dibutyryl-cyclic-gmp and mevalonolactone

dibutyryl-cyclic-gmp has been researched along with mevalonolactone* in 1 studies

Other Studies

1 other study(ies) available for dibutyryl-cyclic-gmp and mevalonolactone

Article	Year
Rapid modulation of rat hepatocyte HMG-CoA reductase activity by cyclic AMP or cyclic GMP. Physiological chemistry and physics and medical NMR, 1985, Volume: 17, Issue:1 Rat hepatocytes were used to demonstrate rapid, transient effects on the modulation state (defined as the fraction of the enzyme present in the catalytically active form) of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase, E.C. 1.1.1.34). Insulin elevated, while glucagon, cAMP or cGMP lowered HMG-CoA reductase modulation state within 10 to 15 min. These changes were accompanied by a parallel change in sterol synthesis. Total HMG-CoA reductase activity was not altered. Rapid modulation of HMG-CoA reductase activity therefore constitutes a viable in vivo control mechanism. By contrast to the hormones and second messengers, mevalonolactone lowered both HMG-CoA reductase modulation state and total reductase quantity. Topics: Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Glucagon; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Insulin; Kinetics; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains	1985

Article

Year

Rapid modulation of rat hepatocyte HMG-CoA reductase activity by cyclic AMP or cyclic GMP.

Physiological chemistry and physics and medical NMR, 1985, Volume: 17, Issue:1

Rat hepatocytes were used to demonstrate rapid, transient effects on the modulation state (defined as the fraction of the enzyme present in the catalytically active form) of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase, E.C. 1.1.1.34). Insulin elevated, while glucagon, cAMP or cGMP lowered HMG-CoA reductase modulation state within 10 to 15 min. These changes were accompanied by a parallel change in sterol synthesis. Total HMG-CoA reductase activity was not altered. Rapid modulation of HMG-CoA reductase activity therefore constitutes a viable in vivo control mechanism. By contrast to the hormones and second messengers, mevalonolactone lowered both HMG-CoA reductase modulation state and total reductase quantity.

Topics: Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Glucagon; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Insulin; Kinetics; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains

1985