dichloroacetic acid has been researched along with pyruvic acid in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (23.81) | 18.7374 |
| 1990's | 18 (28.57) | 18.2507 |
| 2000's | 11 (17.46) | 29.6817 |
| 2010's | 16 (25.40) | 24.3611 |
| 2020's | 3 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Delehanty, JM; Imai, N; Liang, CS | 1 |
| Grill, V; Jalkanen, P; Ostenson, CG; Sako, Y | 1 |
| Herndon, DN; Jahoor, F; Miyoshi, H; Wolfe, RR | 1 |
| Hashimoto, T; Ito, M; Kuroda, Y; Naito, E; Saijo, T; Takeda, E | 1 |
| Burns, AH; Burns, LA; Jurenka, LU; Summer, WR | 1 |
| Bünger, R; Hartman, DA; Mallet, RT | 1 |
| Cardell, M; Koide, T; Wieloch, T | 1 |
| Ito, M; Kobashi, H; Kuroda, Y; Naito, E; Saijo, T; Takeda, E; Toshima, K; Yokota, I | 1 |
| Kobashi, H; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Yokota, I | 1 |
| Kamoshita, S; Kodama, H; Kodama, M; Okabe, I; Orii, T; Yamaguchi, S | 1 |
| Agius, L; Alberti, KG; Battersby, C | 1 |
| Agius, L; Vaartjes, WJ | 1 |
| Radeck, W; Schadewaldt, P; Staib, W | 1 |
| Fuller, SJ; Randle, PJ | 1 |
| Casanello-Ertl, D; Duducgian-Vartavarian, L; Pardridge, WM | 1 |
| Hellige, G; Hunnemann, DH; Junggeburth, J; Kahles, H; Kochsiek, K | 1 |
| Ito, M; Kobashi, H; Kuroda, Y; Miyao, M; Takeda, E; Toshima, K; Watanabe, T | 1 |
| Münch, U; Schadewaldt, P; Staib, W | 1 |
| Evans, OB; Stacpoole, PW | 1 |
| Goodman, MN; Komanicky, PM; Ruderman, NB; Schneider, SH | 1 |
| Baudry, M; Bennett, WF; Browning, M; Lynch, G | 1 |
| Doi, K; Uchida, K | 1 |
| Bünger, R; Mallet, RT | 1 |
| Ayuso, MS; Ciprés, G; González-Manchón, C; Martín-Requero, A; Parrilla, R | 1 |
| Brown, J; Gore, DC; Lee, R | 1 |
| Arai, K; Harada, M; Hashimoto, T; Miyoshi, H; Nishitani, H; Tanouchi, M | 1 |
| Beylot, M; Brunengraber, H; Large, V; Odeon, M | 1 |
| Dickson, AJ; Murray, K | 1 |
| Grattan, RM; Kline, JA; Maiorano, PC; Schroeder, JD; Vary, TC; Watts, JA | 1 |
| Hamlin, RL; Jiang, Z; Rath, DP; Robitaille, PM; Tong, X; Zhu, H | 1 |
| Patel, KP; Rozanski, GJ; Xu, Z; Zhang, K | 1 |
| Barak, C; Jessen, ME; Malloy, CR; Maniscalco, SP; Reed, MK; Sherry, AD | 1 |
| Constantin-Teodosiu, D; Greenhaff, PL; Simpson, EJ | 1 |
| Baker, JC; Kasten, S; Peng, T; Roche, TE; Yan, X | 1 |
| Amrani, M; Goodwin, AT; Gray, CC; Jagodzinski, P; Jayakumar, J; Sammut, IA; Smolenski, RT; Yacoub, MH | 1 |
| Bangsbo, J; Gibala, MJ; González-Alonso, J; Krustrup, P; Saltin, B | 1 |
| Brocks, C; Chatham, JC; Lloyd, S | 1 |
| Jahoor, F; Shangraw, RE | 1 |
| Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T | 1 |
| Bao, H; Kasten, SA; Roche, TE; Yan, X | 1 |
