Page last updated: 2024-08-17

dichloroacetic acid and phosphocreatine

dichloroacetic acid has been researched along with phosphocreatine in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (13.33)	18.7374
1990's	6 (40.00)	18.2507
2000's	6 (40.00)	29.6817
2010's	1 (6.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abiko, H; Chang, LH; Faden, AI; James, TL; Shimizu, H; Swanson, RA; Weinstein, PR	1
Mizushima, M	1
Burns, AH; Racey-Burns, LA; Shepherd, RE; Summer, WR	1
Goodman, MN; Komanicky, PM; Ruderman, NB; Schneider, SH	1
Brown, RA; Curry, S; Peeling, J; Sutherland, G	1
Constantin-Teodosiu, D; Greenhaff, PL; Macdonald, IA; Poucher, SM; Timmons, JA	1
Chwalbinska-Moneta, J; Constantin-Teodosiu, D; Greenhaff, PL; Gustafsson, T; Hultman, E; Jansson, E; Kaijser, L; Macdonald, IA; Sundberg, CJ; Timmons, JA	1
Greenhaff, PL; Gustafsson, T; Jansson, E; Sundberg, CJ; Timmons, JA	1
Heigenhauser, GJ; Hollidge-Horvat, MG; Hultman, E; Jones, NL; Matsos, MP; Parolin, ML; Spriet, LL	1
Amrani, M; Goodwin, AT; Gray, CC; Jagodzinski, P; Jayakumar, J; Sammut, IA; Smolenski, RT; Yacoub, MH	1
Bangsbo, J; Gibala, MJ; González-Alonso, J; Krustrup, P; Saltin, B	1
Evans, MK; Heigenhauser, GJ; Savasi, I; Spriet, LL	1
Griffiths, JR; Howe, FA; Kowalchuk, JM; Rossiter, HB; Ward, SA; Whipp, BJ; Wood, DM	1
Constantin-Teodosiu, D; Greenhaff, PL; Poucher, SM; Timmons, JA	1
Boobis, L; Bowtell, J; Casey, E; Constantin-Teodosiu, D; Marwood, S; Whyte, M	1

Trials

2 trial(s) available for dichloroacetic acid and phosphocreatine

Article	Year
Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia. American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:4 Topics: Acetyl Coenzyme A; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Blood Glucose; Blood Pressure; Dichloroacetic Acid; Glycogen; Glycolysis; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Phosphocreatine; Phosphorylases; Physical Exertion; Pyruvate Dehydrogenase Complex; Respiratory Function Tests	2000
Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise. American journal of physiology. Endocrinology and metabolism, 2002, Volume: 283, Issue:1 Topics: Adult; Biopsy, Needle; Dichloroacetic Acid; Enzyme Activation; Exercise; Humans; Hyperoxia; Infusions, Intravenous; Lactic Acid; Male; Muscle, Skeletal; Oxidative Phosphorylation; Phosphocreatine; Phosphorylation; Physical Exertion; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Reference Values	2002

Article

Year

Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.

American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:4

Topics: Acetyl Coenzyme A; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Blood Glucose; Blood Pressure; Dichloroacetic Acid; Glycogen; Glycolysis; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Phosphocreatine; Phosphorylases; Physical Exertion; Pyruvate Dehydrogenase Complex; Respiratory Function Tests

2000

Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise.

American journal of physiology. Endocrinology and metabolism, 2002, Volume: 283, Issue:1

Topics: Adult; Biopsy, Needle; Dichloroacetic Acid; Enzyme Activation; Exercise; Humans; Hyperoxia; Infusions, Intravenous; Lactic Acid; Male; Muscle, Skeletal; Oxidative Phosphorylation; Phosphocreatine; Phosphorylation; Physical Exertion; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Reference Values

