dicarbethoxydihydrocollidine has been researched along with heme in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (65.00) | 18.7374 |
| 1990's | 8 (20.00) | 18.2507 |
| 2000's | 3 (7.50) | 29.6817 |
| 2010's | 3 (7.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liem, H; Muller-Eberhard, U; Smith, A | 1 |
| De Matteis, F; Gibbs, AH; Tephly, TR | 1 |
| Badawy, AA | 1 |
| Liem, HH; Miyai, K; Muller-Eberhard, U | 1 |
| Bickers, DR; Harber, LC; Kappas, A; Keogh, L | 1 |
| De Matteis, F | 2 |
| Kimmett, SM; Mackie, JE; Marks, GS; McCluskey, SA; Riddick, DS; Whitney, RA | 1 |
| Marks, GS; Riddick, DS | 1 |
| Mackie, JE; Marks, GS; Massey, TE; Riddick, DS | 1 |
| Atsmon, A; Bomstein, Y; Mamet, R; Mevasser, R; Schoenfeld, N | 1 |
| Atsmon, A; Bomstein, Y; Lahav, M; Mamet, R; Mevasser, R; Schoenfeld, N | 1 |
| Gelboin, HV; Marks, GS; Park, SS; Riddick, DS | 2 |
| Correia, MA; Lunetta, JM | 1 |
| Bement, WJ; Hamilton, JW; Sinclair, JF; Sinclair, PR; Wetterhahn, KE | 1 |
| Jenkins, TM; Weitzman, PD | 1 |
| Dailey, HA; Fadigan, A | 1 |
| Bornheim, L; Caldera, P; Correia, MA; Decker, C; Rettie, AE; Sugiyama, K; Trager, WF; Wrighton, SA | 1 |
| Allen, DT; Marks, GS; McCluskey, SA; Sutherland, EP; Whitney, RA | 1 |
| Jacobsen, N; Marks, GS; McCluskey, SA; Ortiz de Montellano, PR; Sutherland, EP | 1 |
| Ades, IZ; Drew, PD | 1 |
| Allen, DT; Johnston, CT; Marks, GS; Nakatsu, K; Sutherland, EP; Whitney, RA | 1 |
| Hayashi, N; Kikuchi, G | 1 |
| De Matteis, F; Gibbs, AH; Hollands, C | 1 |
| de Matteis, F; de Sa, N; Gibbs, AH; Hollands, C; Rizzardini, M | 1 |
| Bickers, DR | 1 |
| Cole, SP; Marks, GS; Zelt, DT | 1 |
| De Matteis, F; Smith, AG | 1 |
| de Matteis, F; Gibbs, AH; Jackson, AH; Weerasinghe, S | 1 |
| Hayashi, N; Kikuchi, G; Terasawa, M; Yamauchi, K | 1 |
| Brooker, JD; Elliott, WH; Lim, LK; May, BK; Srivastava, G | 1 |
| Correia, MA; He, K; Licad-Coles, E; Yin, H | 1 |
| Martini, CN; Romero, DG; San Martín de Viale, L; Vaena de Avalos, SG; Vila, Mde C | 1 |
| Correia, MA; Ren, S | 1 |
| Lelli, SM; Mazzetti, MB; San Martín de Viale, LC | 1 |
| Austin, LM; Burk, RF; Ferris, CD; Hill, KE; Levander, XA; Mostert, V; Nakayama, A | 1 |
| Chen, H; Gerhard, GS; Zhang, S | 1 |
| Faut, M; Mazzetti, MB; Paiz, A; San Martín de Viale, LC | 1 |
| Itoh, T; Masui, S; Miyajima, A; Taguchi, K; Yamamoto, M | 1 |
3 review(s) available for dicarbethoxydihydrocollidine and heme
| Article | Year |
|---|---|
The effect of drugs on 5-aminolaevulinate synthetase and other enzymes in the pathway of liver haem biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Animals; Animals, Newborn; Cycloheximide; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Enzyme Induction; Griseofulvin; Heme; Liver; Microsomes, Liver; Pharmacology; Phenylbutazone; Porphyrias; Porphyrins; Proadifen; Protein Biosynthesis | 1975 |
Toxicological aspects of liver heme biosynthesis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Ferrochelatase; Heme; Hexachlorobenzene; Liver; Porphyrias; Protoporphyrins; Rats; Rats, Gunn | 1988 |
Regulation by heme of synthesis and intracellular translocation of delta-aminolevulinate synthase in the liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biological Transport; Cell-Free System; Cobalt; Cytosol; Dicarbethoxydihydrocollidine; Heme; Hemin; Immunodiffusion; Leucine; Liver; Mitochondria, Liver; Molecular Weight; Protoporphyrins; Rabbits; Rats; Tryptophan Oxygenase | 1981 |