| Adams, GA; Burgess, SC; Chao, RY; Hamilton, TT; He, TT; Jessen, ME; Koshy, S; Meyer, DM; Peltz, M | 1 |
| Barrientos, A; Bayona-Bafaluy, MP; Enriquez, JA; Fernández-Silva, P; Perales-Clemente, E; Pérez-Martos, A | 1 |
| Ballal, K; Berkich, DA; Fasano, M; Lanoue, KF; Lewandowski, ED; O'Donnell, JM; Pound, KM; Sorokina, N; Taegtmeyer, H | 1 |
| Sack, MN | 1 |
| Grant, A; Lenkinski, R; Seth, P; Sukhatme, VP; Tang, J; Vinogradov, E; Wang, X | 1 |
| Kakimoto, N; Katayama, K; Koga, Y; Matsuishi, T; Naito, E; Povalko, N; Tanaka, M | 1 |
| Babu, E; CoothanKandaswamy, V; Elangovan, S; Ganapathy, V; Prasad, PD; Ramachandran, S; Thangaraju, M | 1 |
| Bruchelt, G; Deubzer, B; Handgretinger, R; Krampen, L; Kuçi, Z; Niewisch, MR; Sautter, M; Wolburg, H | 1 |
| Bok, R; Hu, S; Kurhanewicz, J; Vigneron, DB; Yoshihara, HA; Zhou, J; Zhu, M | 1 |
| Bok, RA; Hu, S; Keselman, P; Kurhanewicz, J; Larson, PE; Leach, AM; Leon, C; Nelson, SJ; Park, I; Reed, G; Shin, PJ; Vancriekinge, M; Vigneron, DB; von Morze, C; Yoshihara, H; Zhou, J | 1 |
| Luft, FC | 1 |
| Ashrafian, H; Ball, V; Bray, R; Clarke, K; Dodd, MS; Tyler, DJ; Watkins, H | 1 |
| Hurd, R; Josan, S; Mayer, D; Park, JM; Pfefferbaum, A; Spielman, D; Yen, YF | 1 |
| Coats, BS; Dunbar, EM; Forder, JR; Langaee, T; Lew, A; Shroads, AL; Shuster, JJ; Stacpoole, PW; Wagner, DA | 1 |
| Brooks, DM; Jaimes, R; Kay, MW; Kuzmiak-Glancy, S; Posnack, NG; Swift, LM | 1 |
| Bendahan, D; Chung, Y; Hurd, RE; Josan, S; Jue, T; Mayer, D; Park, JM; Spielman, DM | 1 |
| Choi, SC; Croker, BP; Kanda, N; Morel, L; Xu, Z; Yin, Y; Zeumer, L | 1 |
| Bol, A; Brender, JR; De Preter, G; Feron, O; Gallez, B; Grégoire, V; Jordan, BF; Joudiou, N; Kishimoto, S; Krishna, MC; Neveu, MA; Saito, K | 1 |
| Stacpoole, PW | 1 |
| Hu, X; Tam, KY; Zhang, W; Zhou, W | 1 |
| Angus, DC; Bakalov, V; Chang, CH; Deshpande, R; Kaynar, AM; Le Moyec, L; Maloy, AL; Reyes-Uribe, L; Shapiro, SD; Wendell, SG | 1 |
| Bertelsen, LB; Bøgh, N; Hansen, ESS; Laustsen, C; Miller, J; Ringgaard, S; Wohlfart, P | 1 |
| Choi, BY; Choi, HC; Hong, DK; Kang, BS; Kho, AR; Lee, SH; Park, MK; Song, HK; Suh, SW | 1 |
1 review(s) available for dichloroacetic acid and pyruvic acid
| Article | Year |
|---|---|
Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Biomimetics; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Glycolysis; Humans; Isoenzymes; Mitochondria; NAD; Neoplasms; Oxidative Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid | 2017 |
4 trial(s) available for dichloroacetic acid and pyruvic acid
| Article | Year |
|---|---|
Dichloroacetate inhibits peripheral efflux of pyruvate and alanine during hormonally simulated catabolic stress.