2002

Other Studies

13 other study(ies) available for dichloroacetic acid and phosphocreatine

Article	Year
Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1992, Volume: 12, Issue:6 Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cations; Dichloroacetic Acid; Disease Models, Animal; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Water	1992
[Effects of dichloroacetate in the ischemic heart. Analysis of hemodynamics, myocardial energy metabolism and myocardial pH]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1990, Volume: 65, Issue:3 Topics: Acetates; Adenine Nucleotides; Animals; Coronary Disease; Dichloroacetic Acid; Dogs; Energy Metabolism; Glycolysis; Hemodynamics; Hydrogen-Ion Concentration; Myocardium; Phosphocreatine	1990
The effect of dichloroacetate on the isolated no flow arrested rat heart. Life sciences, 1989, Volume: 44, Issue:26 Topics: Acetates; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dichloroacetic Acid; In Vitro Techniques; Lactates; Male; Myocardial Contraction; Myocardium; Phosphocreatine; Pyruvate Dehydrogenase Complex; Rats	1989
Dichloroacetate: effects on exercise endurance in untrained rats. Metabolism: clinical and experimental, 1981, Volume: 30, Issue:6 Topics: 3-Hydroxybutyric Acid; Acetates; Adenosine Triphosphate; Animals; Dichloroacetic Acid; Glycogen; Hydroxybutyrates; Lactates; Lactic Acid; Male; Muscles; Phosphocreatine; Physical Exertion; Pyruvates; Pyruvic Acid; Rats; Time Factors	1981
Protective effect of dichloroacetate in a rat model of forebrain ischemia. Neuroscience letters, 1996, Apr-12, Volume: 208, Issue:1 Topics: Adenosine Triphosphate; Animals; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Dichloroacetic Acid; Hippocampus; Male; Neostriatum; Phosphocreatine; Prosencephalon; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley	1996
Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle. The American journal of physiology, 1997, Volume: 273, Issue:2 Pt 1 Topics: Acetylcarnitine; Animals; Dichloroacetic Acid; Dogs; Homeostasis; In Vitro Techniques; Ischemia; Muscle Contraction; Muscle, Skeletal; NAD; Phosphocreatine; Regional Blood Flow; Rest; Time Factors	1997
Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise. The Journal of clinical investigation, 1998, Jan-01, Volume: 101, Issue:1 Topics: Acetylcarnitine; Adenosine Triphosphate; Adult; Blood Glucose; Cardiovascular Physiological Phenomena; Dichloroacetic Acid; Exercise; Glycogen; Humans; Lactic Acid; Male; Muscle, Skeletal; Phosphocreatine; Pyruvate Dehydrogenase Complex; Time Factors	1998
Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise. The American journal of physiology, 1998, Volume: 274, Issue:2 Topics: Acetylation; Adenosine Triphosphate; Adult; Blood Glucose; Dichloroacetic Acid; Enzyme Activation; Exercise; Humans; Lactic Acid; Male; Mitochondria, Muscle; Muscle, Skeletal; Oxygen Consumption; Phosphocreatine; Pyruvate Dehydrogenase Complex	1998
Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2001, Volume: 19, Issue:6 Topics: Adenosine Triphosphate; Animals; Dichloroacetic Acid; Energy Metabolism; Heart; Heart Arrest, Induced; Magnetic Resonance Spectroscopy; Male; Myocardial Reperfusion; Myocardium; Phosphates; Phosphocreatine; Pyruvic Acid; Rats; Rats, Sprague-Dawley	2001
Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:1 Topics: Adult; Dichloroacetic Acid; Enzyme Activation; Humans; Lactic Acid; Male; Muscle, Skeletal; Oxygen; Oxygen Consumption; Phosphocreatine; Physical Exertion; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Regional Blood Flow; Thigh	2002
Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans. Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 95, Issue:3 Topics: Adenosine Triphosphate; Adult; Algorithms; Dichloroacetic Acid; Exercise; Humans; Hydrogen-Ion Concentration; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Models, Biological; Muscle, Skeletal; Oxygen Consumption; Phosphates; Phosphocreatine; Pulmonary Gas Exchange; Pyruvate Dehydrogenase Complex	2003
Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction. The Journal of physiology, 2004, Dec-15, Volume: 561, Issue:Pt 3 Topics: Adenosine Triphosphate; Animals; Dichloroacetic Acid; Dogs; Enzyme Activation; Muscle Contraction; Muscle Fatigue; Muscles; Phosphocreatine; Pyruvate Dehydrogenase Complex	2004
No acetyl group deficit is evident at the onset of exercise at 90% of maximal oxygen uptake in humans. Journal of sports sciences, 2010, Volume: 28, Issue:3 Topics: Acetylation; Acetylcarnitine; Adenosine Triphosphate; Adult; Creatine; Dichloroacetic Acid; Energy Metabolism; Exercise; Glycogen; Humans; Infusions, Intravenous; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Phosphocreatine; Phosphorylation; Pulmonary Gas Exchange; Pyruvate Dehydrogenase Complex	2010