dichlorocarbene has been researched along with vindoline* in 1 studies
1 other study(ies) available for dichlorocarbene and vindoline
| Article | Year |
|---|---|
Attempted Synthesis of
Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmonsâ»Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid. Halogenated 14,15-cyclopropanovindoline was prepared by reactions with iodoform and bromoform, respectively, in the presence of diethylzinc. Reactions of dichlorocarbene with vindoline resulted in the 10-formyl derivative. Unexpectedly, in the case of the dimer alkaloids vinblastine and vincristine, the rearranged products containing an oxirane ring in the catharanthine part were isolated from the reactions. The attempted epoxidation of vindoline and catharanthine also led to anomalous rearranged products. In the epoxidation reaction of vindoline, an Topics: Catharanthus; Chemistry Techniques, Synthetic; Halogenation; Hydrocarbons, Chlorinated; Molecular Structure; Vinblastine; Vinca Alkaloids | 2018 |