Topics: Adult; Alanine; Dichloroacetic Acid; Epinephrine; Glucagon; Glucose; Humans; Hydrocortisone; Male; Muscle Proteins; Nitrogen; Pyruvates; Pyruvic Acid; Wounds and Injuries | 1993 |
Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis.
Topics: Adult; Alanine; C-Peptide; Dichloroacetic Acid; Female; Gas Chromatography-Mass Spectrometry; Glucagon; Humans; Insulin; Kinetics; Lactates; Liver; Liver Cirrhosis; Male; Oxidation-Reduction; Pyruvic Acid | 2004 |
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.
Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dichloroacetic Acid; Female; Headache; Humans; Hypocalcemia; Lactic Acid; MELAS Syndrome; Mitochondria; Muscle Weakness; Peripheral Nervous System Diseases; Pyruvic Acid; Stroke; Time Factors; Treatment Outcome | 2004 |
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brain Neoplasms; Breath Tests; Dichloroacetic Acid; Female; Glutathione Transferase; Haplotypes; Humans; Male; Maleates; Middle Aged; Pyruvic Acid | 2014 |
58 other study(ies) available for dichloroacetic acid and pyruvic acid
| Article | Year |
|---|---|
Effects of dichloroacetate on hemodynamic responses to dynamic exercise in dogs.
Topics: Adaptation, Physiological; Animals; Cardiac Output; Dichloroacetic Acid; Dogs; Epinephrine; Hemodynamics; Lactates; Lactic Acid; Male; Norepinephrine; Oxygen Consumption; Physical Exertion; Pyruvates; Pyruvic Acid | 1992 |
Multiple abnormalities in insulin responses to nonglucose nutrients in neonatally streptozotocin diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Caprylates; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Drug Synergism; Fatty Acids, Nonesterified; Female; Glucose; Glutamine; Insulin; Insulin Secretion; Male; Pancreas; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Succinates; Succinic Acid | 1991 |
Isotopic evaluation of the metabolism of pyruvate and related substrates in normal adult volunteers and severely burned children: effect of dichloroacetate and glucose infusion.
Topics: Absorption; Adult; Alanine; Burns; Carbon Isotopes; Child; Child, Preschool; Dichloroacetic Acid; Energy Metabolism; Glucose; Humans; Infusions, Intravenous; Lactates; Lactic Acid; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Reference Values | 1991 |
Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS.
Topics: Acidosis, Lactic; Administration, Oral; Adult; Auditory Perception; Dichloroacetic Acid; Hallucinations; Humans; Lactates; Lactic Acid; Male; Mitochondria, Muscle; Neurocognitive Disorders; Neuromuscular Diseases; Pyruvates; Pyruvic Acid; Syndrome; Visual Perception | 1991 |
Myocardial metabolic effects of in vivo hydralazine treatment of streptozotocin-diabetic rats.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Female; Glucose; Heart; Hydralazine; Male; Myocardium; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Triglycerides | 1991 |
Glucose requirement for postischemic recovery of perfused working heart.
Topics: Animals; Blood Pressure; Coronary Disease; Cytosol; Dichloroacetic Acid; Energy Metabolism; Glucose; Glycolysis; Guinea Pigs; Heart Rate; Hemodynamics; Kinetics; Lactates; Liver Glycogen; Male; Myocardial Contraction; Myocardial Reperfusion; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Statistics as Topic | 1990 |
Pyruvate dehydrogenase activity in the rat cerebral cortex following cerebral ischemia.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Carotid Arteries; Cerebral Cortex; Dichloroacetic Acid; Energy Metabolism; Enzyme Activation; Glucose; Glycolysis; Ischemic Attack, Transient; Kinetics; Male; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1989 |
Effect of sodium dichloroacetate on human pyruvate metabolism.
Topics: Acetates; Acidosis, Lactic; Adolescent; Blood Platelets; Dichloroacetic Acid; Humans; Male; Muscular Diseases; Pyruvates; Pyruvic Acid | 1989 |
Detection of pyruvate metabolism disorders by culture of skin fibroblasts with dichloroacetate.
Topics: Acetates; Acidosis, Lactic; Cells, Cultured; Child; Dichloroacetic Acid; Enzyme Activation; Female; Fibroblasts; Humans; Infant; Male; Mitochondria; Phosphoprotein Phosphatases; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid | 1988 |
Renal effects of dichloroacetate in vivo.
Topics: Acetates; Acidosis, Lactic; Administration, Oral; Child, Preschool; Dichloroacetic Acid; Gas Chromatography-Mass Spectrometry; Humans; Kidney; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid | 1986 |
Monolayer culture of parenchymal rat hepatocytes on collagen-coated microcarriers. A hepatocyte system for short- and long-term metabolic studies.
Topics: Animals; Blood; Calcium; Collagen; Culture Media; Culture Techniques; Dichloroacetic Acid; Fatty Acids; Glucose; Insulin; Leucine; Liver; Liver Glycogen; Magnesium; Male; Methods; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Effect of insulin on ketogenesis and fatty acid synthesis in rat hepatocytes incubated with dichloroacetate.
Topics: Acetates; Acetyl Coenzyme A; Animals; Carbon Dioxide; Citrates; Citric Acid; Dichloroacetic Acid; Enzyme Activation; Fatty Acids; Female; Insulin; Ketone Bodies; Liver; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1985 |
Differential effect of dichloroacetate on branched-chain amino acid catabolism in perfused rat hindlimbs.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Acetates; Amino Acids, Branched-Chain; Animals; Carbon Dioxide; Dichloroacetic Acid; Hindlimb; Ketone Oxidoreductases; Leucine; Multienzyme Complexes; Muscles; Pyruvates; Pyruvic Acid; Rats; Valine | 1985 |
Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal-muscle mitochondria. Effects of starvation and diabetes.
Topics: Adenosine Triphosphate; Animals; Calcium; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Enzyme Activation; In Vitro Techniques; Mitochondria, Muscle; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase (Lipoamide)-Phosphatase; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Starvation | 1984 |
Effects of dichloroacetate on the lactate/pyruvate ratio and on aspartate and leucine metabolism in cultured rat skeletal muscle cells.
Topics: Acetates; Animals; Aspartic Acid; Carbon Dioxide; Cells, Cultured; Culture Media; Dichloroacetic Acid; Lactates; Lactic Acid; Leucine; Male; Muscles; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Different effects of interventions suppressing free fatty acid metabolism on myocardial ischemia.
Topics: Animals; Coronary Disease; Dichloroacetic Acid; Dogs; Fatty Acids, Nonesterified; Glucose; Hemodynamics; Infusions, Parenteral; Insulin; Lactates; Lactic Acid; Mannitol; Myocardium; Potassium; Pyruvates; Pyruvic Acid | 1984 |
Effects of dichloroacetate on pyruvate metabolism in rat brain in vivo.
Topics: Acetates; Animals; Blood Glucose; Brain; Dichloroacetic Acid; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Lactates; Lactic Acid; Liver; Male; Muscles; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1984 |
Evidence for the compartmentation of pyruvate metabolism in perfused rat skeletal muscle.
Topics: Animals; Cell Compartmentation; Decarboxylation; Dichloroacetic Acid; Hindlimb; In Vitro Techniques; Lactates; Muscles; Perfusion; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1983 |
Prolonged hypolactatemia and increased total pyruvate dehydrogenase activity by dichloroacetate.
Topics: Acetates; Animals; Blood Glucose; Dichloroacetic Acid; Glyoxylates; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Oxalates; Oxalic Acid; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Dichloroacetate: effects on exercise endurance in untrained rats.