37 other study(ies) available for dicarbethoxydihydrocollidine and heme
| Article | Year |
|---|---|
Effect of desferrioxamine and chronic iron deficiency of heme metabolism--comparison with the porphyrogens 2-allyl-2-isopropylacetamide and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Deferoxamine; Dicarbethoxydihydrocollidine; Heme; Iron Deficiencies; Liver; Male; Mitochondria, Liver; Porphyrins; Pyridines; Rats; Time Factors | 1979 |
Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase.
Topics: Animals; Dicarbethoxydihydrocollidine; Enzyme Inhibitors; Heme; Liver; Lyases; Male; Mice; Porphyrias; Porphyrins; Pyridines; Rats | 1979 |
Tryptophan pyrrolase, the regulatory free haem and hepatic porphyrias. Early depletion of haem by clinical and experimental exacerbators of porphyria.
Topics: Animals; Dicarbethoxydihydrocollidine; Heme; Liver; Liver Diseases; Male; Porphyrias; Rats; Tryptophan Oxygenase | 1978 |
Effect of porphyrinogenic agents on protein synthesis and bilirubin formation by the isolated perfused rat liver.
Topics: Acetamides; Adenine Nucleotides; Allylisopropylacetamide; Animals; Bilirubin; Blood Proteins; Chelating Agents; Dicarbethoxydihydrocollidine; Heme; Iron; Liver; Male; Perfusion; Pyridines; Rats | 1977 |
The effect of environmental light exposure on drug-induced porphyria in the rat.
Topics: Animals; Dicarbethoxydihydrocollidine; Disease Models, Animal; Heme; Light; Male; Porphyrias; Porphyrins; Rats; Skin | 1976 |
Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and 4-dodecyl substituents.
Topics: Animals; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Dicarbethoxydihydrocollidine; Ferrochelatase; Heme; In Vitro Techniques; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Zinc | 1992 |
Irreversible binding of heme to microsomal protein during inactivation of cytochrome P450 by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Isoenzymes; Male; Microsomes, Liver; NADP; Phenobarbital; Proteins; Rats; Rats, Inbred Strains | 1990 |
3,5-Diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine inactivates rat liver cytochrome P-450c, but not its orthologue, rabbit lung form 6.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Dicarbethoxydihydrocollidine; Dihydropyridines; Heme; In Vitro Techniques; Isoenzymes; Liver; Lung; Male; Microsomes; Rabbits; Rats; Species Specificity; Triazoles | 1990 |
L-Alanine: 4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver.
Topics: Alanine; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Chick Embryo; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Liver; Male; Phenobarbital; Porphyrins; Rats; Rats, Inbred Strains; Transaminases; Valerates | 1990 |
Regulation of heme synthesis in the regenerating rat liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Dicarbethoxydihydrocollidine; Heme; Liver Regeneration; Male; Rats; Rats, Inbred Strains | 1990 |
Effects of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on hepatic cytochrome P-450 heme, apoproteins, and catalytic activities following in vivo administration to rats.
Topics: Animals; Apoproteins; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Dihydropyridines; Enzyme Induction; Heme; Immunologic Techniques; Male; Microsomes, Liver; Phenobarbital; Rats; Structure-Activity Relationship; Time Factors | 1990 |
Acute hepatic heme depletion: impaired gluconeogenesis in rats.
