; Samadi-Maybodi, A; Tilehkan, A | 1 |
| Abdel-Razzak, Z; Al-Attrache, H; Chamieh, H; Hamzé, M; Morel, I; Taha, S | 1 |
| Heidarian, E; Nikoukar, M; Nouri, A | 1 |
| Heidarian, E; Nouri, A | 1 |
| Adl, A; Malekzadeh, P; Motamedifar, M; Sedigh-Shams, M | 1 |
2 review(s) available for diclofenac and acetylcysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Remodeling; Celecoxib; Clodronic Acid; Diclofenac; Diphosphonates; Humans; Imidazoles; Interferon-gamma; Isoxazoles; Lactones; Mice; Orthodontic Anchorage Procedures; Osteoclasts; Osteoprotegerin; Pamidronate; Rats; Resveratrol; Stilbenes; Sulfones; Tooth Mobility; Tooth Movement Techniques; Zoledronic Acid | 2015 |
21 other study(ies) available for diclofenac and acetylcysteine
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans.
Topics: Acetylcysteine; Animals; Benzoquinones; Biotransformation; Chromatography, High Pressure Liquid; Diclofenac; Humans; Imines; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley | 2001 |
N-Acetylcysteine enhances the action of anti-inflammatory drugs as suppressors of prostaglandin production in monocytes.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Drug Synergism; Expectorants; Humans; In Vitro Techniques; Lactones; Lipopolysaccharides; Monocytes; Sulfones | 2002 |
Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Female; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Oxidative Stress; Rats | 2003 |
Comparison of different anti-inflammatory agents in suppressing the monocyte response to orthopedic particles.
Topics: Acetylcysteine; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Dexamethasone; Diclofenac; Humans; Interleukin-1; Monocytes; Osteolysis; Polymethyl Methacrylate; Tumor Necrosis Factor-alpha | 2003 |
Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway.
Topics: 2-Methoxyestradiol; Acetylcysteine; Amino Acid Chloromethyl Ketones; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspases; Chromones; Cyclic AMP; Cyclosporine; Cysteine Proteinase Inhibitors; Cytochromes c; Diclofenac; DNA Fragmentation; DNA, Neoplasm; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Estradiol; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2004 |
N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytoprotection; Diclofenac; Dinoprostone; Hydrogen Peroxide; Kidney; Kidney Cortex; Kidney Medulla; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Renal Circulation; Renal Insufficiency; Tissue Distribution | 2007 |
In vitro metabolic activation of lumiracoxib in rat and human liver preparations.
Topics: Acetylcysteine; Animals; Cells, Cultured; Chromatography, Liquid; Cyclooxygenase 2 Inhibitors; Diclofenac; Hepatocytes; Humans; Microsomes, Liver; Rats; Tandem Mass Spectrometry | 2008 |
A liquid chromatography/tandem mass spectrometry method for detecting UGT-mediated bioactivation of drugs as their N-acetylcysteine adducts in human liver microsomes.
Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Diclofenac; Glucuronosyltransferase; Humans; Ketoprofen; Microsomes, Liver; Spectrometry, Mass, Electrospray Ionization | 2009 |
Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chromatography, High Pressure Liquid; Clozapine; Diclofenac; Glutathione; Humans; Microsomes, Liver; Rats; Tandem Mass Spectrometry | 2009 |
Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats.
Topics: Acetylcysteine; Acute Disease; Animals; Carrageenan; Cyclooxygenase Inhibitors; Diclofenac; Drug Synergism; Edema; Free Radical Scavengers; Hindlimb; Histidine; Inflammation; Injections; Male; Neutrophil Infiltration; Rats; Rats, Wistar | 2010 |
Determination of Diclofenac and N-Acetylcysteine by an Optimized Luminescence Method Using CdS Quantum Dots as Sensitizers.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Biosensing Techniques; Cadmium Compounds; Diclofenac; Free Radical Scavengers; Luminescence; Luminescent Measurements; Pharmaceutical Preparations; Quantum Dots; Sulfides | 2017 |
N-acetylcysteine potentiates diclofenac toxicity in Saccharomyces cerevisiae: stronger potentiation in ABC transporter mutant strains.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; ATP-Binding Cassette Transporters; Diclofenac; Disulfides; Dose-Response Relationship, Drug; Drug Synergism; Genotype; Mutation; Oxidative Stress; Phenotype; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Transcription Factors | 2018 |
Effects of N-acetyl cysteine on oxidative stress and TNF-α gene expression in diclofenac-induced hepatotoxicity in rats.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Catalase; Chemical and Drug Induced Liver Injury; Diclofenac; Gene Expression; Lipids; Liver; Liver Function Tests; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Silymarin; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2017 |
Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury in male rats based on serum biochemical parameters, oxidative biomarkers, and histopathological study.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Biomarkers; Creatinine; Diclofenac; Humans; Kidney; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Uric Acid | 2019 |
Disinfection of dentinal tubules with diclofenac sodium and N-Acetylcysteine compared with calcium hydroxide as intracanal medicaments against Enterococcus faecalis.
Topics: Acetylcysteine; Anti-Bacterial Agents; Calcium Hydroxide; Dental Pulp Cavity; Dentin; Diclofenac; Enterococcus faecalis; Root Canal Irrigants | 2022 |