Topics: 3-Hydroxybutyric Acid; Acetates; Adenosine Triphosphate; Animals; Dichloroacetic Acid; Glycogen; Hydroxybutyrates; Lactates; Lactic Acid; Male; Muscles; Phosphocreatine; Physical Exertion; Pyruvates; Pyruvic Acid; Rats; Time Factors | 1981 |
Phosphorylation-mediated changes in pyruvate dehydrogenase activity influence pyruvate-supported calcium accumulation by brain mitochondria.
Topics: Adenosine Triphosphate; Animals; Brain; Calcium; Dichloroacetic Acid; Mitochondria; Phosphorylation; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Succinates; Succinic Acid | 1981 |
Glycolysis vs. respiration as ATP source for the shape of quiescent cardiomyocytes.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Cell Separation; Cell Size; Deoxyglucose; Dichloroacetic Acid; Dinitrophenols; Glycolysis; Iodoacetates; Iodoacetic Acid; Isoproterenol; Male; Myocardium; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Respiration; Sodium Cyanide | 1994 |
Mitochondrial pyruvate transport in working guinea-pig heart. Work-related vs. carrier-mediated control of pyruvate oxidation.
Topics: Adrenergic Agonists; Animals; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Coumaric Acids; Dichloroacetic Acid; Glucose; Guinea Pigs; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Mitochondria, Heart; Monocarboxylic Acid Transporters; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Sarcolemma; Ventricular Function | 1993 |
Interrelationships between ureogenesis and gluconeogenesis in perfused rat liver.
Topics: Ammonium Chloride; Animals; Dichloroacetic Acid; Gluconeogenesis; Glucose; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Liver; Male; Oleic Acid; Oleic Acids; Ornithine; Perfusion; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar; Time Factors; Urea | 1993 |
Therapeutic efficacy of a case of pyruvate dehydrogenase complex deficiency monitored by localized proton magnetic resonance spectroscopy.
Topics: Brain; Brain Chemistry; Dichloroacetic Acid; Humans; Infant; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid | 1996 |
Use of labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis.
Topics: Animals; Citric Acid Cycle; Dichloroacetic Acid; Enzyme Inhibitors; Glucagon; Gluconeogenesis; Glutamic Acid; Lactic Acid; Liver; Methods; Osmolar Concentration; Picolinic Acids; Pyruvate Kinase; Pyruvic Acid; Rats | 1997 |
Dichloroacetate inhibits glutamine oxidation by decreasing pyruvate availability for transamination.
Topics: Alanine; Animals; Cell Line; Cell Survival; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glutamine; Hybridomas; Oxidation-Reduction; Pyruvic Acid; Time Factors | 1997 |
Activation of pyruvate dehydrogenase improves heart function and metabolism after hemorrhagic shock.
Topics: Adenosine Triphosphate; Animals; Arteries; Blood Chemical Analysis; Blood Pressure; Dichloroacetic Acid; Energy Metabolism; Heart; Hemodynamics; Lactic Acid; Male; Myocardium; Phosphates; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Ventricular Function | 1997 |
Dynamic 13C NMR analysis of pyruvate and lactate oxidation in the in vivo canine myocardium: evidence of reduced utilization with increased work.
Topics: Animals; Carbon Radioisotopes; Citric Acid Cycle; Dichloroacetic Acid; Dogs; Glutamic Acid; Heart; Lactic Acid; Magnetic Resonance Spectroscopy; Myocardium; Oxidation-Reduction; Pyruvic Acid | 1997 |
Altered K+ current of ventricular myocytes in rats with chronic myocardial infarction.
Topics: Animals; Cardiomegaly; Cells, Cultured; Coronary Vessels; Dichloroacetic Acid; Evoked Potentials; Heart; Heart Failure; Heart Ventricles; Lung; Male; Membrane Potentials; Myocardial Infarction; Myocardium; Organ Size; Potassium Channels; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors | 1998 |
Effects of dichloroacetate on mechanical recovery and oxidation of physiologic substrates after ischemia and reperfusion in the isolated heart.
Topics: Acetoacetates; Animals; Dichloroacetic Acid; Fatty Acids; Glucose; Heart; In Vitro Techniques; Lactates; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidation-Reduction; Oxygen; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1998 |
The importance of pyruvate availability to PDC activation and anaplerosis in human skeletal muscle.
