diclofenac has been researched along with 5-hydroxydiclofenac in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, MR; Doss, GA; Marchick, MR; Pohl, LR; Shen, S | 1 |
| Baillie, TA; Lin, JH; Miller, RR; Ngui, JS; Shou, M; Stearns, RA; Tang, W; Zhang, Y | 1 |
| Anderson, BJ; Jacqz-Aigrain, E; Rømsing, J; Tibboel, D; van der Marel, CD | 1 |
| Clarke, SE; Meng, X; Naisbitt, DJ; Park, BK; Sanderson, LS; Stachulski, AV | 1 |
| Caminal, G; Cruz-Morató, C; Marco-Urrea, E; Pérez-Trujillo, M; Vicent, T | 1 |
| Kanazawa, T; Kishida, T; Kuroda, J; Onozato, T; Tanaka, S | 1 |
| Boerma, JS; Commandeur, JN; Dragovic, S; Vermeulen, NP | 1 |
| de Graaf, IA; Groothuis, GM; Horvatovich, P; Langelaar-Makkinje, M; Niu, X | 1 |
| Cheng, H; Liu, H; Qu, J; Song, D | 1 |
| Flitsch, SL; Hauer, B; Hayes, MA; Hussain, SA; Klenk, JM; Kulig, JK; Nebel, BA; Porter, JL; Richter, SM; Tavanti, M; Turner, NJ | 1 |
| Miura, T; Murayama, N; Shimizu, M; Suemizu, H; Uehara, S; Utoh, M; Yamazaki, H | 1 |
| Dai, R; Dai, T; Ding, L; Huang, L; Jiang, W; Xie, S | 1 |
12 other study(ies) available for diclofenac and 5-hydroxydiclofenac
| Article | Year |
|---|---|
Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Gas Chromatography-Mass Spectrometry; Humans; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1999 |
Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine.
Topics: Cytochrome c Group; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Humans; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases; Quinidine; Recombinant Proteins | 2000 |
Diclofenac and metabolite pharmacokinetics in children.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Body Weight; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diclofenac; Female; Half-Life; Humans; Male; Pain, Postoperative; Rectum; Suppositories; Tablets, Enteric-Coated; Tonsillectomy | 2004 |
Investigation of the immunogenicity of diclofenac and diclofenac metabolites.
Topics: Animals; Antigens; Cell Proliferation; Diclofenac; Female; Glucuronides; Local Lymph Node Assay; Lymph Nodes; Mice; Mice, Inbred BALB C | 2007 |
Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biodegradation, Environmental; Cytochrome P-450 Enzyme System; Diclofenac; Hydroxylation; Laccase; Magnetic Resonance Spectroscopy; Trametes | 2010 |
Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Diclofenac; Disease Models, Animal; Glutathione; Hydroxylation; In Vitro Techniques; Lipopolysaccharides; Liver; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 2012 |
Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biocatalysis; Cytochrome P-450 Enzyme System; Diclofenac; Glutathione; Glutathione Transferase; Humans; Microsomes, Liver; Mutation; Oxidation-Reduction; Recombinant Proteins; Tandem Mass Spectrometry | 2013 |
Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.
Topics: Adenosine Triphosphate; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Diclofenac; Female; Glucuronides; Humans; Immunohistochemistry; In Vitro Techniques; Jejunum; L-Lactate Dehydrogenase; Male; Middle Aged | 2015 |
Permanganate oxidation of diclofenac: The pH-dependent reaction kinetics and a ring-opening mechanism.
Topics: Chromatography, Liquid; Diclofenac; Hydrogen-Ion Concentration; Kinetics; Manganese Compounds; Mass Spectrometry; Models, Chemical; Nitrogen; Oxidation-Reduction; Oxides; Waste Disposal, Fluid; Water Pollutants, Chemical | 2015 |
The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Proteins; Biodegradation, Environmental; Biotransformation; Catalysis; Cytochrome P-450 Enzyme System; Diclofenac; Fermentation; Hydroxylation; Oxidation-Reduction; Quinones; Rhodococcus | 2017 |
Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice.
Topics: Animals; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Diclofenac; Hepatocytes; Humans; Hydroxylation; Mice; Transplantation Chimera | 2020 |
Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Drug Induced Liver Injury; Cytokines; Diclofenac; Disease Models, Animal; Gene Expression Regulation; Glucuronides; Humans; Immunity; Injections, Intraperitoneal; Interleukin-17; Liver; Mice, Transgenic; Protein Interaction Maps; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |