diclofenac has been researched along with 4'-hydroxyaceclofenac in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashimoto, S; Kaneda, N; Kawai, S; Koshino, T; Matsuzaki, T; Mizushima, Y; Okamoto, R; Yamazaki, R; Yokokura, T | 1 |
| Hashimoto, S; Kawai, S; Koshino, T; Matsumoto, T; Matsuzaki, T; Mizushima, Y; Okamoto, R; Yamazaki, R; Yokokura, T | 1 |
| Hashimoto, S; Ito, A; Kawai, S; Matsuzaki, T; Mizushima, Y; Yamazaki, R; Yokokura, T | 1 |
| Dooley, M; Dunn, CJ; Spencer, CM | 1 |
| Kang, W; Kim, EY | 1 |
| Ahn, B; Gwak, Hs; Kang, W; Kim, E; Noh, K | 1 |
| Ihm, C; Kang, W; Kim, E | 1 |
1 review(s) available for diclofenac and 4'-hydroxyaceclofenac
| Article | Year |
|---|---|
Aceclofenac: a reappraisal of its use in the management of pain and rheumatic disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage Oligomeric Matrix Protein; Diclofenac; Disease Management; Drug Tolerance; Extracellular Matrix Proteins; Glycoproteins; Humans; Matrilin Proteins; Pain; Rheumatic Diseases | 2001 |
6 other study(ies) available for diclofenac and 4'-hydroxyaceclofenac
| Article | Year |
|---|---|
Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Chromatography, Thin Layer; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Monocytes; Neutrophils; Prostaglandin-Endoperoxide Synthases; Synovial Membrane | 1997 |
Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydrolysis; Immunoenzyme Techniques; Isoenzymes; Membrane Proteins; Microsomes; Prostaglandin-Endoperoxide Synthases; Synovial Membrane | 1999 |
A major metabolite of aceclofenac, 4'-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Dinoprostone; Enzyme Precursors; Extracellular Space; Humans; Interleukin-1; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Protease Inhibitors; RNA, Messenger; Synovial Membrane; Tissue Inhibitor of Metalloproteinase-1 | 2000 |
Simultaneous determination of aceclofenac and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Diclofenac; Humans; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Quantitative determination of aceclofenac and its three major metabolites in rat plasma by HPLC-MS/MS.
Topics: Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Diclofenac; Rats; Tandem Mass Spectrometry | 2012 |
Modeling of aceclofenac metabolism to major metabolites in healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Healthy Volunteers; Humans; Male; Models, Biological; Young Adult | 2016 |