Topics: Adult; Biological Availability; Citric Acid Cycle; Dichloroacetic Acid; Enzyme Activation; Epinephrine; Heart Rate; Hormones; Humans; Injections, Intravenous; Male; Muscle, Skeletal; Pyruvate Dehydrogenase Complex; Pyruvic Acid | 1999 |
Marked differences between two isoforms of human pyruvate dehydrogenase kinase.
Topics: Acetyl Coenzyme A; Acetylation; Acetyltransferases; Binding Sites; Buffers; Dichloroacetic Acid; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; NAD; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Recombinant Proteins | 2000 |
Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest.
Topics: Adenosine Triphosphate; Animals; Dichloroacetic Acid; Energy Metabolism; Heart; Heart Arrest, Induced; Magnetic Resonance Spectroscopy; Male; Myocardial Reperfusion; Myocardium; Phosphates; Phosphocreatine; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2001 |
Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans.
Topics: Adult; Dichloroacetic Acid; Enzyme Activation; Humans; Lactic Acid; Male; Muscle, Skeletal; Oxygen; Oxygen Consumption; Phosphocreatine; Physical Exertion; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Regional Blood Flow; Thigh | 2002 |
Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.
Topics: Acetyl Coenzyme A; Alanine; Animals; Buffers; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Glucose; Heart; Heart Function Tests; Heart Rate; Hypoglycemic Agents; In Vitro Techniques; Insulin; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardium; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2003 |
Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.
Topics: Acetyl Coenzyme A; Acetyltransferases; Adenosine Diphosphate; Adenosine Triphosphate; Binding, Competitive; Catalysis; Dichloroacetic Acid; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Activation; Humans; Isoenzymes; Kinetics; Osmolar Concentration; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein Subunits; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Substrate Specificity | 2004 |
Lung preservation solution substrate composition affects rat lung oxidative metabolism during hypothermic storage.
Topics: Adenosine Triphosphate; Animals; Cryoprotective Agents; Dichloroacetic Acid; Energy Metabolism; Glucose; Lung; Lung Transplantation; Male; Organ Preservation; Organ Preservation Solutions; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric | 2005 |
Restoration of electron transport without proton pumping in mammalian mitochondria.
Topics: Animals; Cell Line; Dichloroacetic Acid; DNA, Mitochondrial; Electron Transport; Electron Transport Complex I; Fungal Proteins; Humans; Lactic Acid; Mice; Mitochondria; Mitochondrial Proteins; NADH Dehydrogenase; Oxidation-Reduction; Oxidoreductases; Oxygen; Plant Proteins; Proton Pumps; Protons; Pyruvic Acid; Saccharomyces cerevisiae Proteins; Transformation, Genetic; Ubiquinone; Uridine | 2008 |
Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy.
Topics: Animals; Cardiomegaly; Citric Acid Cycle; Dichloroacetic Acid; Humans; Ketone Oxidoreductases; Malate Dehydrogenase; Male; Myocardium; NADP; Perfusion; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Triglycerides | 2009 |
Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis.
Topics: Animals; Cardiomegaly; Citric Acid Cycle; Dichloroacetic Acid; Humans; Ketone Oxidoreductases; Malate Dehydrogenase; Male; Mitochondria, Heart; Myocardium; NADP; Perfusion; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Triglycerides | 2009 |
On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Down-Regulation; Enzyme Activation; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Magnetic Resonance Imaging; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvic Acid; Reactive Oxygen Species; RNA Interference; Tumor Burden | 2011 |
Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene.
Topics: Alanine; Cells, Cultured; Child, Preschool; Dichloroacetic Acid; Electroencephalography; Fibroblasts; Humans; Lactic Acid; Leigh Disease; Male; Mutation; Pyruvate Dehydrogenase (Lipoamide); Pyruvic Acid; Statistics, Nonparametric | 2012 |
Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cation Transport Proteins; Cell Line, Tumor; Dichloroacetic Acid; Humans; Membrane Transport Proteins; Monocarboxylic Acid Transporters; Pyruvic Acid; Sodium; Tumor Suppressor Proteins; Xenopus laevis | 2011 |
Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy?
