dichloroacetic acid has been researched along with azd 7545 in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, GQ; Fan, SH; Lu, J; Shan, Q; Wang, YJ; Wu, DM; Zhang, ZF; Zheng, YL | 1 |
| Chuang, DT; Chuang, JL; Kato, M; Li, J | 1 |
| Ishiguro, J; Makita, N; Nara, F; Suzuki, K | 1 |
| Hu, X; Tam, KY; Zhang, W; Zhou, W | 1 |
4 other study(ies) available for dichloroacetic acid and azd 7545
| Article | Year |
|---|---|
High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Assays; Glucose; Heterografts; HSP90 Heat-Shock Proteins; Humans; Mice; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Small Molecule Libraries | 2019 |
Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.
Topics: Amino Acid Motifs; Amino Acid Sequence; Anilides; Binding Sites; Crystallography, X-Ray; Dichloroacetic Acid; Dimerization; Dose-Response Relationship, Drug; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Isoenzymes; Macrolides; Models, Molecular; Molecular Structure; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Solubility; Spectrum Analysis, Raman | 2007 |
Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism.
Topics: Anilides; Animals; Cell Differentiation; Cell Proliferation; Dichloroacetic Acid; Enzyme Inhibitors; Male; Mice, Inbred C57BL; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species; T-Lymphocytes, Regulatory; Th17 Cells | 2017 |
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors.
Topics: A549 Cells; Acetyl Coenzyme A; Anilides; Antineoplastic Agents; Chromatography, Liquid; Citric Acid Cycle; Cytosol; Dichloroacetic Acid; Gene Expression Regulation; Glucose; Glycolysis; Humans; Isoenzymes; Lactic Acid; Mitochondria; Oxidative Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvic Acid; Tandem Mass Spectrometry | 2018 |