Topics: Animals; Brain; Dicarbethoxydihydrocollidine; Gluconeogenesis; Glutathione; Glycerol; Heme; Hydroxyindoleacetic Acid; Liver; Phenobarbital; Porphyrias; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1989 |
Effects of a series of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on the major inducible cytochrome P-450 isozymes of rat liver.
Topics: Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Dihydropyridines; Enzyme Induction; Heme; Isoenzymes; Male; NADP; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Cycloheximide; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Dose-Response Relationship, Drug; Enzyme Induction; Heme; Liver; RNA, Messenger | 1988 |
Physiological roles of animal succinate thiokinases. Specific association of the guanine nucleotide-linked enzyme with haem biosynthesis.
Topics: Acyl Coenzyme A; Animals; Bone Marrow; Cattle; Chemical and Drug Induced Liver Injury; Coenzyme A Ligases; Dicarbethoxydihydrocollidine; Female; Gallbladder; Guanosine Triphosphate; Heme; Liver Diseases; Mice; Mitochondria, Liver; Porphyrias; Succinate-CoA Ligases | 1988 |
Inhibition of ferrochelatase during differentiation of murine erythroleukaemia cells.
Topics: Animals; Cations, Divalent; Cell Differentiation; Dicarbethoxydihydrocollidine; Dimethyl Sulfoxide; Ferrochelatase; Heme; Leukemia, Erythroblastic, Acute; Lyases; Mice; Organometallic Compounds; Protoporphyrins | 1987 |
Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts.
Topics: Animals; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Dihydropyridines; Heme; Kinetics; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains | 1987 |
Comparison of the effects of 3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity and heme biosynthesis in chick embryo liver cells in culture.
Topics: Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Ferrochelatase; Heme; Kinetics; Liver; Lyases; Porphyrins; Pyridines; Structure-Activity Relationship | 1986 |
Ferrochelatase-inhibitory activity and N-alkylprotoporphyrin formation with analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) containing extended 4-alkyl groups: implications for the active site of ferrochelatase.
Topics: Alkylation; Animals; Binding Sites; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Dicarbethoxydihydrocollidine; Ferrochelatase; Heme; Liver; Lyases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Protoporphyrins; Pyridines; Structure-Activity Relationship | 1986 |
Regulation of production of embryonic chick liver delta-aminolevulinate synthase: effects of testosterone and of hemin on the mRNA of the enzyme.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Dicarbethoxydihydrocollidine; Heme; Hemin; Liver; RNA, Messenger; Testosterone | 1986 |
Suicidal destruction of cytochrome P-450 and reduction of ferrochelatase activity by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells.
Topics: Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Ferrochelatase; Heme; Liver; Lyases; Nitrophenols; Porphyrins; Pyridines | 1985 |
N-alkylation of the haem moiety of cytochrome P-450 caused by substituted dihydropyridines. Preferential attack of different pyrrole nitrogen atoms after induction of various cytochrome P-450 isoenzymes.
Topics: Alkylation; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; In Vitro Techniques; Isoenzymes; Liver; Male; Phenobarbital; Protoporphyrins; Pyridines; Rats; Rats, Inbred Strains | 1983 |
Inactivation of cytochrome P-450 and production of N-alkylated porphyrins caused in isolated hepatocytes by substituted dihydropyridines. Structural requirements for loss of haem and alkylation of the pyrrole nitrogen atom.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Dicarbethoxydihydrocollidine; Ferrochelatase; Heme; Liver; Male; Mice; Mitochondria, Liver; Porphyrins; Protoporphyrins; Structure-Activity Relationship | 1982 |
Environmental and drug factors in hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Allyl Compounds; Aminolevulinic Acid; Barbiturates; Chemical and Drug Induced Liver Injury; Dicarbethoxydihydrocollidine; Drug-Related Side Effects and Adverse Reactions; Environmental Exposure; Enzyme Activation; Estrogens; Ethanol; Griseofulvin; Heme; Humans; Hydrocarbons, Chlorinated; Iron; Liver; Porphyrias; Porphyrinogens | 1982 |
Comparison of the effects of griseofulvin and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity in chick embryo liver.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Dicarbethoxydihydrocollidine; Ferrochelatase; Griseofulvin; Heme; Liver; Lyases; Porphyrins; Pyridines | 1981 |
Drugs and the hepatic porphyrias.