Topics: Acetyl Coenzyme A; Apoptosis; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Culture Media; Dichloroacetic Acid; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Lactic Acid; Mitochondria; Neuroblastoma; Oxidative Phosphorylation; Oxygen; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Reactive Oxygen Species | 2012 |
Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat.
Topics: Acetoacetates; Acetylcarnitine; Animals; Antineoplastic Agents; Carbon Isotopes; Catalysis; Dichloroacetic Acid; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Mitochondria; Models, Biological; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2012 |
Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer.
Topics: Animals; Carbon Isotopes; Dichloroacetic Acid; Image Enhancement; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metabolic Clearance Rate; Molecular Imaging; Organ Specificity; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution | 2013 |
Finding a job for dichloroacetate.
Topics: Dichloroacetic Acid; Humans; Metabolic Networks and Pathways; Pyruvate Dehydrogenase (Lipoamide)-Phosphatase; Pyruvate Dehydrogenase Complex; Pyruvic Acid | 2013 |
In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy.
Topics: Animals; Carbon Isotopes; Dichloroacetic Acid; Energy Metabolism; Fasting; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Myocardium; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Wistar; Species Specificity; Time Factors | 2013 |
In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate.
Topics: Animals; Carbon Isotopes; Dichloroacetic Acid; Dobutamine; Magnetic Resonance Spectroscopy; Male; Myocardium; Pyruvic Acid; Rats; Rats, Wistar; Time Factors | 2013 |
Functional response of the isolated, perfused normoxic heart to pyruvate dehydrogenase activation by dichloroacetate and pyruvate.
Topics: Animals; Calcium; Dichloroacetic Acid; Glucose; Heart; Isolated Heart Preparation; Myocardial Contraction; Myocardium; NAD; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Ventricular Function | 2016 |
Hyperpolarized 13C NMR observation of lactate kinetics in skeletal muscle.
Topics: Animals; Bicarbonates; Carbon-13 Magnetic Resonance Spectroscopy; Dichloroacetic Acid; Glutamic Acid; Lactic Acid; Male; Muscle, Skeletal; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2015 |
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Glucose; Interferon-gamma; Interleukin-17; Lactic Acid; Lupus Erythematosus, Systemic; Lymphocyte Activation; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pyruvic Acid | 2016 |
Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Energy Metabolism; Enzyme Inhibitors; Female; Glycolysis; Humans; Lactic Acid; Magnetic Resonance Imaging; Oxidation-Reduction; Oxygen Consumption; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvic Acid; Time Factors; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors.
Topics: A549 Cells; Acetyl Coenzyme A; Anilides; Antineoplastic Agents; Chromatography, Liquid; Citric Acid Cycle; Cytosol; Dichloroacetic Acid; Gene Expression Regulation; Glucose; Glycolysis; Humans; Isoenzymes; Lactic Acid; Mitochondria; Oxidative Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvic Acid; Tandem Mass Spectrometry | 2018 |
Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.
Topics: Acetyl Coenzyme A; Animals; Citric Acid Cycle; Dichloroacetic Acid; Drosophila melanogaster; Glycolysis; Inflammation; Lactic Acid; Longevity; Oxidative Phosphorylation; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Sepsis | 2020 |
Concentration-dependent effects of dichloroacetate in type 2 diabetic hearts assessed by hyperpolarized [1-
Topics: Acetates; Animals; Bicarbonates; Diabetes Mellitus, Type 2; Dichloroacetic Acid; Heart; Magnetic Resonance Imaging; Pyruvic Acid; Rats | 2022 |
Combined Treatment of Dichloroacetic Acid and Pyruvate Increased Neuronal Survival after Seizure.
Topics: Adenosine Triphosphate; Animals; Dichloroacetic Acid; Glucose; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Seizures | 2022 |