Topics: Acetamides; Aminolevulinic Acid; Animals; Barbiturates; Cats; Dicarbethoxydihydrocollidine; Dogs; Griseofulvin; Heme; Humans; Hydrocarbons, Halogenated; Hypnotics and Sedatives; Iron; Liver; Liver Diseases; Porphyrias | 1980 |
Conversion of liver haem into N-substituted porphyrins or green pigments. Nature of the substituent at the pyrrole nitrogen atom.
Topics: Animals; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Ethylenes; Heme; Liver; Male; Mass Spectrometry; Mice; Pigments, Biological; Protoporphyrins; Rats; Spectrum Analysis; Zinc | 1980 |
Effects of hemin on the synthesis and intracellular translocation of delta-aminolevulinate synthase in the liver of rats treated with 3,5-dicarbethoxy-1,4-dihydrocollidine.
Topics: 5-Aminolevulinate Synthetase; Animals; Cytosol; Dicarbethoxydihydrocollidine; Enzyme Induction; Female; Heme; Hemin; Mitochondria, Liver; Pyridines; Rats | 1980 |
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Microsomes, Liver; Phenobarbital; Porphyrias; Proadifen | 1980 |
Cytochrome P450 2C11: Escherichia coli expression, purification, functional characterization, and mechanism-based inactivation of the enzyme.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dicarbethoxydihydrocollidine; DNA, Complementary; Enzyme Inhibitors; Escherichia coli; Gene Expression; Heme; In Vitro Techniques; Male; Molecular Sequence Data; Rats; Recombinant Proteins; Sex Characteristics; Spironolactone; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1997 |
Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal.
Topics: 5-Aminolevulinate Synthetase; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Corticosterone; Desoxycorticosterone; Dicarbethoxydihydrocollidine; Ferrochelatase; Heme; Hemin; Liver; Male; Porphyrins; Rats; Rats, Sprague-Dawley | 1997 |
Heme: a regulator of rat hepatic tryptophan 2,3-dioxygenase?
Topics: Animals; Blotting, Western; Cytochrome P-450 Enzyme Inhibitors; Dexamethasone; Dicarbethoxydihydrocollidine; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme; Hemin; Holoenzymes; Liver; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic; Tryptophan Oxygenase | 2000 |
Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species.
Topics: Allylisopropylacetamide; Animals; Dicarbethoxydihydrocollidine; Disease Models, Animal; Female; Glucose; Heme; Lipid Peroxidation; Liver; Luminescent Measurements; Porphyria, Acute Intermittent; Rats; Rats, Wistar; Reactive Oxygen Species; Urine | 2005 |
Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice.
Topics: Animals; Blotting, Western; Dihydropyridines; Enzyme Induction; Heme; Heme Oxygenase-1; Iron; Liver; Male; Mice; Mice, Inbred C57BL; Selenium | 2007 |
Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers.
Topics: Antimalarials; Artemisinins; Catalase; Cell Death; Cell Line, Tumor; Cytotoxins; Dicarbethoxydihydrocollidine; Fluoresceins; Free Radical Scavengers; Glutathione Peroxidase; Heme; Humans; Leukemia; Reactive Oxygen Species; Superoxide Dismutase; Superoxides | 2010 |
Alterations of the redox state, pentose pathway and glutathione metabolism in an acute porphyria model. Their impact on heme pathway.
Topics: Allylisopropylacetamide; Animals; Disease Models, Animal; Glucose; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Heme; Liver; NADP; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway; Porphyria, Acute Intermittent; Pyridines; Rats; Reactive Oxygen Species | 2013 |
Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dicarbethoxydihydrocollidine; Female; Gene Knockdown Techniques; Gene Knockout Techniques; Heme; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Knockout; NF-E2-Related Factor 2 | 2019 |